This report generated on 2021-04-20
!gaf-version: 2.2
GAF lines are parsed according to GAF 2.1 specifications
generated-by: Reactomedate-generated: 2021-03-23No 'NOT' annotations to 'protein binding ; GO:0005515'
IEP and HEP usage is restricted to terms from the Biological Process ontology
IPI should not be used with GO:0003824 catalytic activity or descendents
No annotations should be made to uninformative high level terms
UniProtKB O00148 DX39A_HUMAN enables GO:0016887 PMID:20844015 EXP F protein taxon:9606 20210217 ReactomeUniProtKB O14980 XPO1_HUMAN enables GO:0005215 REACTOME:R-NUL-2169016 TAS F protein taxon:9606 20200515 ReactomeUniProtKB O60231 DHX16_HUMAN enables GO:0016887 PMID:20423332 EXP F protein taxon:9606 20210217 ReactomeUniProtKB O94955 RHBT3_HUMAN enables GO:0016887 REACTOME:R-HSA-6814670 TAS F protein taxon:9606 20210217 ReactomeUniProtKB O94955 RHBT3_HUMAN enables GO:0016887 REACTOME:R-HSA-9706399 TAS F protein taxon:9606 20210217 ReactomeUniProtKB P06821 M2_I34A1 enables GO:0005215 REACTOME:R-HSA-168313 TAS F protein taxon:11320 20200515 ReactomeUniProtKB P07900 HS90A_HUMAN enables GO:0016887 REACTOME:R-HSA-8939203 TAS F protein taxon:9606 20210217 ReactomeUniProtKB P08238 HS90B_HUMAN enables GO:0016887 REACTOME:R-HSA-8939203 TAS F protein taxon:9606 20210217 ReactomeUniProtKB P0DMV8 HS71A_HUMAN enables GO:0016887 REACTOME:R-HSA-3371422 TAS F protein taxon:9606 20210217 ReactomeUniProtKB P0DMV8 HS71A_HUMAN involved_in GO:0033554 REACTOME:R-HSA-2262752 TAS P protein taxon:9606 20210306 ReactomeUniProtKB P0DMV9 HS71B_HUMAN enables GO:0016887 REACTOME:R-HSA-3371422 TAS F protein taxon:9606 20210217 ReactomeUniProtKB P0DMV9 HS71B_HUMAN involved_in GO:0033554 REACTOME:R-HSA-2262752 TAS P protein taxon:9606 20210306 ReactomeUniProtKB P11142 HSP7C_HUMAN enables GO:0016887 REACTOME:R-HSA-3371422 TAS F protein taxon:9606 20210217 ReactomeUniProtKB P11142 HSP7C_HUMAN enables GO:0016887 REACTOME:R-HSA-8868658 TAS F protein taxon:9606 20210217 ReactomeUniProtKB P11142 HSP7C_HUMAN involved_in GO:0033554 REACTOME:R-HSA-2262752 TAS P protein taxon:9606 20210306 ReactomeUniProtKB P24941 CDK2_HUMAN involved_in GO:0000085 REACTOME:R-HSA-68911 TAS P protein taxon:9606 20210306 ReactomeUniProtKB P30291 WEE1_HUMAN involved_in GO:0000084 REACTOME:R-HSA-69242 TAS P protein taxon:9606 20210306 ReactomeUniProtKB P30304 MPIP1_HUMAN involved_in GO:0000084 REACTOME:R-HSA-69242 TAS P protein taxon:9606 20210306 ReactomeUniProtKB P38936 CDN1A_HUMAN involved_in GO:0000084 REACTOME:R-HSA-69242 TAS P protein taxon:9606 20210306 ReactomeUniProtKB P46459 NSF_HUMAN enables GO:0016887 REACTOME:R-HSA-416985 TAS F protein taxon:9606 20210217 ReactomeUniProtKB P46527 CDN1B_HUMAN involved_in GO:0000084 REACTOME:R-HSA-69242 TAS P protein taxon:9606 20210306 ReactomeUniProtKB P53350 PLK1_HUMAN involved_in GO:0000910 REACTOME:R-HSA-68884 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q12154 GET3_YEAST enables GO:0016887 REACTOME:R-SCE-9628646 TAS F protein taxon:4932 20210217 ReactomeUniProtKB Q13838 DX39B_HUMAN enables GO:0016887 PMID:20844015 EXP F protein taxon:9606 20210217 ReactomeUniProtKB Q14674 ESPL1_HUMAN involved_in GO:0000090 REACTOME:R-HSA-68882 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q56NI9 ESCO2_HUMAN involved_in GO:0000084 REACTOME:R-HSA-69242 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q5FWF5 ESCO1_HUMAN involved_in GO:0000084 REACTOME:R-HSA-69242 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q7Z449 CP2U1_HUMAN involved_in GO:0008152 REACTOME:R-HSA-211958 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q8BGG0 ZNT8_MOUSE enables GO:0005215 REACTOME:R-MMU-216806 TAS F protein taxon:10090 20200515 ReactomeUniProtKB Q8TAV3 CP2W1_HUMAN involved_in GO:0008152 REACTOME:R-HSA-211958 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q96GX5 GWL_HUMAN involved_in GO:0000088 REACTOME:R-HSA-68875 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q96SQ9 CP2S1_HUMAN involved_in GO:0008152 REACTOME:R-HSA-211958 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q9HB55 CP343_HUMAN involved_in GO:0008152 REACTOME:R-HSA-211958 TAS P protein taxon:9606 20210305 ReactomeUniProtKB Q9HBI6 CP4FB_HUMAN involved_in GO:0008152 REACTOME:R-HSA-211958 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q9UBN7 HDAC6_HUMAN involved_in GO:0033554 REACTOME:R-HSA-3371511 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q9UN37 VPS4A_HUMAN enables GO:0016887 REACTOME:R-HSA-9668415 TAS F protein taxon:9606 20210217 ReactomeND evidence code should be to root nodes only, and no terms other than root nodes can have the evidence code ND
Taxon-appropriate annotation check
Dual species taxon check
With/From: IC annotations require a With/From GO ID
IDA annotations must not have a With/From entry
IPI annotations require a With/From entry
Automatic repair of annotations to merged or obsoleted terms
UniProtKB P35813 PPM1A_HUMAN involved_in GO:0007050 REACTOME:R-HSA-380972 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q15382 RHEB_HUMAN involved_in GO:0007050 REACTOME:R-HSA-380972 TAS P protein taxon:9606 20210306 ReactomeUniProtKB Q15831 STK11_HUMAN involved_in GO:0007050 REACTOME:R-HSA-380972 TAS P protein taxon:9606 20210305 ReactomeAspect can only be one of C, P, F and should be repaired using the GO term
IEAs should be less than one year old.
Deprecated GO_REFs are not allowed
IBA annotations should ONLY be assigned_by GO_Central and have PMID:21873635 as a reference
Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants
Qualifier: IKR evidence code requires a NOT qualifier
Check for valid combination of evidence code and GO_REF
The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms.
Annotations to ISS, ISA and ISO should not be self-referential
References should have only one ID per ID space
Group specific filter rules should be applied to annotations
Object extensions should conform to the extensions-patterns.yaml file in metadata
Allowed gene product to term relations (gp2term)