Table of contents

Report

Group: goa - Dataset: goa_human_rna

SUMMARY

This report generated on 2021-09-22

Header From Original Association File

!gaf-version: 2.2
!
!Note that the annotation set in this file is filtered in order to reduce redundancy; the full, unfiltered set can be found in
!ftp://ftp.ebi.ac.uk/pub/databases/GO/goa/UNIPROT/goa_uniprot_all.gaf.gz
!
!date-generated: 2021-06-16 11:47
!generated-by: UniProt
!go-version: http://purl.obolibrary.org/obo/go/releases/2021-06-06/extensions/go-plus.owl
!

Contents

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MESSAGES

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No 'NOT' annotations to 'protein binding ; GO:0005515'

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IEP and HEP usage is restricted to terms from the Biological Process ontology

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IPI should not be used with GO:0003824 catalytic activity or descendents

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No annotations should be made to uninformative high level terms

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ND evidence code should be to root nodes only, and no terms other than root nodes can have the evidence code ND

Messages

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Taxon-appropriate annotation check

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Dual species taxon check

Messages

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With/From: IC annotations require a With/From GO ID

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IDA annotations must not have a With/From entry

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IPI annotations require a With/From entry

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Automatic repair of annotations to merged or obsoleted terms

Messages

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Aspect can only be one of C, P, F and should be repaired using the GO term

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IEAs should be less than one year old.

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Deprecated GO_REFs are not allowed

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IBA annotations should ONLY be assigned_by GO_Central and have PMID:21873635 as a reference

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Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants

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Qualifier: IKR evidence code requires a NOT qualifier

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Check for valid combination of evidence code and GO_REF

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The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms.

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Annotations to ISS, ISA and ISO should not be self-referential

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References should have only one ID per ID space

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Group specific filter rules should be applied to annotations

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Object extensions should conform to the extensions-patterns.yaml file in metadata

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Allowed gene product to term relations (gp2term)

Messages

other

Predictions

GO:0032699 negative regulation of interleukin-16 production FoldBasedPredictor GO:0035195 gene silencing by miRNA has_input UniProtKB:Q14005 part_of GO:0032699 negative regulation of interleukin-16 production occurs_in CL:0000235 macrophage IDA
GO:0030856 regulation of epithelial cell differentiation FoldBasedPredictor GO:0035195 gene silencing by miRNA regulates_expression_of UniProtKB:O15353 regulates GO:0030855 epithelial cell differentiation IDA
GO:0030336 negative regulation of cell migration FoldBasedPredictor GO:0035195 gene silencing by miRNA has_input UniProtKB:Q9ULV1 part_of GO:0030336 negative regulation of cell migration IDA
GO:0030336 negative regulation of cell migration FoldBasedPredictor GO:0035195 gene silencing by miRNA regulates_expression_of UniProtKB:P28799 negatively_regulates GO:0016477 cell migration IDA
GO:0035924 cellular response to vascular endothelial growth factor stimulus FoldBasedPredictor GO:1904753 negative regulation of vascular associated smooth muscle cell migration part_of GO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
GO:0071456 cellular response to hypoxia FoldBasedPredictor GO:1905205 positive regulation of connective tissue replacement occurs_in UBERON:0000948 heart part_of GO:0071456 cellular response to hypoxia ISS
GO:0044344 cellular response to fibroblast growth factor stimulus FoldBasedPredictor GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation results_in_division_of CL:0002591 smooth muscle cell of the pulmonary artery part_of GO:0044344 cellular response to fibroblast growth factor stimulus ISS
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process FoldBasedPredictor GO:0035195 gene silencing by miRNA regulates_expression_of UniProtKB:Q07817 positively_regulates GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IDA
GO:0071560 cellular response to transforming growth factor beta stimulus FoldBasedPredictor GO:0140050 negative regulation of endocardial cushion to mesenchymal transition part_of GO:0071560 cellular response to transforming growth factor beta stimulus ISS
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process FoldBasedPredictor GO:0045975 positive regulation of translation, ncRNA-mediated has_input UniProtKB:P05067 part_of GO:0042986 positive regulation of amyloid precursor protein biosynthetic process IDA
GO:1903783 negative regulation of sodium ion import across plasma membrane FoldBasedPredictor GO:1905151 negative regulation of voltage-gated sodium channel activity has_input UniProtKB:Q14524 occurs_in CL:2000046 ventricular cardiac muscle cell part_of GO:1903783 negative regulation of sodium ion import across plasma membrane IDA
GO:0032691 negative regulation of interleukin-1 beta production FoldBasedPredictor GO:0035195 gene silencing by miRNA occurs_in CL:0000214 synovial cell has_input UniProtKB:P01584 part_of GO:0032691 negative regulation of interleukin-1 beta production IDA
GO:0032700 negative regulation of interleukin-17 production FoldBasedPredictor GO:0035195 gene silencing by miRNA has_input UniProtKB:Q16552 part_of GO:0032700 negative regulation of interleukin-17 production IDA
GO:0032717 negative regulation of interleukin-8 production FoldBasedPredictor GO:0035195 gene silencing by miRNA part_of GO:0032717 negative regulation of interleukin-8 production causally_upstream_of GO:0032717 negative regulation of interleukin-8 production has_input ENSEMBL:ENSG00000169429 IDA
GO:0035924 cellular response to vascular endothelial growth factor stimulus FoldBasedPredictor GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis occurs_in CL:0002618 endothelial cell of umbilical vein part_of GO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
GO:0061042 vascular wound healing FoldBasedPredictor GO:1905205 positive regulation of connective tissue replacement part_of GO:0033554 cellular response to stress occurs_in UBERON:0000948 heart part_of GO:0061042 vascular wound healing ISS
GO:0033554 cellular response to stress FoldBasedPredictor GO:1905205 positive regulation of connective tissue replacement part_of GO:0033554 cellular response to stress occurs_in UBERON:0000948 heart part_of GO:0061042 vascular wound healing ISS
GO:0032711 negative regulation of interleukin-27 production FoldBasedPredictor GO:0035195 gene silencing by miRNA has_input UniProtKB:Q8NEV9 part_of GO:0032711 negative regulation of interleukin-27 production IDA
GO:1904881 cellular response to hydrogen sulfide FoldBasedPredictor GO:0043537 negative regulation of blood vessel endothelial cell migration part_of GO:1904881 cellular response to hydrogen sulfide IDA
GO:1903817 negative regulation of voltage-gated potassium channel activity FoldBasedPredictor GO:0035195 gene silencing by miRNA has_input UniProtKB:Q12809 part_of GO:1903817 negative regulation of voltage-gated potassium channel activity IDA
GO:1900408 negative regulation of cellular response to oxidative stress FoldBasedPredictor GO:2001243 negative regulation of intrinsic apoptotic signaling pathway part_of GO:1900408 negative regulation of cellular response to oxidative stress ISS
GO:0032717 negative regulation of interleukin-8 production FoldBasedPredictor GO:0035195 gene silencing by miRNA has_input UniProtKB:P10145 part_of GO:0032717 negative regulation of interleukin-8 production causally_upstream_of GO:0032717 negative regulation of interleukin-8 production IDA
GO:0061042 vascular wound healing FoldBasedPredictor GO:1905205 positive regulation of connective tissue replacement part_of GO:0033554 cellular response to stress occurs_in UBERON:0000948 heart part_of GO:0061042 vascular wound healing ISS
GO:0033554 cellular response to stress FoldBasedPredictor GO:1905205 positive regulation of connective tissue replacement part_of GO:0033554 cellular response to stress occurs_in UBERON:0000948 heart part_of GO:0061042 vascular wound healing ISS
GO:0071404 cellular response to low-density lipoprotein particle stimulus FoldBasedPredictor GO:0090370 negative regulation of cholesterol efflux occurs_in CL:0000235 macrophage part_of GO:0071404 cellular response to low-density lipoprotein particle stimulus IDA

Predictions (experimental)