Table of contents

Report

Group: goa - Dataset: goa_human_complex

SUMMARY

This report generated on 2020-03-30

Header From Original Association File

!gaf-version: 2.1
!
!Note that the annotation set in this file is filtered in order to reduce redundancy; the full, unfiltered set can be found in
!ftp://ftp.ebi.ac.uk/pub/databases/GO/goa/UNIPROT/goa_uniprot_all.gaf.gz
!
!Generated: 2020-02-24 22:20
!GO-version: http://purl.obolibrary.org/obo/go/releases/2020-02-20/extensions/go-plus.owl
!

Contents

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MESSAGES

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No 'NOT' annotations to 'protein binding ; GO:0005515'

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IEP and HEP usage is restricted to terms from the Biological Process ontology

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IPI should not be used with GO:0003824 catalytic activity or descendents

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No annotations should be made to uninformative high level terms

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ND evidence code should be to root nodes only, and no terms other than root nodes can have the evidence code ND

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Taxon-appropriate annotation check

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Dual species taxon check

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With/From: IC annotations require a With/From GO ID

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IDA annotations must not have a With/From entry

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IPI annotations require a With/From entry

Messages

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Automatic repair of annotations to merged or obsoleted terms

Messages

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Aspect can only be one of C, P, F and should be repaired using the GO term

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All IEAs over a year old are removed

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Deprecated GO_REFs are not allowed

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IBA annotations should ONLY be assigned_by GO_Central and have PMID:21873635 as a reference

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Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants

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Qualifier: IKR evidence code requires a NOT qualifier

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Check for valid combination of evidence code and GO_REF

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The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms.

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Annotations to ISS, ISA and ISO should not be self-referential

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Group specific filter rules should be applied to annotations

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Object extensions should conform to the extensions-patterns.yaml file in metadata

other

Predictions

GO:0010950 positive regulation of endopeptidase activity AnnotationPropagation P GO:0061133 endopeptidase activator activity IDA
GO:0006508 proteolysis AnnotationPropagation P GO:0008233 peptidase activity IDA
GO:0051726 regulation of cell cycle AnnotationPropagation P GO:0097472 cyclin-dependent protein kinase activity IDA
GO:0006468 protein phosphorylation AnnotationPropagation P GO:0097472 cyclin-dependent protein kinase activity IDA
GO:0043984 histone H4-K16 acetylation AnnotationPropagation P GO:0046972 histone acetyltransferase activity (H4-K16 specific) IDA
GO:0010466 negative regulation of peptidase activity AnnotationPropagation P GO:0030414 peptidase inhibitor activity IDA
GO:0006508 proteolysis AnnotationPropagation P GO:0008233 peptidase activity IDA
GO:0005739 mitochondrion AnnotationPropagation C GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
GO:0006479 protein methylation AnnotationPropagation P GO:0008276 protein methyltransferase activity IDA
GO:0010950 positive regulation of endopeptidase activity AnnotationPropagation P GO:0061133 endopeptidase activator activity IDA
GO:0051726 regulation of cell cycle AnnotationPropagation P GO:0097472 cyclin-dependent protein kinase activity IDA
GO:0006468 protein phosphorylation AnnotationPropagation P GO:0097472 cyclin-dependent protein kinase activity IDA
GO:0051170 import into nucleus AnnotationPropagation P GO:0061608 nuclear import signal receptor activity IDA
GO:0051726 regulation of cell cycle AnnotationPropagation P GO:0097472 cyclin-dependent protein kinase activity IDA
GO:0006468 protein phosphorylation AnnotationPropagation P GO:0097472 cyclin-dependent protein kinase activity IDA
GO:0006915 apoptotic process AnnotationPropagation P GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process AnnotationPropagation P GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA
GO:0010950 positive regulation of endopeptidase activity AnnotationPropagation P GO:0061133 endopeptidase activator activity IDA
GO:0016925 protein sumoylation AnnotationPropagation P GO:0061665 SUMO ligase activity IDA
GO:0051170 import into nucleus AnnotationPropagation P GO:0061608 nuclear import signal receptor activity IDA
GO:0051726 regulation of cell cycle AnnotationPropagation P GO:0097472 cyclin-dependent protein kinase activity IDA
GO:0006468 protein phosphorylation AnnotationPropagation P GO:0097472 cyclin-dependent protein kinase activity IDA
GO:0010950 positive regulation of endopeptidase activity AnnotationPropagation P GO:0061133 endopeptidase activator activity IDA
GO:0006508 proteolysis AnnotationPropagation P GO:0004198 calcium-dependent cysteine-type endopeptidase activity IDA
GO:0006259 DNA metabolic process AnnotationPropagation P GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity IMP
GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity IMP
GO:0016311 dephosphorylation AnnotationPropagation P GO:0016791 phosphatase activity IDA
GO:0000122 negative regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
GO:0016925 protein sumoylation AnnotationPropagation P GO:0061665 SUMO ligase activity IDA
GO:1904356 regulation of telomere maintenance via telomere lengthening FoldBasedPredictor GO:0098505 G-rich strand telomeric DNA binding part_of GO:0051974 negative regulation of telomerase activity part_of GO:1904356 regulation of telomere maintenance via telomere lengthening IDA
GO:0051974 negative regulation of telomerase activity FoldBasedPredictor GO:0098505 G-rich strand telomeric DNA binding part_of GO:0051974 negative regulation of telomerase activity part_of GO:1904356 regulation of telomere maintenance via telomere lengthening IDA
GO:0033554 cellular response to stress FoldBasedPredictor GO:2000363 positive regulation of prostaglandin-E synthase activity has_output CHEBI:15551 prostaglandin E2 occurs_in CL:0000540 neuron occurs_in UBERON:0001891 midbrain part_of GO:0033554 cellular response to stress regulates_o_occurs_in CL:0000243 glial cell (sensu Vertebrata) ISS
GO:1905581 positive regulation of low-density lipoprotein particle clearance FoldBasedPredictor GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport has_input GO:0034362 low-density lipoprotein particle part_of GO:0001921 positive regulation of receptor recycling part_of GO:0032385 positive regulation of intracellular cholesterol transport part_of GO:1905581 positive regulation of low-density lipoprotein particle clearance part_of GO:1905597 positive regulation of low-density lipoprotein particle receptor binding part_of GO:1905599 positive regulation of low-density lipoprotein receptor activity part_of GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
GO:1905599 positive regulation of low-density lipoprotein receptor activity FoldBasedPredictor GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport has_input GO:0034362 low-density lipoprotein particle part_of GO:0001921 positive regulation of receptor recycling part_of GO:0032385 positive regulation of intracellular cholesterol transport part_of GO:1905581 positive regulation of low-density lipoprotein particle clearance part_of GO:1905597 positive regulation of low-density lipoprotein particle receptor binding part_of GO:1905599 positive regulation of low-density lipoprotein receptor activity part_of GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
GO:1905597 positive regulation of low-density lipoprotein particle receptor binding FoldBasedPredictor GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport has_input GO:0034362 low-density lipoprotein particle part_of GO:0001921 positive regulation of receptor recycling part_of GO:0032385 positive regulation of intracellular cholesterol transport part_of GO:1905581 positive regulation of low-density lipoprotein particle clearance part_of GO:1905597 positive regulation of low-density lipoprotein particle receptor binding part_of GO:1905599 positive regulation of low-density lipoprotein receptor activity part_of GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
GO:0001921 positive regulation of receptor recycling FoldBasedPredictor GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport has_input GO:0034362 low-density lipoprotein particle part_of GO:0001921 positive regulation of receptor recycling part_of GO:0032385 positive regulation of intracellular cholesterol transport part_of GO:1905581 positive regulation of low-density lipoprotein particle clearance part_of GO:1905597 positive regulation of low-density lipoprotein particle receptor binding part_of GO:1905599 positive regulation of low-density lipoprotein receptor activity part_of GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
GO:0007596 blood coagulation FoldBasedPredictor GO:0016485 protein processing has_input UniProtKB:P00742 occurs_in CL:0002618 endothelial cell of umbilical vein part_of GO:0007596 blood coagulation IDA
GO:0006303 double-strand break repair via nonhomologous end joining FoldBasedPredictor GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity occurs_at GO:0000784 nuclear chromosome, telomeric region part_of GO:0006303 double-strand break repair via nonhomologous end joining IMP

Predictions (experimental)