This report generated on 2024-05-05
!gaf-version: 2.2
!
!The set of protein accessions included in this file is based on UniProt complete proteomes, which may provide more than one protein per gene.
!They include all Swiss-Prot entries for the species plus any TrEMBL entries that have an Ensembl DR line. The TrEMBL entries are likely to overlap with the Swiss-Prot entries or their isoforms.
!If a particular protein accession is not annotated with GO, then it will not appear in this file.
!
!Note that the annotation set in this file is filtered in order to reduce redundancy; the full, unfiltered set can be found in
!ftp://ftp.ebi.ac.uk/pub/databases/GO/goa/UNIPROT/goa_uniprot_all.gaf.gz
!
!date-generated: 2024-04-16 15:08
!generated-by: UniProt
!go-version: http://purl.obolibrary.org/obo/go/releases/2024-04-13/extensions/go-plus.owl
!
No 'NOT' annotations to binding ; GO:0005488 or 'protein binding ; GO:0005515'
IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to to 'protein binding ; GO:0005515 or GO:0005488 binding''
IEP and HEP usage is restricted to terms from the Biological Process ontology, except when assigned by GOC
IPI should not be used with GO:0003824 catalytic activity or descendents
No annotations should be made to uninformative high level terms
UniProtKB A0A1D5PCZ1 PRKCB involved_in GO:0018105 PMID:18086859 IMP P Protein kinase C PRKCB protein taxon:9031 20170306 AgBase has_input(UniProtKB:Q5F3W0) UniProtKB:A0A1D5PCZ1UniProtKB A0A1D5PFN2 PALM located_in GO:0005622 PMID:9813098 IDA C Paralemmin-1 PALM protein taxon:9031 20170202 AgBase part_of(UBERON:0000955) UniProtKB:A0A1D5PFN2UniProtKB A0A8V0X793 LOC101749641 involved_in GO:0010033 GO_REF:0000117 IEA ARBA:ARBA00028345 P Fibronectin type-III domain-containing protein LOC101749641 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0X793UniProtKB A0A8V0XI66 PPP1R14C involved_in GO:0042325 GO_REF:0000002 IEA InterPro:IPR008025|InterPro:IPR036658 P Protein phosphatase 1 regulatory inhibitor subunit 14C PPP1R14C protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XI66UniProtKB A0A8V0XMI7 DYNC2H1 involved_in GO:0006996 GO_REF:0000117 IEA ARBA:ARBA00026401 P Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0XMI7UniProtKB A0A8V0XMJ5 DYNC2H1 involved_in GO:0006996 GO_REF:0000117 IEA ARBA:ARBA00026401 P Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0XMJ5UniProtKB A0A8V0XPN8 PPP1R14C involved_in GO:0042325 GO_REF:0000002 IEA InterPro:IPR008025|InterPro:IPR036658 P PP14C phosphatase PPP1R14C protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XPN8UniProtKB A0A8V0XQA0 DYNC2H1 involved_in GO:0006996 GO_REF:0000117 IEA ARBA:ARBA00026401 P Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0XQA0UniProtKB A0A8V0Y7E7 ST3GAL1 involved_in GO:0043603 GO_REF:0000117 IEA ARBA:ARBA00028833 P CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 ST3GAL1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0Y7E7UniProtKB A0A8V0YR15 MUL1L involved_in GO:0006996 GO_REF:0000002 IEA InterPro:IPR022170 P RING-type E3 ubiquitin transferase MUL1L protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YR15UniProtKB A0A8V0YVK2 SYNE2 involved_in GO:0051641 GO_REF:0000117 IEA ARBA:ARBA00028684 P Nesprin-2 SYNE2 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0YVK2UniProtKB A0A8V0YX88 SLX4 involved_in GO:0006996 GO_REF:0000117 IEA ARBA:ARBA00026401 P Structure-specific endonuclease subunit SLX4 SLX4 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0YX88UniProtKB A0A8V0Z0V1 USP8 involved_in GO:0019538 GO_REF:0000117 IEA ARBA:ARBA00028758 P ubiquitinyl hydrolase 1 USP8 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0Z0V1UniProtKB A0A8V0Z202 SYNE2 involved_in GO:0051641 GO_REF:0000117 IEA ARBA:ARBA00028684 P Nesprin-2 SYNE2 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0Z202UniProtKB A0A8V0Z7U9 USP8 involved_in GO:0019538 GO_REF:0000117 IEA ARBA:ARBA00028758 P ubiquitinyl hydrolase 1 USP8 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0Z7U9UniProtKB A0A8V0ZEY4 GBF1 involved_in GO:0051641 GO_REF:0000117 IEA ARBA:ARBA00028684 P SEC7 domain-containing protein GBF1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZEY4UniProtKB A0A8V0ZG97 IFT122 involved_in GO:0051641 GO_REF:0000117 IEA ARBA:ARBA00028684 P Intraflagellar transport protein 122 homolog IFT122 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZG97UniProtKB A0A8V0ZMA9 GBF1 involved_in GO:0051641 GO_REF:0000117 IEA ARBA:ARBA00028684 P SEC7 domain-containing protein GBF1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZMA9UniProtKB A0A8V0ZMC5 GBF1 involved_in GO:0051641 GO_REF:0000117 IEA ARBA:ARBA00028684 P SEC7 domain-containing protein GBF1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZMC5UniProtKB A0A8V0ZMC8 GBF1 involved_in GO:0051641 GO_REF:0000117 IEA ARBA:ARBA00028684 P SEC7 domain-containing protein GBF1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZMC8UniProtKB A0A8V0ZTS8 KIF18B involved_in GO:0006996 GO_REF:0000117 IEA ARBA:ARBA00026401 P Kinesin-like protein KIF18B protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZTS8UniProtKB A0A8V0ZU44 ST3GAL2 involved_in GO:0043603 GO_REF:0000117 IEA ARBA:ARBA00028833 P beta-galactoside alpha-2,3-sialyltransferase ST3GAL2 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZU44UniProtKB A0A8V0ZUT2 PPP1R14D involved_in GO:0042325 GO_REF:0000002 IEA InterPro:IPR008025|InterPro:IPR036658 P Protein phosphatase 1 regulatory subunit 14D PPP1R14D protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZUT2UniProtKB A0A8V0ZV90 METTL16 involved_in GO:0006725 GO_REF:0000117 IEA ARBA:ARBA00027872 P U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase METTL16 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZV90UniProtKB A0A8V1A2N7 METTL16 involved_in GO:0006725 GO_REF:0000117 IEA ARBA:ARBA00027872 P U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase METTL16 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V1A2N7UniProtKB A0A8V1A658 PRKAA2 involved_in GO:0031331 GO_REF:0000117 IEA ARBA:ARBA00028063 P 5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V1A658UniProtKB A2IAR9 CDK2 involved_in GO:0006468 GO_REF:0000024 ISS UniProtKB:P97377 P Cyclin-dependent kinase 2 CDK2 protein taxon:9031 20071004 AgBase UniProtKB:A2IAR9UniProtKB A2IAR9 CDK2 involved_in GO:0010033 GO_REF:0000033 IBA MGI:MGI:1277162|MGI:MGI:88357|PANTHER:PTN000623979|RGD:621120|RGD:70486|TAIR:locus:2011761|TAIR:locus:2037410 P Cyclin-dependent kinase 2 CDK2 protein taxon:9031 20230603 GO_Central UniProtKB:A2IAR9UniProtKB F1P495 IL21R involved_in GO:0010033 GO_REF:0000117 IEA ARBA:ARBA00028345 P Interleukin-21 receptor IL21R protein taxon:9031 20240408 UniProt UniProtKB:F1P495UniProtKB O73933 ID2 involved_in GO:0043392 PMID:19247943 NAS P BHLH domain-containing protein ID2 protein taxon:9031 20130308 AgBase UniProtKB:O73933UniProtKB O93345 Lef-1 enables GO:0008134 PMID:15642085 ISS UniProtKB:P27782 F HMG box domain-containing protein Lef-1|LEF-1|LEF1 protein taxon:9031 20130311 AgBase UniProtKB:O93345UniProtKB Q8QFX0 ADAM10 involved_in GO:0006468 GO_REF:0000024 ISS UniProtKB:O35598 P Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 protein taxon:9031 20041006 UniProt UniProtKB:Q8QFX0UniProtKB Q8QGU2 FKBP12.6 involved_in GO:0000413 PMID:12508222 ISA UniProtKB:P68106 P peptidylprolyl isomerase FKBP12.6|FKBP1B protein taxon:9031 20130311 AgBase UniProtKB:Q8QGU2UniProtKB Q8QGU2 FKBP12.6 involved_in GO:0000413 PMID:12508222 ISA UniProtKB:Q9Z2I2 P peptidylprolyl isomerase FKBP12.6|FKBP1B protein taxon:9031 20141103 AgBase UniProtKB:Q8QGU2UniProtKB Q8QGU2 FKBP12.6 involved_in GO:0010033 PMID:12508222 ISA UniProtKB:P97534 P peptidylprolyl isomerase FKBP12.6|FKBP1B protein taxon:9031 20090204 AgBase UniProtKB:Q8QGU2UniProtKB Q8QGU2 FKBP12.6 involved_in GO:0032515 PMID:12508222 ISA UniProtKB:P68106 P peptidylprolyl isomerase FKBP12.6|FKBP1B protein taxon:9031 20090130 AgBase UniProtKB:Q8QGU2UniProtKB Q8QGU2 FKBP12.6 involved_in GO:0060314 PMID:12508222 ISA UniProtKB:P68106 P peptidylprolyl isomerase FKBP12.6|FKBP1B protein taxon:9031 20090130 AgBase UniProtKB:Q8QGU2UniProtKB Q8QGU2 FKBP12.6 involved_in GO:0060314 PMID:12508222 ISA UniProtKB:Q9Z2I2 P peptidylprolyl isomerase FKBP12.6|FKBP1B protein taxon:9031 20130311 AgBase UniProtKB:Q8QGU2UniProtKB Q8QGU2 FKBP12.6 involved_in GO:0060314 PMID:9857007 IMP P peptidylprolyl isomerase FKBP12.6|FKBP1B protein taxon:9031 20090311 AgBase UniProtKB:Q8QGU2UniProtKB Q8QGU2 FKBP12.6 involved_in GO:0060315 PMID:12508222 ISA UniProtKB:P68106 P peptidylprolyl isomerase FKBP12.6|FKBP1B protein taxon:9031 20130311 AgBase UniProtKB:Q8QGU2UniProtKB Q90874 IL-1 receptor I involved_in GO:0051000 PMID:12543127 IDA P IL-1 receptor I IL-1 receptor I|IL1R1 protein taxon:9031 20090715 AgBase UniProtKB:Q90874UniProtKB Q90W82 HELIOS involved_in GO:0006468 PMID:20602434 IMP P C2H2-type domain-containing protein HELIOS|IKZF2 protein taxon:9031 20120130 AgBase UniProtKB:Q90W82UniProtKB Q91035 SHH involved_in GO:0010694 PMID:9268735 IDA P Sonic hedgehog protein SHH protein taxon:9031 20150522 AgBase UniProtKB:Q91035-PRO_0000013218UniProtKB Q9YGL6 PALM located_in GO:0005622 PMID:9813098 IDA C Paralemmin-1 PALM protein taxon:9031 20170202 AgBase part_of(UBERON:0000955) UniProtKB:Q9YGL6-2UniProtKB Q9YGL6 PALM located_in GO:0005622 PMID:9813098 IDA C Paralemmin-1 PALM protein taxon:9031 20170202 AgBase part_of(UBERON:0000955) UniProtKB:Q9YGL6-3UniProtKB R4GKC8 PDLIM7 enables GO:0008134 PMID:15302601 IPI UniProtKB:O93288 F PDZ and LIM domain protein 7 PDLIM7 protein taxon:9031 20150408 AgBase UniProtKB:R4GKC8UniProtKB R4GKC8 PDLIM7 enables GO:0008134 PMID:15302601 IPI UniProtKB:Q9PWE8 F PDZ and LIM domain protein 7 PDLIM7 protein taxon:9031 20150408 AgBase UniProtKB:R4GKC8UniProtKB R4GKC8 PDLIM7 involved_in GO:0043433 PMID:16880269 IDA P PDZ and LIM domain protein 7 PDLIM7 protein taxon:9031 20151214 AgBase UniProtKB:R4GKC8UniProtKB R4GKC8 PDLIM7 involved_in GO:0043433 PMID:18160705 IDA P PDZ and LIM domain protein 7 PDLIM7 protein taxon:9031 20151215 AgBase UniProtKB:R4GKC8ND evidence code should be to root nodes only, and no terms other than root nodes can have the evidence code ND
Taxon-appropriate annotation check
UniProtKB A0A1L1RPJ2 MAP2K1 located_in GO:0005816 GO_REF:0000044 IEA UniProtKB-SubCell:SL-0252 C Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 protein taxon:9031 20240408 UniProt UniProtKB:A0A1L1RPJ2UniProtKB A0A8V0Z459 MAP2K1 located_in GO:0005816 GO_REF:0000044 IEA UniProtKB-SubCell:SL-0252 C Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0Z459UniProtKB A0A8V0Z5P3 MAP2K1 located_in GO:0005816 GO_REF:0000044 IEA UniProtKB-SubCell:SL-0252 C Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0Z5P3UniProtKB A0A8V0Z5Q1 MAP2K1 located_in GO:0005816 GO_REF:0000044 IEA UniProtKB-SubCell:SL-0252 C Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0Z5Q1UniProtKB A0A8V0ZRU1 KLHL6 involved_in GO:0002467 GO_REF:0000002 IEA InterPro:IPR029851 P BTB domain-containing protein KLHL6 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZRU1UniProtKB A0A8V0ZTT0 DPH5 enables GO:0004164 GO_REF:0000002 IEA InterPro:IPR004551 F diphthine methyl ester synthase DPH5 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZTT0UniProtKB A0A8V0ZVU1 DPH5 enables GO:0004164 GO_REF:0000002 IEA InterPro:IPR004551 F diphthine methyl ester synthase DPH5 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZVU1UniProtKB A0A8V1A1A9 DPH5 enables GO:0004164 GO_REF:0000002 IEA InterPro:IPR004551 F diphthine methyl ester synthase DPH5 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1A1A9UniProtKB E1BT91 EMX2 involved_in GO:0021542 GO_REF:0000107 IEA UniProtKB:Q04744|ensembl:ENSMUSP00000053361 P Empty spiracles homeobox 2 EMX2 protein taxon:9031 20240129 Ensembl UniProtKB:E1BT91UniProtKB F1NTC8 PDLIM5 is_active_in GO:0044305 PMID:19636345 IDA C PDZ and LIM domain 5 PDLIM5 protein taxon:9031 20240306 SynGO UniProtKB:F1NTC8UniProtKB F1P3E0 KLHL6 involved_in GO:0002467 GO_REF:0000002 IEA InterPro:IPR029851 P Kelch like family member 6 KLHL6 protein taxon:9031 20240408 InterPro UniProtKB:F1P3E0UniProtKB G4U4M4 CXCR5 involved_in GO:0048535 GO_REF:0000002 IEA InterPro:IPR001053 P G-protein coupled receptors family 1 profile domain-containing protein CXCR5 protein taxon:9031 20240408 InterPro UniProtKB:G4U4M4UniProtKB O93345 Lef-1 involved_in GO:0021542 PMID:15642085 ISS UniProtKB:P27782 P HMG box domain-containing protein Lef-1|LEF-1|LEF1 protein taxon:9031 20130311 AgBase UniProtKB:O93345UniProtKB O93345 Lef-1 involved_in GO:0021766 GO_REF:0000024 ISS UniProtKB:P27782 P HMG box domain-containing protein Lef-1|LEF-1|LEF1 protein taxon:9031 20100127 AgBase UniProtKB:O93345UniProtKB O93345 Lef-1 involved_in GO:0021766 PMID:15642085 ISS UniProtKB:P27782 P HMG box domain-containing protein Lef-1|LEF-1|LEF1 protein taxon:9031 20130311 AgBase UniProtKB:O93345UniProtKB R4GLC9 TCF21 involved_in GO:0048286 GO_REF:0000024 ISS UniProtKB:O35437 P Transcription factor 21 TCF21 protein taxon:9031 20170216 UniProt UniProtKB:R4GLC9Dual species taxon check
With/From: IC annotations require a With/From GO ID
IDA annotations must not have a With/From entry
IPI annotations require a With/From entry
Automatic repair of annotations to merged or obsoleted terms
UniProtKB A0A8V0ZE48 TET3 involved_in GO:0080111 GO_REF:0000104 IEA UniRule:UR001350777 P Methylcytosine dioxygenase TET TET3 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZE48UniProtKB A0A8V0ZFA1 TET3 involved_in GO:0080111 GO_REF:0000104 IEA UniRule:UR001350777 P Methylcytosine dioxygenase TET TET3 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZFA1UniProtKB A0A8V0ZFI7 TET3 involved_in GO:0080111 GO_REF:0000104 IEA UniRule:UR001350777 P Methylcytosine dioxygenase TET TET3 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZFI7UniProtKB A0A8V0ZL48 TET1 involved_in GO:0080111 GO_REF:0000104 IEA UniRule:UR001350777 P Methylcytosine dioxygenase TET TET1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZL48UniProtKB A0A8V0ZLK1 TET3 involved_in GO:0080111 GO_REF:0000104 IEA UniRule:UR001350777 P Methylcytosine dioxygenase TET TET3 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZLK1UniProtKB A0A8V0ZLL9 TET3 involved_in GO:0080111 GO_REF:0000104 IEA UniRule:UR001350777 P Methylcytosine dioxygenase TET TET3 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZLL9UniProtKB A0A8V0ZTC7 TET1 involved_in GO:0080111 GO_REF:0000104 IEA UniRule:UR001350777 P Methylcytosine dioxygenase TET TET1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZTC7UniProtKB A0A8V0ZTD8 TET1 involved_in GO:0080111 GO_REF:0000104 IEA UniRule:UR001350777 P Methylcytosine dioxygenase TET TET1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZTD8UniProtKB A0A8V0ZTE3 TET1 involved_in GO:0080111 GO_REF:0000104 IEA UniRule:UR001350777 P Methylcytosine dioxygenase TET TET1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZTE3UniProtKB A0A8V0ZV90 METTL16 involved_in GO:0006725 GO_REF:0000117 IEA ARBA:ARBA00027872 P U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase METTL16 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZV90UniProtKB A0A8V1A2N7 METTL16 involved_in GO:0006725 GO_REF:0000117 IEA ARBA:ARBA00027872 P U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase METTL16 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V1A2N7UniProtKB A0A140T8H0 MOCS2 part_of GO:0019008 GO_REF:0000104 IEA UniRule:UR000160817 C Molybdopterin synthase catalytic subunit MOCS2 protein taxon:9031 20240408 UniProt UniProtKB:A0A140T8H0UniProtKB A0A8V0YMJ5 EPHX1 involved_in GO:0019439 GO_REF:0000104 IEA UniRule:UR000396796 P Epoxide hydrolase EPHX1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0YMJ5UniProtKB A0A8V0YU01 EPHX1 involved_in GO:0019439 GO_REF:0000104 IEA UniRule:UR000396796 P Epoxide hydrolase EPHX1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0YU01UniProtKB A0A8V0YUC8 EPHX1 involved_in GO:0019439 GO_REF:0000104 IEA UniRule:UR000396796 P Epoxide hydrolase EPHX1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0YUC8UniProtKB A0A8V0YVX8 EPHX1 involved_in GO:0019439 GO_REF:0000104 IEA UniRule:UR000396796 P Epoxide hydrolase EPHX1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0YVX8UniProtKB A0A8V0Z0Q3 EPHX1 involved_in GO:0019439 GO_REF:0000043 IEA UniProtKB-KW:KW-0058 P microsomal epoxide hydrolase EPHX1 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0Z0Q3UniProtKB A0A8V0ZAR3 EPHX1L involved_in GO:0019439 GO_REF:0000104 IEA UniRule:UR000396796 P Epoxide hydrolase EPHX1L protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0ZAR3GO aspect should match the term's namespace; otherwise it is repaired to the appropriate aspect
IEAs should be less than one year old.
Obsolete GO_REFs are not allowed
IBA annotations should ONLY be assigned_by GO_Central and have GO_REF:0000033 as a reference
Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants
Qualifier: IKR evidence code requires a NOT qualifier
Check for valid combination of evidence code and GO_REF
The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.
UniProtKB A0A1D5P8P4 KCND3 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium voltage-gated channel subfamily D member 3 KCND3 protein taxon:9031 20240408 InterPro UniProtKB:A0A1D5P8P4UniProtKB A0A1D5P9P3 ACTN1 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P12814|ensembl:ENSP00000377941 F Alpha-actinin-1 ACTN1 protein taxon:9031 20240129 Ensembl UniProtKB:A0A1D5P9P3UniProtKB A0A1D5P9P3 ACTN1 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:Q7TPR4|ensembl:ENSMUSP00000021554 F Alpha-actinin-1 ACTN1 protein taxon:9031 20240129 Ensembl UniProtKB:A0A1D5P9P3UniProtKB A0A1D5PA94 KCNV1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium voltage-gated channel subfamily V member 1 KCNV1 protein taxon:9031 20240408 InterPro UniProtKB:A0A1D5PA94UniProtKB A0A1D5PN64 LOC107055327 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein LOC107055327 protein taxon:9031 20240408 InterPro UniProtKB:A0A1D5PN64UniProtKB A0A1D5PVF0 SIGMAR1 involved_in GO:0070207 GO_REF:0000107 IEA UniProtKB:Q99720|ensembl:ENSP00000277010 P Sigma non-opioid intracellular receptor 1 SIGMAR1 protein taxon:9031 20240129 Ensembl UniProtKB:A0A1D5PVF0UniProtKB A0A3Q2TX12 GPD1L2 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR017751 F Glycerol-3-phosphate dehydrogenase [NAD(+)] GPD1L2 protein taxon:9031 20240408 InterPro UniProtKB:A0A3Q2TX12UniProtKB A0A3Q2UJ47 KCNC2 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium voltage-gated channel subfamily C member 2 KCNC2 protein taxon:9031 20240408 InterPro UniProtKB:A0A3Q2UJ47UniProtKB A0A8V0X548 GPD1L enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR017751 F Glycerol-3-phosphate dehydrogenase [NAD(+)] GPD1L protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0X548UniProtKB A0A8V0XB26 KCND2 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium voltage-gated channel subfamily D member 2 KCND2 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XB26UniProtKB A0A8V0XBH4 TERF1 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR013867 F Telomeric repeat-binding factor TERF1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XBH4UniProtKB A0A8V0XBH9 TERF1 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR013867 F Telomeric repeat-binding factor TERF1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XBH9UniProtKB A0A8V0XFI5 GPD1L enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR017751 F Glycerol-3-phosphate dehydrogenase [NAD(+)] GPD1L protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XFI5UniProtKB A0A8V0XH70 TERF1 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR013867 F Telomeric repeat-binding factor TERF1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XH70UniProtKB A0A8V0XI88 TERF1 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR013867 F Telomeric repeat-binding factor TERF1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XI88UniProtKB A0A8V0XMA0 KCTD1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XMA0UniProtKB A0A8V0XVN7 KCTD15 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD15 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0XVN7UniProtKB A0A8V0Y1K7 TERF2 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR013867 F Telomeric repeat-binding factor 2 TERF2 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0Y1K7UniProtKB A0A8V0Y4C7 KCTD15 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium channel tetramerisation-type BTB domain-containing protein KCTD15 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0Y4C7UniProtKB A0A8V0YCC9 USP16 involved_in GO:0051289 GO_REF:0000104 IEA UniRule:UR000160894 P Ubiquitin carboxyl-terminal hydrolase 16 USP16 protein taxon:9031 20240408 UniProt UniProtKB:A0A8V0YCC9UniProtKB A0A8V0YCG1 GRPEL2 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR000740 F GrpE protein homolog GRPEL2 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YCG1UniProtKB A0A8V0YI74 KCTD17 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium channel tetramerisation-type BTB domain-containing protein KCTD17 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YI74UniProtKB A0A8V0YPJ9 KCTD17 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD17 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YPJ9UniProtKB A0A8V0YPK0 KCTD17 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD17 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YPK0UniProtKB A0A8V0YPL2 KCTD17 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD17 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YPL2UniProtKB A0A8V0YPY9 EVL involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR017354 P Ena/VASP-like protein EVL protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YPY9UniProtKB A0A8V0YRB8 KCTD17 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD17 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YRB8UniProtKB A0A8V0YRC8 KCTD17 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD17 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YRC8UniProtKB A0A8V0YWB3 EVL involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR017354 P Ena/VASP-like protein EVL protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YWB3UniProtKB A0A8V0YWR5 EVL involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR017354 P Ena/VASP-like protein EVL protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YWR5UniProtKB A0A8V0YY94 EVL involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR017354 P Ena/VASP-like protein EVL protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YY94UniProtKB A0A8V0YY99 EVL involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR017354 P Ena/VASP-like protein EVL protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0YY99UniProtKB A0A8V0Z506 PRNP involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR000817|InterPro:IPR022416|InterPro:IPR036924 P Prion/Doppel protein beta-ribbon domain-containing protein PRNP protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0Z506UniProtKB A0A8V0Z993 KCTD9 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P KHA domain-containing protein KCTD9 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0Z993UniProtKB A0A8V0ZK54 KCNS1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium voltage-gated channel subfamily S member 1 KCNS1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZK54UniProtKB A0A8V0ZKM1 KCTD10 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD10 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZKM1UniProtKB A0A8V0ZKT0 KCTD5 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD5 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZKT0UniProtKB A0A8V0ZKT9 KCTD5 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD5 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZKT9UniProtKB A0A8V0ZKU4 KCTD5 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD5 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZKU4UniProtKB A0A8V0ZKY7 GPD1L2 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR017751 F Glycerol-3-phosphate dehydrogenase [NAD(+)] GPD1L2 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZKY7UniProtKB A0A8V0ZLG1 GPD1 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR017751 F Glycerol-3-phosphate dehydrogenase [NAD(+)] GPD1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZLG1UniProtKB A0A8V0ZRE2 DGKD enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR037606 F Diacylglycerol kinase DGKD protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZRE2UniProtKB A0A8V0ZRE3 KCTD18 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P KCD18 protein KCTD18 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZRE3UniProtKB A0A8V0ZS35 KCNA6 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNA6 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZS35UniProtKB A0A8V0ZX45 JAM3 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR042974 F Ig-like domain-containing protein JAM3 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZX45UniProtKB A0A8V0ZX91 KCNA6 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNA6 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZX91UniProtKB A0A8V0ZXL4 A0A8V0ZXL4 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium channel tetramerisation-type BTB domain-containing protein protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZXL4UniProtKB A0A8V0ZYV0 DGKD enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR037606 F Diacylglycerol kinase DGKD protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZYV0UniProtKB A0A8V0ZYX2 DGKD enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR037606 F Diacylglycerol kinase DGKD protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZYX2UniProtKB A0A8V0ZZJ4 KCNC1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V0ZZJ4UniProtKB A0A8V1A1E6 KCNC1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1A1E6UniProtKB A0A8V1A1F1 KCNC1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1A1F1UniProtKB A0A8V1A2D2 JAM3 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR042974 F Ig-like domain-containing protein JAM3 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1A2D2UniProtKB A0A8V1A4N9 JAM3 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR042974 F Ig-like domain-containing protein JAM3 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1A4N9UniProtKB A0A8V1A4R7 KCNA6 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNA6 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1A4R7UniProtKB A0A8V1A4X2 KCNC1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1A4X2UniProtKB A0A8V1A9T6 JAM3 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR042974 F Ig-like domain-containing protein JAM3 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1A9T6UniProtKB A0A8V1A9U2 JAM3 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR042974 F Ig-like domain-containing protein JAM3 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1A9U2UniProtKB A0A8V1AAZ1 KCND3 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCND3 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1AAZ1UniProtKB A0A8V1AFL3 CRTC1 involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR024783 P CREB-regulated transcription coactivator 1 CRTC1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1AFL3UniProtKB A0A8V1AJS1 CRTC1 involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR024783 P CREB-regulated transcription coactivator 1 CRTC1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1AJS1UniProtKB A0A8V1AKU9 TNFAIP1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 TNFAIP1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1AKU9UniProtKB A0A8V1AMQ4 TNFAIP1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 TNFAIP1 protein taxon:9031 20240408 InterPro UniProtKB:A0A8V1AMQ4UniProtKB E1BVH8 KCTD15 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium channel tetramerization domain containing 15 KCTD15 protein taxon:9031 20240408 InterPro UniProtKB:E1BVH8UniProtKB E1C3U8 KCNC4 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium voltage-gated channel subfamily C member 4 KCNC4 protein taxon:9031 20240408 InterPro UniProtKB:E1C3U8UniProtKB E1C6X5 CRTC1 involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR024783 P CREB regulated transcription coactivator 1 CRTC1 protein taxon:9031 20240408 InterPro UniProtKB:E1C6X5UniProtKB F7ATV4 KCTD2 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium channel tetramerization domain containing 2 KCTD2 protein taxon:9031 20240408 InterPro UniProtKB:F7ATV4UniProtKB K4HVD3 KCTD15 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD15 protein taxon:9031 20240408 InterPro UniProtKB:K4HVD3UniProtKB P05094 ACTN1 enables GO:0042803 PMID:8037676 IDA F Alpha-actinin-1 ACTN1 protein taxon:9031 20150407 AgBase UniProtKB:P05094-2UniProtKB Q5ZHP4 TPD52 enables GO:0042803 GO_REF:0000024 ISS UniProtKB:P55327 F Tumor protein D52 TPD52|RCJMB04_34n23 protein taxon:9031 20061004 AgBase UniProtKB:Q5ZHP4UniProtKB Q8QFX0 ADAM10 enables GO:0042803 GO_REF:0000024 ISS UniProtKB:O35598 F Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 protein taxon:9031 20090406 UniProt UniProtKB:Q8QFX0Annotations to ISS, ISA and ISO should not be self-referential
References should have only one ID per ID space
Object extensions should conform to the extensions-patterns.yaml file in metadata
Allowed gene product to term relations (gp2term)
Only certain gene product to term relations are allowed for a given GO term but was repaired: RO:0001025 should be one of BFO:0000050. Repaired to BFO:0000050 -- UniProtKB A0A1D5P2B5 RXRA located_in GO:0090575 PMID:22474364 EXP C Retinoic acid receptor RXR RXRA protein taxon:9031 20190415 ComplexPortal UniProtKB:A0A1D5P2B5Annotations using ISS/ISA/ISO evidence should refer to a gene product (in the 'with' column)
TreeGrafter IEAs should be filtered for GO reference species