GORULE violations assigned by ARUK-UCL

Contents

gorule-0000001 GAF lines are parsed according to GAF 2.2 specifications

gorule-0000008 No annotations should be made to uninformative high level terms

gorule-0000013 Taxon-appropriate annotation check

gorule-0000020 Automatic repair of annotations to merged or obsoleted terms

gorule-0000046 The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

gorule-0000065 Annotations to term that are candidates for obsoletion should be removed

MESSAGES

gorule-0000001

GAF lines are parsed according to GAF 2.2 specifications

• total: 8

messages

• WARNING - Invalid subject type:defaulting to 'gene_product'--`RNAcentral URS0000812128_9606 URS0000812128_9606 acts_upstream_of GO:0051897 PMID:31574452 IMP P Homo sapiens (human) H19 imprinted maternally expressed transcript sRNA taxon:9606 20200821 ARUK-UCL occurs_in(CL:0000182) `
• WARNING - Invalid subject type:defaulting to 'gene_product'--`RNAcentral URS0000812128_9606 URS0000812128_9606 acts_upstream_of GO:1900017 PMID:31574452 IMP P Homo sapiens (human) H19 imprinted maternally expressed transcript sRNA taxon:9606 20200821 ARUK-UCL has_input(UniProtKB:P01579),occurs_in(CL:0000182)|has_input(UniProtKB:P05231),occurs_in(CL:0000182)|has_input(UniProtKB:Q14116),occurs_in(CL:0000182) `
• WARNING - Invalid subject type:defaulting to 'gene_product'--`RNAcentral URS0000812128_9606 URS0000812128_9606 acts_upstream_of GO:1903428 PMID:31574452 IMP P Homo sapiens (human) H19 imprinted maternally expressed transcript sRNA taxon:9606 20200821 ARUK-UCL occurs_in(CL:0000182) `
• WARNING - Invalid subject type:defaulting to 'gene_product'--`RNAcentral URS0000812128_9606 URS0000812128_9606 acts_upstream_of GO:1903945 PMID:31574452 IMP P Homo sapiens (human) H19 imprinted maternally expressed transcript sRNA taxon:9606 20200821 ARUK-UCL `
• WARNING - Invalid subject type:defaulting to 'gene_product'--`RNAcentral URS0000812128_9606 URS0000812128_9606 acts_upstream_of GO:2000378 PMID:31574452 IMP P Homo sapiens (human) H19 imprinted maternally expressed transcript sRNA taxon:9606 20230717 ARUK-UCL occurs_in(CL:0000182) `
• WARNING - Invalid subject type:defaulting to 'gene_product'--`RNAcentral URS0000812128_9606 URS0000812128_9606 acts_upstream_of GO:2001170 PMID:31574452 IMP P Homo sapiens (human) H19 imprinted maternally expressed transcript sRNA taxon:9606 20200821 ARUK-UCL occurs_in(CL:0000182) `
• WARNING - Invalid subject type:defaulting to 'gene_product'--`RNAcentral URS0000812128_9606 URS0000812128_9606 involved_in GO:0035196 PMID:31574452 IMP P Homo sapiens (human) H19 imprinted maternally expressed transcript sRNA taxon:9606 20200821 ARUK-UCL has_input(RNAcentral:URS00004E5112_9606),occurs_in(CL:0000182) `
• WARNING - Invalid subject type:defaulting to 'gene_product'--`RNAcentral URS0000812128_9606 URS0000812128_9606 involved_in GO:0098586 PMID:31574452 IMP P Homo sapiens (human) H19 imprinted maternally expressed transcript sRNA taxon:9606|taxon:10407 20200821 ARUK-UCL occurs_in(CL:0000182) `

gorule-0000008

No annotations should be made to uninformative high level terms

• total: 6

messages

• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:107656 Ifng involved_in GO:0019222 PMID:7715705 IGI ComplexPortal:CPX-1062,UniProtKB:P06804 P Interferon gamma protein taxon:10090 20230517 ARUK-UCL occurs_in(CL:0000129),part_of(GO:0001774),occurs_in(UBERON:0000956) `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI MGI:104798 Tnf involved_in GO:0019222 PMID:7715705 IGI ComplexPortal:CPX-1062,UniProtKB:P01579|ComplexPortal:CPX-1062,UniProtKB:P01580 P Tumor necrosis factor protein taxon:10090 20230517 ARUK-UCL occurs_in(CL:0000129),part_of(GO:0001774),occurs_in(UBERON:0000956) `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB P01375 TNF involved_in GO:0019222 GO_REF:0000024 ISS UniProtKB:P06804 P Tumor necrosis factor TNF|TNFA|TNFSF2 protein taxon:9606 20230517 ARUK-UCL occurs_in(CL:0000129),part_of(GO:0001774),occurs_in(UBERON:0000956) UniProtKB:P01375 `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB P01579 IFNG involved_in GO:0019222 PMID:7715705 IGI ComplexPortal:CPX-1062,UniProtKB:P06804 P Interferon gamma IFNG protein taxon:9606 20230517 ARUK-UCL occurs_in(CL:0000129),part_of(GO:0001774),occurs_in(UBERON:0000956) UniProtKB:P01579 `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB Q96QE2 SLC2A13 located_in GO:0043231 PMID:19607714 ISS UniProtKB:Q921A2 C Proton myo-inositol cotransporter SLC2A13 protein taxon:9606 20200225 ARUK-UCL part_of(GO:0005737) UniProtKB:Q96QE2 `
• WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB Q9NSD5 SLC6A13 enables GO:0005368 GO_REF:0000024 ISS UniProtKB:P31646 F Sodium- and chloride-dependent GABA transporter 2 SLC6A13|GAT2 protein taxon:9606 20200608 ARUK-UCL part_of(CL:0000182),has_target_start_location(GO:0009897),has_target_end_location(GO:0009898) UniProtKB:Q9NSD5 `

gorule-0000013

Taxon-appropriate annotation check

• total: 25

messages

• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB O75116 ROCK2 enables GO:0050321 PMID:28386764 NAS F Rho-associated protein kinase 2 ROCK2|KIAA0619 protein taxon:9606 20181030 ARUK-UCL UniProtKB:O75116 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB P06241 FYN enables GO:0050321 PMID:28386764 NAS F Tyrosine-protein kinase Fyn FYN protein taxon:9606 20181030 ARUK-UCL UniProtKB:P06241 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB P27448 MARK3 enables GO:0050321 PMID:28386764 NAS F MAP/microtubule affinity-regulating kinase 3 MARK3|CTAK1|EMK2 protein taxon:9606 20181030 ARUK-UCL UniProtKB:P27448 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB P49840 GSK3A enables GO:0050321 PMID:28386764 NAS F Glycogen synthase kinase-3 alpha GSK3A protein taxon:9606 20181030 ARUK-UCL UniProtKB:P49840 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB P49841 GSK3B enables GO:0050321 PMID:28386764 NAS F Glycogen synthase kinase-3 beta GSK3B protein taxon:9606 20181030 ARUK-UCL UniProtKB:P49841 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q00535 CDK5 enables GO:0050321 PMID:28386764 NAS F Cyclin-dependent kinase 5 CDK5|CDKN5|PSSALRE protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q00535 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q13131 PRKAA1 enables GO:0050321 PMID:28386764 NAS F 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1|AMPK1 protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q13131 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q13464 ROCK1 enables GO:0050321 PMID:28386764 NAS F Rho-associated protein kinase 1 ROCK1 protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q13464 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q13627 DYRK1A enables GO:0050321 PMID:28386764 NAS F Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A|DYRK|MNB|MNBH protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q13627 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q6IQ55 TTBK2 enables GO:0050321 PMID:28386764 NAS F Tau-tubulin kinase 2 TTBK2|KIAA0847 protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q6IQ55 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q7KZI7 MARK2 enables GO:0050321 PMID:28386764 NAS F Serine/threonine-protein kinase MARK2 MARK2|EMK1 protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q7KZI7 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q7L7X3 TAOK1 enables GO:0050321 PMID:28386764 NAS F Serine/threonine-protein kinase TAO1 TAOK1|KIAA1361|MAP3K16|MARKK protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q7L7X3 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q8IWQ3 BRSK2 enables GO:0050321 PMID:28386764 NAS F Serine/threonine-protein kinase BRSK2 BRSK2|C11orf7|PEN11B|SADA|STK29|HUSSY-12 protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q8IWQ3 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q8TDC3 BRSK1 enables GO:0050321 PMID:28386764 NAS F Serine/threonine-protein kinase BRSK1 BRSK1|KIAA1811|SAD1|SADB protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q8TDC3 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q96L34 MARK4 enables GO:0050321 PMID:28386764 NAS F MAP/microtubule affinity-regulating kinase 4 MARK4|KIAA1860|MARKL1 protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q96L34 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q9P0L2 MARK1 enables GO:0050321 PMID:28386764 NAS F Serine/threonine-protein kinase MARK1 MARK1|KIAA1477|MARK protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q9P0L2 `
• ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q9UL54 TAOK2 enables GO:0050321 PMID:28386764 NAS F Serine/threonine-protein kinase TAO2 TAOK2|KIAA0881|MAP3K17|PSK|PSK1|UNQ2971/PRO7431 protein taxon:9606 20181030 ARUK-UCL UniProtKB:Q9UL54 `
• WARNING - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q29599 OAS1 involved_in GO:1904188 PMID:20844035 IDA P 2'-5'-oligoadenylate synthase 1 OAS1 protein taxon:9823|taxon:10310 20230314 ARUK-UCL UniProtKB:Q29599 `
• WARNING - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q29599 OAS1 involved_in GO:1904188 PMID:20844035 IDA P 2'-5'-oligoadenylate synthase 1 OAS1 protein taxon:9823|taxon:11276 20230314 ARUK-UCL UniProtKB:Q29599 `
• WARNING - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q07869 PPARA acts_upstream_of_or_within GO:1904189 PMID:22479552 IMP P Peroxisome proliferator-activated receptor alpha PPARA|NR1C1|PPAR protein taxon:9606|taxon:10407 20230314 ARUK-UCL UniProtKB:Q07869 `
• WARNING - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q5TCY1 TTBK1 enables GO:0050321 PMID:16923168 IDA F Tau-tubulin kinase 1 TTBK1|BDTK|KIAA1855 protein taxon:9606 20190619 ARUK-UCL UniProtKB:Q5TCY1 `
• WARNING - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB Q96L34 MARK4 enables GO:0050321 PMID:27708431 IMP F MAP/microtubule affinity-regulating kinase 4 MARK4|KIAA1860|MARKL1 protein taxon:9606 20180515 ARUK-UCL UniProtKB:Q96L34 `
• WARNING - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`RNAcentral URS000003E1A9_9606 URS000003E1A9_9606 acts_upstream_of GO:1904188 PMID:22479552 IDA P Homo sapiens (human) hsa-miR-141-3p miRNA taxon:9606|taxon:10407 20230314 ARUK-UCL `
• WARNING - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`RNAcentral URS000019907A_9606 URS000019907A_9606 acts_upstream_of GO:1904188 PMID:23418453 IMP P Homo sapiens (human) hsa-miR-30c-5p miRNA taxon:9606|taxon:11103 20230314 ARUK-UCL `
• WARNING - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`RNAcentral URS0000315338_9606 URS0000315338_9606 acts_upstream_of GO:1904187 PMID:23418453 IMP P Homo sapiens (human) hsa-miR-130a-3p miRNA taxon:9606|taxon:11103 20230314 ARUK-UCL `

gorule-0000020

Automatic repair of annotations to merged or obsoleted terms

• total: 4

messages

• ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB Q9H0M4 ZCWPW1 enables GO:0035064 PMID:20826339 IDA F Zinc finger CW-type PWWP domain protein 1 ZCWPW1 protein taxon:9606 20240503 ARUK-UCL UniProtKB:Q9H0M4 `
• ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI MGI:96610 Itgb1 acts_upstream_of_or_within_negative_effect GO:0150103 PMID:25716834 IMP P Integrin beta-1 protein taxon:10090 20200116 ARUK-UCL occurs_in(UBERON:0003528),causally_upstream_of(GO:0150003),causally_upstream_of(GO:1901979)|occurs_in(UBERON:0003528),causally_upstream_of(GO:0150003),causally_upstream_of(GO:0051951) `
• ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB P05556 ITGB1 acts_upstream_of_or_within_negative_effect GO:0150103 GO_REF:0000024 ISS UniProtKB:P09055 P Integrin beta-1 ITGB1|FNRB|MDF2|MSK12 protein taxon:9606 20200116 ARUK-UCL occurs_in(UBERON:0003528),causally_upstream_of(GO:0150003),causally_upstream_of(GO:1901979)|occurs_in(UBERON:0003528),causally_upstream_of(GO:0150003),causally_upstream_of(GO:0051951) UniProtKB:P05556 `
• WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`UniProtKB Q86XX4 FRAS1 colocalizes_with GO:0062023 GO_REF:0000024 ISS UniProtKB:K7GLL6 C Extracellular matrix organizing protein FRAS1 FRAS1|KIAA1500 protein taxon:9606 20250115 ARUK-UCL part_of(UBERON:0002084) UniProtKB:Q86XX4 `

gorule-0000046

The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

• total: 14

messages

• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:1196458 Scarb2 enables GO:0042803 PMID:29199275 IPI UniProtKB:O35114 F Lysosome membrane protein 2 protein taxon:10090 20181031 ARUK-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:97275 Myod1 enables GO:0042803 PMID:10652346 IPI UniProtKB:P10085 F Myoblast determination protein 1 protein taxon:10090 20230314 ARUK-UCL `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI MGI:894311 Pirb enables GO:0042803 PMID:24052308 IPI UniProtKB:P97484 F Paired immunoglobulin-like receptor B protein taxon:10090 20230314 ARUK-UCL causally_upstream_of(GO:0001540) `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P05067 APP enables GO:0042803 PMID:15447668 IPI UniProtKB:P05067-PRO_0000000092 F Amyloid-beta precursor protein APP|A4|AD1 protein taxon:9606 20230314 ARUK-UCL UniProtKB:P05067-PRO_0000000092 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P05067 APP enables GO:0042803 PMID:15447668 IPI UniProtKB:P05067-PRO_0000000093 F Amyloid-beta precursor protein APP|A4|AD1 protein taxon:9606 20230314 ARUK-UCL UniProtKB:P05067-PRO_0000000093 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P05067 APP enables GO:0042803 PMID:18568035 IPI UniProtKB:P05067-PRO_0000000092 F Amyloid-beta precursor protein APP|A4|AD1 protein taxon:9606 20170213 ARUK-UCL UniProtKB:P05067-PRO_0000000092 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P05067 APP enables GO:0042803 PMID:22179788 IPI UniProtKB:P05067-PRO_0000000093 F Amyloid-beta precursor protein APP|A4|AD1 protein taxon:9606 20230314 ARUK-UCL UniProtKB:P05067-PRO_0000000093 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P05067 APP enables GO:0042803 PMID:23386614 IPI UniProtKB:P05067-PRO_0000000092 F Amyloid-beta precursor protein APP|A4|AD1 protein taxon:9606 20230314 ARUK-UCL UniProtKB:P05067-PRO_0000000092 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P05067 APP involved_in GO:0051260 PMID:15447668 IPI UniProtKB:P05067-PRO_0000000092 P Amyloid-beta precursor protein APP|A4|AD1 protein taxon:9606 20230314 ARUK-UCL UniProtKB:P05067-PRO_0000000092 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P05067 APP involved_in GO:0051260 PMID:15447668 IPI UniProtKB:P05067-PRO_0000000093 P Amyloid-beta precursor protein APP|A4|AD1 protein taxon:9606 20230314 ARUK-UCL has_input(UniProtKB:P05067-PRO_0000000093) UniProtKB:P05067-PRO_0000000093 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P05067 APP involved_in GO:0051260 PMID:18602473 IPI UniProtKB:P05067-PRO_0000000093 P Amyloid-beta precursor protein APP|A4|AD1 protein taxon:9606 20230314 ARUK-UCL UniProtKB:P05067-PRO_0000000093 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P05067 APP involved_in GO:0051260 PMID:23386614 IPI UniProtKB:P05067-PRO_0000000092 P Amyloid-beta precursor protein APP|A4|AD1 protein taxon:9606 20230314 ARUK-UCL has_input(UniProtKB:P05067) UniProtKB:P05067-PRO_0000000092 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P10636 MAPT involved_in GO:0051260 PMID:26704708 IPI UniProtKB:P10636-8 P Microtubule-associated protein tau MAPT|MAPTL|MTBT1|TAU protein taxon:9606 20230314 ARUK-UCL happens_during(UBERON:0000112),happens_during(GO:0018105),occurs_in(UBERON:0002421),regulates(GO:0007611)|happens_during(UBERON:0018241),happens_during(GO:0018105),occurs_in(UBERON:0002421),regulates(GO:0007611) UniProtKB:P10636-8 `
• WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB P15172 MYOD1 enables GO:0042803 GO_REF:0000024 ISS UniProtKB:P10085 F Myoblast determination protein 1 MYOD1|BHLHC1|MYF3|MYOD protein taxon:9606 20230314 ARUK-UCL UniProtKB:P15172 `

gorule-0000065

Annotations to term that are candidates for obsoletion should be removed

• total: 26

messages

• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`MGI MGI:101765 Cdk5 involved_in GO:0018105 PMID:24607229 IMP P Cyclin-dependent kinase 5 protein taxon:10090 20171030 ARUK-UCL has_input(UniProtKB:Q01097),occurs_in(UBERON:0002421),regulates(GO:0072659) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`MGI MGI:101765 Cdk5 involved_in GO:0018107 PMID:24607229 IMP P Cyclin-dependent kinase 5 protein taxon:10090 20171030 ARUK-UCL has_input(UniProtKB:Q60829),occurs_in(UBERON:0002421) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`MGI MGI:107926 Rock2 involved_in GO:0018107 PMID:29353861 IMP P Rho-associated protein kinase 2 protein taxon:10090 20181204 ARUK-UCL causally_upstream_of(GO:0050115),occurs_in(CL:2000044)|causally_upstream_of(GO:0050115),occurs_in(CL:0010008) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`MGI MGI:107926 Rock2 involved_in GO:0018107 PMID:29353861 IMP P Rho-associated protein kinase 2 protein taxon:10090 20181204 ARUK-UCL has_input(UniProtKB:P10126),occurs_in(CL:2000044),part_of(GO:0061157) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`MGI MGI:2147036 Ttbk1 involved_in GO:0018105 PMID:16923168 ISS UniProtKB:Q5TCY1 P Tau-tubulin kinase 1 protein taxon:10090 20190619 ARUK-UCL has_input(UniProtKB:P10637),positively_regulates(GO:0051258) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`MGI MGI:2147036 Ttbk1 involved_in GO:0018107 PMID:16923168 ISS UniProtKB:Q5TCY1 P Tau-tubulin kinase 1 protein taxon:10090 20190619 ARUK-UCL has_input(UniProtKB:P10637),positively_regulates(GO:0051258) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`MGI MGI:2147036 Ttbk1 involved_in GO:0018108 PMID:16923168 ISS UniProtKB:Q5TCY1 P Tau-tubulin kinase 1 protein taxon:10090 20190619 ARUK-UCL has_input(UniProtKB:P10637) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`RGD 3395 Prkca involved_in GO:0018107 PMID:16717194|RGD:13602002 IMP P protein kinase C, alpha gene taxon:10116 20180508 ARUK-UCL occurs_in(CL:0000540),has_input(UniProtKB:O08679),negatively_regulates(GO:0018105) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`RGD 620788 Slc6a13 involved_in GO:0071705 PMID:21997971|RGD:30309942 IDA P solute carrier family 6 member 13 gene taxon:10116 20200608 ARUK-UCL has_target_start_location(GO:0009897),has_target_end_location(GO:0009898),has_input(CHEBI:16244) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`RGD 620788 Slc6a13 involved_in GO:0071705 PMID:22384273|RGD:30309936 IMP P solute carrier family 6 member 13 gene taxon:10116 20200608 ARUK-UCL has_input(CHEBI:16344),has_target_start_location(GO:0009897),has_target_end_location(GO:0009898),occurs_in(CL:0000182) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`RGD 708483 Mark2 involved_in GO:0018105 PMID:10542369|RGD:13524612 IDA P microtubule affinity regulating kinase 2 gene taxon:10116 20180328 ARUK-UCL has_input(UniProtKB:P15146),negatively_regulates(GO:0000226)|has_input(UniProtKB:Q5M7W5),negatively_regulates(GO:0000226) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`RGD 708483 Mark2 involved_in GO:0018105 PMID:16717194|RGD:13602002 IMP P microtubule affinity regulating kinase 2 gene taxon:10116 20180508 ARUK-UCL occurs_in(CL:0000540),has_input(UniProtKB:P19332) `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB O14522 PTPRT involved_in GO:0035335 PMID:17360477 IDA P Receptor-type tyrosine-protein phosphatase T PTPRT|KIAA0283 protein taxon:9606 20180803 ARUK-UCL has_input(UniProtKB:P40763),part_of(GO:1904893) UniProtKB:O14522 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB P17252 PRKCA involved_in GO:0018107 PMID:16717194 ISS UniProtKB:P05696 P Protein kinase C alpha type PRKCA|PKCA|PRKACA protein taxon:9606 20180508 ARUK-UCL occurs_in(CL:0000540),has_input(UniProtKB:Q7KZI7),negatively_regulates(GO:0018105) UniProtKB:P17252 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB P18031 PTPN1 acts_upstream_of GO:0043507 GO_REF:0000024 ISS UniProtKB:P35821 P Tyrosine-protein phosphatase non-receptor type 1 PTPN1|PTP1B protein taxon:9606 20210421 ARUK-UCL part_of(GO:0034976) UniProtKB:P18031 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB P48029 SLC6A8 acts_upstream_of GO:0071705 PMID:24842606 IDA P Sodium- and chloride-dependent creatine transporter 1 SLC6A8 protein taxon:9606 20200603 ARUK-UCL has_input(CHEBI:15430) UniProtKB:P48029 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB P53041 PPP5C involved_in GO:0035970 PMID:16262633 TAS P Serine/threonine-protein phosphatase 5 PPP5C|PPP5 protein taxon:9606 20171207 ARUK-UCL UniProtKB:P53041 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB P53041 PPP5C involved_in GO:0070262 PMID:16262633 TAS P Serine/threonine-protein phosphatase 5 PPP5C|PPP5 protein taxon:9606 20171207 ARUK-UCL UniProtKB:P53041 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB Q5TCY1 TTBK1 involved_in GO:0018105 PMID:16923168 IDA P Tau-tubulin kinase 1 TTBK1|BDTK|KIAA1855 protein taxon:9606 20190619 ARUK-UCL has_input(UniProtKB:P10636),positively_regulates(GO:0051258) UniProtKB:Q5TCY1 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB Q5TCY1 TTBK1 involved_in GO:0018107 PMID:16923168 IDA P Tau-tubulin kinase 1 TTBK1|BDTK|KIAA1855 protein taxon:9606 20190619 ARUK-UCL has_input(UniProtKB:P10636),positively_regulates(GO:0051258) UniProtKB:Q5TCY1 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB Q5TCY1 TTBK1 involved_in GO:0018108 PMID:16923168 IDA P Tau-tubulin kinase 1 TTBK1|BDTK|KIAA1855 protein taxon:9606 20190619 ARUK-UCL has_input(UniProtKB:P10636),positively_regulates(GO:0051258) UniProtKB:Q5TCY1 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB Q7KZI7 MARK2 involved_in GO:0018105 PMID:10542369 IDA P Serine/threonine-protein kinase MARK2 MARK2|EMK1 protein taxon:9606 20180328 ARUK-UCL has_input(UniProtKB:P11137),negatively_regulates(GO:0000226)|has_input(UniProtKB:P27816),negatively_regulates(GO:0000226) UniProtKB:Q7KZI7 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB Q7KZI7 MARK2 involved_in GO:0018105 PMID:16717194 IDA P Serine/threonine-protein kinase MARK2 MARK2|EMK1 protein taxon:9606 20180508 ARUK-UCL has_input(UniProtKB:P10636) UniProtKB:Q7KZI7 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB Q7KZI7 MARK2 involved_in GO:0018105 PMID:16717194 ISS UniProtKB:O08679 P Serine/threonine-protein kinase MARK2 MARK2|EMK1 protein taxon:9606 20180508 ARUK-UCL occurs_in(CL:0000540),has_input(UniProtKB:P10636) UniProtKB:Q7KZI7 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB Q8TDC3 BRSK1 involved_in GO:0006468 PMID:27626661 TAS P Serine/threonine-protein kinase BRSK1 BRSK1|KIAA1811|SAD1|SADB protein taxon:9606 20180516 ARUK-UCL has_input(UniProtKB:Q86UR5) UniProtKB:Q8TDC3 `
• WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`ComplexPortal CPX-1134 abeta-42-oligomer_human involved_in GO:0010800 GO_REF:0000024 ISS ComplexPortal:CPX-1183 P Amyloid-beta protein 42 oligomeric complex pre-fibrillar amyloid-beta oligomer|prefibrillar amyloid-beta oligomer|Type 2 amyloid-beta oligomer|fibrillar amyloid-beta oligomer|Annular protofibril complex|Amyloid-beta fibrils|beta-amyloid protein 42 heterooligomer|beta-amyloid protein 42 complex|beta-amyloid-42 complex|beta amyloid protein 42 complex|amyloid-beta-42 complex|amyloid beta protein 42 complex|amyloid-beta protein 42 heterooligomer|amyloid-beta-42 heterooligomer|amyloid beta protein 42 heterooligomer|beta-amyloid-42 heterooligomer|beta amyloid protein 42 heterooligomer|Abeta protein 42 complex|APP oligomer|Type 1 amyloid-beta oligomer|ADDL complex protein_complex taxon:9606 20170831 ARUK-UCL has_input(UniProtKB:Q15418),occurs_in(UBERON:0002421) `