Identifier Name defined_class R-HSA-1008248 Adenylate Kinase 3 is a GTP-AMP phosphotransferase GO:0046899 R-HSA-1013020 Activation of GIRK/Kir3 Channels GO:0015467 R-HSA-1022127 OS9:SEL1:ERAD E3 ligase:DERL2 transports Ub-unfolded protein:(GlcNAc)2 (Man)9-5 from ERQC to cytosol GO:0034437 R-HSA-1022129 ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans GO:0003836 R-HSA-1022133 ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans GO:0003828 R-HSA-1028788 FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP GO:0008424 R-HSA-109278 NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP GO:0008253 R-HSA-109291 CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] GO:0008253 R-HSA-109338 Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA GO:0004165 R-HSA-109341 dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA GO:0003995 R-HSA-109343 Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA GO:0016651 R-HSA-109380 (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) GO:0008253 R-HSA-109387 (d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) GO:0008253 R-HSA-109415 AMP + H2O => adenosine + orthophosphate [NT5C1B] GO:0008253 R-HSA-109449 (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) GO:0008253 R-HSA-109470 (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) GO:0008253 R-HSA-109480 TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] GO:0008253 R-HSA-109514 TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] GO:0008253 R-HSA-109527 Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 GO:0005337 R-HSA-109529 Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 GO:0005337 R-HSA-109530 Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 GO:0005415 R-HSA-109534 Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 GO:0005337 R-HSA-109536 Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 GO:0005337 R-HSA-109538 Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 GO:0005415 R-HSA-109539 Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 GO:0005415 R-HSA-109624 (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) GO:0004001 R-HSA-109671 deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) GO:0019206 R-HSA-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3 GO:0016303 R-HSA-109702 PDPK1 phosphorylates AKT2 GO:0004674 R-HSA-109759 deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] GO:0019206 R-HSA-109807 GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS GO:0005088 R-HSA-109817 GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS GO:0005088 R-HSA-109822 MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 GO:0016301 R-HSA-109823 MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 GO:0016301 R-HSA-109860 MAP2K1 phosphorylates MAPK3 GO:0004674 R-HSA-109862 MAP2K2 phosphorylates MAPK1 GO:0004674 R-HSA-109903 cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] GO:0019206 R-HSA-109998 Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA GO:0016860 R-HSA-110133 (d)GDP + ADP <=> (d)GMP + ATP (GUK1) GO:0004385 R-HSA-110137 (d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP GO:0019206 R-HSA-110138 AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs GO:0019206 R-HSA-110141 (d)ADP + ADP <=> (d)AMP + ATP (AK1) GO:0004017 R-HSA-110144 ADP + ADP <=> AMP + ATP [AK2] GO:0004017 R-HSA-110145 AMP + ATP <=> ADP + ADP [AK2] GO:0004017 R-HSA-110215 Cleavage of uracil by UNG glycosylase GO:0004844 R-HSA-110217 Cleavage of 5-hydroxyluracil by UNG glycosylase GO:0004844 R-HSA-110218 Cleavage of uracil by TDG glycosylase GO:0019104 R-HSA-110219 Cleavage of thymine by TDG glycosylase GO:0019104 R-HSA-110221 Cleavage of uracil by SMUG1 glycosylase GO:0017065 R-HSA-110224 Cleavage of thymine glycol by NTHL1 glycosylase GO:0000703 R-HSA-110226 Cleavage of cytosine glycol by NTHL1 glycosylase GO:0000703 R-HSA-110227 Cleavage of dihydrouracil by NTHL1 glycosylase GO:0000703 R-HSA-110229 Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase GO:0008534 R-HSA-110231 Cleavage of uracil by MBD4 glycosylase GO:0019104 R-HSA-110232 Cleavage of thymine by MBD4 glycosylase GO:0019104 R-HSA-110234 Cleavage of ethenocytosine by TDG glycosylase GO:0019104 R-HSA-110243 Cleavage of 8-oxoguanine by OGG1 glycosylase GO:0008534 R-HSA-110244 Cleavage of formamidopyrimidine (FapyG) by OGG1 glycosylase GO:0008534 R-HSA-110246 Cleavage of adenine mispaired with 8-oxoguanine by MUTYH GO:0019104 R-HSA-110248 Cleavage of 3-methyladenine by MPG glycosylase GO:0019104 R-HSA-110250 Cleavage of ethenoadenine by MPG glycosylase GO:0019104 R-HSA-110251 Cleavage of hypoxanthine by MPG glycosylase GO:0019104 R-HSA-110308 REV1 inserts dCMP opposite to AP sites in DNA GO:0017125 R-HSA-110311 POLZ extends translesion synthesis GO:0003887 R-HSA-110317 Insertion of correct bases opposite the lesion by POLH GO:0003887 R-HSA-110319 Elongation by POLH GO:0003887 R-HSA-110359 APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site GO:0004520 R-HSA-110363 FEN1 bound to PCNA and APEX1 cleaves flap ssDNA GO:0017108 R-HSA-110368 POLD,POLE-mediated DNA strand displacement synthesis GO:0003887 R-HSA-110375 Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break GO:0003906 R-HSA-111215 D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate GO:0004749 R-HSA-111253 POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site GO:0003887 R-HSA-1112602 Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor GO:0004715 R-HSA-111264 Addition of nucleotides between position +11 and +30 GO:0003899 R-HSA-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate GO:0004629 R-HSA-1112703 PTPN11 is phosphorylated GO:0004715 R-HSA-111524 IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] GO:0004019 R-HSA-111742 RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) GO:0036175 R-HSA-111746 glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) GO:0015038 R-HSA-111751 RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) GO:0004748 R-HSA-111804 RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) GO:0004748 R-HSA-111879 PIP2 hydrolysis GO:0004435 R-HSA-111883 Hydrolysis of phosphatidylcholine GO:0047498 R-HSA-111898 Phosphorylation of cPLA2 by ERK-2 GO:0016301 R-HSA-111912 CaMK4 phosphorylates CREB1 GO:0004683 R-HSA-111915 CAMK4 autophosphorylates GO:0004683 R-HSA-111919 PKA phosphorylates CREB1 GO:0004674 R-HSA-111930 Adenylate cyclase produces cAMP GO:0008294 R-HSA-111955 cAMP hydrolysis by Cam-PDE 1 GO:0004117 R-HSA-111962 cAMP hydrolysis by PDE 4 GO:0004115 R-HSA-111970 PKC phosphorylates GRK2 GO:0004672 R-HSA-112033 hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP) GO:0004731 R-HSA-112034 guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP) GO:0004731 R-HSA-112118 Oxidative demethylation of 1-meA damaged DNA by ALKBH2 GO:0043734 R-HSA-112120 Oxidative demethylation of 3-meC damaged DNA by ALKBH2 GO:0051213 R-HSA-112121 Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 GO:0051213 R-HSA-112123 Oxidative demethylation of 1-meA damaged DNA By ALKBH3 GO:0043734 R-HSA-112124 Oxidative demethylation of 3-meC damaged DNA By ALKBH3 GO:0051213 R-HSA-112125 Oxidative dealkylation of 1-EtA damaged DNA by ABH3 GO:0051213 R-HSA-112265 thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] GO:0016763 R-HSA-112266 thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] GO:0016763 R-HSA-112333 SRC autophosphorylation is positively regulated by InlA-bound CDH1 GO:0004713 R-HSA-112342 Inactivation of MAP2K1 by CDK1 GO:0004674 R-HSA-112381 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex GO:0016301 R-HSA-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein GO:0004721 R-HSA-113503 PP2A mediated localization of RB1 protein in chromatin GO:0004721 R-HSA-114252 Cleavage of Procaspase-3 by the apoptosome GO:0004197 R-HSA-114259 Cleavage of Procaspase9 to caspase9 GO:0004197 R-HSA-114261 Cleavage of Procaspase-7 by the apoptosome GO:0004197 R-HSA-114544 p115-RhoGEF activation of RHOA GO:0005085 R-HSA-114552 G12/13 activation by PAR GO:0004930 R-HSA-114558 Gq activation by PAR GO:0004930 R-HSA-114600 Fyn/Lyn-mediated phosphorylation of FcR1 gamma GO:0004713 R-HSA-114683 Phosphorylation of Platelet Sec-1 GO:0004698 R-HSA-114684 Phosphorylation of Syntaxin-4 GO:0004698 R-HSA-114688 PLC-beta hydrolyses PIP2 to DAG and IP3 GO:0004629 R-HSA-114689 PLC gamma 2-mediated PIP2 hydrolysis GO:0004629 R-HSA-114697 Thrombin-mediated activation of Proteinase-activated receptors GO:0004252 R-HSA-1168376 STIM1 oligomerizes GO:0005261 R-HSA-1168394 STAT5 tyrosine phosphorylation GO:0004713 R-HSA-1168423 JAK2 phosphorylation of IRS-1/2 GO:0004715 R-HSA-1168459 Lyn activates ERK GO:0004715 R-HSA-1168635 PRKCB (PKC-beta) phosphorylates CARMA1 GO:0004674 R-HSA-1168636 p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP GO:0005085 R-HSA-1168638 Activated IKK phosphorylates I-kappaB GO:0004674 R-HSA-1168640 Ubiquitinated IkB is degraded GO:0004175 R-HSA-1168641 TAK1 associated with the CBM complex phosphorylates IKKbeta GO:0004674 R-HSA-1168767 JAK2 phosphorylates STAT1/STAT3 GO:0004715 R-HSA-1168777 Metalloprotease cleavage of GHR GO:0004222 R-HSA-1169188 SHP1 (PTPN6) dephosphorylates JAK2 GO:0004725 R-HSA-1169192 PTP1B dephosphorylates GHR GO:0004725 R-HSA-1169210 PTP1B dephosphorylates JAK2 GO:0004725 R-HSA-1169394 ISGylation of IRF3 GO:0004842 R-HSA-1169395 ISGylation of viral protein NS1 GO:0004842 R-HSA-1169397 Activation of ISG15 by UBA7 E1 ligase GO:0004842 R-HSA-1169398 ISGylation of host protein filamin B GO:0004842 R-HSA-1169402 ISGylation of E2 conjugating enzymes GO:0004842 R-HSA-1169404 Transfer of ISG15 from E1 to E2 (UBCH8) GO:0043130 R-HSA-1169405 ISGylation of protein phosphatase 1 beta (PP2CB) GO:0004842 R-HSA-1169406 ISGylation of host proteins GO:0004842 R-HSA-1169421 Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers GO:0004713 R-HSA-1176059 Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus GO:0017056 R-HSA-1181149 ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin GO:0004674 R-HSA-1181152 Cleavage of NODAL proprotein GO:0004252 R-HSA-1181156 Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL GO:0004674 R-HSA-1181355 Phosphorylation of R-SMAD2/3 by NODAL receptor GO:0004674 R-HSA-1183128 PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins GO:0004668 R-HSA-1214188 PRDM9 trimethylates histone H3 GO:0042800 R-HSA-1222346 AhpC reduces H2O2 GO:0004601 R-HSA-1222363 MsrA/B reduces peptide-methionine S/R-sulfoxides GO:0008113 R-HSA-1222376 NOX2 generates superoxide from oxygen GO:0016175 R-HSA-1222399 Iron is reduced and separates from mycobactin GO:0052873 R-HSA-1222412 Lpd reactivates dlaT GO:0004148 R-HSA-1222417 TrxA reactivates AhpC GO:0015036 R-HSA-1222431 Peroxynitrite is reduced to nitrite by AhpC GO:0051920 R-HSA-1222462 SodB reduces superoxide to H2O2 GO:0004784 R-HSA-1222469 SodC reduces superoxide to H2O2 GO:0004784 R-HSA-1222485 TrxB reactivates TrxA GO:0004791 R-HSA-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase GO:0015078 R-HSA-1222523 SodB gets secreted GO:0015450 R-HSA-1222526 AhpC reduces peroxidated lipids GO:0008785 R-HSA-1222583 MscR reduces nitrosomycothiol to ammonia GO:0016620 R-HSA-1222597 Loaded mycobactin gets imported GO:0015343 R-HSA-1222644 TrxA/B1 reactivates Tpx GO:0015036 R-HSA-1222655 AhpD reactivates AhpC GO:0015036 R-HSA-1222690 DlaT reactivates AhpD GO:0015036 R-HSA-1222704 KatG reduces H2O2 GO:0004096 R-HSA-1222712 Nitrosoglutathione gets cleaved to Cys(NO)-Gly GO:0036374 R-HSA-1222723 Nitric oxide is oxidized to nitrate GO:0008941 R-HSA-1222755 Peroxynitrite is reduced to nitrite by Tpx GO:0051920 R-HSA-1225894 Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL GO:0004674 R-HSA-1225951 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) GO:0005088 R-HSA-1225952 Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants GO:0004713 R-HSA-1225956 Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL GO:0061630 R-HSA-1225957 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) GO:0005088 R-HSA-1225960 Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants GO:0004713 R-HSA-1226014 Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants GO:0046934 R-HSA-1226094 Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex GO:0004693 R-HSA-1226095 Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex GO:0004693 R-HSA-1234159 Proteasome proteolyzes ub-HIF-alpha GO:0004175 R-HSA-1234163 Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha GO:0004842 R-HSA-1234164 Cytosolic hydroxylation of asparagine residue in HIF alpha GO:0016706 R-HSA-1234165 Nuclear PHD1,3 hydroxylates proline residues on HIF3A GO:0031545 R-HSA-1234166 Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) GO:0031545 R-HSA-1234172 Nuclear VBC complex ubiquitinylates HIF-alpha GO:0004842 R-HSA-1234173 Cytosolic PHD2,3 hydroxylates proline residues on HIF3A GO:0031545 R-HSA-1234177 Cytosolic PHD2,3 hydroxylates proline residues on HIF1A GO:0031545 R-HSA-1234179 Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) GO:0031545 R-HSA-1234181 Nuclear PHD1,3 hydroxylates proline residues on HIF1A GO:0031545 R-HSA-1236935 Proteasomal cleavage of substrate GO:0004175 R-HSA-1236938 Partial proteolysis of antigen in phagolysosomes GO:0016787 R-HSA-1236947 Egress of internalized antigen to the cytosol via sec61 GO:0022857 R-HSA-1236948 Antigen processing by cathepsin S in endosoytic vesicle GO:0004197 R-HSA-1236949 Translocation of antigenic peptides back to phagosomes via TAP GO:0015433 R-HSA-1236954 Trimming of peptides by IRAP in endocytic vesicles GO:0004177 R-HSA-1236967 Alkalization of the phagosomal lumen by NOX2 GO:0016175 R-HSA-1236970 Proteasomal clevage of exogenous antigen GO:0004175 R-HSA-1237038 SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- GO:0005452 R-HSA-1237042 AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol GO:0035379 R-HSA-1237045 Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton GO:0004089 R-HSA-1237047 Carbonic anhydrase IV hydrates carbon dioxide to bicarbonate and a proton GO:0004089 R-HSA-1237059 Carbonic anhydrase IV dehydrates bicarbonate to water and carbon dioxide GO:0004089 R-HSA-1237069 RhAG passively translocates carbon dioxide from the extracellular region to the cytosol GO:0035379 R-HSA-1237081 Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide GO:0004089 R-HSA-1237096 Methylthio-ribose-P = Methylthio-ribulose-P GO:0046523 R-HSA-1237102 Transamination of MOB to methionine GO:0008483 R-HSA-1237119 Acireductone is oxidized to MOB GO:0010309 R-HSA-1237129 Acireductone is created GO:0043874 R-HSA-1237140 Dehydration of methylthio-ribulose-P GO:0046570 R-HSA-1237160 MTA is cleaved and phosphorylated GO:0017061 R-HSA-1247645 RhAG passively translocates carbon dioxide from the cytosol to the extracellular region GO:0035379 R-HSA-1247649 AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region GO:0035379 R-HSA-1247665 Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate GO:0005452 R-HSA-1247844 Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants GO:0004713 R-HSA-1247910 CNDP2:2Mn2+ dimer hydrolyses CysGly GO:0004180 R-HSA-1247922 GGCT transforms gGluCys to OPRO GO:0003839 R-HSA-1247935 OPLAH hydrolyses OPRO to L-Glu GO:0017168 R-HSA-1247960 Activation of p38 MAPK GO:0004708 R-HSA-1248655 Trans-autophosphorylation of EGFRvIII mutant dimers GO:0004713 R-HSA-1250195 SHC1 phosphorylation by ERBB2 heterodimers GO:0004713 R-HSA-1250315 Trans-autophosphorylation of ERBB4 homodimers GO:0004713 R-HSA-1250348 Phosphorylation of SHC1 by ERBB4 homodimers GO:0004713 R-HSA-1250370 Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers GO:0046934 R-HSA-1250383 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 GO:0005088 R-HSA-1250462 PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 GO:0046934 R-HSA-1250463 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers GO:0005088 R-HSA-1250498 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. GO:0005088 R-HSA-1251922 PLCG1 phosphorylation by p-EGFR:p-ERBB2 GO:0004713 R-HSA-1251992 Cleavage of P-ERBB4jmA isoforms by ADAM17 GO:0004222 R-HSA-1251997 Cleavage of ERBB4m80 by gamma-scretase complex GO:0004175 R-HSA-1253282 ERBB4 ubiquitination by WWP1/ITCH GO:0004842 R-HSA-1268022 TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space GO:0008320 R-HSA-1268025 SAM50 complex inserts proteins into mitochondrial outer membrane GO:0032977 R-HSA-1295519 IL7R is phosphorylated on Y499 GO:0004715 R-HSA-1295540 IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 GO:0004713 R-HSA-1295609 SRC phosphorylates SPRY2 on Y55 and Y227 GO:0004713 R-HSA-1295632 PPA2A dephosphorylates SPRY2 GO:0004722 R-HSA-1296024 Activation of ATP sensitive Potassium channels in neuroendocrine cells GO:0005267 R-HSA-1296035 Activation of Ca2+ activated Potassium channels with Intermeidtance conductance GO:0005267 R-HSA-1296037 Activation of Ca2+ activated Potassium channels with large conductance GO:0005267 R-HSA-1296039 Activation of Ca2+ activated Potassium channels with small conductance GO:0005267 R-HSA-1296043 Activation of HCN channels GO:0005261 R-HSA-1296045 Activation of Potassium transport channels GO:0005242 R-HSA-1296046 KCNJs transport K+ from the extracellular region to cytosol GO:0005242 R-HSA-1296127 Activation of voltage gated Potassium channels GO:0005249 R-HSA-1296348 Activation of TWIK-related K+ channel (TREK) GO:0005267 R-HSA-1297354 Acrosin Cleavage GO:0002020 R-HSA-1299297 Activation of THIK GO:0005267 R-HSA-1299304 Activation of tandem pore domain in a weak inwardly rectifying K+ channels GO:0005267 R-HSA-1299318 Activation of TASK GO:0005267 R-HSA-1299338 Activation of TRESK GO:0005267 R-HSA-1299359 Activation of TALK GO:0005267 R-HSA-1299475 TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix GO:0008320 R-HSA-1299476 MPP cleaves targeting peptide (presequence) of inner membrane precursors GO:0004222 R-HSA-1299478 MPP cleaves targeting peptide (presequence) of matrix precursors GO:0004222 R-HSA-1299482 TIMM23 SORT inserts proteins into inner membrane GO:0032977 R-HSA-1299507 Methylthio-ribulose-P = Methylthio-ribose-P GO:0046523 R-HSA-1306957 PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR GO:0046934 R-HSA-1306972 RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers GO:0005088 R-HSA-1306979 PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 GO:0046934 R-HSA-1307802 MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds GO:0015035 R-HSA-1307803 TIMM22 inserts proteins into inner membrane GO:0032977 R-HSA-1307963 Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 GO:0004713 R-HSA-1358789 Self-ubiquitination of RNF41 GO:0004842 R-HSA-1358790 RNF41 ubiquitinates ERBB3 GO:0004842 R-HSA-1358791 Phosphorylation of USP8 by P-AKT GO:0004674 R-HSA-1358792 RNF41 ubiquitinates activated ERBB3 GO:0004842 R-HSA-1358795 Deubiquitination of RNF41 by P-USP8 GO:0004843 R-HSA-1362270 Phosphorylation of LIN52 component of MuvB by DYRK1A GO:0004672 R-HSA-1362408 FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster GO:0009055 R-HSA-1362408 FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster GO:0031071 R-HSA-1362417 Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix GO:0015093 R-HSA-1363274 Dephosphorylation of p107 (RBL1) by PP2A GO:0004721 R-HSA-1363276 Dephosphorylation of p130 (RBL2) by PP2A GO:0004721 R-HSA-1363331 Ubiquitination of p130 (RBL2) by SCF (Skp2) GO:0004842 R-HSA-1369017 Activation of ATP sensitive Potassium channels in muscle cells GO:0005242 R-HSA-1369028 ABCAs mediate lipid efflux GO:0005319 R-HSA-1369052 ABCAs mediate lipid influx GO:0005319 R-HSA-1369065 ABCB6 transports porphyrin from cytosol to mitchondrial matrix GO:0015232 R-HSA-1369115 SHP2 is phosphorylated GO:0004715 R-HSA-139854 IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol GO:0005262 R-HSA-139855 P2X1-mediated entry of Ca++ from plasma GO:0005262 R-HSA-139893 Granzyme-B activates BID by cleavage GO:0004252 R-HSA-139898 Caspase-8 activates BID by cleavage GO:0004197 R-HSA-139906 Activation of BAD by calcineurin GO:0008597 R-HSA-139908 Phosphorylation of DLC2 by MAPK8 GO:0016301 R-HSA-139918 Phosphorylation of BIM by JNK GO:0016301 R-HSA-139952 Caspase-8 processing in the DISC GO:0004197 R-HSA-139970 FMO3:FAD N-oxidises TMA to TMAO GO:0004499 R-HSA-140355 Arachidonic acid is oxidised to PGG2 by PTGS1 GO:0004666 R-HSA-140359 PGG2 is reduced to PGH2 by PTGS1 GO:0004601 R-HSA-140599 factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides GO:0004252 R-HSA-140664 prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) GO:0004252 R-HSA-140696 factor V -> factor Va + factor V activation peptide GO:0004252 R-HSA-140700 prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) GO:0004252 R-HSA-140736 factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) GO:0004252 R-HSA-140769 factor VII -> factor VIIa GO:0004252 R-HSA-140777 factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) GO:0004252 R-HSA-140823 factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) GO:0004252 R-HSA-140840 fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B GO:0004252 R-HSA-140851 fibrin multimer -> fibrin multimer, crosslinked + NH4+ GO:0003810 R-HSA-140870 thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin GO:0004252 R-HSA-141026 Activated protein C cleaves factor Va to factor Vi intermediate form GO:0004252 R-HSA-141040 Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C GO:0004252 R-HSA-141186 MAOA:FAD oxidatively deaminates of 5HT GO:0008131 R-HSA-141200 MAOB:FAD oxidatively deaminates of PEA GO:0008131 R-HSA-141202 MAOB:FAD oxidatively deaminates TYR GO:0008131 R-HSA-141341 SMOX-3 oxidises SPN to SPM GO:0052901 R-HSA-141348 PAO:FAD oxidises NASPM to PTCN GO:0052904 R-HSA-141351 PAOX:FAD oxidises NASPN to SPM GO:0052904 R-HSA-141367 Myristoylation of tBID by NMT1 GO:0019107 R-HSA-1433374 Processing of SCF isoform 1 GO:0004175 R-HSA-1433415 Activation of RAC1 GO:0005085 R-HSA-1433418 Phosphorylation of JAK2 GO:0004713 R-HSA-1433454 Phosphorylation of GAB2 by SFKs GO:0004713 R-HSA-1433471 Activation of RAS by p-KIT bound SOS1 GO:0005088 R-HSA-1433488 Phosphorylation of SHP2 by SFKs GO:0004713 R-HSA-1433506 Phosphorylation of APS GO:0004713 R-HSA-1433508 PKC alpha interacts with and phosphorylates KIT GO:0004674 R-HSA-1433514 Synthesis of PIP3 from PIP2 by PI3K GO:0035004 R-HSA-1433542 Phosphorylation and activation of VAV1 GO:0004713 R-HSA-143468 MEOS oxidizes ethanol to acetaldehyde GO:0004497 R-HSA-1445143 RAB8A,10,13,14 hydrolyze GTP GO:0003924 R-HSA-1445144 p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) GO:0004674 R-HSA-1449597 p-AKT2 phosphorylates Myosin 5A GO:0004674 R-HSA-1454699 AMPK-alpha2 phosphorylates TBC1D1 GO:0004674 R-HSA-1454757 Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 GO:0004222 R-HSA-1454822 Collagen type I degradation by MMP1,2,8,13, PRSS2 GO:0004222 R-HSA-1454843 E-cadherin degradation by MMP3, MMP7 and plasmin. GO:0004252 R-HSA-1454916 The ABCC family mediates organic anion transport GO:0043225 R-HSA-1454928 ABCG4 may mediate cholesterol efflux GO:0017127 R-HSA-1458433 Collagen type I degradation by MMP14 GO:0004222 R-HSA-1458463 p-AKT2 phosphorylates RGC2 GO:0004674 R-HSA-1458485 RALA hydrolyzes GTP GO:0003924 R-HSA-1461993 pro-HD5 is cleaved by trypsin GO:0008236 R-HSA-1467457 ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region GO:0008559 R-HSA-1467466 ABCA4 mediates atRAL transport GO:0005395 R-HSA-1470009 Phosphorylation of STATs GO:0004713 R-HSA-1474146 GCH1 reduces GTP to dihydroneopterin triphosphate GO:0003934 R-HSA-1474184 DHNTP is dephosphorylated by PTPS to PTHP GO:0003874 R-HSA-1474196 Collagen type II degradation by MMP14 GO:0004222 R-HSA-1474197 Collagen type II degradation by MMP1,3,8,13,PRSS2 GO:0004252 R-HSA-1474210 Collagen type III degradation by MMP14 GO:0004222 R-HSA-1474213 Collagen type III degradation by MMP1,8,9,13 GO:0004222 R-HSA-1475017 Carbonic anhydrase dehydrates bicarbonate (plasma membrane) GO:0004089 R-HSA-1475022 Carbonic anhydrase dehydrates bicarbonate (cytosol) GO:0004089 R-HSA-1475025 Carbonic anhydrase hydrates carbon dioxide (plasma membrane) GO:0004089 R-HSA-1475026 Carbonic anhydrase hydrates carbon dioxide (cytosol) GO:0004089 R-HSA-1475028 Carbonic anhydrase dehydrates bicarbonate (mitochondria) GO:0004089 R-HSA-1475032 Carbonic anhydrase hydrates carbon dioxide (mitochondria) GO:0004089 R-HSA-1475414 PTHP is reduced to BH4 by sepiapterin reductase (SPR) GO:0004757 R-HSA-1475422 PTPS is phosphorylated by cGMP-dependant protein kinase II GO:0004692 R-HSA-1475435 Carbonic anhydrase I/II hydrates carbon dioxide GO:0004089 R-HSA-1475436 Carbonic anhydrase I/II dehydrates bicarbonate GO:0004089 R-HSA-1482533 2-acyl LPC is acylated to PC by LPCAT GO:0047144 R-HSA-1482539 1-acyl LPG is acylated to PG by LPGAT GO:0003841 R-HSA-1482543 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL GO:0047372 R-HSA-1482545 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C GO:0004622 R-HSA-1482546 2-acyl LPG is acylated to PG by CRLS1 (IM) GO:0047144 R-HSA-1482547 1-acyl LPC is acylated to PC by LPCAT GO:0003841 R-HSA-1482548 1-acyl LPA is acylated to PA by AGPAT5 (OM) GO:0003841 R-HSA-1482571 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C GO:0004622 R-HSA-1482598 1-acyl LPI is acylated to PI by MBOAT7 GO:0003841 R-HSA-1482604 PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) GO:0004623 R-HSA-1482612 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] GO:0004622 R-HSA-1482626 2-acyl LPI is acylated to PI by MBOAT7 GO:0047144 R-HSA-1482629 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C GO:0004622 R-HSA-1482635 2-acyl LPG is acylated to PG by LPGAT GO:0047144 R-HSA-1482636 1-acyl LPS is acylated to PS by LPSAT GO:0003841 R-HSA-1482646 2-acyl LPE is acylated to PE by LPEAT GO:0047144 R-HSA-1482647 2-MAG and DAG are transacylated to TAG by PNPLA2/3 GO:0016411 R-HSA-1482654 2-MAG is transacylated to DAG by PNPLA2/3 GO:0016411 R-HSA-1482656 PA is hydrolysed to 1-acyl LPA by PLA2[1] GO:0004623 R-HSA-1482667 1-acyl LPE is acylated to PE by LPEAT GO:0003841 R-HSA-1482679 PA is hydrolysed to 1-acyl LPA by PLA2G2A GO:0004623 R-HSA-1482685 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] GO:0004622 R-HSA-1482689 1-acyl LPG is acylated to PG by CRLS1 (IM) GO:0003841 R-HSA-1482691 2-acyl LPS is acylated to PS by LPSAT GO:0047144 R-HSA-1482695 G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) GO:0004366 R-HSA-1482696 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C GO:0004622 R-HSA-1482745 PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) GO:0004623 R-HSA-1482759 MLCL is hydrolyzed to DLCL by PLA2G4A (IM) GO:0004623 R-HSA-1482771 PS is hydrolyzed to 1-acyl LPS by PLA2[9] GO:0004623 R-HSA-1482775 MLCL is acylated to CL by HADH (IM) GO:0008374 R-HSA-1482776 PS is hydrolyzed to 1-acyl LPS by PLA2G2A GO:0004623 R-HSA-1482777 TAG is hydrolyzed to DAG by PNPLA2/3 GO:0004806 R-HSA-1482778 CL is hydrolyzed to MLCL by PLA2G6 (IM) GO:0004623 R-HSA-1482781 MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) GO:0008374 R-HSA-1482794 CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) GO:0047184 R-HSA-1482811 DAG is hydrolyzed to 2-MAG by PNPLA2/3 GO:0004465 R-HSA-1482816 PC is hydrolyzed to 1-acyl LPC by PLA2[6] GO:0004623 R-HSA-1482825 PI is hydrolyzed to 1-acyl LPI by PLA2[11] GO:0004623 R-HSA-1482827 PC is hydrolyzed to 2-acyl LPC by PLA2G4C GO:0008970 R-HSA-1482828 PE is hydrolyzed to 2-acyl LPE by PLA2[4] GO:0008970 R-HSA-1482847 PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) GO:0008970 R-HSA-1482850 MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) GO:0008374 R-HSA-1482856 PC is hydrolyzed to 1-acyl LPC by PLA2[5] GO:0004623 R-HSA-1482861 MLCL is acylated to CL by LCLAT1 (ER) GO:0008374 R-HSA-1482862 PC is hydrolysed to 2-acyl LPC by PLA2[7] GO:0008970 R-HSA-1482867 DLCL is acylated to MLCL by LCLAT1 (ER) GO:0008374 R-HSA-1482868 PI is hydrolyzed to 1-acyl LPI by PLA2[12] GO:0004623 R-HSA-1482884 PE is hydrolyzed to 1-acyl LPE by PLA2[2] GO:0004623 R-HSA-1482887 PE is hydrolyzed to 1-acyl LPE by PLA2[3] GO:0004623 R-HSA-1482889 DAG is acylated to TAG by DGAT1/2 GO:0004144 R-HSA-1482892 PE is hydrolyzed to 2-acyl LPE by PLA2G4C GO:0008970 R-HSA-1482894 CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) GO:0003841 R-HSA-1482897 PS is hydrolyzed to 2-acyl LPS by PLA2[10] GO:0004623 R-HSA-1482900 PG is hydrolyzed to 1-acyl LPG by PLA2[1] GO:0004623 R-HSA-1482907 PG is hydrolyzed to 1-acyl LPG by PLA2G2A GO:0004623 R-HSA-1482920 PG is hydrolyzed to 2-acyl LPG by PLA2[14] GO:0008970 R-HSA-1482932 PI is hydrolyzed to 2-acyl LPI by PLA2[13] GO:0008970 R-HSA-1482939 CDP-DAG is converted to PGP by PGS1 GO:0008444 R-HSA-1482961 CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane GO:0004142 R-HSA-1482962 CDP-ETA and DAG are converted to PE by CEPT1/EPT1 GO:0004307 R-HSA-1482973 CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane GO:0004142 R-HSA-1482976 CDP-DAG is converted to PI by CDIPT GO:0003881 R-HSA-1483002 DHAP is converted to 1-acyl GO3P by GNPAT GO:0016287 R-HSA-1483004 Cho is phosphorylated to PCho by CHK dimer GO:0004103 R-HSA-1483063 PG and CDP-DAG are converted to CL by CRLS1 GO:0043337 R-HSA-1483081 PCho and CTP are condensed to CDP-Cho by PCYT1 dimer GO:0004105 R-HSA-1483089 PE is converted to PS by PTDSS2 GO:0016740 R-HSA-1483096 PETA is dephosphorylated to ETA by PHOSPHO1 GO:0052732 R-HSA-1483107 GPETA is hydrolyzed to ETA and G3P by GPCPD1 GO:0008889 R-HSA-1483116 GPCho is hydrolyzed to Cho and G3P by GPCPD1 GO:0008889 R-HSA-1483121 PA is converted to CDP-DAG by CDS1 GO:0004605 R-HSA-1483142 PC is transphosphatidylated to PG by PLD1-4/6 GO:0004630 R-HSA-1483159 PCho is dephosphorylated to Cho by PHOSPHO1 GO:0052731 R-HSA-1483165 PA is converted to CDP-DAG by CDS2 GO:0004605 R-HSA-1483174 PE is methylated to PC by PEMT GO:0004608 R-HSA-1483182 PC is hydrolyzed to PA and choline by PLD1/2 GO:0004630 R-HSA-1483186 PC is converted to PS by PTDSS1 GO:0016740 R-HSA-1483190 PETA and CTP are condensed to CDP-ETA by PCY2 GO:0004306 R-HSA-1483197 PTPMT1 dephosphorylates PGP to PG GO:0008962 R-HSA-1483203 PA is dephosphorylated to DAG by LPIN GO:0008195 R-HSA-1483212 PS is decarboxylated to PE by PISD GO:0004609 R-HSA-1483222 ETA is phosphorylated to PETA by CHK/ETNK GO:0004305 R-HSA-1497794 Salvage - BH2 is reduced to BH4 by DHFR GO:0004146 R-HSA-1497810 Uncoupled eNOS favours the formation of superoxide GO:0016175 R-HSA-1497853 Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II GO:0004692 R-HSA-1497869 Salvage - Sepiapterin is reduced to BH2 GO:0004757 R-HSA-1500781 Fgd1 reactivates F420 GO:0016614 R-HSA-1500804 Peroxynitrite is reduced by AhpE GO:0051920 R-HSA-1500817 Glutathione is taken up by the bacterium GO:1904680 R-HSA-1504190 DVL is ubiquitinated by CUL3:KLHL12:RBX1 GO:0061630 R-HSA-1504193 Ubiquitinated DVL is degraded by the proteasome GO:0004175 R-HSA-1524186 Phosphorylation of PLCgamma by PDGFR GO:0004713 R-HSA-1549526 Phosphorylation of SMAD2/3 by Activin:Activin Receptor GO:0004674 R-HSA-1549564 PPTN11 dephosphorylates SPRY2 GO:0004725 R-HSA-1562603 BfrB stores iron GO:0004322 R-HSA-1562604 BfrA stores iron GO:0004322 R-HSA-1562626 Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) GO:0004322 R-HSA-1564112 Collagen type VI degradation by MMP2,9,11 GO:0004222 R-HSA-1564117 Collagen type XIV degradation by MMP9,13 GO:0004222 R-HSA-1564120 Collagen type VII degradation by MMP1,2,3 GO:0004222 R-HSA-1564142 Collagen type IV degradation by MMP2,3,4,9,10,12 GO:0004222 R-HSA-1564143 Collagen type X degradation by MMP1,2 GO:0004222 R-HSA-1564164 Collagen type V degradation by MMP2,9,10 GO:0004222 R-HSA-1564169 Collagen type VIII degradation by MMP1 GO:0004222 R-HSA-1564179 Collagen type XI degradation by MMP1,2,3,9 GO:0004222 R-HSA-1564184 Collagen type IX degradation by MMP3,13 GO:0004222 R-HSA-156526 CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO GO:0004497 R-HSA-156673 Regulation of KIF23 (MKLP1) by phosphorylation GO:0004674 R-HSA-156678 Activation of Cdc25C GO:0004674 R-HSA-156682 Regulation of NUDC by phosphorylation GO:0004674 R-HSA-1566962 Elastin degradation by elastin-degrading extracellular proteinases GO:0004252 R-HSA-1566979 Laminin-332 degradation by laminin-322 degrading extracellular proteinases GO:0004252 R-HSA-1566981 Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS GO:0004252 R-HSA-156699 Inactivation of Wee1 kinase GO:0004674 R-HSA-156723 Regulation of KIF20A (MKL2) by phosphorylation GO:0004674 R-HSA-156832 INF-gamma induced phosphorylation of L13a GO:0004672 R-HSA-156909 eEF1A complexes with GTP GO:0019001 R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA GO:0000048 R-HSA-156913 Regeneration of eEF1A:GTP by eEF1B activity GO:0005085 R-HSA-156923 Hydrolysis of eEF1A:GTP GO:0003924 R-HSA-157353 NEXT1 is cleaved to produce NICD1 GO:0004190 R-HSA-157629 NOTCH2-ligand complex is cleaved to produce NEXT2 GO:0008237 R-HSA-157632 Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 GO:0008237 R-HSA-157640 NEXT2 is cleaved to produce NICD2 GO:0004190 R-HSA-158137 factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer GO:0004252 R-HSA-158164 factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) GO:0004252 R-HSA-158251 prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer GO:0004185 R-HSA-158300 factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) GO:0004252 R-HSA-158311 kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin GO:0004252 R-HSA-158313 factor XII -> factor XIIa GO:0004252 R-HSA-158333 factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) GO:0004252 R-HSA-158419 factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) GO:0004252 R-HSA-158468 SULT1A1 dimer sulfonates PARA to PARA-SO4 GO:0004062 R-HSA-158609 TPMT transfers CH3 from AdoMet to 6MP GO:0008119 R-HSA-158744 crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin GO:0004252 R-HSA-158747 crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) GO:0004252 R-HSA-158750 crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin GO:0004252 R-HSA-158766 fibrin multimer, crosslinked -> fibrin digestion products (plasmin) GO:0004252 R-HSA-158795 fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 GO:0004867 R-HSA-158800 fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 GO:0004867 R-HSA-158849 Phenol can form a sulfate conjugate GO:0004062 R-HSA-158860 SULT1A1 dimer sulfonates NHABP GO:0004062 R-HSA-158893 alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin GO:0004867 R-HSA-158925 plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) GO:0004252 R-HSA-158942 urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR GO:0004252 R-HSA-158982 plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) GO:0004252 R-HSA-159001 urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR GO:0004867 R-HSA-159005 urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR GO:0004867 R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) GO:0016887 R-HSA-159179 UGT1A1 tetramer, UGT1A4 transfer GlcA from UDP-GlcA to BMG to form BDG GO:0015020 R-HSA-159194 UGT1A1,4 transfer GlcA from UDP-GlcA to BIL to form BMG GO:0015020 R-HSA-1592233 p38 MAPK phosphorylates PPARGC1A GO:0004674 R-HSA-1592244 AMPK phosphorylates PPARGC1A GO:0004679 R-HSA-1592270 NID1 degradation by MMP1, 9, 12, ELANE GO:0004252 R-HSA-1592278 Autocatalytic activation of proMMP2 GO:0004252 R-HSA-1592297 Full activation of MMP1 GO:0004252 R-HSA-1592310 Aggrecan degradation by ADAMTSs GO:0004222 R-HSA-1592314 HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) GO:0004252 R-HSA-1592316 Initial activation of proMMP1 GO:0004252 R-HSA-1592362 Activation of proMMP7 by MMP3 GO:0004252 R-HSA-1592371 Initial activation of proMMP3 GO:0004252 R-HSA-1592398 Activation of proMMP8 GO:0004252 R-HSA-1592436 Initial activation of proMMP9 by MMPs GO:0004252 R-HSA-159358 SULT1A3,4 dimers sulfate DA to DAOS GO:0004062 R-HSA-159425 Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) GO:0004467 R-HSA-159431 Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine GO:0016746 R-HSA-159443 benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate GO:0016405 R-HSA-159566 benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A GO:0047962 R-HSA-159567 salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate GO:0016405 R-HSA-159574 salicylate-CoA + glycine => salicyluric acid + Coenzyme A GO:0047962 R-HSA-159728 Furin cleaves pro-prothrombin to prothrombin GO:0004252 R-HSA-159733 Furin cleaves pro-factor X to factor X GO:0004252 R-HSA-159752 GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) GO:0008488 R-HSA-159761 GGCX gamma-carboxylates F7(21-466) (pro-factor VII) GO:0008488 R-HSA-159771 Furin cleaves pro-protein C to protein C GO:0004252 R-HSA-159773 Furin cleaves pro-protein S to protein S GO:0004252 R-HSA-159790 VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) GO:0047057 R-HSA-159795 GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) GO:0008488 R-HSA-159796 Furin cleaves pro-factor IX to factor IX GO:0004252 R-HSA-159803 GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) GO:0008488 R-HSA-159819 GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) GO:0008488 R-HSA-159826 GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) GO:0008488 R-HSA-159868 Furin cleaves pro-factor VII to factor VII GO:0004252 R-HSA-1602368 PG is hydrolyzed to 1-acyl LPG by PLA2[16] GO:0004623 R-HSA-1602374 PS is hydrolyzed to 1-acyl LPS by PLA2[15] GO:0004623 R-HSA-1602377 PI is hydrolyzed to 1-acyl LPI by PLA2[15] GO:0004623 R-HSA-1602398 PE is hydrolyzed to 1-acyl LPE by PLA2[16] GO:0004623 R-HSA-1602399 PC is hydrolyzed to 1-acyl LPC by PLB1 GO:0004623 R-HSA-1602417 PC is hydrolyzed to 1-acyl LPC by PLA2[16] GO:0004623 R-HSA-1602446 PA is hydrolyzed to 1-acyl LPA by PLA2[15] GO:0004623 R-HSA-1602458 Activation of proMMP10 GO:0004252 R-HSA-1602466 Activation of MT-MMPs by FURIN GO:0004252 R-HSA-1602473 Autocatalytic activation of MMP1 GO:0004252 R-HSA-1602484 Activation of proMMP11 by FURIN GO:0004252 R-HSA-1602488 Initial activation of proMMP13 by plasmin and trypsin GO:0004252 R-HSA-1604359 Initial activation of proMMP2 by MMP1, 7 GO:0004252 R-HSA-1604360 Initial activation of proMMP2 by MMP14 GO:0004252 R-HSA-1604368 Autocatalytic activation of bound proMMP2 GO:0004252 R-HSA-1604690 Activation of MMP9 intermediate form by MMPs GO:0004252 R-HSA-1604712 Initial activation of proMMP7 by trypsin GO:0004252 R-HSA-1604722 Activation of proMMP9 by proteases GO:0004252 R-HSA-1604731 Autocatalytic activation of MMP3 GO:0004252 R-HSA-1604732 Autocatalytic activation of proMMP13 GO:0004252 R-HSA-1604741 Initial activation of proMMP13 by MMP14 (MT1-MMP) GO:0004252 R-HSA-1604752 Initial activation of proMMP13 by MMP3 GO:0004252 R-HSA-1604763 Autocatalytic activation of MMP7 GO:0004252 R-HSA-1605591 Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide GO:0004348 R-HSA-1605595 Hexosaminidase A cleaves GalNAc from GM2 to form GM3 GO:0004563 R-HSA-1605624 Beta-galactosidase hydrolyses GM1 to GM2 GO:0004565 R-HSA-1605632 Both hexosaminidase A and B can cleave GalNAc from globoside GO:0004563 R-HSA-1605717 Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage GO:0030290 R-HSA-1605723 Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) GO:0004308 R-HSA-1605724 Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) GO:0004308 R-HSA-1605736 Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers GO:0004557 R-HSA-1605768 Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) GO:0004308 R-HSA-1605797 Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome) GO:0004767 R-HSA-1606273 Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane) GO:0004767 R-HSA-1606288 Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane) GO:0004767 R-HSA-1606312 Beta-galactosidase can also hydrolyse globosides to form cerebrosides GO:0004565 R-HSA-1606564 Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide GO:0004336 R-HSA-1606583 Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane) GO:0017040 R-HSA-1606602 Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome) GO:0017040 R-HSA-1606789 ARSB hydrolyses DS GO:0003943 R-HSA-1606807 Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside GO:0004098 R-HSA-1606839 Steryl sulfatase hydrolyses sulfate from steroid sulfates GO:0004773 R-HSA-1614362 SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases GO:0016491 R-HSA-1614524 Cystathionine is formed from homocysteine and serine GO:0004122 R-HSA-1614544 Sulfite is oxidized to sulfate GO:0008482 R-HSA-1614546 Sulfate is exported to the cytosol in exchange for dicarboxylate GO:0005310 R-HSA-1614567 Excess homocysteine yields homolanthionine and H2S GO:0016846 R-HSA-1614583 Cleavage of cystathionine into cysteine GO:0004123 R-HSA-1614591 Excess cysteine yields lanthionine and H2S GO:0080146 R-HSA-1614605 Persulfide sulfur is dioxygenated GO:0050313 R-HSA-1614614 Cysteine is degraded to serine and H2S GO:0080146 R-HSA-1614618 Persulfide sulfur is transferred onto sulfite GO:0016783 R-HSA-1614631 Homocysteine is degraded to oxobutanoate and H2S GO:0047982 R-HSA-1614645 CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine GO:0017172 R-HSA-1614654 BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY GO:0047150 R-HSA-1614665 SQR oxidizes sulfide to bound persulfide GO:0070224 R-HSA-162363 p-T309,S474-AKT2:PIP3 phosphorylates PDE3B GO:0004674 R-HSA-162425 p-S295-PDE3B hydrolyses cAMP to AMP GO:0004114 R-HSA-162657 Inactivation of Myt1 kinase GO:0004674 R-HSA-162683 glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH GO:0008374 R-HSA-162721 dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose GO:0004582 R-HSA-162729 uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid GO:0016788 R-HSA-162730 phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP GO:0008194 R-HSA-162742 (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI GO:0016780 R-HSA-162797 mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI GO:0000030 R-HSA-162798 mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol GO:0051377 R-HSA-162821 mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate GO:0004376 R-HSA-162830 glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate GO:0000030 R-HSA-162836 uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide GO:0003923 R-HSA-162857 N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate GO:0000225 R-HSA-162873 (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate GO:0004376 R-HSA-162914 Myristoylation of Nef GO:0019107 R-HSA-163010 Down Regulation of Emi1 through Phosphorylation of Emi1 GO:0004674 R-HSA-1630304 GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate GO:0043890 R-HSA-1630306 GLB1 hydrolyses a glycosaminoglycan GO:0004565 R-HSA-163069 mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol GO:0016780 R-HSA-163090 Elongation Of The Telomeric Chromosome End GO:0003720 R-HSA-163213 Transfer of electrons through the succinate dehydrogenase complex GO:0008177 R-HSA-163214 Electron transfer from reduced cytochrome c to molecular oxygen GO:0004129 R-HSA-163215 SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane GO:0015207 R-HSA-163217 Complex I oxidises NADH to NAD+, reduces CoQ to QH2 GO:0008137 R-HSA-1632857 ULK1 phosphorylates AMBRA1:Beclin-1 complex GO:0004674 R-HSA-163402 diacylglycerol + H2O -> 2-acylglycerol + fatty acid GO:0016298 R-HSA-163416 hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP GO:0004674 R-HSA-163418 perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP GO:0004674 R-HSA-163432 cholesterol ester + H2O -> cholesterol + fatty acid GO:0016298 R-HSA-163551 triacylglycerol + H2O -> diacylglycerol + fatty acid GO:0004806 R-HSA-163568 phosphorylated perilipin + H2O -> perilipin + orthophosphate GO:0004722 R-HSA-163595 2-acylglycerol + H2O -> glycerol + fatty acid GO:0047372 R-HSA-163672 Phosphorylation of ChREBP at Thr(666) by PKA GO:0004691 R-HSA-163676 Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA GO:0004691 R-HSA-163688 Dephosphorylation of pChREBP (Thr 666) by PP2A GO:0008195 R-HSA-163689 Dephosphorylation of pChREBP (Ser 196) by PP2A GO:0008195 R-HSA-163691 Phosphorylation of ChREBP at Serine 568 by AMPK GO:0004679 R-HSA-163741 D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate GO:0004802 R-HSA-163750 Dephosphorylation of phosphoPFKFB1 by PP2A complex GO:0008195 R-HSA-163751 D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate GO:0004802 R-HSA-163764 D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate GO:0004801 R-HSA-163773 Phosphorylation of PF2K-Pase by PKA catalytic subunit GO:0004691 R-HSA-163798 Furin cleaves pro-protein Z to protein Z GO:0004252 R-HSA-1638032 N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate GO:0008449 R-HSA-1638053 HEXA,B cleave the terminal GalNAc from keratan sulfate GO:0004563 R-HSA-163810 GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) GO:0008488 R-HSA-1638104 Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide GO:0008120 R-HSA-163820 GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) GO:0008488 R-HSA-163843 Furin cleaves pro-GAS6 to GAS6 GO:0004252 R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres GO:0004674 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin GO:0004722 R-HSA-1638845 CERK phosphorylates CERA to form C1P GO:0001729 R-HSA-1640164 Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin GO:0004767 R-HSA-164056 Dephosphorylation of pChREBP (Ser 568) by PP2A GO:0008195 R-HSA-164151 LKB1 phosphorylates the alpha subunit of AMPK heterotrimer GO:0004672 R-HSA-164377 Activated Adenylate cyclase catalyses cAMP synthesis GO:0004016 R-HSA-164381 G alpha (s) auto-inactivates by hydrolysing GTP to GDP GO:0003924 R-HSA-164504 Synthesis of minus strand strong stop DNA (-sssDNA) GO:0003964 R-HSA-164505 Synthesis of full-length duplex viral DNA with a discontinuous plus strand GO:0003887 R-HSA-164513 3' PPT-primed initiation of plus-strand DNA synthesis GO:0003887 R-HSA-164519 RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex GO:0004523 R-HSA-164520 Minus strand DNA synthesis resumes GO:0003964 R-HSA-164523 Transesterification to connect viral DNA 3' ends to host DNA 5' ends GO:0008907 R-HSA-164528 RNase H-mediated cleavage of the template strand GO:0004523 R-HSA-164617 Elongation of Extended Telomeric Chromosome End GO:0003720 R-HSA-164651 Electron transfer from ubiquinol to cytochrome c of complex III GO:0045153 R-HSA-164832 ATPase synthesizes ATP GO:0046933 R-HSA-164834 Enzyme-bound ATP is released GO:0015078 R-HSA-164967 Unknown carnitine exporter transports CAR from the cytosol to the extracellular space GO:0015226 R-HSA-165026 OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol GO:0015226 R-HSA-165055 Hydrolysis of Ran:GTP to Ran:GDP GO:0003924 R-HSA-1650808 Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines GO:0004656 R-HSA-165162 Phosphorylation of TSC2 by PKB GO:0004674 R-HSA-165182 Phosphorylation of complexed TSC2 by PKB GO:0004674 R-HSA-1655443 CSAD decarboxylates 3-sulfinoalanine to hypotaurine GO:0004782 R-HSA-1655453 HTAUDH oxidises HTAU to TAU GO:0047822 R-HSA-1655842 S1P hydrolyzes SREBP1A,1C,2 GO:0004252 R-HSA-1655851 S2P hydrolyzes SREBP1A,1C,2 GO:0004222 R-HSA-1655879 Thiosulfate can transfer its sulfur atom to glutathione GO:0050337 R-HSA-165692 Phosphorylation of 4E-BP1 by activated mTORC1 GO:0016301 R-HSA-165718 mTORC1 phosphorylation of RPS6KB1 (S6K) GO:0016301 R-HSA-165726 Phosphorylation of Ribosomal protein S6 by activated S6K1 GO:0016301 R-HSA-165758 Phosphorylation and inactivation of eEF2K by activated S6K1 GO:0016301 R-HSA-165766 Phosphorylation and activation of eIF4G by activated S6K1 GO:0016301 R-HSA-165777 Phosphorylation and activation of eIF4B by activated S6K1 GO:0016301 R-HSA-166119 First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal GO:0004674 R-HSA-166214 FA anion flip-flops to the opposite surface GO:0008509 R-HSA-166245 Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex GO:0004674 R-HSA-166284 Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP GO:0004674 R-HSA-166286 Multiple IRAK1 autophosphorylation steps GO:0004672 R-HSA-166544 TrkA receptor autophosphorylates GO:0004714 R-HSA-1667005 Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) GO:0030305 R-HSA-166753 Conversion of C4 into C4a and C4b GO:0004252 R-HSA-166792 Conversion of C2 into C2a and C2b GO:0004252 R-HSA-166817 Cleavage of C3 by C3 convertases GO:0004252 R-HSA-167019 SHC, complexed with TrkA, is tyrosine-phosphorylated GO:0004714 R-HSA-167072 Hypophosphorylation of RNA Pol II CTD by FCP1P protein GO:0004721 R-HSA-167084 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex GO:0016301 R-HSA-167097 HIV Promoter Opening: First Transition GO:0004386 R-HSA-167098 Phosphorylation (Ser5) of RNA pol II CTD GO:0016301 R-HSA-167113 Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition GO:0003899 R-HSA-167115 Addition of nucleotides between position +11 and +30 on HIV-1 transcript GO:0003899 R-HSA-167117 Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition GO:0003899 R-HSA-167121 Addition of the third nucleotide on the nascent HIV-1 transcript GO:0003899 R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript GO:0003899 R-HSA-1671691 PRLR-bound STAT5 is phosphorylated GO:0004713 R-HSA-167191 Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex GO:0016301 R-HSA-167408 The high affinity receptor complex binds to G-protein GO:0004930 R-HSA-167415 G-protein alpha subunit is inactivated GO:0003924 R-HSA-167429 The receptor:G-protein complex binds GTP GO:0005525 R-HSA-1675773 PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane GO:0052812 R-HSA-1675776 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane GO:0016309 R-HSA-1675780 PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane GO:0004430 R-HSA-1675795 PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane GO:0004438 R-HSA-1675810 PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane GO:0052810 R-HSA-1675813 PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane GO:0004430 R-HSA-1675824 PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane GO:0004439 R-HSA-1675836 PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane GO:0043813 R-HSA-1675866 PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane GO:0052810 R-HSA-1675883 PI is phosphorylated to PI4P by PI4KB at the Golgi membrane GO:0004430 R-HSA-1675910 PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane GO:0000285 R-HSA-1675921 PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane GO:0000285 R-HSA-1675928 PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane GO:0035005 R-HSA-1675939 PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane GO:0016303 R-HSA-1675949 PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane GO:0034485 R-HSA-1675961 PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane GO:0016303 R-HSA-1675974 PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane GO:0004430 R-HSA-1675988 PI4P is dephosphorylated to PI by SYNJ at the plasma membrane GO:0034596 R-HSA-1675994 PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane GO:0004438 R-HSA-1676005 PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane GO:0043813 R-HSA-1676020 PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane GO:0043813 R-HSA-1676024 PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane GO:0016303 R-HSA-1676048 PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane GO:0046934 R-HSA-1676065 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane GO:0052629 R-HSA-1676082 PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane GO:0016308 R-HSA-1676105 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane GO:0052629 R-HSA-1676109 PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane GO:0035005 R-HSA-1676114 PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane GO:0004438 R-HSA-1676124 PI4P is dephosphorylated to PI by SACM1L at the ER membrane GO:0034596 R-HSA-1676133 PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane GO:0034596 R-HSA-1676134 PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane GO:0000285 R-HSA-1676141 PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane GO:0004438 R-HSA-1676145 PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane GO:0052811 R-HSA-1676149 PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane GO:0051800 R-HSA-1676162 PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane GO:0016316 R-HSA-1676164 PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane GO:0016316 R-HSA-1676168 PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane GO:0000285 R-HSA-1676174 PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane GO:0043813 R-HSA-1676177 PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane GO:0004439 R-HSA-1676185 PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane GO:0004430 R-HSA-1676203 PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane GO:0052629 R-HSA-1676204 PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane GO:0051800 R-HSA-1676206 PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane GO:0035005 R-HSA-167683 TrkA phosphorylates PLCG1 GO:0004714 R-HSA-167686 Active PLCG1 hydrolyses PIP2 GO:0004435 R-HSA-1678650 IDS hydrolyses Heparan sulfate chain(5) GO:0004423 R-HSA-1678660 HGSNAT oligomer acetylates Heparan sulfate chain(3) GO:0015019 R-HSA-1678694 Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane) GO:0030305 R-HSA-1678708 SGSH hydrolyses Heparan sulfate chain(2) GO:0016250 R-HSA-1678716 IDUA hydrolyses Heparan sulfate chain(1) GO:0003940 R-HSA-1678742 NAGLU hydrolyses Heparan sulfate chain(4) GO:0004561 R-HSA-1678841 Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 GO:0019785 R-HSA-1678854 GUSB tetramer hydrolyses CS/HS precursor GO:0004566 R-HSA-1678920 TLR processing at low pH GO:0004197 R-HSA-1678981 TLR9 processing at neutral pH GO:0004197 R-HSA-168053 Phosphorylated MAPKs phosphorylate ATF-2 GO:0004674 R-HSA-168136 Activated JNKs phosphorylate c-JUN GO:0004705 R-HSA-168140 Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex GO:0004674 R-HSA-168162 Phosphorylation of human JNKs by activated MKK4/MKK7 GO:0008545 R-HSA-168184 Activated TAK1 mediates phosphorylation of the IKK Complex GO:0004674 R-HSA-168280 Priming and Initiation of Transcription GO:0003968 R-HSA-168301 Polyadenylation and Termination GO:0003968 R-HSA-168313 Virion-associated M2 protein mediated ion infusion GO:0005215 R-HSA-168334 Elongation of viral mRNA GO:0003968 R-HSA-168865 NA activation of TGF-beta GO:0016504 R-HSA-168870 Neuraminidase enzymatic release from sialic acid GO:0004308 R-HSA-168915 K63-linked ubiquitination of RIP1 bound to the activated TLR complex GO:0004842 R-HSA-169260 Reducing equivalents from beta-oxidation of fatty acids transfer to ETF GO:0009055 R-HSA-169270 ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 GO:0004174 R-HSA-169461 MCM8 mediated fork unwinding GO:0004386 R-HSA-169468 MCM2-7 mediated fork unwinding GO:0004386 R-HSA-169683 IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol GO:0005261 R-HSA-169904 C3G stimulates nucleotide exchange on Rap1 GO:0005085 R-HSA-169905 ARMS is phosphorylated by active TrkA receptor GO:0004714 R-HSA-170026 Protons are translocated from the intermembrane space to the matrix GO:0015078 R-HSA-170055 Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes GO:0016301 R-HSA-170070 Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes GO:0016301 R-HSA-170076 CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes GO:0016301 R-HSA-170087 CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes GO:0016301 R-HSA-170116 Myt-1 mediated phosphorylation of Cyclin A:Cdc2 GO:0016301 R-HSA-170126 Phosphorylation of Cyclin B1 in the CRS domain GO:0016301 R-HSA-170153 Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases GO:0004721 R-HSA-170156 Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes GO:0016301 R-HSA-170158 Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes GO:0004721 R-HSA-170161 Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B GO:0004721 R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf GO:0003924 R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it GO:0008179 R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP GO:0004016 R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf GO:0003924 R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha GO:0003924 R-HSA-170704 Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex GO:0016301 R-HSA-170706 Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex GO:0016301 R-HSA-170796 NPC transports GCK1:GKRP from cytosol to nucleoplasm GO:0017056 R-HSA-170835 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 GO:0005515 R-HSA-170843 TGFBR2 phosphorylates TGFBR1 GO:0005026 R-HSA-170844 Latent TGF-beta-1 is cleaved by furin GO:0004252 R-HSA-170846 TGFBR2 recruits TGFBR1 GO:0005515 R-HSA-170861 Dimeric TGF-beta-1 binds to the receptor GO:0005160 R-HSA-170868 Activated type I receptor phosphorylates SMAD2/3 directly GO:0004675 R-HSA-170977 FRS2 is phosphorylated by active TrkA receptor GO:0004674 R-HSA-170979 (Frs2)C3G stimulates nucleotide exchange on Rap1 GO:0005085 R-HSA-170991 SRC-1 autophosphorylates GO:0004713 R-HSA-171011 Binding and activation of MAP Kinase GO:0004713 R-HSA-171026 Guanine nucleotide exchange on RAL GO:0008321 R-HSA-171288 Cleavage of the viral Env gp160 precursor polyprotein GO:0004252 R-HSA-173542 SMURF2 ubiquitinates SMAD2 GO:0004842 R-HSA-173545 Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling GO:0004842 R-HSA-173597 UDP-glucose is oxidised to UDP-glucuronate GO:0003979 R-HSA-173626 Activation of C1r GO:0004252 R-HSA-173631 Activation of C1s GO:0004252 R-HSA-173680 Activation of C5 GO:0004252 R-HSA-173745 Factor D cleaves C3(H2O)-bound Factor B GO:0004252 R-HSA-173769 RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers GO:0004523 R-HSA-174057 Multiubiquitination of APC/C-associated Cdh1 GO:0004842 R-HSA-174058 Degradation of multiubiquitinated Cdh1 GO:0004175 R-HSA-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 GO:0004693 R-HSA-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex GO:0004842 R-HSA-174105 Degradation of multiubiquitinated cell cycle proteins GO:0004175 R-HSA-174110 Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 GO:0004721 R-HSA-174119 Free APC/C phosphorylated by Plk1 GO:0004674 R-HSA-174122 Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 GO:0004693 R-HSA-174124 Dephosphorylation of phospho-Cdh1 GO:0004721 R-HSA-174132 Free APC/C phosphorylated by Cyclin B:Cdc2 GO:0004693 R-HSA-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex GO:0004842 R-HSA-174159 Ubiquitination of Emi1 by SCF-beta-TrCP GO:0004842 R-HSA-174164 Phosphorylation of Cyclin A:Cdk2 at Tyr 15 GO:0016301 R-HSA-174174 Phosphorylation of the Emi1 DSGxxS degron by Plk1 GO:0004674 R-HSA-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex GO:0004842 R-HSA-174202 Degradation of multiubiquitinated Securin GO:0004175 R-HSA-174203 SCF-mediated degradation of Emi1 GO:0004175 R-HSA-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex GO:0004842 R-HSA-174251 Phosphorylation of Cdh1 by Cyclin B1:Cdc2 GO:0004693 R-HSA-174255 Degradation multiubiquitinated Cyclin A GO:0004175 R-HSA-174367 GCL ligates L-Glu to L-Cys GO:0004357 R-HSA-174368 SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen GO:0005461 R-HSA-174374 MTR transfers CH3 from MeCbl to HCYS GO:0008705 R-HSA-174389 PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS GO:0004020 R-HSA-174391 MAT1A multimers transfer Ado from ATP to L-Met GO:0004478 R-HSA-174392 PAPSS1,2 transfer SO4(2-) group to ATP to form APS GO:0004781 R-HSA-174394 GSS:Mg2+ dimer synthesizes GSH GO:0004363 R-HSA-174401 AHCY:NAD+ tetramer hydrolyses AdoHcy GO:0004013 R-HSA-174425 The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere GO:0003899 R-HSA-174427 The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere GO:0003887 R-HSA-174444 Formation of C-strand Okazaki fragments GO:0003887 R-HSA-174446 Removal of remaining Flap from the C-strand GO:0017108 R-HSA-174456 Joining of adjacent Okazaki fragments of the C-strand GO:0003909 R-HSA-174551 Formation of alternative pathway C5 convertase GO:0004252 R-HSA-174757 chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols GO:0004465 R-HSA-174786 ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex GO:0005319 R-HSA-174916 Formation of N-glucuronides GO:0015020 R-HSA-174931 UGTs transfer GlcA from UDP-GlcA to O-centre substrates GO:0015020 R-HSA-174963 NAT1 acetylation GO:0004060 R-HSA-174967 NAT2 acetylation GO:0004060 R-HSA-175258 2-LTR formation due to circularization of viral DNA GO:0003909 R-HSA-175976 TMT transfers CH3 from AdoMet to BME GO:0018708 R-HSA-175983 COMT transfer CH3 from AdoMet to 3,4DHBNZ GO:0016206 R-HSA-175987 NNMT transfers CH3 from AdoMet to PY GO:0030760 R-HSA-175993 HNMT transfers CH3 group from AdoMet to Hist GO:0046539 R-HSA-176054 GST dimers conjugate GSH with cytosolic substrates GO:0004364 R-HSA-176059 GST trimers transfer GS from GSH to luminal substrates GO:0004364 R-HSA-176116 Recruitment and activation of Chk1 GO:0004674 R-HSA-176264 Recruitment of the Rad9-Hus1-Rad1 complex to DNA GO:0003689 R-HSA-176298 Activation of claspin GO:0004674 R-HSA-176474 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP GO:0004062 R-HSA-176494 SULTs transfer (SO4)2- group to 27HCHOL GO:0004027 R-HSA-176517 SULTs transfer (SO4)2- group to PREG GO:0050294 R-HSA-176521 beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP GO:0050294 R-HSA-176585 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP GO:0004062 R-HSA-176588 lithocholate + PAPS => lithocholate sulfate + PAP GO:0008146 R-HSA-176604 taurolithocholate + PAPS => taurolithocholate sulfate + PAP GO:0008146 R-HSA-176606 Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate GO:0008441 R-HSA-176609 cholesterol + PAPS => cholesterol sulfate + PAP GO:0004027 R-HSA-176631 dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP GO:0050294 R-HSA-176646 p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP GO:0004062 R-HSA-176664 estrone + PAPS => estrone 3-sulfate + PAP GO:0004304 R-HSA-176669 N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP GO:0008146 R-HSA-177157 phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate GO:0016405 R-HSA-177160 phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A GO:0016410 R-HSA-177275 PKA phosphorylates DARPP-32 on Thr34 GO:0004691 R-HSA-177284 PKA phosphorylates PDE4B GO:0004691 R-HSA-177479 Axonal transport of NGF:Trk complexes GO:0003777 R-HSA-177501 Endocytosis (internalization) of clathrin-coated vesicle GO:0003924 R-HSA-177692 Activation of recruited TAK1 within the activated TLR3 complex GO:0004674 R-HSA-177784 ribose 5-phosphate <=> D-ribulose 5-phosphate GO:0004751 R-HSA-177923 Sustained activation of SRC kinase by SHP2 GO:0004726 R-HSA-177924 Dephosphorylation of Gab1 by SHP2 GO:0004726 R-HSA-177926 Dephosphorylation of PAG by SHP2 GO:0004726 R-HSA-177930 GAB1 phosphorylation by EGFR kinase GO:0004713 R-HSA-177933 SHC1 phosphorylation by phosphorylated EGFR GO:0004714 R-HSA-177934 EGFR autophosphorylation GO:0004713 R-HSA-177935 SHP2 dephosphorylates Tyr 992 on EGFR GO:0004726 R-HSA-177937 Phosphorylation of EGFR by SRC kinase GO:0004713 R-HSA-177938 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) GO:0005088 R-HSA-177939 PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) GO:0046934 R-HSA-177945 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) GO:0005088 R-HSA-177946 Pro-EGF is cleaved to form mature EGF GO:0004222 R-HSA-178178 PP1 dephosphorylates TGFBR1 GO:0004721 R-HSA-178215 SMAD7:SMURF1 complex is exported to the cytosol GO:0005215 R-HSA-1793176 DS is cleaved from its proteoglycan GO:0016798 R-HSA-1793182 IDS hydrolyses dermatan sulfate (Chebi:63517 chain) GO:0004423 R-HSA-1793186 IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS GO:0003940 R-HSA-1793207 ARSB hydrolyses C4S/C6S chains GO:0003943 R-HSA-1793209 HYAL1 hydrolyses Chondroitin chains GO:0004415 R-HSA-1793217 Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase GO:0004565 R-HSA-179417 Multiubiquitination of Nek2A GO:0004842 R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein GO:0004252 R-HSA-180038 DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function GO:0019888 R-HSA-180047 CDK5 phosphorylates DARPP-32 on Thr75 GO:0004693 R-HSA-180073 DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function GO:0004862 R-HSA-180540 Multi-ubiquitination of APOBEC3G GO:0004842 R-HSA-180573 Degradation of ubiquitinated CD4 GO:0004175 R-HSA-180597 Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex GO:0004842 R-HSA-180603 Proteosome-mediated degradation of APOBEC3G GO:0004175 R-HSA-180632 Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand GO:0008829 R-HSA-180687 Conversion of Ran-GDP to Ran-GTP GO:0005087 R-HSA-181567 BoNT/C LC cleaves target cell STX1 GO:0004222 R-HSA-182795 RNase H-mediated degradation of the template strand GO:0004523 R-HSA-182859 RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex GO:0004523 R-HSA-182969 Phosphorylation of CBL (EGFR:CBL) GO:0004713 R-HSA-182986 CBL-mediated ubiquitination of CIN85 GO:0004842 R-HSA-182993 Ubiquitination of stimulated EGFR (CBL) GO:0004842 R-HSA-183036 Ubiquitination of stimulated EGFR (CBL:GRB2) GO:0004842 R-HSA-183051 CBL ubiquitinates Sprouty GO:0004842 R-HSA-183058 Phosphorylation of CBL (EGFR:GRB2:CBL) GO:0004713 R-HSA-183084 CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix GO:0004842 R-HSA-183089 CBL binds and ubiquitinates phosphorylated Sprouty GO:0004842 R-HSA-183122 Factor D cleaves C3b-bound Factor B GO:0004252 R-HSA-183130 C3(H2O):Factor Bb cleaves C3 to C3b and C3a GO:0004252 R-HSA-1839065 Phosphorylation of cytosolic FGFR1 fusion dimers GO:0004713 R-HSA-1839067 Phosphorylation of BCR moiety of BCR-FGFR1 GO:0004713 R-HSA-1839091 Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-1839098 Activated FGFR1 mutants and fusions phosphorylate PLCG1 GO:0004713 R-HSA-1839107 BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. GO:0016301 R-HSA-1839110 p-BCR-p-FGFR1 phosphorylates GAB2 GO:0016301 R-HSA-1839112 Phosphorylation of STAT5 by cytosolic FGFR1 fusions GO:0004713 R-HSA-184269 Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex GO:0008565 R-HSA-184392 N-myristoylation of GAG polyprotein by NMT2 GO:0004379 R-HSA-1852623 Ubiquitination of NICD1 by FBWX7 GO:0004842 R-HSA-1855153 I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol GO:0008440 R-HSA-1855154 I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol GO:0008934 R-HSA-1855157 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus GO:0000829 R-HSA-1855158 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol GO:0052836 R-HSA-1855159 I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol GO:0052831 R-HSA-1855162 I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol GO:0047325 R-HSA-1855163 I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen GO:0030351 R-HSA-1855165 (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol GO:0052841 R-HSA-1855166 PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol GO:0052840 R-HSA-1855169 I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol GO:0052835 R-HSA-1855171 I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol GO:0052830 R-HSA-1855172 I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol GO:0052726 R-HSA-1855174 I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol GO:0052658 R-HSA-1855176 I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus GO:0035299 R-HSA-1855177 PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane GO:0004435 R-HSA-1855178 Glc6P is isomerised to I3P by ISYNA1 in the cytosol GO:0004512 R-HSA-1855179 I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol GO:0035299 R-HSA-1855180 I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol GO:0017161 R-HSA-1855181 I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus GO:0000827 R-HSA-1855182 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol GO:0000829 R-HSA-1855185 I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus GO:0000824 R-HSA-1855193 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol GO:0052839 R-HSA-1855194 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol GO:0000829 R-HSA-1855197 I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol GO:0052725 R-HSA-1855198 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol GO:0052842 R-HSA-1855200 I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen GO:0051717 R-HSA-1855202 I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol GO:0052828 R-HSA-1855205 I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol GO:0051717 R-HSA-1855206 I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus GO:0000825 R-HSA-1855207 IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus GO:0000828 R-HSA-1855208 I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol GO:0004441 R-HSA-1855210 I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol GO:0052832 R-HSA-1855211 I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol GO:0052833 R-HSA-1855213 I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane GO:0052659 R-HSA-1855214 PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane GO:0004435 R-HSA-1855216 IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol GO:0000828 R-HSA-1855218 I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol GO:0052659 R-HSA-1855219 I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol GO:0052825 R-HSA-1855221 PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane GO:0004435 R-HSA-1855222 I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane GO:0052658 R-HSA-1855223 I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol GO:0000827 R-HSA-1855224 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus GO:0052836 R-HSA-1855225 IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen GO:0052826 R-HSA-1855227 IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol GO:0000828 R-HSA-1855228 I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus GO:0047326 R-HSA-1855230 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus GO:0052839 R-HSA-1855232 I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol GO:0052829 R-HSA-1855233 I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus GO:0008440 R-HSA-1861595 Extension of pseudopodia by myosin-X in a PI3K dependent manner GO:0003774 R-HSA-1861788 Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane) GO:0004348 R-HSA-1861789 Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) GO:0004348 R-HSA-186785 PDGF-AA clevage by Furin GO:0004252 R-HSA-186786 Autophosphorylation of PDGF beta receptors GO:0004713 R-HSA-186800 PI3K catalyses the phosphorylation of PIP2 to PIP3 GO:0046934 R-HSA-186834 Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) GO:0005088 R-HSA-187020 Part of pro-beta-NGF is processed to mature beta-NGF GO:0004252 R-HSA-187520 Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 GO:0004693 R-HSA-187574 Degradation of ubiquitinated p27/p21 by the 26S proteasome GO:0004175 R-HSA-187575 Ubiquitination of phospho-p27/p21 GO:0004842 R-HSA-187688 p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 GO:0004674 R-HSA-187746 RIT/RIN are activated GO:0005085 R-HSA-1878002 XYLTs transfer Xyl to core protein GO:0030158 R-HSA-187916 Cyclin A:Cdk2 mediated phosphorylation of p27/p21 GO:0004693 R-HSA-187948 Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 GO:0004693 R-HSA-187949 CAK-mediated phosphorylation of Cyclin A:Cdk2 GO:0016301 R-HSA-187959 Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) GO:0004693 R-HSA-188191 APC/C:Cdh1-mediated degradation of Skp2 GO:0004175 R-HSA-188350 CAK-mediated phosphorylation of Cyclin E:Cdk2 GO:0016301 R-HSA-188390 Cyclin E:Cdk2-mediated phosphorylation of Rb GO:0004693 R-HSA-188467 Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) GO:0004368 R-HSA-1888198 FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 GO:0004713 R-HSA-188979 Digestion of linear starch (amylose) by extracellular amylase GO:0004556 R-HSA-188985 trehalose + H2O => 2 D-glucose GO:0004555 R-HSA-1889955 B3GATs transfer GlcA to tetrasaccharide linker GO:0015018 R-HSA-1889978 B3GALT6 transfers Gal to the tetrasaccharide linker GO:0047220 R-HSA-1889981 B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker GO:0046525 R-HSA-189053 Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose GO:0004558 R-HSA-189062 lactose + H2O => D-glucose + D-galactose GO:0000016 R-HSA-189069 sucrose + H2O => glucose + fructose GO:0004575 R-HSA-189102 maltose + H2O => 2 D-glucose (maltase-glucoamylase) GO:0004558 R-HSA-189208 SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol GO:0005412 R-HSA-189222 SLC2A5 transports fructose from extracellular region to cytosol GO:0005353 R-HSA-189242 SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region GO:0015149 R-HSA-189384 Biliverdin is reduced to bilirubin GO:0004074 R-HSA-189398 HMOX1,2 cleave heme GO:0004392 R-HSA-189406 4 PBGs bind to form HMB GO:0004418 R-HSA-189421 CPO transforms COPRO3 to PPGEN9 GO:0004109 R-HSA-189423 PPO oxidises PPGEN9 to PRIN9 GO:0004729 R-HSA-189425 UROD decarboxylates URO3 to COPRO3 GO:0004853 R-HSA-189439 ALAD condenses 2 dALAs to form PBG GO:0004655 R-HSA-189442 ALAS condenses SUCC-CoA and Gly to form dALA GO:0003870 R-HSA-189465 FECH binds Fe2+ to PRIN9 to form heme GO:0004325 R-HSA-189488 UROS transforms HMB to URO3 GO:0004852 R-HSA-190182 UROD decarboxylates URO1 to COPRO1 GO:0004853 R-HSA-190326 Autocatalytic phosphorylation of FGFR4 GO:0004713 R-HSA-190385 Autocatalytic phosphorylation of FGFR3b GO:0004713 R-HSA-190388 Autocatalytic phosphorylation of FGFR3c GO:0004713 R-HSA-190408 Autocatalytic phosphorylation of FGFR2b GO:0004713 R-HSA-190413 Autocatalytic phosphorylation of FGFR2c GO:0004713 R-HSA-190427 Autocatalytic phosphorylation of FGFR1b GO:0004713 R-HSA-190429 Autocatalytic phosphorylation of FGFR1c GO:0004713 R-HSA-190681 Connexin oligomerization in endoplasmic reticulum membrane GO:0005243 R-HSA-191062 Autocatalytic phosphorylation of Klotho-bound FGFR1c GO:0004713 R-HSA-191101 maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) GO:0004558 R-HSA-191108 maltose + H2O => 2 D-glucose (sucrase-isomaltase) GO:0004558 R-HSA-191114 Digestion of branched starch (amylopectin) by extracellular amylase GO:0004556 R-HSA-191116 maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) GO:0004558 R-HSA-1912349 Fucosylation of Pre-NOTCH by POFUT1 GO:0046922 R-HSA-1912352 Galactosylation of Pre-NOTCH GO:0003831 R-HSA-1912353 Glucosylation of Pre-NOTCH by POGLUT1 GO:0035251 R-HSA-1912355 Glycosylation of Pre-NOTCH by FRINGE GO:0033829 R-HSA-1912357 ITCH ubiquitinates DTX GO:0004842 R-HSA-1912369 NOTCH precursor cleaved to form mature NOTCH GO:0004252 R-HSA-1912372 Fringe-modified Pre-NOTCH is cleaved by FURIN GO:0004252 R-HSA-1912378 Sialylation of Pre-NOTCH GO:0003836 R-HSA-1912386 Ubiquitination of NOTCH1 by ITCH in the absence of ligand GO:0004842 R-HSA-1912391 NICD1 is phosphorylated by CDK8 GO:0004693 R-HSA-191299 Squalene is oxidized to its epoxide GO:0004506 R-HSA-191303 Another isopentenyl pyrophosphate is added to geranyl pyrophosphate GO:0004337 R-HSA-191322 Addition of isopentenyl pyrophosphate to DMAPP GO:0004161 R-HSA-191323 HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA GO:0004421 R-HSA-191352 Reduction of HMG-CoA produces mevalonate GO:0004420 R-HSA-191366 Squalene 2,3-epoxide cyclizes, forming lanosterol GO:0000250 R-HSA-191380 Mevalonate is phosphorylated to mevalonate-5-phosphate GO:0004496 R-HSA-191382 Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate GO:0004452 R-HSA-191402 Reduction of presqualene diphosphate to form squalene GO:0004310 R-HSA-191405 Two FPP molecules dimerize to form presqualene diphosphate GO:0004310 R-HSA-191414 MVD decarboxylates MVA5PP to IPPP GO:0004163 R-HSA-191422 Mevalonate-5-phosphate is further phosphorylated. GO:0004631 R-HSA-191636 Phosphorylation of Cx43 by c-src GO:0016301 R-HSA-191784 snRNA Cap hypermethylation GO:0008173 R-HSA-191790 Loading and methylation of Sm proteins onto SMN Complexes GO:0016274 R-HSA-1918092 CHIP (STUB1) mediates ubiquitination of ERBB2 GO:0004842 R-HSA-1918095 CUL5 mediates ubiquitination of ERBB2 GO:0004842 R-HSA-191972 27-hydroxycholesterol is 7alpha-hydroxylated GO:0008396 R-HSA-191983 Cholesterol is hydroxylated to 25-hydroxycholesterol GO:0008395 R-HSA-191999 CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol GO:0008395 R-HSA-192033 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one GO:0004033 R-HSA-192036 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol GO:0004033 R-HSA-192042 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al GO:0008395 R-HSA-192051 CYP7A1 7-hydroxylates CHOL GO:0008123 R-HSA-192054 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) GO:0008395 R-HSA-192056 Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA GO:0008111 R-HSA-192061 CYP46A1 24-hydroxylates CHOL GO:0033781 R-HSA-192065 CYP7B1 7-hydroxylates 25OH-CHOL GO:0008396 R-HSA-192067 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one GO:0004033 R-HSA-192097 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one GO:0003854 R-HSA-192123 CYP27A1 27-hydroxylates CHOL GO:0008395 R-HSA-192137 THCA is conjugated with Coenzyme A (SLC27A5 BACS) GO:0004467 R-HSA-192157 CYP8B1 12-hydroxylates 4CHOL7aOLONE GO:0033778 R-HSA-192160 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol GO:0004033 R-HSA-192178 CYP39A1 7-hydroxylates 24OH-CHOL GO:0008396 R-HSA-192312 Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate GO:0016746 R-HSA-192331 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA GO:0033989 R-HSA-192335 25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) GO:0003997 R-HSA-192341 Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA GO:0050632 R-HSA-192417 Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) GO:0004771 R-HSA-192422 Digestion of triacylglycerols by extracellular PTL:colipase GO:0047372 R-HSA-192425 Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) GO:0047372 R-HSA-192430 Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) GO:0047372 R-HSA-192434 Digestion of diacylglycerols by extracellular PTL:colipase GO:0047372 R-HSA-192475 Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 GO:0047372 R-HSA-192624 cRNA Extension GO:0003968 R-HSA-192627 Viral mRNA Export GO:0017056 R-HSA-192704 Synthesis of PB1-F2 GO:0003746 R-HSA-192832 Initiation of cRNA Synthesis GO:0003968 R-HSA-192841 Viral Protein Synthesis GO:0003746 R-HSA-192851 vRNA Extension GO:0003968 R-HSA-192916 Initiation of vRNA Synthesis GO:0003968 R-HSA-192925 Export of Spliced Viral mRNA GO:0017056 R-HSA-193052 Pregn-5-ene-3,20-dione isomerizes to progesterone GO:0004769 R-HSA-193054 Oxidation of cholesterol to 22beta-hydroxycholesterol GO:0008386 R-HSA-193060 CYP19A1 hydroxylates ANDST to E1 GO:0008395 R-HSA-193064 Reduction of androstenedione to testosterone GO:0030283 R-HSA-193065 Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol GO:0008386 R-HSA-193068 CYP17A1 17-hydroxylates PREG GO:0004508 R-HSA-193070 Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA GO:0004508 R-HSA-193072 CYP17A1 17-hydroxylates P4 GO:0004508 R-HSA-193073 DHA isomerizes to 4-Androstene3,17-dione GO:0004769 R-HSA-193099 CYP17A1 cleaves 17aHPROG to ANDST GO:0004508 R-HSA-193101 CYP11A1 cleaves 20a,22b-DHCHOL GO:0008386 R-HSA-193143 CYP19A1 hydroxylates TEST to EST17b GO:0008395 R-HSA-193362 ABCB11 transports bile salts from cytosol to extracellular region GO:0015432 R-HSA-193369 25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA GO:0003997 R-HSA-193385 Hydrolysis of choloyl-CoA to cholate and CoASH GO:0016289 R-HSA-193393 5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol GO:0008395 R-HSA-193401 THCA is conjugated with Coenzyme A (SLC27A2 VLCS) GO:0004467 R-HSA-193407 DHCA is conjugated with Coenzyme A (SLC27A5 BACS) GO:0004467 R-HSA-193424 DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) GO:0004467 R-HSA-193452 Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA GO:0008111 R-HSA-193455 (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA GO:0003857 R-HSA-193460 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) GO:0008395 R-HSA-193491 Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate GO:0016746 R-HSA-193497 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al GO:0008395 R-HSA-193508 (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA GO:0003857 R-HSA-193533 Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA GO:0050632 R-HSA-193535 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA GO:0033989 R-HSA-193647 IRAK is activated GO:0004674 R-HSA-193672 Sphingomyelinase is activated by the NGF:p75NTR complex GO:0004888 R-HSA-193679 alpha-secretase cleaves the p75NTR extracellular domain GO:0008237 R-HSA-193682 gamma-secretase cleaves the p75NTR transmembrane domain GO:0004175 R-HSA-193703 IKKbeta is activated GO:0004674 R-HSA-193705 IKKbeta phosphorylates IkB causing NF-kB to dissociate GO:0004674 R-HSA-193706 Production of ceramide which can activate JNK and other targets GO:0004767 R-HSA-193709 CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL GO:0033778 R-HSA-193711 3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) GO:0004467 R-HSA-193713 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) GO:0008395 R-HSA-193719 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al GO:0008395 R-HSA-193727 TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) GO:0004467 R-HSA-193736 Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA GO:0008111 R-HSA-193737 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) GO:0008395 R-HSA-193743 3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) GO:0004467 R-HSA-193746 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one GO:0004033 R-HSA-193755 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one GO:0004033 R-HSA-193758 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol GO:0004033 R-HSA-193763 Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA GO:0008111 R-HSA-193766 TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) GO:0004467 R-HSA-193780 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al GO:0008395 R-HSA-193781 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol GO:0004033 R-HSA-193787 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol GO:0008395 R-HSA-193789 Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one GO:0003854 R-HSA-193792 CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol GO:0008395 R-HSA-193800 5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol GO:0004033 R-HSA-193816 Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one GO:0003854 R-HSA-193821 4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one GO:0004033 R-HSA-193824 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one GO:0004033 R-HSA-193841 5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol GO:0004033 R-HSA-193845 CYP8B1 12-hydroxylates 4CHOL7a,27DONE GO:0033778 R-HSA-193961 Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone GO:0004769 R-HSA-193964 CYP21A2 21-hydroxylates PROG GO:0004509 R-HSA-193965 CYP11B2 oxidises 18HCORST to ALDO GO:0008395 R-HSA-193981 CYP21A2 oxidises 17HPROG GO:0004509 R-HSA-193995 CYP11B2 18-hydroxylates CORST to 18HCORST GO:0008395 R-HSA-193997 CYP11B1 oxidises 11DCORT GO:0004507 R-HSA-194017 CYP11B2 oxidises 11DCORST to CORST GO:0004507 R-HSA-194023 HSD11B2,HSD11B1 dimer oxidise CORT to COR GO:0003845 R-HSA-194079 SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol GO:0015125 R-HSA-194083 SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol GO:0015125 R-HSA-194121 Co-transport (influx) of bile salts and sodium ions by NTCP GO:0008508 R-HSA-194130 Transport (influx) of bile salts and acids by OATP-A GO:0015125 R-HSA-194153 Transport (efflux) of bile salts by ABCC3 (MRP3) GO:0015432 R-HSA-194187 SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol GO:0008508 R-HSA-194518 RhoA is activated by nucleotide exchange and inhibits axonal growth GO:0005089 R-HSA-194632 Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) GO:0000253 R-HSA-194641 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol GO:0000254 R-HSA-194642 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one GO:0000252 R-HSA-194669 4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol GO:0000254 R-HSA-194674 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] GO:0050613 R-HSA-194678 CYP51A1 demethylates LNSOL GO:0008398 R-HSA-194689 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol GO:0000253 R-HSA-194698 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] GO:0050613 R-HSA-194718 4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) GO:0000252 R-HSA-194793 BoNT/C LC cleaves target cell SNAP25 GO:0004222 R-HSA-194796 BoNT/B LC cleaves target cell VAMP2 GO:0004222 R-HSA-194800 BoNT/E LC cleaves target cell SNAP25 GO:0004222 R-HSA-194808 BoNT/F LC cleaves target cell VAMP1 GO:0004222 R-HSA-194809 BoNT/D LC cleaves target cell VAMP1 GO:0004222 R-HSA-194818 BoNT/A LC cleaves target cell SNAP25 GO:0004222 R-HSA-194913 GEFs activate Rho GTPase:GDP GO:0005089 R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis GO:0005096 R-HSA-195275 Phosphorylation of APC component of the destruction complex GO:0016301 R-HSA-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 GO:0016301 R-HSA-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 GO:0016301 R-HSA-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 GO:0016301 R-HSA-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha GO:0016301 R-HSA-195664 Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol GO:0000248 R-HSA-195690 Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol GO:0004769 R-HSA-196060 Reduction of isocaproaldehyde to 4-methylpentan-1-ol GO:0004032 R-HSA-196350 Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione GO:0003854 R-HSA-1963581 Trans-autophosphorylation of p-Y877-ERBB2 heterodimers GO:0004713 R-HSA-1963582 Trans-autophosphorylation of ERBB2 heterodimers GO:0004713 R-HSA-1963586 SRC family kinases phosphorylate ERBB2 GO:0004713 R-HSA-196372 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol GO:0003854 R-HSA-196402 Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol GO:0047598 R-HSA-196417 Reduction of desmosterol to cholesterol GO:0050614 R-HSA-1964482 RNA polymerase III transcribes microbial dsDNA to dsRNA GO:0001056 R-HSA-1964501 Addition of galactose to Core 6 glycoprotein GO:0008378 R-HSA-1964505 C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) GO:0016263 R-HSA-196753 2xPPCS ligates PPanK with Cys GO:0004632 R-HSA-196754 COASY transfers an adenylyl group from ATP to PPANT GO:0004595 R-HSA-196761 2xTPK1:Mg2+ phosphorylates THMN GO:0004788 R-HSA-196773 COASY phosphorylates DP-CoA GO:0004140 R-HSA-196840 3xPPCDC:3FMN decarboxylates PPC GO:0004633 R-HSA-196857 PANK2 phosphorylates PanK GO:0004594 R-HSA-196929 FLAD1 phosphorylates FMN GO:0003919 R-HSA-196950 2xTRAP hydrolyzes FMN to RIB GO:0003993 R-HSA-196955 2xENPP1 hydrolyzes FAD to FMN GO:0004551 R-HSA-196964 RFK:Mg2+ phosphorylates RIB GO:0008531 R-HSA-1971482 The addition of GalNAc to the terminal glucuronate residue forms chondroitin GO:0047238 R-HSA-1971483 Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 GO:0047756 R-HSA-1971487 CHPF,CHSY1,CHSY3 transfer GalNAc to chondroitin GO:0047238 R-HSA-1971491 CHPF,CHPF2,CHSY1,CHSY3 transfer GlcA to chondroitin GO:0050510 R-HSA-197186 NAPRT1 dimer transfers PRIB to NCA to form NAMN GO:0004516 R-HSA-197198 NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ GO:0003951 R-HSA-197235 NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD GO:0004515 R-HSA-1972385 ADP-Ribosylation of HNP-1 GO:0003956 R-HSA-197250 NAMPT transfers PRIB to NAM to form NAMN GO:0047280 R-HSA-197268 QPRT transfers PRIB to QUIN to form NAMN GO:0004514 R-HSA-197271 NADSYN1 hexamer amidates NAAD to NAD+ GO:0003952 R-HSA-1977296 NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer GO:0004842 R-HSA-197958 Conversion of cytosolic THF to THF-polyglutamate GO:0004326 R-HSA-197963 Folate is reduced to dihydrofolate (DHF) GO:0033560 R-HSA-197972 DHF is reduced to tetrahydrofolate (THF) GO:0033560 R-HSA-1980074 Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 GO:0004842 R-HSA-1980118 ARRB mediates NOTCH1 ubiquitination GO:0004842 R-HSA-1980233 Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen GO:0019797 R-HSA-1981104 Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines GO:0008475 R-HSA-1981120 Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. GO:0050211 R-HSA-1981128 Galactosylation of collagen propeptide hydroxylysines by PLOD3 GO:0050211 R-HSA-1981157 Glucosylation of collagen propeptide hydroxylysines GO:0033823 R-HSA-1982066 Ligand-independent phosphorylation of overexpressed FGFR1 GO:0004713 R-HSA-198266 PI3K produces PIP3 and other phosphatidyl inositides GO:0046934 R-HSA-198270 PDPK1 phosphorylates AKT at T308 GO:0004674 R-HSA-198295 TRKA phosphorylates IRS GO:0004714 R-HSA-198314 DAG stimulates protein kinase C-delta GO:0004697 R-HSA-198347 AKT phosphorylates BAD GO:0004674 R-HSA-198371 AKT phosphorylates GSK3 GO:0004674 R-HSA-198440 malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] GO:0015367 R-HSA-198508 malate + NAD+ <=> oxaloacetate + NADH + H+ GO:0030060 R-HSA-198513 Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4 GO:0061513 R-HSA-198563 IDO1 dioxygenates L-Trp to NFK GO:0004833 R-HSA-198599 AKT phosphorylates MDM2 GO:0004674 R-HSA-198609 AKT phosphorylates TSC2, inhibiting it GO:0004674 R-HSA-198611 AKT phosphorylates IKKalpha GO:0004674 R-HSA-198613 AKT phosphorylates p21Cip1 and p27Kip1 GO:0004674 R-HSA-198621 AKT phosphorylates caspase-9 GO:0004674 R-HSA-198640 TORC2 (mTOR) phosphorylates AKT at S473 GO:0004674 R-HSA-198669 p38MAPK phosphorylates MSK1 GO:0004674 R-HSA-198731 ERK1/2 activates ELK1 GO:0004674 R-HSA-198732 STAT3 activation GO:0004675 R-HSA-198733 ERK5 is activated GO:0004707 R-HSA-198746 ERK1/2/5 activate RSK1/2/3 GO:0004674 R-HSA-198756 ERK1/2 phosphorylates MSK1 GO:0004674 R-HSA-198813 2xGSTOs reduce DHvitC to VitC GO:0045174 R-HSA-198818 GLUT1/3 transports extracellular DHvitC to cytosol GO:0033300 R-HSA-198824 CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme GO:0004128 R-HSA-198845 CYB5A:heme reduces SDA to VitC GO:0004033 R-HSA-198870 SVCT1/2 cotransports extracellular VitC and 2Na+ to cytosol GO:0015229 R-HSA-199202 Phosphopantetheine conjugation of the ACP domain of FAS GO:0008897 R-HSA-199203 PANK1/3/4 phosphorylate PanK GO:0004594 R-HSA-199206 SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol GO:0008523 R-HSA-199216 SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix GO:0015291 R-HSA-199219 SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol GO:0008523 R-HSA-199298 AKT phosphorylates CREB1 GO:0004674 R-HSA-199299 AKT phosphorylates FOXO transcription factors GO:0004674 R-HSA-199425 PHLPP dephosphorylates S473 in AKT GO:0004722 R-HSA-199456 PTEN dephosphorylates PIP3 GO:0016314 R-HSA-199626 SLC19A2/3 transport extracellular THMN to cytosol GO:0015234 R-HSA-199803 xylulose 5-phosphate <=> D-ribulose 5-phosphate GO:0004750 R-HSA-199839 AKT can phosphorylate RSK GO:0004674 R-HSA-199863 AKT can phosphorylate NR4A1 (NUR77) GO:0004674 R-HSA-199895 RSK1/2/3 phosphorylates CREB at Serine 133 GO:0004674 R-HSA-199910 MSK1 activates ATF1 GO:0004674 R-HSA-199917 MAPKAPK2 phosphorylates CREB at Serine 133 GO:0004674 R-HSA-199929 ERK5 activates the transcription factor MEF2 GO:0004674 R-HSA-199935 MSK1 activates CREB GO:0004674 R-HSA-199959 ERKs are inactivated by protein phosphatase 2A GO:0004722 R-HSA-200143 AKT phosphorylates AKT1S1 (PRAS40) GO:0004674 R-HSA-2002428 Removal of fibrillar collagen N-propeptides GO:0004222 R-HSA-2002440 Removal of fibrillar collagen C-propeptides GO:0004222 R-HSA-2002466 Formation of allysine by LOX GO:0004720 R-HSA-200318 creatine + ATP => phosphocreatine + ADP [CKB,CKM] GO:0004111 R-HSA-200326 creatine + ATP => phosphocreatine + ADP [CK octamer] GO:0004111 R-HSA-200396 Creatine transport across the plasma membrane GO:0005309 R-HSA-200406 CPT1A,B transfers PALM to CAR GO:0004095 R-HSA-200410 palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine GO:0004095 R-HSA-200421 Activation of cytosolic AMPK by phosphorylation GO:0004674 R-HSA-200423 pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis GO:0004679 R-HSA-200424 Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane GO:0015227 R-HSA-200474 NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD GO:0004515 R-HSA-200512 NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD GO:0004515 R-HSA-200555 acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate GO:0003989 R-HSA-200644 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ GO:0004486 R-HSA-200646 Cytosolic folate export across the plasma membrane GO:0008517 R-HSA-200651 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine GO:0004372 R-HSA-200652 Extracellular 5-methyltetrahydrofolate import across the plasma membrane GO:0008517 R-HSA-200661 10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O GO:0004477 R-HSA-200676 5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ GO:0004489 R-HSA-200680 Cytosolic tetrahydrofolate import across the inner mitochondrial membrane GO:0008517 R-HSA-200681 Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate GO:0004326 R-HSA-200682 Conversion of mitochondrial THF to THF-polyglutamate GO:0004326 R-HSA-200711 THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate GO:0004329 R-HSA-200718 5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+ GO:0004486 R-HSA-200720 Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane GO:0008517 R-HSA-200729 Extracellular folate import across the plasma membrane GO:0008517 R-HSA-200735 Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine GO:0004372 R-HSA-200740 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate GO:0004477 R-HSA-201035 ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA GO:0004467 R-HSA-2012073 Autocatalytic phosphorylation of FGFR3c P250R mutant GO:0004713 R-HSA-2012082 Autocatalytic phosphorylation of FGFR3 cysteine mutants GO:0004713 R-HSA-2012087 Autocatalytic phosphorylation of FGFR4 Y367C mutant GO:0004713 R-HSA-201425 Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling GO:0004842 R-HSA-201443 Type II receptor phosphorylates type I receptor GO:0016362 R-HSA-201445 Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 GO:0061630 R-HSA-201457 BMP2 binds to the receptor complex GO:0005160 R-HSA-201476 Activated type I receptor phosphorylates R-Smad1/5/8 directly GO:0004675 R-HSA-201595 Caspase-mediated cleavage of plakophilin-1 GO:0004197 R-HSA-201603 Caspase-mediated cleavage of PKC theta GO:0004197 R-HSA-201608 Caspase-mediated cleavage of alpha adducin GO:0004197 R-HSA-201611 Caspase-mediated cleavage of Rock-1 GO:0004197 R-HSA-201622 Caspase-mediated cleavage of gelsolin GO:0004197 R-HSA-201628 Caspase-mediated cleavage of vimentin at DSVD (85) GO:0004197 R-HSA-201629 Caspase-mediated cleavage of Tau GO:0004197 R-HSA-201630 Caspase-mediated cleavage of Acinus GO:0004197 R-HSA-201631 Caspase-mediated cleavage of Desmoglein 3 GO:0004197 R-HSA-201634 Caspase-mediated cleavage of FADK 1 GO:0004197 R-HSA-201636 Caspase-mediated cleavage of Desmoplakin GO:0004197 R-HSA-201637 Caspase-mediated cleavage of plectin-1 GO:0004197 R-HSA-201639 Caspase-mediated cleavage of GAS2 GO:0004197 R-HSA-201640 Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha GO:0004197 R-HSA-201677 Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta GO:0004674 R-HSA-201691 Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI GO:0004674 R-HSA-201717 CSNK2-mediated phosphorylation of DVL GO:0016301 R-HSA-201787 PPP3 complex dephosphorylates DARPP-32 on Thr34 GO:0004722 R-HSA-201790 DARPP-32 is dephosphorylated on Thr75 by PP2A GO:0004722 R-HSA-2018659 Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 GO:0050659 R-HSA-2018682 CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains GO:0008459 R-HSA-202127 eNOS synthesizes NO GO:0004517 R-HSA-202165 Phosphorylation of ITAM motifs in CD3 complexes GO:0004713 R-HSA-202168 Phosphorylation of ZAP-70 by Lck GO:0004713 R-HSA-202174 Activation of ZAP-70 GO:0004713 R-HSA-2022052 Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) GO:0047757 R-HSA-2022061 Dermatan sulfate can be further sulfated on position 2 of iduronate GO:0008146 R-HSA-2022063 CHST14 transfers SO4(2-) to GalNAc in dermatan or DS GO:0001537 R-HSA-2022073 Procollagen triple helix formation GO:0003755 R-HSA-202214 Dephosphorylation of Lck-pY505 by CD45 GO:0004725 R-HSA-2022141 Prolysyl oxidase activation GO:0004222 R-HSA-202216 Phosphorylation of SLP-76 GO:0004713 R-HSA-202222 Phosphorylation of PKC theta GO:0004674 R-HSA-202233 Inactivation of Lck by Csk GO:0004713 R-HSA-2022368 Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) GO:0008237 R-HSA-202237 Hydrolysis of PIP3 to PI(3,4)P2 GO:0016314 R-HSA-2022378 ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) GO:0004181 R-HSA-2022379 ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) GO:0004181 R-HSA-2022381 Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) GO:0008234 R-HSA-2022383 Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) GO:0008236 R-HSA-2022393 ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8) GO:0008237 R-HSA-2022396 Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7) GO:0008237 R-HSA-2022398 ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) GO:0070573 R-HSA-2022399 ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) GO:0008237 R-HSA-2022403 Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) GO:0004190 R-HSA-2022405 ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) GO:0070573 R-HSA-2022411 Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) GO:0004252 R-HSA-2022412 Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) GO:0004190 R-HSA-202245 Phosphorylation of TBSMs in LAT GO:0004713 R-HSA-202248 Phosphorylation of PLC-gamma1 GO:0004713 R-HSA-2022851 EXT1:EXT2 transfer GlcNAc to the heparan chain GO:0050508 R-HSA-2022856 EXT1:EXT2 transfers GlcNAc to heparan GO:0050509 R-HSA-2022860 NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) GO:0015016 R-HSA-2022887 NDST1-4 N-deacetylates GlcNAc residues in heparan GO:0050119 R-HSA-202291 Activation of Lck GO:0004713 R-HSA-2022919 EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue GO:0050508 R-HSA-202307 Change of PKC theta conformation GO:0004713 R-HSA-2023455 Autocatalytic phosphorylation of FGFR1c P252X mutant dimers GO:0004713 R-HSA-2023460 Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity GO:0004713 R-HSA-202365 PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 GO:0046934 R-HSA-2023971 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol GO:0052842 R-HSA-2023973 (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol GO:0052841 R-HSA-202407 PLC-gamma1 hydrolyses PIP2 GO:0004435 R-HSA-2024100 GLCE epimerises GlcA to IdoA GO:0050379 R-HSA-202437 Phosphorylation of CARMA1 GO:0004674 R-HSA-202453 Auto-ubiquitination of TRAF6 GO:0004842 R-HSA-202459 Phosphorylation of Bcl10 GO:0004674 R-HSA-202500 Activation of IKK complex GO:0004674 R-HSA-202510 Activation of TAK1-TAB2 complex GO:0004674 R-HSA-202534 Ubiquitination of NEMO by TRAF6 GO:0004842 R-HSA-202541 p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB GO:0004674 R-HSA-2025723 B4GALTs transfer Gal to the N-glycan precursor GO:0003831 R-HSA-2025724 B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG GO:0008532 R-HSA-2025882 Calcineurin dephosphorylates NFATC1,2,3 GO:0004723 R-HSA-2028284 Phosphorylation of STK4 (MST1) and SAV1 by STK4 GO:0004674 R-HSA-2028294 Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) GO:0004181 R-HSA-2028555 Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) GO:0004674 R-HSA-2028583 Phosphorylation of YAP by LATS2 GO:0004674 R-HSA-2028589 Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) GO:0004674 R-HSA-2028591 Phosphorylation of STK3 (MST2) and SAV1 by STK3 GO:0004674 R-HSA-2028598 Phosphorylation of YAP by LATS1 GO:0004674 R-HSA-2028629 Phosphorylation of MOB1A and B by p-STK4 (p-MST1) GO:0004674 R-HSA-2028635 Phosphorylation of MOB1A and B by p-STK3 (p-MST2) GO:0004674 R-HSA-2028661 Phosphorylation of WWTR1 (TAZ) by LATS2 GO:0004674 R-HSA-2028670 Phosphorylation of MOB1A and B by p-STK4(MST1)/N GO:0004674 R-HSA-2028673 Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N GO:0004674 R-HSA-2028675 Phosphorylation of MOB1A and B by p-STK3(MST2)/N GO:0004674 R-HSA-2028679 Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N GO:0004674 R-HSA-2028692 Cleavage of p-STK4 (p-MST1) by caspase 3 GO:0004197 R-HSA-2028697 Cleavage of p-STK3 (p-MST2) by caspase 3 GO:0004197 R-HSA-202917 Caspase-mediated cleavage of Desmoglein 1 GO:0004197 R-HSA-2029268 Phosphorylation and activation of PLCG GO:0004713 R-HSA-2029271 PI3K phosphorylates PIP2 to PIP3 GO:0046934 R-HSA-202939 Caspase-mediated cleavage of E-Cadherin GO:0004197 R-HSA-2029445 Activation of CDC42 by unknown mechanism GO:0005085 R-HSA-2029449 Phosphorylation of SYK by Src kinases GO:0004713 R-HSA-2029451 Activation of RAC1 by VAV GO:0005085 R-HSA-2029453 Phosphorylation of VAV GO:0004713 R-HSA-2029454 Autophosphorylation of PAK1 GO:0004674 R-HSA-2029459 Sequestering and phosphorylation Fc gamma receptors in the lipid rafts GO:0004713 R-HSA-2029460 PAK1 phosphorylates LIMK1 GO:0004674 R-HSA-2029467 Activation of RAC1 by CRKII:DOCK180:ELMO GO:0005085 R-HSA-2029468 Conversion of PA into DAG by PAP-1 GO:0008195 R-HSA-2029469 p-ERK phosphorylates WAVEs and ABI GO:0004674 R-HSA-202947 Caspase mediated cleavage of APC GO:0004197 R-HSA-2029471 Hydrolysis of PC to PA by PLD GO:0004630 R-HSA-2029475 Production of AA by iPLA2 upon FCGR activation GO:0016787 R-HSA-202960 Caspase mediated cleavage of C-IAP1 GO:0004197 R-HSA-202966 Caspase mediated cleavage of HIP-55 GO:0004197 R-HSA-202967 Caspase mediated cleavage of alpha-II-Fodrin GO:0004197 R-HSA-202969 Caspase mediated cleavage of beta-catenin GO:0004197 R-HSA-2029984 Autocatalytic phosphorylation of FGFR2 ligand-independent mutants GO:0004713 R-HSA-2029989 Autocatalytic phosphorylation of overexpressed FGFR2 variants GO:0004713 R-HSA-2033485 Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity GO:0004713 R-HSA-2033486 Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding GO:0004713 R-HSA-2033488 Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding GO:0004713 R-HSA-2033490 Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity GO:0004713 R-HSA-203567 palmitoylation of eNOS GO:0016409 R-HSA-203613 depalmitoylation of eNOS GO:0008474 R-HSA-203797 ERKs are inactivated by dual-specific phosphatases (DUSPs) GO:0004725 R-HSA-2038387 Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants GO:0004713 R-HSA-203862 Dicer cleaves pre-miRNA to yield duplex miRNA GO:0004525 R-HSA-203893 Microprocessor complex cleaves pri-miRNA to pre-miRNA GO:0004525 R-HSA-2038944 Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity GO:0004713 R-HSA-203901 Pol II mediated transcription of microRNA genes GO:0003899 R-HSA-203906 Exportin complex translocates pre-miRNA to cytosol GO:0051033 R-HSA-203922 Exportin-5 recognizes 3' overhang of pre-miRNA GO:0003723 R-HSA-203946 PDK isoforms phosphorylate lipo-PDH GO:0004740 R-HSA-203973 Vesicle budding GO:0003924 R-HSA-203977 SAR1 Activation And Membrane Binding GO:0005085 R-HSA-204169 PDP dephosphorylates p-lipo-PDH GO:0004741 R-HSA-2045911 BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 GO:0035004 R-HSA-2046083 Elongation of arachidonyl-CoA to docosatetraenoyl-CoA GO:0009922 R-HSA-2046084 Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA GO:0016213 R-HSA-2046085 Activation of alpha-linolenic acid to alpha-linolenoyl-CoA GO:0004467 R-HSA-2046087 Translocation of tetracosahexaenoyl-CoA to peroxisomes GO:0005324 R-HSA-2046088 Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA GO:0009922 R-HSA-2046089 Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA GO:0045485 R-HSA-2046090 Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA GO:0009922 R-HSA-2046092 Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA GO:0045485 R-HSA-2046093 Translocation of tetracosapentaenoyl-CoA to peroxisomes GO:0005324 R-HSA-2046094 Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA GO:0009922 R-HSA-2046095 Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA GO:0009922 R-HSA-2046096 Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA GO:0016213 R-HSA-2046097 Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA GO:0016213 R-HSA-2046098 Activation of linoleic acid to linoleoyl-CoA GO:0004467 R-HSA-2046099 Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA GO:0016213 R-HSA-2046100 Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA GO:0009922 R-HSA-204617 DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A GO:0034038 R-HSA-2046175 Further sulfation on galactose residues produces KSPG GO:0045130 R-HSA-2046222 CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG GO:0001517 R-HSA-2046265 B4GALTs transfer Gal to the keratan chain GO:0003831 R-HSA-2046285 The keratan chain can be capped by N-acetylneuraminic acid GO:0003836 R-HSA-2046298 B4GALTs transfer Gal to a branch of keratan GO:0003831 R-HSA-204647 DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine GO:0034038 R-HSA-204662 DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A GO:0019135 R-HSA-204949 NRIF and TRAF6 may activate JNK GO:0004705 R-HSA-205008 Polyubiquitinated NRIF binds to p62 (Sequestosome) GO:0043130 R-HSA-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor GO:0005085 R-HSA-205075 JNK phosphorylates BIM, BAD and other targets GO:0004705 R-HSA-205112 gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 GO:0008233 R-HSA-205117 p75NTR:NADE promotes caspase2/3 activation GO:0008656 R-HSA-205118 TRAF6 polyubiquitinates NRIF GO:0004842 R-HSA-205132 NRAGE activates JNK GO:0004705 R-HSA-205289 Autophosphorylation of KIT GO:0004713 R-HSA-2060328 Phosphorylation of WWTR1 (TAZ) by LATS1 GO:0004674 R-HSA-2065233 CS is cleaved from its proteoglycan GO:0016798 R-HSA-2065355 Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) GO:0070573 R-HSA-2065357 Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) GO:0004190 R-HSA-2066778 Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA GO:0016508 R-HSA-2066779 Conversion of DHA-CoA to docosahexaenoic acid (DHA) GO:0003986 R-HSA-2066780 Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA GO:0016508 R-HSA-2066781 Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) GO:0050632 R-HSA-2066787 Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA GO:0003997 R-HSA-2066788 Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase GO:0008775 R-HSA-2076220 CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 GO:0046934 R-HSA-2076371 GLCE epimerises more GlcA to IdoA as sulfate content rises GO:0050379 R-HSA-2076383 HS3ST1 sulfates GlcN at C3 in heparan sulfate GO:0008467 R-HSA-2076392 EXT1:EXT2 transfers GlcA to heparan GO:0050509 R-HSA-2076419 HS6STs sulfate GlcN at C6 in heparan sulfate/heparin GO:0017095 R-HSA-2076508 HS2ST1 sulfates IdoA at C2 in heparan sulfate GO:0004394 R-HSA-2076611 HS3STs sulfate GlcN at C3 in heparan sulfate GO:0008467 R-HSA-2089943 TRPC1 translocates calcium from the extracellular region to the cytosol GO:0005261 R-HSA-2090037 IDUA hydrolyses Heparan sulfate chain(6) GO:0003940 R-HSA-2090038 NAGLU hydrolyses heparan chain(2) GO:0004561 R-HSA-2090043 SGSH hydrolyses Heparan sulfate chain(7) GO:0016250 R-HSA-2090079 GLB1 hydrolyses linker chain(2) GO:0004565 R-HSA-2090085 HGSNAT oligomer acetylates Heparan chain(1) GO:0015019 R-HSA-209055 PPM1A dephosphorylates nuclear SMAD2/3 GO:0004722 R-HSA-209061 Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex GO:0004175 R-HSA-209063 Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex GO:0004842 R-HSA-209087 IKBA is phosphorylated by Phospho IKKB kinase GO:0004674 R-HSA-209765 CYP24A1 hydroxylates 1,25(OH)2D, inactivating it GO:0030342 R-HSA-209772 Thyroxine is deiodinated to triiodothyronine GO:0004800 R-HSA-209792 N-acetylation of serotonin GO:0004059 R-HSA-209815 Tyrosine is monoiodinated GO:0004601 R-HSA-209821 Methylation of N-acetyl-5-HT to form melatonin GO:0008172 R-HSA-209823 Tyrosine is hydroxylated to dopa GO:0004511 R-HSA-209828 Tryptophan is hydroxylated GO:0004510 R-HSA-209840 Two DITs combine to form thyroxine GO:0004601 R-HSA-209845 CYP2R1 25-hydroxylates VD3 to 25(OH)D GO:0030343 R-HSA-209859 Decarboxylation of 5-hydroxytryptophan forms serotonin GO:0004058 R-HSA-209868 CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D GO:0004498 R-HSA-209891 Dopamine is oxidised to noradrenaline GO:0004500 R-HSA-209903 Noradrenaline is converted to adrenaline GO:0004603 R-HSA-209910 Iodide is taken up by thyroid epithelial cells GO:0015111 R-HSA-209921 Monoiodinated tyrosine can be deiodinated GO:0016491 R-HSA-209924 Dopa is decarboxylated to dopamine GO:0004058 R-HSA-209925 DIT and MIT combine to form triiodothyronine GO:0004601 R-HSA-209960 Diiodinated tyrosine can be deiodinated GO:0016491 R-HSA-209973 Tyrosine is diiodinated GO:0004601 R-HSA-210291 Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src GO:0004713 R-HSA-210404 SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ GO:0015171 R-HSA-210420 Ca2+ influx through voltage gated Ca2+ channels GO:0005262 R-HSA-210426 Glutamate synaptic vesicle docking and priming GO:0000149 R-HSA-210430 release of L-Glutamate at the synapse GO:0000149 R-HSA-210439 glutamate uptake by astrocytes GO:0015171 R-HSA-210444 L-Glutamate loading of synaptic vesicle GO:0005313 R-HSA-2105001 HEXA,B cleaves the terminal GalNAc from DS GO:0004563 R-HSA-210872 Trans-phosphorylation of Tie2 GO:0004713 R-HSA-210977 Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) GO:0005088 R-HSA-211164 AKT phosphorylates FOXO1A GO:0004674 R-HSA-211186 Cleavage of DFF45 (224) by caspase-3 GO:0004197 R-HSA-211190 Caspase 3-mediated cleavage of DFF45 (117) GO:0004197 R-HSA-211247 Cleavage of DNA by DFF40 GO:0004536 R-HSA-211583 Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 GO:0016301 R-HSA-211650 Autophosphorylation of PAK-2p34 in the activation loop GO:0016301 R-HSA-211651 Cleavage of PAK-2 at 212 GO:0004197 R-HSA-211715 Proteasome mediated degradation of PAK-2p34 GO:0004175 R-HSA-211734 Ubiquitination of PAK-2p34 GO:0004842 R-HSA-211873 CYP4F2, 4F3 20-hydroxylate LTB4 GO:0050051 R-HSA-211874 CYP2S1 4-hydroxylates atRA GO:0008401 R-HSA-211881 Coumarin is 7-hydroxylated by CYP2A13 GO:0008389 R-HSA-211882 CYP3A7 can 6beta-hydroxylate testosterone GO:0004497 R-HSA-211904 CYP4F12 18-hydroxylates ARA GO:0004497 R-HSA-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation GO:0004497 R-HSA-211919 CYP4F8 19-hydroxylates PGH2 GO:0004497 R-HSA-211923 CYP26C1 4-hydroxylates 9cRA GO:0008401 R-HSA-211924 CYP4B1 12-hydroxylates ARA GO:0004497 R-HSA-211929 CYP2C19 5-hydroxylates omeprazole GO:0004497 R-HSA-211948 CYP3A4 can N-demethylate loperamide GO:0004497 R-HSA-211950 CYP24A1 24-hydroxylates CTL GO:0030342 R-HSA-211951 CYP1B1 4-hydroxylates EST17b GO:0004497 R-HSA-211959 CYP3A43 6b-hydroxylates TEST GO:0004497 R-HSA-211960 CYP2U1 19-hydroxylates ARA GO:0004497 R-HSA-211962 CYP4F11 16-hydroxylates 3OH-PALM GO:0004497 R-HSA-211966 CYP2D6 4-hydroxylates debrisoquine GO:0016712 R-HSA-211968 CYP2W1 oxidises INDOL GO:0004497 R-HSA-211983 CYP2J2 oxidises ARA GO:0008392 R-HSA-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation GO:0004497 R-HSA-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 GO:0004497 R-HSA-212004 CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation GO:0004497 R-HSA-212005 CYP2F1 dehydrogenates 3-methylindole GO:0004497 R-HSA-212007 CYP26A1,B1 4-hydroxylate atRA GO:0008401 R-HSA-212263 PRC2 trimethylates histone H3 at lysine-27 GO:0016279 R-HSA-212269 DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 GO:0016279 R-HSA-212269 DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 GO:0009008 R-HSA-212552 Caspase 3-mediated cleavage of PKC delta GO:0004197 R-HSA-212614 Glutamine transport from astrocytes GO:0015179 R-HSA-212642 L-Glutamine transport into neurons GO:0015171 R-HSA-212710 EGFR activates PLC-gamma1 by phosphorylation GO:0004713 R-HSA-2129357 Fibrillin C-terminal processing GO:0004252 R-HSA-2129375 Elastin cross-linking by lysyl oxidase GO:0004720 R-HSA-2130194 ABL phosphorylates WAVEs GO:0004713 R-HSA-2130282 Degradation of ubiquitinated beta catenin by the proteasome GO:0004175 R-HSA-2130336 Initial proteolyis of Ii by aspartic proteases to lip22 GO:0004197 R-HSA-2130349 Generation of CLIP from lip10 GO:0004197 R-HSA-2130504 Cleavage of lip22 to lip10 GO:0004197 R-HSA-2130641 Translocation of TGN-lysosome vesicle to lysosome GO:0003924 R-HSA-2130706 MHC class II antigen processing GO:0004197 R-HSA-2130725 Internalization of MHC II:Ii clathrin coated vesicle GO:0003924 R-HSA-213175 CYP3A4,5 oxidise AFB1 to AFXBO GO:0004497 R-HSA-2142859 Growing HA is extruded from the cell by ABCC5 GO:0008514 R-HSA-215526 CYP4F3 20-hydroxylates LTB4 GO:0004497 R-HSA-2160492 IL4I1:FAD oxidises L-Phe to kPPV GO:0001716 R-HSA-2160851 HAS1,2,3 mediate the polymerisation of HA GO:0050501 R-HSA-2160874 HYAL1 hydrolyses (HA)50 GO:0004415 R-HSA-2160892 Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments GO:0004415 R-HSA-2161187 N6-methyl-AMP + H2O => IMP + methylamine GO:0004000 R-HSA-2161193 abacavir + AMP => abacavir monophosphate + adenosine GO:0016773 R-HSA-2161195 abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine GO:0004000 R-HSA-2161500 abacavir [extracellular] => abacavir [cytosol] GO:0015101 R-HSA-2161506 abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate GO:0008559 R-HSA-2161538 abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate GO:0008559 R-HSA-2161549 PGH2 is reduced to PGF2a by AKR1C3 GO:0036130 R-HSA-2161567 LTB4 is oxidised to 12-oxoLTB4 by PTGR1 GO:0097257 R-HSA-2161612 PGH2 is reduced to PGF2a by FAM213B GO:0008379 R-HSA-2161613 PGH2 is degraded to 12S-HHT and MDA by TBXAS1 GO:0036134 R-HSA-2161614 PGD2 is reduced to 11-epi-PGF2a by AKRIC3 GO:0036131 R-HSA-2161620 PGH2 is isomerised to PGD2 by PTGDS GO:0004667 R-HSA-2161651 PGE2 is converted to PGF2a by CBR1 GO:0050221 R-HSA-2161660 PGH2 is isomerised to PGE2 by PTGES GO:0050220 R-HSA-2161662 PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD GO:0016404 R-HSA-2161692 15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 GO:0036132 R-HSA-2161701 PGH2 is isomerised to PGD2 by HPGDS GO:0004667 R-HSA-2161732 TXB2 is converted to 11dh-TXB2 by TXDH GO:0036133 R-HSA-2161745 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 GO:0097258 R-HSA-2161768 EXA4 is converted to EXC4 by LTC4S GO:0097261 R-HSA-2161775 ALOX12 oxidises LTA4 to LXA4/B4 GO:0016702 R-HSA-2161776 5S-HETE is oxidised to 5-oxoETE by 5-HEDH GO:0097265 R-HSA-2161779 LXA4 is oxidised to 15k-LXA4 by HPGD GO:0016404 R-HSA-2161789 15S-HETE is oxidised to 15-oxoETE by 15-HEDH GO:0047034 R-HSA-2161791 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 GO:0004602 R-HSA-2161792 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 GO:0097259 R-HSA-2161794 Arachidonic acid is converted to HXA3/B3 by ALOX12 GO:0051120 R-HSA-2161795 Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) GO:0004497 R-HSA-2161814 Arachidonic acid is hydroxylated to 19-HETE by CYP(2) GO:0004497 R-HSA-2161844 15k-LXA4 is reduced to dhk-LXA4 by PTGR1 GO:0036185 R-HSA-2161868 EXD4 is converted to EXE4 by DPEP GO:0097263 R-HSA-2161890 Arachidonic acid is epoxidated to 5,6-EET by CYP(4) GO:0004497 R-HSA-2161899 Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) GO:0004497 R-HSA-2161907 ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 GO:0016702 R-HSA-2161917 ALOX5 oxidises 15S-HpETE to LXA4/B4 GO:0016702 R-HSA-2161940 Arachidonic acid is hydroxylated to 20-HETE by CYP(3) GO:0004497 R-HSA-2161945 EXC4 is converted to EXD4 by GGT GO:0097262 R-HSA-2161946 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 GO:0004602 R-HSA-2161948 Arachidonic acid is converted to 12-oxoETE by ALOX12 GO:0004052 R-HSA-2161949 HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH GO:0047977 R-HSA-2161950 Arachidonic acid is oxidised to 12R-HpETE by ALOX12B GO:0004052 R-HSA-2161951 Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 GO:0050473 R-HSA-2161959 12R-HpETE is reduced to 12R-HETE by GPX1/2/4 GO:0004602 R-HSA-2161961 EET(1) is hydrolysed to DHET(1) by EPHX2 GO:0004301 R-HSA-2161964 Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 GO:0004052 R-HSA-2161979 20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH GO:0097259 R-HSA-2161999 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 GO:0004602 R-HSA-2162002 Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B GO:0050473 R-HSA-2162019 LTA4 is converted to EXA4 by ALOX15 GO:0097260 R-HSA-2162066 carbovir + IMP => carbovir monophosphate + inosine GO:0050146 R-HSA-2162078 abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ GO:0004022 R-HSA-2162092 carbovir monophosphate + ATP => carbovir diphosphate + ADP GO:0050145 R-HSA-2162096 carbovir diphosphate + ATP => carbovir triphosphate + ADP GO:0004550 R-HSA-2162099 abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP GO:0015020 R-HSA-2162186 DeMQ10H2 is methylated to Q10H2 by COQ3 GO:0044596 R-HSA-2162187 DHB is hydroxylated to DHDB by COQ6 GO:0016709 R-HSA-2162188 MDMQ10H2 is methylated to DMQ10H2 by COQ5 GO:0043430 R-HSA-2162191 DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase GO:0004497 R-HSA-2162192 PHB and all-E-10PrP2 are combined into DHB by COQ2 GO:0002083 R-HSA-2162193 DHDB is methylated to MHDB by COQ3 GO:0044595 R-HSA-2162194 COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2 GO:0016709 R-HSA-2162195 MHDB is decarboxylated to DMPhOH by MHDB decarboxylase GO:0036169 R-HSA-2162225 HEXA,B cleave the terminal GalNAc from small HA fragments GO:0004563 R-HSA-2162226 GUSB tetramer hydrolyses GlcA-1,3-GlcNAc GO:0004566 R-HSA-2162227 GUSB tetramer hydrolyses (HA)2 GO:0004566 R-HSA-2162253 FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer GO:0097269 R-HSA-216723 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane GO:0017127 R-HSA-216757 4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane GO:0005548 R-HSA-2168046 Collagen type XII degradation by MMP12 GO:0004222 R-HSA-2168079 MASTL (GWL) phosphorylates ARPP19 GO:0004674 R-HSA-2168923 Collagen type XVIII endostatin release GO:0004252 R-HSA-2168960 Collagen type XVII ectodomain shedding GO:0004252 R-HSA-2168982 Collagen type XVI degradation by MMP9 GO:0004222 R-HSA-2169050 SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 GO:0004842 R-HSA-2172172 Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 GO:0004842 R-HSA-2172183 Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB GO:0004693 R-HSA-2172405 Collagen type XXIII ectodomain shedding GO:0004252 R-HSA-217255 FMO1:FAD N-oxidises TAM GO:0004499 R-HSA-217258 FMO2:FAD:Mg2+ S-oxidises MTZ GO:0004497 R-HSA-2172678 PHF8 demethylates histone H4K20me1 GO:0035575 R-HSA-2176475 Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 GO:0004674 R-HSA-2179276 SMURF2 monoubiquitinates SMAD3 GO:0004842 R-HSA-2179291 UCHL5, USP15 deubiquitinate TGFBR1 GO:0004843 R-HSA-2179402 Active MMP3 can cleave pro-HBEGF to form active HBEGF GO:0004222 R-HSA-2179407 SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) GO:0005088 R-HSA-2179413 Activated PKC-alpha activate MMP3 GO:0004697 R-HSA-2186747 Ubiquitination of SKI/SKIL by RNF111/SMURF2 GO:0004842 R-HSA-2186785 RNF111 ubiquitinates SMAD7 GO:0004842 R-HSA-2187325 PARP1 ADP-ribosylates SMAD3 and SMAD4 GO:0003950 R-HSA-2187368 STUB1 (CHIP) ubiquitinates SMAD3 GO:0004842 R-HSA-2187401 MTMR4 dephosphorylates SMAD2/3 GO:0004722 R-HSA-2197698 Phosphorylation of WASP/N-WASP GO:0004713 R-HSA-2201322 TIRAP is phosphorylated by BTK GO:0004713 R-HSA-2213017 Auto-ubiquitination of TRAF3 GO:0004842 R-HSA-2213200 Release of endostatin-like peptides GO:0004175 R-HSA-2213240 Reduction of disulphide bonds in MHC II antigens GO:0016667 R-HSA-2214330 Cleavage of collagen VII NC2 region by BMP1 GO:0004252 R-HSA-2214351 PLK1 phosphorylates GORASP1 GO:0016301 R-HSA-2220944 ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants GO:0008237 R-HSA-2220971 CDK8 phosphorylates NICD1 PEST domain mutants GO:0004693 R-HSA-2220976 NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding GO:0008237 R-HSA-2220988 NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants GO:0004190 R-HSA-2243938 AKT1 E17K mutant is phosphorylated by TORC2 complex GO:0004674 R-HSA-2243942 PDPK1 phosphorylates AKT1 E17K mutant GO:0004674 R-HSA-2245218 CDK1 phosphorylates PHF8 GO:0004693 R-HSA-2267372 ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 GO:0052725 R-HSA-2294580 PLK1 hyperphosphorylates Condensin II complex GO:0016301 R-HSA-2294600 CDK1 phosphorylates condensin II subunit NCAPD3 GO:0004693 R-HSA-2301205 SETD8 monomethylates histone H4 GO:0042799 R-HSA-2309773 PGG2 is reduced to PGH2 by PTGS2 GO:0004601 R-HSA-2309787 Arachidonic acid is oxidised to PGG2 by PTGS2 GO:0004666 R-HSA-2316352 SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane GO:0000146 R-HSA-2316352 SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane GO:0000146 R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3 GO:0046934 R-HSA-2393939 Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP GO:0047631 R-HSA-2393954 Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP GO:0047631 R-HSA-2394007 PI3K gain of function mutants phosphorylate PIP2 to PIP3 GO:0046934 R-HSA-2395340 Formation of hydroxyallysine by LOX GO:0004720 R-HSA-2395412 Phosphorylation of SYK GO:0004713 R-HSA-2395439 Phosphorylation of DAP12 GO:0004713 R-HSA-2395768 LPL hydrolyses TGs from mature CMs GO:0004465 R-HSA-2395801 Phosphorylation of LAT by p-SYK GO:0004713 R-HSA-2395818 NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP GO:0044714 R-HSA-2395849 NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP GO:0035539 R-HSA-2395869 NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP GO:0035539 R-HSA-2395872 NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP GO:0044713 R-HSA-2395873 NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP GO:0044715 R-HSA-2395876 NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP GO:0017110 R-HSA-2395879 NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP GO:0044715 R-HSA-2395965 NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP GO:0044717 R-HSA-2396007 IRF3 is phosphorylated by TBK1 GO:0004674 R-HSA-2396594 Phosphorylation of SLP-76 by p-SYK GO:0004713 R-HSA-2399941 AKT1 E17K mutant phosphorylates BAD GO:0004674 R-HSA-2399966 AKT1 E17K mutant phosphorylates GSK3 GO:0004674 R-HSA-2399969 AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 GO:0004674 R-HSA-2399977 AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) GO:0004674 R-HSA-2399981 AKT1 E17K mutant phosphorylates MDM2 GO:0004674 R-HSA-2399982 AKT1 E17K mutant phosphorylates TSC2, inhibiting it GO:0004674 R-HSA-2399985 AKT1 E17K mutant phosphorylates caspase-9 GO:0004674 R-HSA-2399988 AKT1 E17K mutant phosphorylates NR4A1 (NUR77) GO:0004674 R-HSA-2399992 AKT1 E17K mutant phosphorylates forkhead box transcription factors GO:0004674 R-HSA-2399996 AKT1 E17K mutant phosphorylates CREB1 GO:0004674 R-HSA-2399999 AKT1 E17K mutant phosphorylates RSK GO:0004674 R-HSA-2400001 AKT1 E17K mutant phosphorylates CHUK (IKKalpha) GO:0004674 R-HSA-2404131 LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol GO:0005041 R-HSA-2404133 A REH hydrolses atREs to atROL and FAs GO:0050253 R-HSA-2404137 LRAT esterifies RBP1:atROL and FACYLs to atREs GO:0016416 R-HSA-2404140 NREH hydrolyses atREs to atROL and FAs GO:0047376 R-HSA-2404193 IGF1R phosphorylates SHC1 GO:0004713 R-HSA-2404199 IGF1,2:IGF1R autophosphorylates GO:0004713 R-HSA-2408507 Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK GO:0098620 R-HSA-2408524 Sec is reduced to H2Se by SCLY GO:0009000 R-HSA-2408525 H2SeO4 is converted to APSe by PAPSS1,2 GO:0098616 R-HSA-2408526 tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer GO:0098619 R-HSA-2408530 MeSeH is hydrolysed to H2Se by methylselenol demethylase GO:0098608 R-HSA-2408532 AdeSeHCys is hydrolysed to SeHCys by AHCY GO:0098604 R-HSA-2408536 H2Se is methylated to MeSeH by H2Se methyltransferase GO:0098614 R-HSA-2408537 Excess SeMet is cleaved into MeSeH by CTH GO:0098600 R-HSA-2408539 MeSec is hydrolysed to MeSeH by CTH GO:0098607 R-HSA-2408540 APSe is phosphorylated to PAPSe by PAPSS1,2 GO:0098617 R-HSA-2408541 MeSeH is methylated to Me2Se by MeSeH methyltransferase GO:0098613 R-HSA-2408542 GSSeSG is reduced to GSSeH and GSH by GSR GO:0098622 R-HSA-2408543 SeCysta is hydrolysed to Sec by CTH GO:0098606 R-HSA-2408544 AdoSeMet is converted to AdeSeHCys by MetTrans(1) GO:0098603 R-HSA-2408546 tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex GO:0098618 R-HSA-2408548 PAPSe is reduced to SeO3(2-) by PAPSe reductase GO:0098624 R-HSA-2408551 SeMet is converted to AdoSeMet by MAT GO:0098601 R-HSA-2408554 Me2Se is methylated to Me3Se+ by INMT GO:0098615 R-HSA-2408555 Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by SEPSECS tetramer GO:0098621 R-HSA-2408558 SeO3(2-) is reduced to H2Se by TXNRD1 GO:0098623 R-HSA-2408559 SeHCys and Ser are dehydrated into SeCysta by CBS GO:0098605 R-HSA-2422927 MAPK3-3 or MAPK1 phosphorylate GORASP2 GO:0004674 R-HSA-2424254 LDLR transports extracellular CR:atREs to cytosol GO:0005041 R-HSA-2424476 Activation of RAC1 by VAV2/3 GO:0005085 R-HSA-2424477 SOS mediated nucleotide exchange of RAS (SHC) GO:0005088 R-HSA-2424480 PI3K phosphorylates PIP2 to PIP3 GO:0046934 R-HSA-2424484 Phosphorylation of BTK by p-SYK GO:0004713 R-HSA-2424486 Phosphorylation and activation of VAV2/VAV3 by SYK GO:0004713 R-HSA-2424487 Phosphorylation of PLC-gamma by p-BTK/p-SYK GO:0004713 R-HSA-2428926 IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 GO:0004713 R-HSA-2429643 NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs GO:0047376 R-HSA-2430533 CDK1 phosphorylates MASTL GO:0004693 R-HSA-2430535 MASTL phosphorylates ENSA GO:0004674 R-HSA-2453833 RPE65 isomero-hydrolyses atREs to 11cROL GO:0052884 R-HSA-2453855 LRAT esterifies RBP1:atROL and FACYLs to atREs GO:0016416 R-HSA-2454081 RDH5 oxidises 11cROL to 11cRAL GO:0004745 R-HSA-2454113 RBP3 transports 11cRAL to rod photoreceptor outer segment GO:0005501 R-HSA-2454208 Phosphorylation of beta and gamma subunits by LYN GO:0004713 R-HSA-2454239 Phosphorylation of SYK GO:0004713 R-HSA-2464803 RDH8 reduces atRAL to atROL GO:0052650 R-HSA-2464809 RBP3 regulates the transport of atROL from ROS to RPE GO:0005501 R-HSA-2464822 RDH12 reduces atRAL to atROL GO:0052650 R-HSA-2465917 Photons induce isomerisation of 11c-retinyl to at-retinyl GO:0009881 R-HSA-2465919 AWAT2 transfers PALM to 11cROL forming 11cRPALM GO:0050252 R-HSA-2465921 11cRDH oxidises 11cROL to 11cRAL GO:0052650 R-HSA-2465926 An atROL isomerase isomerises atROL to 11cROL GO:0050251 R-HSA-2465934 11cROL translocates from Muller cells to cone photoreceptor cells GO:0005501 R-HSA-2465938 RBP3 regulates atROL taken up by Muller cells GO:0005501 R-HSA-2465940 atRAL is reduced to atROL GO:0052650 R-HSA-2465941 A REH hydrolyses 11cRE to 11cROL GO:0047520 R-HSA-2466068 Phosphorylation of cohesin by PLK1 at chromosomal arms GO:0004674 R-HSA-2466749 ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol GO:0005395 R-HSA-2466831 A2PE hydrolyses to A2E GO:0070290 R-HSA-2467775 Autocleavage of ESPL1 (Separase) GO:0008234 R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin GO:0008234 R-HSA-2468039 Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 GO:0008080 R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres GO:0004693 R-HSA-2468293 CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms GO:0004693 R-HSA-2470508 ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin GO:0004674 R-HSA-2471621 Endostatin degradation by cathepsins GO:0004252 R-HSA-2471842 Collagen type XXV ectomain shedding GO:0004252 R-HSA-2473152 Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 GO:0008080 R-HSA-2473584 Collagen type III degradation by MMP15 GO:0004222 R-HSA-2473594 Collagen type II degradation by MMP15 GO:0004222 R-HSA-2473596 Collagen type I degradation by MMP15 GO:0004222 R-HSA-2482180 Collagen type VIII degradation by ELANE GO:0004252 R-HSA-2484882 Collagen type X degradation by MMP3, 13 GO:0004222 R-HSA-2485111 Collagen type III degradation by MMP10 GO:0004222 R-HSA-2485148 Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 GO:0004222 R-HSA-2485180 MII catalyses GDP/GTP exchange on Gt GO:0005085 R-HSA-2509793 NUDT16 hydrolyses dIDP to dIMP GO:0097383 R-HSA-2509816 NUDT16 hydrolyses IDP to IMP GO:1990003 R-HSA-2509827 ITPA hydrolyses ITP to IMP GO:0036220 R-HSA-2509831 ITPA hydrolyses XTP to XMP GO:0036222 R-HSA-2509838 ITPA hydrolyses dITP to dIMP GO:0035870 R-HSA-2514772 Fibrillin-1 degradation by MMP3, CTSK, CTSL2 GO:0004252 R-HSA-2514790 Elastin degradation by MMP14 GO:0004222 R-HSA-2514823 Fibrillin-1 degradation by ELANE GO:0004252 R-HSA-2514831 Fibrillin-1 degradation by MMP14 GO:0004222 R-HSA-2514854 CDK1 phosphorylates condensin I GO:0004693 R-HSA-2514867 cGMP:CNG transports Na+ and Ca2+ into the rod outer segment GO:0005221 R-HSA-2514891 SLC24A1 exchanges 4Na+ for Ca2+, K+ GO:0008273 R-HSA-2529015 Dephosphorylation of CK2-modified condensin I GO:0004721 R-HSA-2529020 CK2 phosphorylates condensin I subunits GO:0016301 R-HSA-2530501 FNTA:FNTB transfers FARN to GNGT1 GO:0004660 R-HSA-2533874 Laminin-511 degradation by MMP14 GO:0004222 R-HSA-2533944 Fibronectin degradation by MMP10 GO:0004222 R-HSA-2533950 Fibronectin degradation by MMP14, TMPRSS6 GO:0004222 R-HSA-2533965 NID1 degradation by MMP14, MMP15 GO:0004222 R-HSA-2533970 NID1 degradation by MMP3, 7 GO:0004222 R-HSA-2534040 Unknown NAT N-acylates Gly in GNAT1 GO:0047961 R-HSA-2534087 NMT1/2 transfer MYS to GNAT1 GO:0004379 R-HSA-2534096 METAP1/2 demethylates GNAT1 GO:0004177 R-HSA-2534160 HSPG2 (perlecan) degradation by MMP13, CTSS GO:0004252 R-HSA-2534206 E-cadherin degradation by PS1:NCSTN (Gamma-secretase) GO:0004252 R-HSA-2534240 HSPG2 (perlecan) degradation by MMP14, MMP15 GO:0004222 R-HSA-2534248 DCN (decorin) degradation by MMP2, MMP3, MMP7 GO:0004222 R-HSA-2534260 E-cadherin degradation by caspase-3 and calpain-1 GO:0004252 R-HSA-2534359 CatSper Channel Mediated Calcium Transport GO:0015085 R-HSA-2534365 Slo3 Potassium Transport GO:0005267 R-HSA-2534378 Hv1 Mediated H+ Permeability GO:0022843 R-HSA-2537499 Gelatin degradation by MMP19 GO:0004222 R-HSA-2545203 Deacetylation of cleaved cohesin GO:0004407 R-HSA-2545253 Deacetylation of cohesin GO:0004407 R-HSA-2559639 Collagen type IV sulfilimine cross-linking by peroxidasin GO:0004601 R-HSA-2562526 PLK1 phosphorylates OPTN GO:0004674 R-HSA-2562564 Caspase-8 processing within TLR4 complex GO:0004197 R-HSA-2564826 4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold GO:0009055 R-HSA-2564828 CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins GO:0036455 R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation GO:0004674 R-HSA-2581474 GRK1,4,7 phosphorylate MII to p-MII GO:0050254 R-HSA-2584246 GNAT1-GTP hydrolyses its bound GTP to GDP GO:0003924 R-HSA-2586553 JAK2 Phosphorylates LEPR GO:0004713 R-HSA-2586555 JAK2 Autophosphorylates in Response to Leptin GO:0004713 R-HSA-264444 Autoubiquitination of phospho-COP1(Ser-387 ) GO:0004842 R-HSA-264458 Proteasome mediated degradation of COP1 GO:0004175 R-HSA-264615 Loading of acetylcholine in synaptic vesicle GO:0005277 R-HSA-264622 Cho is acetylated to AcCho by CHAT GO:0004102 R-HSA-264695 cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) GO:0004607 R-HSA-264758 BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 GO:0004222 R-HSA-264865 Caspase-mediated cleavage of Lamin A GO:0004197 R-HSA-264871 Caspase-mediated cleavage of Lamin B1 GO:0004197 R-HSA-264997 Oxidation of cysteine to cystine in Proinsulin GO:0015036 R-HSA-265160 Insulin secretory granule translocates to cell cortex GO:0003777 R-HSA-265166 Exocytosis of Insulin GO:0000149 R-HSA-265295 Prostaglandin E synthase isomerizes PGH2 to PGE2 GO:0050220 R-HSA-265296 Arachidonic acid is oxidised to 5S-HpETE by ALOX5 GO:0004051 R-HSA-265301 Corticotropin cleavage from POMC GO:0004252 R-HSA-265443 NPC1L1-mediated cholesterol uptake GO:0017127 R-HSA-265545 NPC1L1-mediated phytosterol uptake GO:0017127 R-HSA-265645 Calcium Influx through Voltage-gated Calcium Channels GO:0005245 R-HSA-265682 KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel GO:0005524 R-HSA-265783 ABCG5:ABCG8 transports sterols from cytosol to extracellular region GO:0015248 R-HSA-266012 LTD4 is converted to LTE4 by DPEP1/2 GO:0016805 R-HSA-266046 GGT1, 5 dimers hydrolyse LTC4 to LTD4 GO:0036374 R-HSA-266050 LTA4 is converted to LTC4 by LTC4S GO:0004464 R-HSA-266051 5S-HpETE is dehydrated to LTA4 by ALOX5 GO:0004051 R-HSA-266070 LTC4 is exported from the cytosol by ABCC1 GO:0042626 R-HSA-266072 LTA4 is hydolysed to LTB4 by LTA4H GO:0004463 R-HSA-266082 ABCG1-mediated transport of intracellular cholesterol to the cell surface GO:0017127 R-HSA-2666278 NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 GO:0008237 R-HSA-2671742 JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin GO:0004713 R-HSA-2671829 JAK2 Phosphorylates STAT5 in Response to Leptin GO:0004713 R-HSA-2671850 JAK2 Phosphoryates STAT3 in Response to Leptin GO:0004713 R-HSA-2671885 ASICs transport extracellular Na+ to cytosol GO:0044736 R-HSA-2672334 SCNN channels transport extracellular Na+ to cytosol GO:0015280 R-HSA-2682349 RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels GO:0004842 R-HSA-2684901 ANOs transport cytosolic Cl- to extracellular region GO:0005229 R-HSA-2685505 TPCN1/2 transport lysosomal Ca2+ to cytosol GO:0072345 R-HSA-2730664 UNC79:UNC80:NALCN transports cytosolic Na+ to extracellular region GO:0005272 R-HSA-2730692 CLCN4/5/6 exchange Cl- for H+ GO:0015297 R-HSA-2730752 NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding GO:0008237 R-HSA-2730833 Phosphorylation of TEC kinases by p-SYK GO:0004713 R-HSA-2730840 Activation of RAC1 by VAV GO:0005085 R-HSA-2730843 Phosphorylation of LAT by p-SYK GO:0004713 R-HSA-2730847 Hydrolysis of PIP2 by PLCG GO:0004435 R-HSA-2730849 Calcineurin binds and dephosphorylates NFAT GO:0033192 R-HSA-2730851 Phosphorylation of SLP-76 by p-SYK GO:0004713 R-HSA-2730856 Autophosphorylation of PAK GO:0004674 R-HSA-2730858 Autophosphorylation of BTK/ITK GO:0004713 R-HSA-2730860 Phosphorylation of GAB2 by SYK/FYN GO:0004713 R-HSA-2730862 Autophosphorylation of LYN kinase GO:0004713 R-HSA-2730863 Phosphorylation of CARMA1 by PKC-theta GO:0004674 R-HSA-2730868 Phosphorylation of MEK7 by MEKK1 GO:0004674 R-HSA-2730870 Phosphorylation of PIP2 to PIP3 by PI3K GO:0046934 R-HSA-2730876 Phosphorylation of IKK-beta by TAK1 GO:0004674 R-HSA-2730882 Phosphorylation of PKC-theta GO:0004713 R-HSA-2730884 Phosphorylation of NTAL by p-SYK/Lyn GO:0004713 R-HSA-2730886 Phosphorylation of SHC by SYK kinase GO:0004713 R-HSA-2730887 Autophosphorylation and activation of MEKK1 GO:0004672 R-HSA-2730888 Phosphorylation of PLC-gamma GO:0004713 R-HSA-2730896 Phosphorylation of MEK4 by MEKK1 GO:0004674 R-HSA-2730900 Activation of TAK1 complex bound to pUb-TRAF6 GO:0004674 R-HSA-2730904 Auto-ubiquitination of TRAF6 GO:0004842 R-HSA-2730959 CLCN7:OSTM1 exchanges Cl- for H+ GO:0015297 R-HSA-2731002 CLCN3 exchanges Cl- for H+ GO:0015297 R-HSA-2737728 Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants GO:0004842 R-HSA-2744228 CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region GO:0005247 R-HSA-2744242 TTYH2/3 transport cytosolic Cl- to extracellular region GO:0005229 R-HSA-2744349 TTYH1 transports cytosolic Cl- to extracellular region GO:0005254 R-HSA-2744361 BESTs transport cytosolic Cl- to extracellular region GO:0005229 R-HSA-2752067 BESTs transport cytosolic HCO3- to extracellular region GO:0015106 R-HSA-2769007 Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants GO:0004842 R-HSA-2855020 RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol GO:0005219 R-HSA-2855252 AKRs reduce RBP2:atRAL to RBP2:atROL GO:0004033 R-HSA-2872444 SLC9B1/C2 exchange Na+ for H+ GO:0015385 R-HSA-2872463 SLC9C1 exchanges Na+ for H+ GO:0015385 R-HSA-2872497 SLC17A3-2 transports cytosolic urate to extracellular region GO:0015143 R-HSA-2872498 SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol GO:0005436 R-HSA-2889070 SLC9B2 exchanges Na+, Li+ for H+ GO:0005451 R-HSA-2900765 Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants GO:0004842 R-HSA-2984220 CDK1:CCNB phosphorylates NEK9 GO:0004693 R-HSA-2984226 PLK1 phosphorylates NEK9 GO:0004674 R-HSA-2984258 NEK9 phosphorylates NEK6/NEK7 GO:0004674 R-HSA-2990833 Conjugation of SUMO1 to UBA2:SAE1 GO:0019948 R-HSA-2990840 SENP1,2,5 proteolytically process SUMO1 GO:0070139 R-HSA-2990842 SEN1,2,5 proteolytically process SUMO2 GO:0070139 R-HSA-2990880 NEK6/NEK7 phosphorylates NUP98 GO:0004674 R-HSA-2990882 CDK1 phosphorylates NUP98 GO:0004693 R-HSA-2993447 HLCS biotinylates 6x(PCCA:PCCB) GO:0018271 R-HSA-2993763 SENP1,2,5 proteolytically process SUMO3 GO:0070139 R-HSA-2993769 Transfer of SUMO3 from E1 to UBE2I (UBC9) GO:0019789 R-HSA-2993780 Transfer of SUMO1 from E1 to UBE2I (UBC9) GO:0019789 R-HSA-2993781 Conjugation of SUMO3 to UBA2:SAE1 GO:0019948 R-HSA-2993784 Conjugation of SUMO2 to UBA2:SAE1 GO:0019948 R-HSA-2993790 Transfer of SUMO2 from E1 to UBE2I (UBC9) GO:0019789 R-HSA-2993799 HLCS biotinylates 6xMCCC1:6xMCCC2 GO:0018271 R-HSA-2993802 HLCS biotinylates PC:Mn2+ GO:0018271 R-HSA-2993814 HLCS biotinylates ACACA:Mn2+ GO:0018271 R-HSA-2993898 VRK1/VRK2 phosphorylate BANF1 GO:0004674 R-HSA-2995330 COX10 transforms heme to heme O GO:0008495 R-HSA-2995334 COX15 transforms heme O to heme A GO:0016627 R-HSA-2995388 PP2A dephosphorylates BANF1 GO:0004722 R-HSA-2997616 PIAS1,4 SUMOylates BRCA1 with SUMO2,3 GO:0019789 R-HSA-2997706 MDM2 SUMOylates TP53 with SUMO2,3 GO:0019789 R-HSA-2997709 PIAS1,4 SUMOylates BRCA1 with SUMO1 GO:0019789 R-HSA-2997723 PIAS4 SUMOylates TP53BP1 with SUMO1 GO:0019789 R-HSA-3000122 CD320 transports extracellular TCII:Cbl to endosome GO:0015420 R-HSA-3000238 LMBRD1 transports lysosomal Cbl to cytosol GO:0015420 R-HSA-3000243 Unknown protease degrades GIF:Cbl to release Cbl GO:0008233 R-HSA-3000310 AURKA phosphorylates PLK1 GO:0004674 R-HSA-3000327 PLK1 phosphorylates BORA GO:0004674 R-HSA-3000335 SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA GO:0004842 R-HSA-3000348 RANBP2 SUMOylates SP100 with SUMO2 GO:0019789 R-HSA-3000383 UBE2I, HDAC7 SUMOylate PML with SUMO1 GO:0019789 R-HSA-3000399 RANBP2 SUMOylates SP100 with SUMO1 GO:0019789 R-HSA-3000411 RANBP2 SUMOylates PML with SUMO2 GO:0019789 R-HSA-3000433 SUMOylation of PML with SUMO3 GO:0019789 R-HSA-3000434 PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 GO:0019789 R-HSA-3002811 Myosin phosphatase dephosphorylates PLK1 GO:0004722 R-HSA-3065958 An unknown protease degrades ACACA GO:0070011 R-HSA-3065959 An unknown protease degrades hCBXs GO:0070011 R-HSA-3076905 Extracellular BTD hydrolyses BCTN GO:0047708 R-HSA-3095889 MMACHC reduces Cbl GO:0016491 R-HSA-3095901 ABCC1 transports cytosolic Cbl to extracellular region GO:0015420 R-HSA-3108203 PRC1 SUMOylates CTBP1 with SUMO2,3 GO:0019789 R-HSA-3108209 PRC1 SUMOylates CTBP1 with SUMO1 GO:0019789 R-HSA-3108212 SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 GO:0019789 R-HSA-3132737 MAPKs phosphorylate ETS1 and ETS2 GO:0004674 R-HSA-3132753 Pancreatic proteases degrade TCN1:Cbl GO:0008236 R-HSA-3134804 STING ubiquitination by TRIM32 or TRIM56 GO:0004842 R-HSA-3134946 DDX41 ubiquitination by TRIM21 GO:0004842 R-HSA-3139027 Maturation of HIV Virion GO:0008233 R-HSA-3149434 Transport of GAG to the Plasma Membrane GO:0008565 R-HSA-3149518 MTRR reduces cob(II)alamin to meCbl GO:0030586 R-HSA-3149519 MMACHC decyanates CNCbl GO:0033787 R-HSA-3149539 MTR transfers CH3 group from MTHF to cob(I)alamin GO:0008705 R-HSA-3149560 Unknown reductase reduces cob(II)alamin to cob(I)alamin GO:0050453 R-HSA-3159253 MMAB transfers adenosyl group from ATP to cob(I)alamin GO:0008817 R-HSA-3165230 SLC52A1,2,3 transport RIB from extracellular region to cytosol GO:0032217 R-HSA-3204311 AOX1 oxidises PXL to PDXate GO:0004031 R-HSA-3209160 Activated ERKs phosphorylate ERF GO:0004674 R-HSA-3214912 KDM1A, KDM1B demethylate MeK5-histone H3 GO:0032452 R-HSA-3215295 USP7 deubiquitinates MDM2 GO:0004843 R-HSA-3215310 USP7 deubiquitinates TP53 and counteracts MDM2 GO:0004843 R-HSA-3215385 CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 GO:0016538 R-HSA-3215391 PRMT5 is tyrosine phosphorylated by JAK2 V617F GO:0004713 R-HSA-3222006 STK11 (LKB1) phosphorylates NUAK1 GO:0004674 R-HSA-3222020 NUAK1 phosphorylates TP53 GO:0004674 R-HSA-3222237 SMYD2 methylates TP53 GO:0016278 R-HSA-3222593 KDM6B demethylates H3K27me3 on p16-INK4A promoter GO:0071558 R-HSA-3228469 MAP3K5 phosphorylates MKK3 and MKK6 GO:0004674 R-HSA-3229102 p-MAPKAPK3 phosphorylates BMI1 GO:0004674 R-HSA-3229152 MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) GO:0004674 R-HSA-3232162 PIAS3 SUMOylates MITF with SUMO1 GO:0019789 R-HSA-3234081 SUMOylation of TFAP2A with SUMO1 GO:0019789 R-HSA-3234084 SUMOylation of TFAP2B with SUMO1 GO:0019789 R-HSA-3234094 SUMOylation of TFAP2C with SUMO1 GO:0019789 R-HSA-3238694 PORCN palmitoleoylates N-glycosyl WNTs GO:0008374 R-HSA-3238999 Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 GO:0004712 R-HSA-3239014 MAPKAPK5 phosphorylates TP53 GO:0004674 R-HSA-3239019 Active p38 MAPK phosphorylates MAPKAPK5 GO:0004674 R-HSA-3240295 PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter GO:0046976 R-HSA-3244614 cGAS produces cyclic GMP-AMP GO:0061501 R-HSA-3245943 Viral DNA cleavage by TREX1 GO:0008408 R-HSA-3247493 PIAS1 SUMOylates SP3 with SUMO1 GO:0019789 R-HSA-3247569 PADI4 deiminates Histones GO:0004668 R-HSA-3249371 TBK1 phosphorylates STAT6 at Ser407 GO:0004674 R-HSA-3249386 DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 GO:0004842 R-HSA-3257122 SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane GO:0061513 R-HSA-3262512 G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous) GO:0004346 R-HSA-3266557 Factor I cleaves iC3b GO:0004252 R-HSA-3266566 G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet) GO:0004346 R-HSA-3295579 TRPs transport extracellular Ca2+ to cytosol GO:0005262 R-HSA-3295580 TRPM4,5 transport extracellular Na+ to cytosol GO:0005272 R-HSA-3296126 CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 GO:0019789 R-HSA-3299680 SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) GO:0004784 R-HSA-3299682 SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) GO:0004784 R-HSA-3299691 SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) GO:0004784 R-HSA-3299753 CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 GO:0015035 R-HSA-3301237 KAT2 complexes acetylate histone H3 GO:0004402 R-HSA-3301345 Elongator complex acetylates replicative histone H3, H4 GO:0004402 R-HSA-3301943 GSTK1 dimer transfers GS from GSH to CDNB GO:0004364 R-HSA-3318413 KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 GO:0004402 R-HSA-3318415 ATF2 acetylates histone H2B, H4 GO:0004402 R-HSA-3318486 KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 GO:0004402 R-HSA-3321805 NSL acetylates histone H4 GO:0004402 R-HSA-3321883 MSL acetylates histone H4 GO:0004402 R-HSA-3321975 NuA4 complex acetylates histone H2A, HIST1H4 GO:0004402 R-HSA-3322001 GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 GO:0004373 R-HSA-3322003 Autoglucosylation of GYG1 complexed with GYS1-b GO:0008466 R-HSA-3322005 GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a GO:0003844 R-HSA-3322009 GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 GO:0004373 R-HSA-3322014 Autoglucosylation of GYG2 complexed with GYS2-a GO:0008466 R-HSA-3322016 GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a GO:0003844 R-HSA-3322019 Autoglucosylation of GYG2 complexed with GYS2-b GO:0008466 R-HSA-3322025 Autoglucosylation of GYG1 complexed with GYS1-a GO:0008466 R-HSA-3322041 Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 GO:0004373 R-HSA-3322057 GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b GO:0003844 R-HSA-3322429 XIAP monoubiquinates TLE GO:0061630 R-HSA-3322995 PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O GO:0008379 R-HSA-3323013 GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O GO:0004602 R-HSA-3323050 TXNRD2 catalyzes the reduction of TXN2 by NADPH GO:0004791 R-HSA-3323079 GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ GO:0004362 R-HSA-3341277 GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O GO:0004602 R-HSA-3341296 GPX7,8 catalyze peroxidation of P4HB (PDI) GO:0004601 R-HSA-3341343 PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O GO:0008379 R-HSA-3341397 GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O GO:0004602 R-HSA-3343700 PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O GO:0004602 R-HSA-3364026 SET1 complex trimethylates H3K4 at the MYC gene GO:0042800 R-HSA-3371385 TNF-alpha is cleaved by ADAM17 (TACE) GO:0004222 R-HSA-3371422 ATP hydrolysis by HSP70 GO:0042623 R-HSA-3371435 Constitutive phosphorylation by GSK3 GO:0004674 R-HSA-3371467 SIRT1 deacetylates HSF1 GO:0034979 R-HSA-3371531 Constitutive phosphorylation by pERK1/2 GO:0004674 R-HSA-3371554 HSF1 acetylation at Lys80 GO:0034212 R-HSA-3371567 DBC1 is phosphorylated by ATM/ART GO:0004674 R-HSA-3451147 KAT5 HAT complex acetylates TCF4 gene at histone H4 GO:0004402 R-HSA-3465448 Caspase-8 and FLIP(L) processing at DISC GO:0004197 R-HSA-3465545 PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 GO:0019789 R-HSA-349426 Phosphorylation of MDM4 by CHEK2 GO:0004674 R-HSA-349444 Phosphorylation of COP1 at Ser-387 by ATM GO:0004674 R-HSA-349455 Phosphorylation of MDM4 by ATM GO:0004674 R-HSA-350158 LGMN degrades GC GO:0004197 R-HSA-350168 LRP2 transports CUBN:GC:25(OH)D from extracellular region to cytosol GO:0042954 R-HSA-350318 Caspase-mediated cleavage of vimentin at TNLD (429) GO:0004197 R-HSA-350319 Caspase mediated cleavage of vimentin at IDVD (259) GO:0004197 R-HSA-350598 Arginine<=>Agmatine+CO2 GO:0008792 R-HSA-350604 Agmatine + H2O <=> putrescine + urea GO:0008783 R-HSA-350651 Caspase-mediated cleavage of MASK GO:0004197 R-HSA-350769 trans-Golgi Network Coat Activation GO:0005086 R-HSA-350869 Thyroxine is deiodinated to reverse triiodothyronine (RT3) GO:0004800 R-HSA-350901 Iodide is organified GO:0004601 R-HSA-351207 Spermine => N-acetylated spermine GO:0004145 R-HSA-351208 Spermidine => N-acetylated spermidine GO:0004145 R-HSA-351210 dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine GO:0016768 R-HSA-351215 Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine GO:0004766 R-HSA-351222 S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 GO:0004014 R-HSA-351849 Caspase-mediated cleavage of Etk GO:0004197 R-HSA-351871 Caspase-mediated cleavage of Z0-2 GO:0004197 R-HSA-351876 Caspase-mediated cleavage of occludin GO:0004197 R-HSA-351877 Caspase-mediated cleavage of Desmoglein 2 GO:0004197 R-HSA-351894 Caspase mediated cleavage of BAP31 GO:0004197 R-HSA-351901 Caspase-mediated cleavage of MST3 GO:0004197 R-HSA-351913 Caspase-mediated cleavage of TJP1 GO:0004197 R-HSA-351936 Caspase-mediated cleavage of claspin GO:0004197 R-HSA-351963 SLC6A18 transports Gly from extracellular region to cytosol GO:0015171 R-HSA-351987 SLC6A6-mediated uptake of taurine and beta-alanine GO:0015171 R-HSA-352029 SLC6A12 (BGT-1)-mediated uptake of GABA and betaine GO:0015171 R-HSA-352052 SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol GO:0015171 R-HSA-352059 SLC6A15-mediated amino acid uptake GO:0015171 R-HSA-352103 SLC43A1 (LAT3)-mediated uptake of large neutral amino acids GO:0015171 R-HSA-352107 SLC43A2 (LAT4)-mediated uptake of large neutral amino acids GO:0015171 R-HSA-352108 SLC38A2 (ATA2)-mediated uptake of neutral amino acids GO:0015171 R-HSA-352119 SLC38A1 (ATA1)-mediated uptake of neutral amino acids GO:0015171 R-HSA-352136 SLC38A4 (ATA3)-mediated uptake of arginine and lysine GO:0015171 R-HSA-352158 SLC16A10-mediated uptake of aromatic amino acids GO:0015171 R-HSA-352174 SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine GO:0015171 R-HSA-352182 SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine GO:0015171 R-HSA-352191 SLC7A8-mediated uptake of neutral amino acids GO:0015171 R-HSA-352232 SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol GO:0015171 R-HSA-352268 Cleavage of Satb1 GO:0004197 R-HSA-352347 SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine GO:0015171 R-HSA-352354 SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine GO:0015171 R-HSA-352364 SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine GO:0015171 R-HSA-352371 SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine GO:0015171 R-HSA-352379 SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane GO:0015171 R-HSA-352385 SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane GO:0015171 R-HSA-353125 26S proteosome degrades ODC holoenzyme complex GO:0004175 R-HSA-354073 Autophosphorylation of FADK1 at Y397 GO:0004672 R-HSA-354124 Phosphorylation of pFADK1 by SRC GO:0004672 R-HSA-354173 Activation of Rap1 by cytosolic GEFs GO:0005085 R-HSA-3601585 PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex GO:0004722 R-HSA-3640858 Tankyrase ADP-ribosylates AXIN GO:0003950 R-HSA-3640861 RNF146 ubiquitinates ADP-ribosylated AXIN GO:0061630 R-HSA-3640872 USP34 deubiquitinates AXIN1,AXIN2 GO:0036459 R-HSA-3640874 Ub-RibC-AXIN is degraded by the proteasome GO:0004175 R-HSA-3645786 TGFBR2 mutant dimers recruit TGFBR1 GO:0005515 R-HSA-3656484 TGFBR2 recruits TGFBR1 KD Mutants GO:0005515 R-HSA-3656517 TGFBR2 phosphorylates TGFBR1 KD Mutants GO:0004674 R-HSA-3662318 Type B histone acetlytransferase complex acetylates histone H4 GO:0004402 R-HSA-3662335 EP300 acetylates histone H2A, H2B, H3, H4 GO:0004402 R-HSA-3697008 CREBBP acetylates histone H2B, H3, H4 GO:0004402 R-HSA-3697838 ATP7A transfers Cu from ATOX1 to SOD3 GO:0043682 R-HSA-3697882 PRDX5 reduces peroxynitrite to nitrite using TXN GO:0008379 R-HSA-3697894 PRDX5 reduces peroxynitrite to nitrite using TXN2 GO:0008379 R-HSA-3697920 CLOCK acetylates lysine-10 of histone H3, H4 GO:0004402 R-HSA-3702153 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 MH2 domain mutants GO:0005515 R-HSA-3702184 Activated type I receptor phosphorylates SMAD2/3 MH2 domain mutants directly GO:0004675 R-HSA-3713560 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 phosphorylation motif mutants GO:0005515 R-HSA-372342 MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix GO:0050833 R-HSA-372448 SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp GO:0015172 R-HSA-372449 phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] GO:0015142 R-HSA-372480 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] GO:0015139 R-HSA-372505 Acetylcholine synaptic vesicle docking and priming GO:0000149 R-HSA-372519 AcCho is hydrolyzed to Cho and acetate by ACHE GO:0003990 R-HSA-372529 Release of acetylcholine at the synapse GO:0000149 R-HSA-372542 Loading of dopamine into synaptic veiscles GO:0008504 R-HSA-372693 Phosphorylation of p130Cas by SRC-FADK1 complex GO:0004672 R-HSA-372819 oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] GO:0004613 R-HSA-372843 malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] GO:0005310 R-HSA-373705 Caspase cleavage of DCC GO:0004190 R-HSA-373747 Phosphorylation of nephrin by FYN GO:0004713 R-HSA-373750 SEMA4D interacts with Plexin-B1:ErbB2 GO:0004713 R-HSA-373867 BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol GO:0015129 R-HSA-373875 BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region GO:0015129 R-HSA-374664 Phosphorylation and activation of Ezrin GO:0004672 R-HSA-374696 Phosphorylation of L1 by p90rsk GO:0004674 R-HSA-374701 Phosphorylation of DCC by Fyn GO:0004713 R-HSA-374896 Uptake of Noradrenaline GO:0005326 R-HSA-374899 Release of noradrenaline at the synapse GO:0000149 R-HSA-374909 Metabolism of Noradrenaline GO:0008131 R-HSA-374919 Noradrenaline clearance from the synaptic cleft GO:0005326 R-HSA-374922 Noradrenalin synaptic vesicle docking and priming GO:0000149 R-HSA-375330 Connexin 45/Connexin 36 mediated neuronal gap junction communication GO:0005243 R-HSA-375339 Pannexin 1/Pannexin2 mediated neuronal gap junction communication GO:0005243 R-HSA-375340 Connexin 62 mediated neuronal gap junction communication GO:0005243 R-HSA-375342 Connexin 36 mediated neuronal gap junction communication GO:0005243 R-HSA-375405 SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol GO:0015171 R-HSA-375417 SLC36A1-mediated uptake of glycine, proline, and alanine GO:0015171 R-HSA-375473 SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol GO:0015171 R-HSA-375487 SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol GO:0015171 R-HSA-375768 SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids GO:0015171 R-HSA-375770 SLC7A3 (CAT-3)-mediated uptake of cationic amino acids GO:0015171 R-HSA-375776 SLC7A1 (CAT-1)-mediated uptake of cationic amino acids GO:0015171 R-HSA-375790 SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids GO:0015171 R-HSA-376149 Proteolytic processing of SLIT GO:0008233 R-HSA-376200 SLC7A10-mediated uptake of small neutral amino acids GO:0015171 R-HSA-376357 Vamp7 associated Lysosome to Plasma membrane transport GO:0000149 R-HSA-376364 Vamp8 associated secretory vesicle to plasma membrane transport GO:0000149 R-HSA-376369 Vamp2 associated secretory vesicle to plasma membrane transport GO:0000149 R-HSA-376851 Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane GO:0015367 R-HSA-3769394 AKT phosphorylates CBY1 GO:0004674 R-HSA-3769447 HDAC1/2 containing-complexes deacetylate histones GO:0004407 R-HSA-377186 Activated Akt1 phosphorylates AKT1S1 (PRAS40) GO:0004674 R-HSA-3772435 WNT signaling stimulates CSNK1-dependent phosphorylation of DVL GO:0004674 R-HSA-3772436 DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 GO:0016308 R-HSA-377640 Autophosphorylation of SRC GO:0004713 R-HSA-377643 Dephosphorylation of inactive SRC by PTPB1 GO:0004725 R-HSA-3777112 SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) GO:0004784 R-HSA-3777129 HDAC3 containing complexes deacetylate histone GO:0004407 R-HSA-3779381 H2O2 diffuses from the mitochondrial matrix to the cytosol GO:0015267 R-HSA-3780994 GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 GO:0061547 R-HSA-3780995 NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 GO:0004842 R-HSA-3781009 NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 GO:0004842 R-HSA-3781011 EPM2A dimer dephosphorylates phosphoglycogen-GYG2 GO:0019203 R-HSA-3781018 EPM2A dimer dephosphorylates phosphoglycogen-GYG1 GO:0019203 R-HSA-3781024 GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 GO:0061547 R-HSA-3782535 TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 GO:0019789 R-HSA-3782637 HDAC8 deacetylates histones GO:0004407 R-HSA-3782655 HDAC10 deacetylates histone GO:0004407 R-HSA-378513 SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate GO:0015171 R-HSA-3785684 Fibronectin degradation by CTSG GO:0004252 R-HSA-3788061 Fibronectin degradation by ADAM8 GO:0004252 R-HSA-3788075 Brevican degradation by ADAMTS4, ADAMTS5 GO:0004222 R-HSA-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 GO:0004693 R-HSA-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 GO:0004842 R-HSA-3788745 EHMT1:EHMT2 methylates IL8 promoter GO:0018024 R-HSA-3788748 EHMT1:EHMT2 methylates IL6 promoter GO:0018024 R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs GO:0005085 R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 GO:0005085 R-HSA-3791149 Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 GO:0004222 R-HSA-3791155 Laminin-322 degradation by MMP14 GO:0004222 R-HSA-3791295 Aggrecan degradation by MMP1,2,3,7,9,12,13 GO:0004222 R-HSA-3791319 NID1 degradation by MMP19 GO:0004222 R-HSA-379382 oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC) GO:0008131 R-HSA-379387 methylation of Dopamine to form 3-Methoxytyramine GO:0008168 R-HSA-379393 SLC6A3 cotransports DA, Na+ from extracellular region to cytosol GO:0008504 R-HSA-379395 Oxidation of 3-Methoxytyramine to homovanillic acid GO:0008131 R-HSA-379415 SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane GO:0015171 R-HSA-379426 SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine GO:0015171 R-HSA-379432 SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu GO:0015171 R-HSA-379464 Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid GO:0008168 R-HSA-379844 histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate GO:0004821 R-HSA-379848 phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate GO:0004826 R-HSA-379861 glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate GO:0004818 R-HSA-379864 alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate GO:0004813 R-HSA-379865 proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate GO:0004827 R-HSA-379867 aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate GO:0004815 R-HSA-379887 cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate GO:0004817 R-HSA-379893 isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate GO:0004822 R-HSA-379974 leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate GO:0004823 R-HSA-379977 tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate GO:0004830 R-HSA-379980 tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate GO:0004831 R-HSA-379982 glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate GO:0004819 R-HSA-379992 serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate GO:0004828 R-HSA-379993 arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate GO:0004814 R-HSA-379994 methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate GO:0004825 R-HSA-379996 asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate GO:0004816 R-HSA-380002 threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate GO:0004829 R-HSA-380008 lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate GO:0004824 R-HSA-380042 valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate GO:0004832 R-HSA-380048 glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate GO:0004820 R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi GO:0005085 R-HSA-380157 methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate GO:0004825 R-HSA-380158 cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate GO:0004817 R-HSA-380170 tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate GO:0004831 R-HSA-380176 isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate GO:0004822 R-HSA-380177 alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate GO:0004813 R-HSA-380198 proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate GO:0004827 R-HSA-380199 valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate GO:0004832 R-HSA-380200 leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate GO:0004823 R-HSA-380201 threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate GO:0004829 R-HSA-380203 phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate GO:0004826 R-HSA-380216 glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate GO:0004818 R-HSA-380222 tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate GO:0004830 R-HSA-380224 arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate GO:0004814 R-HSA-380227 asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate GO:0004816 R-HSA-380229 aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate GO:0004815 R-HSA-380233 lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate GO:0004824 R-HSA-380234 histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate GO:0004821 R-HSA-380239 serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate GO:0004828 R-HSA-380240 glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate GO:0004820 R-HSA-380241 glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate GO:0004819 R-HSA-380272 Plk1-mediated phosphorylation of Nlp GO:0004674 R-HSA-380278 CCNB1:p-T160-CDK1 phosphorylates NUMA1 GO:0004693 R-HSA-380574 Dopamine synaptic vesicle docking and priming GO:0000149 R-HSA-380586 loading of Serotonin in synaptic vesicles GO:0008504 R-HSA-380608 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid GO:0004029 R-HSA-380620 Reuptake of serotonin from the synapse GO:0008504 R-HSA-380780 Activation of Src GO:0004713 R-HSA-380869 Release of docked dopamine loaded synaptic vesicle GO:0000149 R-HSA-380901 Release of docked serotonin loaded synaptic vesicle GO:0000149 R-HSA-380905 Serotonin loaded synaptic vesicle docking and priming GO:0000149 R-HSA-380927 p-AMPK phosphorylates TSC1:TSC2 GO:0004679 R-HSA-380949 AMPK is dephosphorylated GO:0004722 R-HSA-380979 RHEB in mTORC1:RHEB:GTP hydrolyses GTP GO:0003924 R-HSA-381091 IRE1 dimer autophosphorylates GO:0004674 R-HSA-381111 Phosphorylation of eIF2-alpha by PERK GO:0004674 R-HSA-381135 MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) GO:0004252 R-HSA-381435 Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS GO:0004222 R-HSA-381446 Thrombin proteolyzes IGF:IGFBP3:ALS GO:0004252 R-HSA-381461 Plasmin proteolyzes IGF:IGFBP-3:ALS GO:0004252 R-HSA-381466 Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS GO:0004252 R-HSA-3814820 HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 GO:0004252 R-HSA-381500 Cathepsin G proteolyzes IGF:IGFBP3:ALS GO:0004252 R-HSA-381518 PAAP-A proteolyzes IGF:IGFBP4 GO:0004222 R-HSA-381537 PAPP-A2 proteolyzes IGF:IGFBP5:ALS GO:0004222 R-HSA-381607 Activated Adenylyl cyclase synthesizes cyclic AMP GO:0004016 R-HSA-381798 PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 GO:0004252 R-HSA-382061 Extracellular processing of novel PDGFs GO:0004252 R-HSA-382553 ABCA7:Apo1A-mediated phospholipid efflux GO:0005548 R-HSA-382560 ABC7, mABC1 and mABC2 mediate heme transport GO:0015232 R-HSA-382575 ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix GO:0005324 R-HSA-3827958 E-cadherin degradation by MMP9, KLK7 GO:0004222 R-HSA-3828025 DCN (decorin) degradation by MMP14 GO:0004222 R-HSA-383190 HCO3- transport through ion channel GO:0017081 R-HSA-3857328 RPS6KA1/2/3 phosphorylates CEBPB on S321 GO:0004674 R-HSA-3857329 MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB GO:0004674 R-HSA-3858480 WNT-dependent phosphorylation of DVL GO:0004674 R-HSA-388831 Phosphorylation of CD28 GO:0004713 R-HSA-388833 Phosphorylation of CTLA-4 GO:0004713 R-HSA-389083 Autophosphorylation of PDGF alpha receptors GO:0004713 R-HSA-389086 Autophosphorylation of PDGF alpha/beta receptors GO:0004713 R-HSA-389158 CD28 bound PI3K phosphorylates PIP2 to PIP3 GO:0046934 R-HSA-389348 Activation of Rac1 by pVav1 GO:0005085 R-HSA-389350 Activation of Cdc42 by pVav1 GO:0005085 R-HSA-389354 Activation of Vav1 GO:0004713 R-HSA-389540 isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ GO:0004450 R-HSA-389550 isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ GO:0004450 R-HSA-389609 ALDH3A2-2 oxidizes pristanal to pristanate GO:0004029 R-HSA-389611 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA GO:0016830 R-HSA-389622 phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate GO:0050197 R-HSA-389632 pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate GO:0070251 R-HSA-389639 phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 GO:0048244 R-HSA-389652 PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP GO:0000295 R-HSA-389684 glyoxylate + alanine => glycine + pyruvate [peroxisome] GO:0008453 R-HSA-389756 AKT interacts and phosphorylates Cot GO:0004674 R-HSA-389758 Dephosphorylation of CD3-zeta by PD-1 bound phosphatases GO:0004725 R-HSA-389762 Phosphorylation of PD-1 GO:0016301 R-HSA-389821 glycine + O2 => glyoxylate + H2O2 + NH4+ GO:0003884 R-HSA-389826 glyoxylate + NADPH + H+ => glycolate + NADP+ GO:0030267 R-HSA-389842 HAO1 tetramer oxidizes glycolate to glyoxylate GO:0008891 R-HSA-389862 Conversion of glyoxylate to oxalate GO:0047969 R-HSA-389889 ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA GO:0016402 R-HSA-389891 (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) GO:0016402 R-HSA-389897 Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA GO:0008111 R-HSA-3899291 SUMOylation of EP300 with SUMO1 GO:0019789 R-HSA-389986 trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA GO:0016508 R-HSA-389995 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ GO:0003857 R-HSA-3900047 SUMOylation of DDX17 with SUMO1 GO:0019789 R-HSA-3900070 SUMOylation of MKL1 with SUMO1 GO:0019789 R-HSA-3900177 SUMOylation of DDX5 with SUMO1 GO:0019789 R-HSA-3900194 PIAS1 SUMOylates DDX5 with SUMO2 GO:0019789 R-HSA-390224 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA GO:0050632 R-HSA-390250 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA GO:0003988 R-HSA-390251 HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA GO:0003857 R-HSA-390252 HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA GO:0016508 R-HSA-390256 hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 GO:0003997 R-HSA-390281 4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH GO:0008458 R-HSA-390284 propionyl-CoA + carnitine => propionylcarnitine + CoASH GO:0004092 R-HSA-390291 acetyl-CoA + carnitine => acetylcarnitine + CoASH GO:0004092 R-HSA-3903017 SUMOylation of PPARGC1A with SUMO1 GO:0019789 R-HSA-390304 acetyl-CoA + H2O => acetate + CoASH GO:0003986 R-HSA-390329 Dephosphorylation of AKT by PP2A GO:0008195 R-HSA-390347 Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane GO:0046943 R-HSA-390393 Peroxisomal uptake of very long-chain fatty acyl CoA GO:0005324 R-HSA-390425 FAR1 reduces PalmCoA to HXOL GO:0016491 R-HSA-390427 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate GO:0008609 R-HSA-390438 FAR2 reduces PalmCoA to HXOL GO:0016491 R-HSA-390593 ATP Hydrolysis By Myosin GO:0017018 R-HSA-391156 Phosphorylation of ITIM motif in SIRP alpha GO:0004713 R-HSA-391865 Recruitment of FAK to NCAM1:Fyn in lipid rafts GO:0004713 R-HSA-391866 Phosphorylation of FAK by Src kinase GO:0004713 R-HSA-391868 Dephosphorylation of NCAM1 bound pFyn GO:0004725 R-HSA-391871 Autophosphorylation of NCAM1 bound Fyn GO:0004713 R-HSA-392054 NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras GO:0005088 R-HSA-392129 Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate GO:0004016 R-HSA-392133 G alpha (z) auto-inactivates by hydrolysing GTP to GDP GO:0003924 R-HSA-392152 Soluble guanylate cyclase converts GTP to cGMP GO:0004383 R-HSA-392195 Gi activation by P2Y purinoceptor 12 GO:0005085 R-HSA-392212 G alpha (i) auto-inactivates by hydrolysing GTP to GDP GO:0003924 R-HSA-392300 G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 GO:0046934 R-HSA-392513 Rap1 signal termination by Rap1GAPs GO:0005096 R-HSA-392530 p-S400-Cot phosphorylates NIK GO:0004709 R-HSA-392752 Phosphorylation of L1 by CK-II GO:0016301 R-HSA-3927824 PRC1 SUMOylates CASP8AP2 with SUMO1 GO:0019789 R-HSA-3927886 SUMOylation of NCOR2 with SUMO1 GO:0019789 R-HSA-3927959 SUMOylation of CREBBP with SUMO1 GO:0019789 R-HSA-3928577 ROCK phosphorylates LIMK1,2 GO:0004674 R-HSA-3928578 EPH receptors autophosphorylate GO:0004713 R-HSA-3928580 SFKs phosphorylate EFNBs GO:0004713 R-HSA-3928583 FYN phosphorylates NMDAR2B GO:0004713 R-HSA-3928592 p190RhoGEF exchanges GTP for GDP on RHOA, activating it GO:0005085 R-HSA-3928594 SFKs phosphorylate GIT1 GO:0004713 R-HSA-3928604 SFKs phosphorylate VAV2,3 GO:0004713 R-HSA-3928608 LIMK phosphorylates CFL1, inactivating it GO:0004674 R-HSA-3928610 PTK2 autophosphorylates at Y397 GO:0004713 R-HSA-3928612 KALRN exchanges GTP for GDP on RAC1, activating it GO:0005085 R-HSA-3928616 Activated ROCK phosphorylates MRLCs GO:0004674 R-HSA-3928620 PAK1 autophosphorylates GO:0004674 R-HSA-3928625 PAKs autophosphorylate GO:0004674 R-HSA-3928627 EPHB phosphorylates TIAM1 GO:0004713 R-HSA-3928628 VAV exchanges GTP for GDP on RAC1, activating it GO:0005085 R-HSA-3928632 ITSN1 exchanges GTP for GDP on CDC42, activating it GO:0005085 R-HSA-3928633 bPIX exchanges GTP for GDP on RAC, activating it GO:0005085 R-HSA-3928640 PAKs phosphorylate MLC GO:0004674 R-HSA-3928642 TIAM1 exchanges GTP for GDP on RAC1, activating it GO:0005085 R-HSA-3928648 SFKs phosphorylate NGEF GO:0004713 R-HSA-3928651 NGEF exchanges GTP for GDP on RHOA GO:0005085 R-HSA-3928656 gamma-secretase cleaves EPHB2 GO:0004175 R-HSA-3928657 MMP2,9 cleave EPHB GO:0004252 R-HSA-3928660 ADAM10 cleaves EFNAs GO:0008237 R-HSA-392870 Gs activation by prostacyclin receptor GO:0005085 R-HSA-3965444 WNT:FZD complex promotes G-protein nucleotide exchange GO:0005085 R-HSA-3968362 SUMOylation of PIAS4 with SUMO1 GO:0019789 R-HSA-3968414 UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 GO:0019789 R-HSA-398193 PLC beta-mediated PIP2 hydrolysis GO:0004629 R-HSA-399711 Activation of Ca impermeable AMPA receptors GO:0005231 R-HSA-399712 Activation of Ca permeable AMPA receptors GO:0005231 R-HSA-399934 Phosphorylation of Plexin-A GO:0004713 R-HSA-399935 Inactivation of R-Ras by Sema3A-Plexin-A GAP activity GO:0005096 R-HSA-399938 Activation of Rac1 by FARP2 GO:0030676 R-HSA-399939 Autophosphorylation of PAK GO:0004674 R-HSA-399944 Phosphorylation of CRMPs by Cdk5 GO:0004674 R-HSA-399946 Recruitment and activation of Cdk5 GO:0004713 R-HSA-399947 Tyrosine phosphorylation of CRMPs by Fes GO:0004713 R-HSA-399950 Phosphorylation of cofilin by LIMK-1 GO:0004674 R-HSA-399951 Phosphorylation of CRMPs by GSK3beta GO:0004674 R-HSA-399952 Phosphorylation of LIMK-1 by PAK GO:0004674 R-HSA-399978 Protein kinase C, alpha type phosphorylates MARCKS GO:0004674 R-HSA-399995 Muscarinic Acetylcholine Receptor M3 activates Gq GO:0005085 R-HSA-399998 Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate GO:0004629 R-HSA-400267 BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins GO:0004842 R-HSA-400382 CSNK1E,CSNK1D phosphorylate CRY and PER proteins GO:0004674 R-HSA-400459 Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 GO:0004252 R-HSA-400492 PCSK1 hydrolyzes proGIP to GIP GO:0004252 R-HSA-400496 Signal peptidase hydrolyzes preproGIP to proGIP GO:0004252 R-HSA-4084976 NANS converts ManNAc-6-P to Neu5Ac-9-P GO:0047444 R-HSA-4084978 ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues GO:0003828 R-HSA-4084980 ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) GO:0001665 R-HSA-4084982 CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac GO:0008781 R-HSA-4084984 ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) GO:0003836 R-HSA-4084989 NANP dephosphorylates Neu5Ac-9-P to Neu5Ac GO:0050124 R-HSA-4084994 NEU3 hydrolyzes Neu5Ac from glycoconjugates GO:0004308 R-HSA-4084999 NEU1,4 hydrolyses Neu5Ac from glycoconjugates GO:0004308 R-HSA-4085021 GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP GO:0008761 R-HSA-4085028 GNE phosphorylates ManNAc to ManNAc-6-P GO:0009384 R-HSA-4085029 NEU2 hydrolyzes Neu5Ac from glycoconjugates GO:0004308 R-HSA-4085033 ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) GO:0003835 R-HSA-4085217 NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate GO:0008747 R-HSA-4085296 SUMOylation of NCOA1 with SUMO1 GO:0019789 R-HSA-4085318 SUMOylation of NCOA2 with SUMO1 GO:0019789 R-HSA-4085331 PIAS2-1 SUMOylates PARK7 with SUMO1 GO:0019789 R-HSA-4085347 PIAS1 SUMOylates SAFB with SUMO1 GO:0019789 R-HSA-4085350 SUMOylation of UBE2I with SUMO1 GO:0019789 R-HSA-4085372 PIAS1 SUMOylates SAFB with SUMO2,3 GO:0019789 R-HSA-4085992 SUMOylation of DAXX with SUMO1 GO:0019789 R-HSA-4085994 TOPORS SUMOylates SIN3A with SUMO1 GO:0019789 R-HSA-4086036 PIAS1,3 SUMOylate NRIP1 with SUMO1 GO:0019789 R-HSA-4086059 SUMOylation of NPM1 with SUMO2,3 GO:0019789 R-HSA-4086083 SUMOylation of ING2 with SUMO1 GO:0019789 R-HSA-4086088 SUMOylation of NPM1 with SUMO1 GO:0019789 R-HSA-4086205 OPN (osteopontin) degradation by MMP3, MMP7 GO:0004222 R-HSA-4086392 PDE6 hydrolyses cGMP to GMP GO:0047555 R-HSA-4086410 CDK1 phosphorylates BORA GO:0004693 R-HSA-4088024 CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 GO:0004693 R-HSA-4088134 PLK1 phosphorylates FOXM1 GO:0004674 R-HSA-4088141 PP2A-PPP2R2A dephosphorylates FOXM1 GO:0004722 R-HSA-4090281 PIAS1,2-1 SUMOylate HIC1 with SUMO1 GO:0019789 R-HSA-4090284 SUMOylation of HIPK2 with SUMO1 GO:0019789 R-HSA-4090288 PIAS1,3 SUMOylate MBD1 with SUMO1 GO:0019789 R-HSA-4090390 PIAS1,2-1 SUMOylates AR with SUMO1 GO:0019789 R-HSA-4090408 PIAS1,3 SUMOylate ESR1 with SUMO1 GO:0019789 R-HSA-4093332 p-EPHB phosphorylates SDC2 GO:0004713 R-HSA-4093336 p-TIAM1 exchanges GTP for GDP on RAC1, activating it GO:0005085 R-HSA-4093339 p120-RasGAP activates GTP hydrolysis on RAS, inactivating it GO:0005096 R-HSA-416320 Trafficking of GluR1-containing AMPA receptors GO:0004683 R-HSA-416530 GPR40:fatty acid activates Gq GO:0005085 R-HSA-416546 Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity GO:0005096 R-HSA-416559 Inactivation of Rho-GTP by p190RhoGAP GO:0005096 R-HSA-416588 Activation of Rho by LARG and PDZ-RhoGEF GO:0005089 R-HSA-416639 Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites GO:0004698 R-HSA-4167501 An unknown protease degrades ACACB GO:0070011 R-HSA-4167509 Mitochondrial BTD hydrolyses BCTN GO:0047708 R-HSA-4167511 HLCS biotinylates ACACB GO:0018271 R-HSA-416985 Trafficking of GluR2-containing AMPA receptors to synapse GO:0016887 R-HSA-418163 Activated Src activates ERK GO:0004672 R-HSA-418309 ATP2B1-4 transport cytosolic Ca2+ to extracellular region GO:0005388 R-HSA-418365 ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen GO:0005388 R-HSA-418436 Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) GO:0004517 R-HSA-418442 PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release GO:0004692 R-HSA-418456 cGMP is degraded by PDEs GO:0047555 R-HSA-418549 PKG1 phosphorylates BK channels GO:0004692 R-HSA-418553 cAMP degradation by Phosphodiesterases GO:0004115 R-HSA-418574 G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP GO:0003924 R-HSA-418579 Gq activation by P2Y purinoceptor 1 GO:0005085 R-HSA-418582 G alpha (q) auto-inactivates by hydrolysing GTP to GDP GO:0003924 R-HSA-418845 Activation of caspase-3 GO:0004197 R-HSA-418846 Caspase cleavage of UNC5A GO:0004197 R-HSA-418850 Activation of Cdc42 GO:0005089 R-HSA-418852 Caspase cleavage of UNC5B GO:0004197 R-HSA-418856 Activation of Rac1 GO:0005089 R-HSA-418859 Phosphorylation of Unc5C GO:0004713 R-HSA-418872 Phosphorylation of FADK1 GO:0004713 R-HSA-419083 Myosin phosphatase inactivation by ROCK GO:0004674 R-HSA-419087 LIM kinase phosphorylation by ROCK GO:0004674 R-HSA-419166 GEFs activate RhoA,B,C GO:0005089 R-HSA-419197 Myosin regulatory light chain phosphorylation by ROCK GO:0004674 R-HSA-419232 Myosin phosphatase dephosphorylates myosin regulatory light chain GO:0050115 R-HSA-419644 Transphosphorylation of pLIMK1 GO:0004674 R-HSA-419646 SEMA4D interacts with Plexin-B1:Met GO:0004713 R-HSA-420818 MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) GO:0004222 R-HSA-420883 Opsins act as GEFs for G alpha-t GO:0005085 R-HSA-420980 Activation of Ca permeable AMPA receptors GO:0005231 R-HSA-421007 Endocytosis of Ca impermeable AMPA receptors GO:0004698 R-HSA-421835 trans-Golgi Network Vesicle Scission GO:0003924 R-HSA-422017 Ghrelin O-acyltransferase decanoylates Proghrelin GO:0008374 R-HSA-422021 PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin GO:0004252 R-HSA-422051 Cleavage of the signal peptide of Preproghrelin GO:0004252 R-HSA-422104 Ghrelin O-acyltransferase octanoylates Proghrelin GO:0008374 R-HSA-4224014 E-cadherin degradation by ADAM10, ADAM15 GO:0004222 R-HSA-422454 Polysialylation of NCAM1 GO:0003828 R-HSA-425482 SLC4A1,2,3 exchanges HCO3- for Cl- GO:0005452 R-HSA-425483 SLC4A5,7,9 cotransport Na+ with 3HCO3- GO:0008510 R-HSA-425577 Na+-driven Cl-/HCO3- exchanger transport GO:0005452 R-HSA-425661 SLC8A1,2,3 exchange 3Na+ for Ca2+ GO:0005432 R-HSA-425678 SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ GO:0008273 R-HSA-425822 K+-independent Li+/Ca2+ exchanger transport GO:0015368 R-HSA-425923 IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced GO:0004521 R-HSA-425965 SLC9A9 exchanges Na+ for H+ across the late endosome membrane GO:0015385 R-HSA-425983 SLC9A6,7 exchange Na+ for H+ across the early endosome membrane GO:0015385 R-HSA-425994 Na+/H+ exchanger transport (at cell membrane) GO:0015385 R-HSA-426015 Na+/H+ exchanger transport (at trans-golgi membrane) GO:0015385 R-HSA-426032 DAG is metabolized by DAGL to 2-AG GO:0047372 R-HSA-426043 2-AG hydrolysis to arachidonate by MAGL GO:0047372 R-HSA-426086 SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol GO:0008511 R-HSA-426130 SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol GO:0015378 R-HSA-426155 SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region GO:0015379 R-HSA-426223 Cation influx mediated by TRPC3/6/7 GO:0005261 R-HSA-426240 DAG kinase produces phosphatidic acid from DAG GO:0004143 R-HSA-426464 Dicer cleaves double-stranded RNA to yield double-stranded siRNA GO:0004525 R-HSA-426520 Endonucleolytic RISC hydrolyzes target RNAs GO:0004521 R-HSA-427336 TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. GO:0046974 R-HSA-427366 Transcription of intergenic spacer of the rRNA gene GO:0003899 R-HSA-427514 eNoSC deacetylates histone H3 GO:0004407 R-HSA-427527 eNoSC dimethylates histone H3 at lysine-9 GO:0046974 R-HSA-427555 SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol GO:0015116 R-HSA-427570 Group 3 - Selective Cl- transport GO:0005254 R-HSA-427605 SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol GO:0015321 R-HSA-427645 SLC34A3 cotransports Pi, 2Na+ GO:0015321 R-HSA-427656 SLC34A1,2 cotransports HPO4(2-), 3Na+ from extracellular region to cytosol GO:0015321 R-HSA-427666 SLC26A3,6 exchange Cl- for HCO3- GO:0005452 R-HSA-427910 ATP2A1-3 transport Ca2+ from cytosol to ER lumen GO:0005388 R-HSA-427998 Proton-coupled di- and tri-peptide cotransport GO:0015333 R-HSA-428007 Proton-coupled histidine and di-peptide cotransport GO:0015333 R-HSA-428015 SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol GO:0005314 R-HSA-428052 SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ GO:0005313 R-HSA-428123 3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ GO:0047560 R-HSA-428127 palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 GO:0004758 R-HSA-428185 sphinganine + stearyl-CoA => dihydroceramide + CoASH GO:0050291 R-HSA-428205 ceramide + H2O => stearate + sphingosine [Golgi] GO:0017040 R-HSA-428214 sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP GO:0008481 R-HSA-428231 ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] GO:0017040 R-HSA-428259 dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O GO:0042284 R-HSA-428260 dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O GO:0000170 R-HSA-428262 phytoceramide + H2O => stearate + phytosphingosine GO:0070774 R-HSA-428273 sphingosine +ATP => sphingosine 1-phosphate + ADP GO:0017050 R-HSA-428522 Inactivation of RAC1 GO:0005096 R-HSA-428533 Inactivation of CDC42 GO:0005096 R-HSA-428535 Activation of RAC1 by SOS GO:0030676 R-HSA-428585 SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol GO:0015538 R-HSA-428609 Type I Na+-coupled phosphate co-transport GO:0015321 R-HSA-428625 Vesicular inhibitory amino acid transport GO:0015495 R-HSA-428664 sphinganine 1-phosphate + H2O => sphinganine + orthophosphate GO:0070780 R-HSA-428676 sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal GO:0008117 R-HSA-428681 sphinganine 1-phosphate => phosphoethanolamine + hexadecanal GO:0008117 R-HSA-428690 sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] GO:0042392 R-HSA-428696 sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] GO:0042392 R-HSA-428701 sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] GO:0042392 R-HSA-428750 Gq activation by TP receptor GO:0005085 R-HSA-428779 GLUT7 and GLUT11 transport glucose and fructose GO:0051119 R-HSA-428888 Phosphorylation of ROBO1 by ABL kinase GO:0004713 R-HSA-428917 G13 activation by TP receptor GO:0005085 R-HSA-428941 P2Y purinoceptor 1 activates MAP kinase p38 alpha GO:0003924 R-HSA-428961 Phosphorylation of cPLA2 by MAPK p38 alpha GO:0004674 R-HSA-429016 ALOX5 is phosphorylated by MAPKAP2 GO:0004674 R-HSA-429036 SLC2A9 transports Fru, Glc, urate GO:0022857 R-HSA-429094 SLC2A6,8,10,12 transport Glc from extracellular region to cytosol GO:0055056 R-HSA-429101 HMIT co-transports myo-inositol with a proton GO:0005366 R-HSA-429157 ABCC4 accumulation of dense granule contents GO:0015662 R-HSA-429441 SYK activation by SRC GO:0004713 R-HSA-429449 Syk activation leads to SLP-76 activation GO:0004713 R-HSA-429567 Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 GO:0005362 R-HSA-429571 Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 GO:0015166 R-HSA-429581 SLC5A6 transports vitamins from extracellular region to cytosol GO:0008523 R-HSA-429591 SLC5A5 cotransports Na+ with I- from extracellular region to cytosol GO:0008507 R-HSA-429594 SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol GO:0015220 R-HSA-429613 SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol GO:0005412 R-HSA-429663 SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol GO:0005367 R-HSA-429698 PRKD1,2,3 phosphorylates COL4A3BP-2 GO:0004674 R-HSA-429714 monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP GO:0004674 R-HSA-429730 multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate GO:0004722 R-HSA-429749 SLC5A8 transports monocarboxylates from extracellular region to cytosol GO:0008028 R-HSA-429767 Passive I- efflux mediated by SMCT1 GO:0022803 R-HSA-429786 phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] GO:0033188 R-HSA-429798 phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] GO:0033188 R-HSA-429845 5' to 3' exoribonuclease hydrolyzes decapped mRNA GO:0004534 R-HSA-429860 DCP1-DCP2 complex decaps mRNA GO:0016896 R-HSA-429955 CCR4-NOT complex deadenylates mRNA GO:0004535 R-HSA-429961 DCPS scavenges the 7-methylguanosine cap of mRNA GO:0004532 R-HSA-429992 PARN deadenylates mRNA GO:0004535 R-HSA-430021 PAN2-PAN3 complex partially deadenylates mRNA GO:0004535 R-HSA-430028 Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion GO:0000175 R-HSA-432010 Aquaporin-1 passively transports water into cell GO:0015250 R-HSA-432034 Aquaporin-6 passively transports anions into vesicles GO:0005253 R-HSA-432036 Aquaporin-6 passively transports anions out of vesicles GO:0005253 R-HSA-432049 Aquaporin-9 passively transports glycerol into cell GO:0015254 R-HSA-432054 Aquaporin-1 passively transports water out of cell GO:0015250 R-HSA-432065 p-S256-Aquaporin-2 passively transports water into cell GO:0015250 R-HSA-432067 Aquaporin-4 passively transports water out of cell GO:0015250 R-HSA-432074 Aquaporin-7 passively transports glycerol out of cell GO:0015254 R-HSA-432110 Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding GO:0004674 R-HSA-432129 FGR binds and phosphorylates LRP8 GO:0004713 R-HSA-432148 Fgr may phosphorylate p38 MAPK GO:0004715 R-HSA-432164 Ca2+ influx into the post-synaptic cell GO:0005231 R-HSA-432232 Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) GO:0004691 R-HSA-432237 Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane GO:0000146 R-HSA-432707 trans-Golgi Network Lysosomal Vesicle Scission GO:0003924 R-HSA-433089 SOAT can transport taurolithocholate-3-sulphate GO:0008508 R-HSA-433099 NaS2 co-transports sulphate and two sodium ions GO:0015382 R-HSA-433101 NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion GO:0015362 R-HSA-433104 NACT co-transports trivalent citrate and a sodium ion GO:0015137 R-HSA-433114 NaS1 co-transports sulphate and a sodium ion GO:0015382 R-HSA-433131 NaDC1 co-transports dicarboxylic acids and a sodium ion GO:0015361 R-HSA-4332236 CBL neddylates TGFBR2 GO:0004842 R-HSA-4332358 Dissociation of CaM and CAMK2 autophosphorylation GO:0004674 R-HSA-4332363 Autophosphorylation and activation of CAMK2 GO:0004674 R-HSA-4332388 Activation of MAP3K7 in response to WNT GO:0004674 R-HSA-433672 NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 GO:0004407 R-HSA-433698 SLC16A1,3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol GO:0008028 R-HSA-4341016 PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 GO:0019789 R-HSA-4341025 SUMOylation of NR3C1 (GR) with SUMO1 GO:0019789 R-HSA-4341048 SUMOylation of RXRA with SUMO1 GO:0019789 R-HSA-4341070 PIAS4 SUMOylates PPARA with SUMO1 GO:0019789 R-HSA-4341072 SUMOylation of RARA with SUMO2 GO:0019789 R-HSA-4341073 PIAS3 SUMOylates PGR with SUMO1 GO:0019789 R-HSA-434650 MATEs mediate extrusion of xenobiotics GO:0015307 R-HSA-434798 CRAC translocates calcium from the extracellular region to the cytosol GO:0015279 R-HSA-434836 Syk/Lck phosphorylate LAT GO:0004713 R-HSA-435171 NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages GO:0051139 R-HSA-435349 SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol GO:0005381 R-HSA-435366 ZnT1 mediates the efflux of zinc from the cell GO:0005385 R-HSA-435375 ZnT2 facilitates zinc vesicular sequestration GO:0005385 R-HSA-437084 ZnT3 transports zinc into synaptic vesicles GO:0005385 R-HSA-437085 ZnT5 transports zinc into secretory granules in pancreatic beta cells GO:0005385 R-HSA-437129 ZnT7 transports zinc into the golgi apparatus GO:0005385 R-HSA-437136 SLC30A8 transports Zn2+ from cytosol to secretory granule GO:0005385 R-HSA-437139 ZnT6 transports zinc into the golgi apparatus GO:0005385 R-HSA-437162 PI3K alpha, beta, gamma convert PIP2 to PIP3 GO:0046934 R-HSA-437195 PDK1 activates PKC zeta GO:0004676 R-HSA-437300 SLC31A1 transports Cu2+ from extracellular region to cytosol GO:0005375 R-HSA-437936 p-Y348-SYK phosphorylates VAV family GO:0004715 R-HSA-438037 Membrane depolarization upon activation of Ca impermeable AMPA receptors GO:0005231 R-HSA-4411383 NLK phosphorylates TCF/LEF GO:0004674 R-HSA-4411402 Activation of NLK GO:0004674 R-HSA-4419948 CTDNEP1:CNEP1R1 dephosphorylates LPIN GO:0004722 R-HSA-4419978 DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP GO:0016765 R-HSA-4419979 SRD5A3 reduces pPNOL to DCHOL GO:0016628 R-HSA-4419986 Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL GO:0016791 R-HSA-4420052 Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT GO:0005261 R-HSA-4420117 VEGFR2 autophosphorylates GO:0004713 R-HSA-4420121 SFKs phosphorylate PLCG1 GO:0004713 R-HSA-4420128 SRC-1 phosphorylates SHB GO:0004713 R-HSA-4420206 Phosphorylation of SRC-1 GO:0004713 R-HSA-442273 VAV1 is a GEF for Rho/Rac family kinases GO:0005085 R-HSA-442291 VAV2 is a GEF for Rho/Rac family kinases GO:0005085 R-HSA-442314 VAV3 is a GEF for Rho/Rac family kinases GO:0005085 R-HSA-442317 ZIP6 and ZIP14 mediate zinc influx into cells GO:0005385 R-HSA-442345 hZIP10 mediates zinc influx into cells GO:0005385 R-HSA-442368 SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region GO:0015093 R-HSA-442387 ZIP8 mediates zinc influx into cells GO:0005385 R-HSA-442393 ZIP7 mediates zinc efflux from the endoplasmic reticulum GO:0005385 R-HSA-442405 hZIP5 mediates zinc uptake by cells GO:0005385 R-HSA-442422 SLC39A1-4 transports Zn2+ from extracellular region to cytosol GO:0005385 R-HSA-442661 SLC41A1,2 transport Mg2+ from extracellular region to cytosol GO:0015095 R-HSA-442715 Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP GO:0008294 R-HSA-442724 Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) GO:0016301 R-HSA-442732 NMDA-activated RASGRF1 activates RAS GO:0005088 R-HSA-442739 PDPK1 phosphorylates RSKs GO:0004674 R-HSA-442749 CaMKK autophosphorylates in the nucleus GO:0004683 R-HSA-442832 PAK phosphorylates cortactin GO:0004674 R-HSA-443817 Phosphorylation of L1 by EPHB2 GO:0004713 R-HSA-443997 SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol GO:0005334 R-HSA-444007 GAT1-3 mediate Na+/Cl- dependent GABA transport GO:0005332 R-HSA-444008 SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol GO:0005335 R-HSA-444100 PROT mediates L-proline uptake GO:0005298 R-HSA-444120 SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol GO:0015375 R-HSA-444126 HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively GO:0015204 R-HSA-444160 VMAT1/2 can mediate the transport of biogenic amines GO:0008504 R-HSA-444393 RhCG mediates ammonium influx into kidney collecting duct cells GO:0008519 R-HSA-444416 RHAG transports NH4+ from cytosol to extracellular region (red blood cells) GO:0008519 R-HSA-444419 RhBG mediates ammonium effflux out of kidney collecting duct cells GO:0008519 R-HSA-444433 Cho transports from the extracellular space to the cytosol GO:0015220 R-HSA-445064 Activation of Rac1 by VAV2 GO:0005085 R-HSA-445072 Interaction of PAK1 with Rac1-GTP GO:0004674 R-HSA-445076 Phosphorylation of Y1229 in L1 GO:0004713 R-HSA-445079 Phosphorylation of L1 by ERK GO:0016301 R-HSA-445084 Phosphorylation of L1 by SRC GO:0004713 R-HSA-445085 Phosphorylation of VAV2 GO:0004713 R-HSA-445089 Dephosphorylation of pL1 (Y1176) GO:0004725 R-HSA-445091 Phosphorylation of Neurofascin GO:0004713 R-HSA-445699 ATP Hydrolysis By Myosin GO:0017018 R-HSA-445714 Aquaporin-3 passively transports water out of cell GO:0015250 R-HSA-445813 Phosphorylation of Smooth Muscle Myosin Light Chains GO:0004687 R-HSA-446185 Isomerization of GlcNAc6P to GlcNAc1P GO:0004610 R-HSA-446187 ALG11 transfers the fourth and fifth Man to the N-glycan precursor GO:0000026 R-HSA-446188 ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 GO:0000033 R-HSA-446189 Addition of a second glucose to the N-glycan precursor by ALG8 GO:0004583 R-HSA-446191 Addition of N-acetyl-D-glucosamine to Dolichyl phosphate GO:0003975 R-HSA-446194 Addition of a third glucose to the N-glycan precursor by an ALG10 homologue GO:0004583 R-HSA-446195 DOLK phosphorylates DCHOL to DOLP GO:0004168 R-HSA-446198 ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 GO:0000030 R-HSA-446200 DOLPP1 dephosphorylates DOLDP to DOLP GO:0047874 R-HSA-446201 PMM1,2 isomerise Man6P to Man1P GO:0004615 R-HSA-446202 Addition of the first glucose to the N-glycan precursor by ALG6 GO:0004583 R-HSA-446204 GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine GO:0003977 R-HSA-446207 ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP GO:0004577 R-HSA-446208 Addition of a second mannose to the N-glycan precursor by ALG2 GO:0000033 R-HSA-446209 Transfer of N-glycan to the protein GO:0004579 R-HSA-446212 Flipping of the N-glycan precursor to inside the ER GO:0034202 R-HSA-446214 Synthesis of dolichyl-phosphate-glucose GO:0004581 R-HSA-446215 ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 GO:0000026 R-HSA-446216 ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 GO:0000026 R-HSA-446218 Addition of the first mannose to the N-glycan precursor by ALG1 GO:0004578 R-HSA-446221 Mannose-1-phosphate converted to GDP-Mannose GO:0004475 R-HSA-446277 RhCG mediates ammonium efflux out of kidney collecting duct cells GO:0008519 R-HSA-446278 RhBG mediates ammonium influx into kidney collecting duct cells GO:0008519 R-HSA-446694 IRAK4 phosphorylates IRAK1 GO:0004674 R-HSA-446701 IRAK4-activated IRAK1 autophosphorylates GO:0004674 R-HSA-446877 TRAF6 is K63 poly-ubiquitinated GO:0004842 R-HSA-447074 AMPK phosphorylates Raptor in the mTORC1 complex GO:0004679 R-HSA-448703 Interleukin-1 family precursors are cleaved by caspase-1 GO:0004197 R-HSA-448948 Phosphorylation of E proteins by p38 MAPK GO:0004674 R-HSA-448951 Activation of p38 alpha/beta MAPK GO:0004708 R-HSA-448955 Phosphorylation of MEF2 proteins by p38 GO:0004674 R-HSA-449073 Caspase-3 cleaves pro-interleukin-16 GO:0008656 R-HSA-449715 GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P GO:0004360 R-HSA-449718 Addition of a third mannose to the N-glycan precursor by ALG2 GO:0000009 R-HSA-449734 Acetylation of glucosamine 6-phosphate to GlcNAc6P GO:0004343 R-HSA-449911 acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] GO:0003987 R-HSA-449937 pyrophosphate + H2O => 2 orthophosphate [mitochondrial] GO:0004427 R-HSA-450095 GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region GO:0055056 R-HSA-450222 Active p38 MAPK phosphorylates MAPKAPK2 or 3 GO:0004674 R-HSA-450325 c-FOS activation by phospho ERK1/2 GO:0004674 R-HSA-450333 Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 GO:0004712 R-HSA-450337 Activated TAK1 phosphorylates MKK4/MKK7 GO:0004674 R-HSA-450346 activated human TAK1 phosphorylates MKK3/MKK6 GO:0004674 R-HSA-450358 Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation GO:0004842 R-HSA-450463 MK2 phosphorylates ZFP36 (Tristetraproline, TTP) GO:0004674 R-HSA-450466 AUF1:mRNA complex is destroyed GO:0004175 R-HSA-450474 MK2 phosphorylates BRF1 GO:0004674 R-HSA-450490 Protein Kinase B/Akt phosphorylates BRF1 GO:0004674 R-HSA-450499 Protein Kinase B (AKT) phosphorylates KSRP GO:0004674 R-HSA-450533 PKCdelta phosphorylates HuR GO:0004674 R-HSA-450550 PKCalpha phosphorylates HuR GO:0004674 R-HSA-450827 hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. GO:0004674 R-HSA-450971 NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] GO:0008746 R-HSA-450975 isocitrate <=> citrate GO:0003994 R-HSA-450984 isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] GO:0004450 R-HSA-451033 (S)-Malate <=> Fumarate + H2O GO:0004333 R-HSA-451152 MAP kinase p38 phosphorylates KSRP GO:0004674 R-HSA-451310 Activation of Edited Kainate receptors GO:0015276 R-HSA-451311 Activation of Ca-permeable Kainate receptors GO:0015276 R-HSA-451347 Activation of JNK by DSCAM GO:0004674 R-HSA-451366 Activation of p38MAPK by DSCAM GO:0004707 R-HSA-451418 Pellino ubiquitinates IRAK1 GO:0004842 R-HSA-451649 TPL2 phosphorylates MEK1, SEK1 GO:0004709 R-HSA-451942 Within the IL-2R complex JAK3 phosphorylates JAK1 GO:0004713 R-HSA-452036 arginine + H2O => ornithine + urea [ARG2] GO:0004053 R-HSA-452097 Recruited STAT5 is phosphorylated GO:0004713 R-HSA-452100 SHC1 bound to IL2 receptor is phosphorylated GO:0004713 R-HSA-452122 JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB GO:0004713 R-HSA-452392 Transcription of POU5F1 (OCT4) GO:0003899 R-HSA-452838 Expression of NANOG GO:0003899 R-HSA-452894 Expression of SOX2 GO:0003899 R-HSA-453200 SYK autophosphorylates GO:0004715 R-HSA-453337 glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP GO:0004689 R-HSA-453339 poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] GO:0008184 R-HSA-453358 poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] GO:0008184 R-HSA-4546385 PIAS1,3 SUMOylates NR5A1 with SUMO2 GO:0019789 R-HSA-4546386 PIAS1,3 SUMOylates NR5A1 with SUMO1 GO:0019789 R-HSA-4546387 PIAS4 SUMOylates VDR with SUMO2 GO:0019789 R-HSA-4551451 Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling GO:0033192 R-HSA-4551570 VANGL2 is phosphorylated in response to WNT5A GO:0004674 R-HSA-4551604 PIAS4 SUMOylates PARP1 with SUMO1 GO:0019789 R-HSA-4551616 SUMOylation of RPA1 (RPA70) with SUMO2,3 GO:0019789 R-HSA-4551648 SUMOylation of TDG with SUMO1 GO:0019789 R-HSA-4551649 RANBP2 SUMOylates RANBP2 with SUMO1 GO:0019789 R-HSA-4551655 CBX4 SUMOylates BMI1 in PRC1 with SUMO1 GO:0019789 R-HSA-4551661 PIAS4 SUMOylates RNF168 with SUMO1 GO:0019789 R-HSA-4551679 RANBP2 SUMOylates RANBP2 with SUMO2 GO:0019789 R-HSA-4551683 SUMOylation of TOPORS with SUMO1 GO:0019789 R-HSA-4551721 PIAS4 SUMOylates VHL with SUMO1 GO:0019789 R-HSA-4551724 PIAS4 SUMOylates HERC2 with SUMO1 GO:0019789 R-HSA-4551727 CBX4 SUMOylates CBX4 in PRC1 with SUMO1 GO:0019789 R-HSA-4551738 SUMOylation of TDG with SUMO2,3 GO:0019789 R-HSA-4551768 PIAS4 SUMOylates PARP1 with SUMO2,3 GO:0019789 R-HSA-4568846 CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 GO:0019789 R-HSA-4568848 PIAS1,2-1 SUMOylates XRCC4 with SUMO1 GO:0019789 R-HSA-4568863 SUMOylation of RAD52 with SUMO1 GO:0019789 R-HSA-4568914 SUMOylation of BLM with SUMO2,3 GO:0019789 R-HSA-4570463 CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 GO:0019789 R-HSA-4570467 SUMOylation of NOP58 with SUMO1 GO:0019789 R-HSA-4570485 SUMOylation of Histone H4 with SUMO3 GO:0019789 R-HSA-4570489 SUMOylation of NOP58 with SUMO2 GO:0019789 R-HSA-4570493 RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 GO:0019789 R-HSA-4570496 SUMOylation of Histone H4 with SUMO1 GO:0019789 R-HSA-4570499 CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 GO:0019789 R-HSA-4570528 SUMOylation of XPC with SUMO1 GO:0019789 R-HSA-4570553 SUMOylation of MDC1 with SUMO2,3 GO:0019789 R-HSA-4570554 SUMOylation of MDC1 with SUMO1 GO:0019789 R-HSA-4608825 DVL2 is phosphorylated after WNT5A binding to FZD GO:0004674 R-HSA-4608852 SMURF1/2 ubiquitinates PRICKLE1 GO:0061630 R-HSA-4608855 PRICKLE1 is degraded by the proteasome GO:0004175 R-HSA-4615839 PIAS1 SUMOylates SATB1 with SUMO2,3 GO:0019789 R-HSA-4615872 RANBP2 SUMOylates HDAC4 with SUMO1 GO:0019789 R-HSA-4615873 PIAS2-2 SUMOylates SUZ12 with SUMO1 GO:0019789 R-HSA-4615889 SUMOylation of HDAC1 with SUMO1 GO:0019789 R-HSA-4615900 PIAS1 SUMOylates SATB2 with SUMO3 GO:0019789 R-HSA-4615905 PIAS1 SUMOylates SATB1 with SUMO1 GO:0019789 R-HSA-4615910 SUMOylation of PCNA with SUMO1 GO:0019789 R-HSA-4615933 SUMOylation of CBX5 with SUMO1 GO:0019789 R-HSA-4615987 RANBP2 SUMOylates HDAC4 with SUMO2,3 GO:0019789 R-HSA-4616015 SUMOylation of HDAC2 with SUMO1 GO:0019789 R-HSA-4641129 AXIN is ubiquitinated by SMURF2 GO:0061630 R-HSA-4641159 DVL1 is ubiquitinated by HECW1 GO:0061630 R-HSA-4641236 USP8 deubiquitinates FZD to potentiate WNT signaling GO:0004843 R-HSA-4641246 ZNRF3 autoubiquitinates to promote its internalization GO:0061630 R-HSA-4641253 ZNRF3 ubiquitinates FZD to promote its downregulation GO:0061630 R-HSA-4641256 Ubiquitinated AXIN is degraded by the proteasome GO:0004175 R-HSA-4641260 Ubiquitinated DVL1 is degraded by the proteasome GO:0004175 R-HSA-4641342 SUMOylation of TOP2A with SUMO1 GO:0019789 R-HSA-4641345 SUMOylation of TOP2B with SUMO1 GO:0019789 R-HSA-4641350 PIAS4 SUMOylates TOP2A with SUMO2,3 GO:0019789 R-HSA-4641362 SUMOylation of TOP1 with SUMO1 GO:0019789 R-HSA-4655355 RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) GO:0019789 R-HSA-4655355 RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) GO:0019789 R-HSA-4655374 SUMOylation of DNMT3B with SUMO1 GO:0019789 R-HSA-4655431 SUMOyation of DNMT1 with SUMO1 GO:0019789 R-HSA-4655440 CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 GO:0019789 R-HSA-4656914 SUMOylation of NFKBIA with SUMO1 GO:0019789 R-HSA-469659 Testosterone is converted to 5-alpha-dihydroxytestosterone GO:0003865 R-HSA-4717461 PIAS1,2-2 SUMOylate PPARG with SUMO1 GO:0019789 R-HSA-4717521 PIAS1 SUMOylates NR2C1 (TR2) GO:0019789 R-HSA-4719413 PIAS2,3,4 SUMOylate RORA with SUMO2 GO:0019789 R-HSA-4719423 PIAS2-2 SUMOylates THRA with SUMO3 GO:0019789 R-HSA-4719424 PIAS1 SUMOylates THRB with SUMO1. GO:0019789 R-HSA-4719436 PIAS2,3,4 SUMOylate RORA with SUMO1 GO:0019789 R-HSA-4719447 PIAS2-2 SUMOylates THRA with SUMO1 GO:0019789 R-HSA-4719448 PIAS1 SUMOylates THRB with SUMO3 GO:0019789 R-HSA-4720432 HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 GO:0019789 R-HSA-4720446 HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 GO:0019789 R-HSA-4722133 KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 GO:0032452 R-HSA-4724279 KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 GO:0032452 R-HSA-4724284 KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 GO:0032452 R-HSA-4754176 JMJD6 demethylates MeR3-histone H3 GO:0032452 R-HSA-4754181 KDM5A-D demethylate Me2K5-histone H3 GO:0032452 R-HSA-4754187 KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 GO:0032452 R-HSA-4755411 PIAS4 SUMOylates IKBKG with SUMO1 GO:0019789 R-HSA-4755478 TOPORS SUMOylates IKBKE with SUMO1 GO:0019789 R-HSA-4755479 SUMOylation of NFKB2 with SUMO1 GO:0019789 R-HSA-4755494 PIAS1,2-1 SUMOylate NR5A2 with SUMO1 GO:0019789 R-HSA-4755526 PIAS4 SUMOylates NR4A2 with SUMO2,3 GO:0019789 R-HSA-4755536 PIAS3 SUMOylates RELA with SUMO3 GO:0019789 R-HSA-4793911 MAPKAPK2 phosphorylates HSF1 GO:0004674 R-HSA-480301 Expression of EPAS1 (HIF2A) GO:0003899 R-HSA-480520 Expression of SALL4 GO:0003899 R-HSA-482619 (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) GO:0004550 R-HSA-482621 (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) GO:0004550 R-HSA-4827382 SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) GO:0018024 R-HSA-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) GO:0018024 R-HSA-482804 (d)NDP + ATP <=> (d)NTP + ADP (NME4) GO:0004550 R-HSA-482812 (d)NTP + ADP <=> (d)NDP + ATP (NME4) GO:0004550 R-HSA-499981 Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 GO:0005355 R-HSA-500717 Activation of GRIK3 homomer GO:0001664 R-HSA-504054 UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] GO:0003883 R-HSA-507749 pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] GO:0004021 R-HSA-507775 alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2] GO:0004021 R-HSA-507868 Aquaporins passively transport water into cells GO:0015250 R-HSA-507869 Aquaporins passively transport glycerol into cells GO:0015254 R-HSA-507870 Aquaporins passively transport water out of cells GO:0015250 R-HSA-507871 Aquaporins passively transport glycerol out of cells GO:0015254 R-HSA-507873 Aquaporins passively transport urea out of cells GO:0015265 R-HSA-507875 Aquaporins passively transport urea into cells GO:0015265 R-HSA-508040 glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] GO:0017084 R-HSA-508179 a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] GO:0004084 R-HSA-508189 a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] GO:0004084 R-HSA-5082387 Phosphorylation of HSF1 at Ser230 induces transactivation GO:0004674 R-HSA-5082405 Phosphorylation of HSF1 at Ser326 induces transactivation GO:0004674 R-HSA-508282 SYK is a substrate for JAK1 GO:0004713 R-HSA-508308 beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] GO:0004485 R-HSA-508369 alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ GO:0003857 R-HSA-508473 methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ GO:0008442 R-HSA-508561 alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate GO:0047536 R-HSA-5138432 DVL2 is phosphorylated by PKC GO:0004697 R-HSA-5144542 CLOCK acetylates lysine-15 of histone H3, H4 GO:0004402 R-HSA-514604 GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) GO:0003920 R-HSA-5159245 SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) GO:0018024 R-HSA-5164399 BCO2:Fe2+ cleaves betaC to APO10al and bION GO:0016702 R-HSA-5173005 B3GALTL transfers glucose to O-fucosyl-proteins GO:0016757 R-HSA-5173192 POFUT2 transfers fucose to TSR domain-containing proteins GO:0046922 R-HSA-517444 p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate GO:0004838 R-HSA-5195402 CDK1 phosphorylates LPIN GO:0004693 R-HSA-5205661 Pink1 is recruited from the cytoplasm to the mitochondria GO:0008320 R-HSA-5205682 Parkin promotes the ubiquitination of mitochondrial substrates GO:0004842 R-HSA-5205798 PRMT1,PRMT6 methylate arginine-4 of histone H4 GO:0016274 R-HSA-5205799 CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) GO:0008469 R-HSA-5205820 PRMT6 methylates arginine-4 of histone H2A (H2AR3) GO:0016274 R-HSA-5205822 CARM1 methylates arginine-18 (H3R17) of histone H3 GO:0016274 R-HSA-5205824 CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) GO:0016274 R-HSA-5205861 COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) GO:0008469 R-HSA-5205867 PRMT1 methylates arginine-12 of histone H2A (H2AR11) GO:0016274 R-HSA-5210912 Furin cleaves ANTXR2-bound PA83 to yield PA63 GO:0004252 R-HSA-5210935 Furin cleaves ANTXR1-bound PA83 to yield PA63 GO:0004252 R-HSA-5210943 PA63:ANTRX2 oligomer transports EF and LF (target cell endosome to cytosol) GO:0008320 R-HSA-5210947 PA63:ANTRX1 oligomer transports EF and LF (target cell endosome to cytosol) GO:0008320 R-HSA-5211224 Anthrax EF catalyzes the conversion of ATP to cAMP GO:0004016 R-HSA-5211239 SIRT1 deacetylates TAF1B in SL1 complex GO:0034979 R-HSA-5211340 Anthrax LF cleaves target cell MAP2K1 (MEK1) GO:0008237 R-HSA-5211356 Anthrax LF cleaves target cell MAP2K2 (MEK2) GO:0008237 R-HSA-5211387 Anthrax LF cleaves target cell MAP2K7 (MEK7) GO:0008237 R-HSA-5211391 Anthrax LF cleaves target cell MAP2K4 (MEK4) GO:0008237 R-HSA-5211400 Anthrax LF cleaves target cell MAP2K3 (MEK3) GO:0008237 R-HSA-5211405 Anthrax LF cleaves target cell MAP2K6 (MEK6) GO:0008237 R-HSA-5213464 RIPK1 is phosphorylated GO:0004674 R-HSA-5213466 RIPK3 is phosphorylated GO:0004674 R-HSA-5216234 PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) GO:0008469 R-HSA-5218640 SRC-1 phosphorylates p-Y397-PTK2 GO:0004713 R-HSA-5218642 PTK2 autophosphorylates GO:0004713 R-HSA-5218804 p38 MAPK activation by VEGFR GO:0004672 R-HSA-5218805 PKC autophosphorylates GO:0004697 R-HSA-5218806 FYN autophosphorylates GO:0004713 R-HSA-5218809 PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 GO:0004713 R-HSA-5218812 FYN phosphorylates PAK2 GO:0004713 R-HSA-5218814 PAK2 autophorylates GO:0004674 R-HSA-5218819 VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 GO:0046934 R-HSA-5218820 Src kinases phosphorylate VAV GO:0004713 R-HSA-5218821 PDK1 phosphorylates PKC GO:0004674 R-HSA-5218823 PKC phosphorylates sphingosine kinase 1 GO:0004674 R-HSA-5218826 Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 GO:0004674 R-HSA-5218828 PTK2/SRC-1 phosphorylates BCAR1 GO:0004713 R-HSA-5218829 VEGF induces CDC42 activation by unknown mechanism GO:0005085 R-HSA-5218830 SRC-1 phosphorylates PTK2-beta GO:0004713 R-HSA-5218839 DOCK180:ELMO exchanges GTP for GDP, activating RAC1 GO:0005085 R-HSA-5218841 NADPH oxidase 2 generates superoxide from oxygen GO:0016175 R-HSA-5218845 p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate GO:0017050 R-HSA-5218850 VAV exchanges GTP for GDP on RAC1, activating it GO:0005085 R-HSA-5218851 p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 GO:0004713 R-HSA-5218854 p-Y420-FYN is phosphorylated on S21 GO:0004674 R-HSA-5218906 RIPK3 phosphorylates MLKL GO:0004674 R-HSA-5218916 p-MAPK2/3 phosphorylates HSP27 GO:0004674 R-HSA-5218952 PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) GO:0016274 R-HSA-5220952 TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine GO:0070579 R-HSA-5220959 TDG excises 5-formylcytosine GO:0019104 R-HSA-5220990 TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine GO:0070579 R-HSA-5221014 TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine GO:0070579 R-HSA-5221061 TDG excises 5-carboxylcytosine GO:0019104 R-HSA-5221130 LPIN catalyzes conversion of phosphatidic acid to diacylglycerol GO:0008195 R-HSA-5223313 ABCD4 may transport Cbl from lysosomal lumen to cytosol GO:0042626 R-HSA-5223317 ABCB9 transports peptides from cytosol to lysosomal lumen GO:0015421 R-HSA-5226964 ANKH transports PPi from cytosol to extracellular region GO:0030504 R-HSA-5227490 NoRC:HDAC:DNMT methylates cytosine of the rRNA genes GO:0009008 R-HSA-5228406 TeNT HC transports TeNT LC from target cell endosome membrane into cytosol GO:0008320 R-HSA-5228508 RANBP2 SUMOylates PML with SUMO1 GO:0019789 R-HSA-5228521 PIAS1,4 SUMOylate CASP8AP2 with SUMO1 GO:0019789 R-HSA-5228523 RANBP2 SUMOylates MDM2 with SUMO1 GO:0019789 R-HSA-5228525 RANBP2 SUMOylates TOP2A with SUMO1 GO:0019789 R-HSA-5228578 TeNT LC cleaves target cell VAMP2 GO:0004222 R-HSA-5228811 IkBA variant is not phosphorylated within IkBA:NF-kappaB GO:0004674 R-HSA-5229010 CARM1 methylates arginine-27 of histone H3 (H3R26) GO:0016274 R-HSA-5229111 AP4 transports APP from trans-Golgi network to endosome lumen GO:0008565 R-HSA-5229194 Depolymerization of lamin filaments after PKC-mediated phosphorylation GO:0004674 R-HSA-5229203 PRMT6 methylates histone H2A arginine-30 (H2AR29) GO:0016274 R-HSA-5229343 AXIN is phosphorylated in the destruction complex GO:0004674 R-HSA-5244404 BoNT/B HC transports BoNT/B LC from target cell synaptic vesicle membrane into cytosol GO:0008320 R-HSA-5244428 BoNT/A HC transports BoNT/A LC from target cell synaptic vesicle membrane into cytosol GO:0008320 R-HSA-5244506 BoNT/E HC transports BoNT/E LC from target cell synaptic vesicle membrane into cytosol GO:0008320 R-HSA-5244669 CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments GO:0004693 R-HSA-5244692 Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) GO:0018024 R-HSA-5246514 BoNT/C HC transports BoNT/C LC from target cell synaptic vesicle membrane to cytosol GO:0008320 R-HSA-5246693 APC is K63-polyubiquitinated GO:0061630 R-HSA-5250531 ARV1 transports CHOL from ER membrane to plasma membrane GO:0015248 R-HSA-5250579 ASNA1 transports TA proteins from cytosol to ER membrane GO:0043492 R-HSA-5250606 BoNT/D LC cleaves target cell VAMP2 GO:0004222 R-HSA-5250616 BoNT/D HC transports BoNT/D LC from target cell synaptic vesicle membrane into cytosol GO:0008320 R-HSA-5250884 BoNT/F HC transports BoNT/F LC from target cell synaptic vesicle membrane into cytosol GO:0008320 R-HSA-5250892 BoNT/F LC cleaves target cell VAMP2 GO:0004222 R-HSA-5250938 B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 GO:0004402 R-HSA-5250962 BoNT/G LC cleaves target cell VAMP2 GO:0004222 R-HSA-5250972 BoNT/G HC transports BoNT/G LC from target cell synaptic vesicle membrane into cytosol GO:0008320 R-HSA-5250978 BoNT/G LC cleaves target cell VAMP1 GO:0004222 R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm GO:0001671 R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol GO:0001671 R-HSA-5251989 ATP13A4,5 transport divalent ions from extracellular region to cytosol GO:0019829 R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm GO:0017056 R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP GO:0000774 R-HSA-5260201 p-AKT2 phosphorylates C2CD5 GO:0004674 R-HSA-5263614 MeSeOH is reduced to MeSeH by TXNRD1 GO:0098625 R-HSA-5263616 MeSeO2H is reduced to MeSeOH by TXNRD1 GO:0098626 R-HSA-5263618 CACFD1 dimer transports Ca2+ from extracellular region to cytosol GO:0005262 R-HSA-5324632 Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates GO:0051787 R-HSA-532549 MPI isomerises Fru6P to Man6P GO:0004476 R-HSA-532667 Removal of the second glucose by glucosidase II GO:0033919 R-HSA-532678 Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase GO:0004573 R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC GO:0003924 R-HSA-5333671 CLCAs self cleave GO:0004222 R-HSA-5334097 DNMT3B:DNMT3L methylates cytosine in DNA GO:0051719 R-HSA-5334151 DNMT1 methylates cytosine in hemimethylated DNA GO:0051718 R-HSA-5334152 DNMT3A:DNMT3L methylates cytosine in DNA GO:0051719 R-HSA-5336420 DT fragment B transports DT fragment A from target cell endosome membrane GO:0008320 R-HSA-5336421 DT fragment A ADP-ribosylates target cell EEF GO:0047286 R-HSA-5336453 NIPAs transport Mg2+ from extracellular region to cytosol GO:0015095 R-HSA-5336454 MMGT1 transports Mg2+ from cytosol to Golgi lumen GO:0015095 R-HSA-5336466 MRS2 transports Mg2+ from cytosol to mitochondrial matrix GO:0015095 R-HSA-5339524 GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol GO:0055056 R-HSA-5339528 TUSC3 transports Mg2+ from extracellular region to cytosol GO:0015095 R-HSA-5339535 GLTPD1 transports C1P from plasma membrane to Golgi membrane GO:1902388 R-HSA-5339538 MAGT1 transports Mg2+ from extracellular region to cytosol GO:0015095 R-HSA-5340130 CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol GO:0015184 R-HSA-5340226 CYGB dioxygenates NO GO:0008941 R-HSA-5340320 GLTP transports GSL from plasma membrane to ER membrane GO:0017089 R-HSA-5357429 AXL autophosphorylates on Y772 and Y814 GO:0004713 R-HSA-5357472 PAK1-3 autophosphorylates GO:0004674 R-HSA-5357477 PAK1-3 phosphorylates VE-cadherin GO:0004674 R-HSA-5357757 BIRC(cIAP1/2) ubiquitinates RIPK1 GO:0004842 R-HSA-5357828 RIP1 is cleaved by CASP8 GO:0004197 R-HSA-5357831 CYLD is phosphorylated by IKK GO:0004674 R-HSA-5357845 RIPK1 is deubiquitinated GO:0061578 R-HSA-5358340 Autoproteolytic cleavage of Hh precursors GO:0004175 R-HSA-5358343 HHAT palmitoylates Hh N-terminal fragment GO:0008374 R-HSA-5358460 HPE SHH variants don't undergo autoproteolytic cleavage GO:0004175 R-HSA-5358475 DPH6 ligates ammonium to diphthine-EEF2 GO:0017178 R-HSA-5358484 DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 GO:0004164 R-HSA-5358494 DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 GO:0090560 R-HSA-5358512 MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more GO:0004519 R-HSA-5358518 MLH1:PMS2 makes single strand incision near 1-2 base mismatch GO:0004519 R-HSA-5358579 DNA polymerase delta polymerizes DNA across single stranded gap GO:0003887 R-HSA-5358592 DNA ligase I ligates single stranded nick in double stranded DNA GO:0003909 R-HSA-5358599 EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch GO:0008409 R-HSA-5358619 EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) GO:0008409 R-HSA-5359451 NNMT transfers CH3 from SAM to NAM to form MNA GO:0008112 R-HSA-5362412 SYVN1 ubiquitinates Hh C-terminal fragments GO:0004842 R-HSA-5362448 Hh C-terminal fragments are degraded by the proteasome GO:0004175 R-HSA-5362459 VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol GO:0042626 R-HSA-5362518 RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL GO:0004745 R-HSA-5362522 ALDHs oxidise atRAL to atRA GO:0001758 R-HSA-5362525 CYP26A1,B1,C1 4-hydroxylate atRA GO:0008401 R-HSA-5362553 NOTUM releases Hh-Np:GPC5 from the plasma membrane GO:0004629 R-HSA-5362564 ADH1A,1C,4 oxidise atROL to atRAL in vitro GO:0004745 R-HSA-5362721 RDH5,RDH11 oxidise 11cROL to 11cRAL GO:0004745 R-HSA-5362793 Hh-Np is cleaved by ADAM17 to promote ligand shedding GO:0004222 R-HSA-5367022 DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 GO:0051723 R-HSA-5387389 Hh processing variants are translocated to the cytosol in a VCP-dependent manner GO:0042626 R-HSA-5387392 processing defective Hh variants are degraded by the proteasome GO:0004175 R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA GO:0003924 R-HSA-5389841 MTFMT formylates methionyl-tRNA GO:0004479 R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome GO:0003924 R-HSA-5419165 RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL GO:0052650 R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits GO:0003924 R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) GO:0003924 R-HSA-5423038 SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) GO:0018024 R-HSA-5423117 PHF8 demethylates MeK21-histone H4 GO:0032452 R-HSA-5423637 AKR dimers reduce AFBDHO to AFBDOH GO:0004033 R-HSA-5423647 CYP2A13 oxidises AFM1 to AFM1E GO:0004497 R-HSA-5423653 MGST trimers transfer GS from GSH to AFXBO and AFNBO GO:0004364 R-HSA-5423664 CYP3A4,5 hydroxylates AFB1 to AFQ1 GO:0004497 R-HSA-5423672 CYP1A2, 3A4 oxidise AFB1 to AFNBO GO:0004497 R-HSA-5423678 CYP1A2 hydroxylates AFB1 to AFM1 GO:0004497 R-HSA-5433066 Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C GO:0047198 R-HSA-5433067 DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG GO:0016805 R-HSA-5433072 GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG GO:0036374 R-HSA-5433074 ACY:Zn2+ dimers hydrolyse mercapturic acids GO:0004046 R-HSA-5483238 Hh processing variants are ubiquitinated GO:0004842 R-HSA-548800 ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA GO:0009922 R-HSA-548814 ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA GO:0009922 R-HSA-548815 ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA GO:0009922 R-HSA-548818 HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA GO:0016509 R-HSA-548830 ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA GO:0009922 R-HSA-548831 TECR,TECRL dehydrogenate TOD-CoA to ST-CoA GO:0017099 R-HSA-548843 ACSL3,4 ligate CoA to AA to form AA-CoA GO:0004467 R-HSA-548884 UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b GO:0003980 R-HSA-548890 Removal of the third glucose by glucosidase II and release from the chaperone GO:0033919 R-HSA-549112 G3P is acylated to 1-acyl LPA by AGPAT6 GO:0004366 R-HSA-549129 OCT1 transports organic cations into hepatic cells GO:0015101 R-HSA-549192 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] GO:0004144 R-HSA-549241 SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol GO:0008513 R-HSA-549279 OCT2 mediates tubular uptake of organic cations in the kidney GO:0015101 R-HSA-549297 SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol GO:0015226 R-HSA-549304 OCT3 mediates renal clearance of organic cations GO:0015101 R-HSA-549322 OCT1 transports organic cations out of hepatic cells GO:0015101 R-HSA-555065 Formation of clathrin coated vesicle GO:0003924 R-HSA-5576895 SCNAs:SNCBs transport Na+ from extracellular region to cytosol GO:0005248 R-HSA-5577050 AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region GO:0005251 R-HSA-5577213 LTCC heteropentamer (open) transports Ca2+ from extracellular region to cytosol GO:0005245 R-HSA-5577234 KCND tetramer:KCNIP tetramer transport K+ from cytosol to extrqcellular region GO:0005250 R-HSA-5577237 KCNH2:KCNE transport K+ from cytosol to extracellular region GO:0005251 R-HSA-5578717 BCDIN3D dimethylates 5' phosphate of pre-miR-145 GO:0008171 R-HSA-5578744 Importin-8 imports AGO2:miRNA into the nucleus GO:0017056 R-HSA-5578777 DMPK phosphorylates PLN GO:0004674 R-HSA-5578783 CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) GO:0004252 R-HSA-5578910 KCNK dimers transport K+ from cytosol to extracellular region GO:0005267 R-HSA-5591040 Activated protein C cleaves Factor Va intermediate form for Factor Va GO:0004252 R-HSA-5601887 PLD6 dimer cleaves primary piRNA transcript to pre-piRNA GO:0004521 R-HSA-5601910 Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA GO:0004521 R-HSA-5601926 RNA polymerase II polymerizes primary piRNA transcript GO:0003899 R-HSA-5602295 CYP4F22 20-hydroxylates TrXA3 GO:0004497 R-HSA-5603114 MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met GO:0004478 R-HSA-5607002 Activated protein C cleaves factor VIIIa GO:0004252 R-HSA-5607722 Active NIK phosphorylates IKKA dimer GO:0004674 R-HSA-5607724 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex GO:0004175 R-HSA-5607725 SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP GO:0004842 R-HSA-5607726 Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB GO:0004672 R-HSA-5607728 beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex GO:0004842 R-HSA-5607731 26S proteasome processes p-7S-p100:RELB to form p52:RELB GO:0004175 R-HSA-5607732 K63polyUb-TAK1 autophosphorylates GO:0004674 R-HSA-5607735 p-Y753,Y759-PLCG2 hydrolyses PIP2 GO:0004435 R-HSA-5607740 PKC-delta phosphorylates CARD9 GO:0004699 R-HSA-5607742 K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta GO:0004674 R-HSA-5607745 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG GO:0004713 R-HSA-5607750 SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan GO:0004713 R-HSA-5607756 TRAF6 oligomer autoubiquitinates GO:0004842 R-HSA-5607757 K63polyUb-TRAF6 ubiquitinates TAK1 GO:0004842 R-HSA-561041 OAT1-3 transport organic anions with antiport of dicarboxylic acids GO:0015301 R-HSA-561054 OCT2 mediates tubular secretion of organic cations in the kidney GO:0015101 R-HSA-561059 OAT2 and OAT4 mediate transport of sulphate conjugates GO:0015347 R-HSA-5610717 PKA phosphorylates GLI2 GO:0004691 R-HSA-5610718 CK1 phosphorylates p-GLI2 GO:0004674 R-HSA-561072 OCT3 mediates renal uptake of organic cations GO:0015101 R-HSA-5610720 PKA phosphorylates GLI3 GO:0004691 R-HSA-5610722 CK1 phosphorylates p-GLI3 GO:0004674 R-HSA-5610727 GPR161 promotes cAMP production in a G alpha(s)-dependent manner GO:0004016 R-HSA-5610730 GSK3 phosphorylates p-GLI2 GO:0004674 R-HSA-5610732 GSK3 phosphorylates p-GLI3 GO:0004674 R-HSA-5610737 NUMB:ITCH bind and ubiquitnate GLI1 GO:0061630 R-HSA-5610741 PKA phosphorylates GLI1 GO:0004691 R-HSA-5610742 SCF(beta-TrCP) ubiquitinates p-GLI1 GO:0004842 R-HSA-5610745 SCF(beta-TrCP) ubiquitinates p-GLI2 GO:0004842 R-HSA-5610746 SCF(beta-TrCP) ubiquitinates p-GLI3 GO:0004842 R-HSA-5610754 GLI3 is partially degraded by the proteasome to yield the GLI3 repressor GO:0004175 R-HSA-5610757 GLI2 is degraded by the proteasome GO:0004175 R-HSA-5610758 GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP GO:0004175 R-HSA-5610760 GLI1 is degraded by the proteasome after ubiquitination by ITCH GO:0004175 R-HSA-561253 SLC22A12 exchanges extracellular urate for cytosolic LACT GO:0015143 R-HSA-5615637 POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) GO:0004169 R-HSA-5615668 AKR1C3 reduces atRAL to atROL GO:0052650 R-HSA-5617037 POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 GO:0047223 R-HSA-5617138 B4GAT1:LARGE,GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA GO:0035252 R-HSA-5617143 B4GAT1:LARGE,GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA GO:0015020 R-HSA-5617179 PRKACA phosphorylates TNNI3 GO:0004691 R-HSA-5617182 PRKACA phosphorylates PLN GO:0004691 R-HSA-5617431 Retinoic acid activates HOXA1 chromatin GO:0071558 R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A GO:0017112 R-HSA-5617887 HOXC4 chromatin is activated GO:0071558 R-HSA-5618093 ATP hydrolysis by HSP90 GO:0042623 R-HSA-5618328 ATAT acetylates microtubules GO:0004468 R-HSA-5618331 HDAC6 deacetylates microtubules GO:0042903 R-HSA-5621355 LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG GO:0004713 R-HSA-5621363 SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 GO:0004713 R-HSA-5621370 SYK autophosphorylates GO:0004713 R-HSA-5623508 GBF1 stimulates nucleotide exchange on ARF4 GO:0005086 R-HSA-5623513 ASAP1 stimulates GTPase activity of ARF4 GO:0003924 R-HSA-5623521 RAB3IP stimulates nucleotide exchange on RAB8A GO:0017112 R-HSA-5623643 RDH13 reduces atRAL to atROL GO:0052650 R-HSA-5623667 PDPK1 phosphorylates PKN1,2,3 GO:0004674 R-HSA-5624473 Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit GO:0004674 R-HSA-5624486 SFKs phosphorylates RAF1 on Y340,Y341 GO:0004713 R-HSA-5624492 PAK phosphorylates p21 RAF1 on S338 GO:0004674 R-HSA-5625784 PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters GO:0004674 R-HSA-5625797 KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters GO:0032452 R-HSA-5625848 KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters GO:0032452 R-HSA-5625870 KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters GO:0032452 R-HSA-5626316 SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ GO:0008273 R-HSA-5627775 Autophosphorylation of PAK1,2,3 GO:0004674 R-HSA-5627802 SLC26A4 transports I- from cytosol to extracellular region GO:0015111 R-HSA-5628871 BRD7 promotes EP300-mediated acetylation of TP53 GO:0016407 R-HSA-5628905 TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate GO:0004331 R-HSA-5629203 HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH GO:0008171 R-HSA-5629218 HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 GO:0008171 R-HSA-5629237 HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH GO:0008171 R-HSA-5631885 PRDX1 overoxidizes GO:0004601 R-HSA-5632648 SMURF1/2 ubiquitinates PTCH1 GO:0061630 R-HSA-5632670 CSNK1A1 phosphorylates SMO dimer GO:0004674 R-HSA-5632672 ADRBK1 phosphorylates SMO dimer GO:0004674 R-HSA-5634228 TRAF1 is cleaved by caspases GO:0004197 R-HSA-5634729 EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) GO:0018024 R-HSA-5634750 EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) GO:0018024 R-HSA-5634802 MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) GO:0018024 R-HSA-5635841 GLI proteins are phosphorylated GO:0004674 R-HSA-5635842 ULK3 phosphorylates GLI GO:0004674 R-HSA-5635854 GLI2,3 are degraded by the proteasome GO:0004175 R-HSA-5635856 SPOP:CUL3:RBX1 ubiquitinates GLI2,3 GO:0061630 R-HSA-5635864 NUMB:ITCH ubiquitinates GLI1 GO:0061630 R-HSA-5635868 ub-GLI is degraded by the proteasome GO:0004175 R-HSA-5637686 WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) GO:0018024 R-HSA-5637795 Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant GO:0004713 R-HSA-5637796 Phosphorylation of SHC1 by p-5Y-EGFRvIII GO:0004713 R-HSA-5637801 Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII GO:0046934 R-HSA-5637806 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) GO:0005088 R-HSA-5637808 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) GO:0005088 R-HSA-5638006 ARL3 hydrolyzes GTP GO:0003924 R-HSA-5638007 RP2 activates the GTPase activity of ARL3 GO:0005096 R-HSA-5638141 SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) GO:0018024 R-HSA-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) GO:0018024 R-HSA-5638332 PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) GO:0018024 R-HSA-5638333 WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) GO:0018024 R-HSA-5649658 NEIL1 cleaves DHU from damaged DNA GO:0019104 R-HSA-5649664 NEIL1 cleaves FapyG from damaged DNA GO:0019104 R-HSA-5649673 NEIL1 cleaves FapyA from damaged DNA GO:0019104 R-HSA-5649681 NEIL2 cleaves 5-OHU from damaged DNA GO:0019104 R-HSA-5649705 PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) GO:0046403 R-HSA-5649711 NEIL1,NEIL2 incises DNA strand 5' to the AP site GO:0003906 R-HSA-5649723 POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution GO:0003887 R-HSA-5649725 POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) GO:0003906 R-HSA-5649734 LIG3 ligates NEIL1,NEIL2-generated single strand break GO:0003909 R-HSA-5649764 DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) GO:0018024 R-HSA-5649799 DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) GO:0018024 R-HSA-5649800 WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) GO:0018024 R-HSA-5649801 DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) GO:0018024 R-HSA-5649802 WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) GO:0018024 R-HSA-5649883 POLB-mediated DNA strand displacement synthesis GO:0003887 R-HSA-5651654 SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) GO:0018024 R-HSA-5651657 SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) GO:0018024 R-HSA-5651723 PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate GO:0003950 R-HSA-5651782 FEN1 bound to POLB cleaves displaced DNA strand (flap) GO:0017108 R-HSA-5651789 LIG1 bound to POLB ligates SSB GO:0003909 R-HSA-5651805 LIG1 bound to APEX1 and PCNA ligates SSB GO:0003909 R-HSA-5651828 PARG dePARylates PARP1,PARP2 GO:0004649 R-HSA-5652009 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA GO:0004842 R-HSA-5652172 AKR1B1 reduces Glc to D-sorbitol GO:0004032 R-HSA-5652195 SORD oxidizes D-sorbitol to Fru GO:0003939 R-HSA-5653754 UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA GO:0042296 R-HSA-5653770 USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA GO:0004843 R-HSA-5653786 USP43 deISGylates ISG:K164,ISG:K168-PCNA GO:0019785 R-HSA-5653840 POLD,POLE complete replication of damaged DNA after TLS GO:0003887 R-HSA-5653873 SLC2A1 tetramer transports Glc from cytosol to Golgi lumen GO:0005355 R-HSA-5653878 B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac GO:0004461 R-HSA-5654147 Activated FGFR2 phosphorylates PLCG1 GO:0004713 R-HSA-5654149 Activated FGFR1 phosphorylates PLCG1 GO:0004713 R-HSA-5654151 Activated FGFR4 phosphorylates PLCG1 GO:0004713 R-HSA-5654222 Activated FGFR3 phosphorylates PLCG1 GO:0004713 R-HSA-5654392 Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5654397 Activated FGFR2 phosphorylates FRS2 GO:0004713 R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5654407 Activated FGFR2 phosphorylates SHC1 GO:0004713 R-HSA-5654408 Activated FGFR3 phosphorylates FRS2 GO:0004713 R-HSA-5654413 Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5654418 Activated FGFR4 phosphorylates FRS2 GO:0004713 R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5654428 Activated FGFR4 phosphorylates SHC1 GO:0004713 R-HSA-5654545 Ligand-independent phosphorylation of overexpressed FGFR1c GO:0004713 R-HSA-5654560 Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. GO:0004707 R-HSA-5654562 Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 GO:0004707 R-HSA-5654565 Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. GO:0004707 R-HSA-5654566 Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. GO:0004707 R-HSA-5654575 Activated FGFR1 phosphorylates FRS2 GO:0004713 R-HSA-5654578 Activated FGFR1 phosphorylates FRS3 GO:0004713 R-HSA-5654582 Activated FGFR1 phosphorylates SHC1 GO:0004713 R-HSA-5654587 Activated FGFR1:p-FRS phosphorylates PPTN11 GO:0004713 R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5654605 Activated FGFR2 phosphorylates FRS3 GO:0004713 R-HSA-5654607 Activated FGFR2 phosphorylates PPTN11 GO:0004713 R-HSA-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5654628 Activated FGFR3 phosphorylates FRS3 GO:0004713 R-HSA-5654631 Activated FGFR3 phosphorylates PPTN11 GO:0004713 R-HSA-5654634 Activated FGFR3 phosphorylates SHC1 GO:0004713 R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5654653 Activated FGFR4 phosphorylates FRS3 GO:0004713 R-HSA-5654655 Activated FGFR4 phosphorylates PPTN11 GO:0004713 R-HSA-5654663 Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5654672 CBL ubiquitinates FRS2 and FGFR1 GO:0061630 R-HSA-5654677 CBL ubiquitinates FRS2 and FGFR2 GO:0061630 R-HSA-5654679 CBL ubiquitinates FRS2 and FGFR3 GO:0061630 R-HSA-5654684 CBL ubiquitinates FRS2 and FGFR4 GO:0061630 R-HSA-5654690 FGFR1-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5654692 FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5654705 FGFR3-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5654709 FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5654714 FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5654717 FGFR4-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5654989 SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA GO:0016887 R-HSA-5655170 RCHY1 monoubiquitinates POLH GO:0004842 R-HSA-5655235 Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5655241 Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5655243 Activated FGFR3 mutants phosphorylate PLCG1 GO:0004713 R-HSA-5655268 Activated FGFR2 mutants phosphorylate FRS2 GO:0004713 R-HSA-5655270 Activated FGFR3 mutants phosphorylate FRS2 GO:0004713 R-HSA-5655277 Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5655278 Activated FGFR1 mutants phosphorylate FRS2 GO:0004713 R-HSA-5655284 Activated FGFR4 mutants phosphorylate FRS2 GO:0004713 R-HSA-5655289 Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5655290 Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5655301 Activated FGFR2 mutants phosphorylate PLCG1 GO:0004713 R-HSA-5655323 Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-5655326 Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5655341 Activated FGFR4 mutants phosphorylate PLCG1 GO:0004713 R-HSA-5655347 Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-5655466 USP1:WDR48 deubiquitinates monoUb:K164-PCNA GO:0004843 R-HSA-5655483 USP1 autocleavage GO:0008233 R-HSA-5655892 POLK incorporates dNMP opposite to damaged DNA base GO:0003887 R-HSA-5655955 OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer GO:0016297 R-HSA-5655965 POLK and POLZ cooperate in elongation of mispaired primer termini GO:0003887 R-HSA-5656148 POLI incorporates dNMP opposite to damaged DNA base GO:0003887 R-HSA-5656158 POLZ elongates POLI-incorporated dNMP GO:0003887 R-HSA-5658231 RAS GAPs stimulate RAS GTPase activity GO:0003924 R-HSA-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 GO:0061630 R-HSA-5658430 NF1 is degraded by the proteasome GO:0004175 R-HSA-5659861 isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) GO:0004558 R-HSA-5660660 p300 acetylates RELA subunit GO:0016407 R-HSA-5660663 Caspase-8 cleaves IL1B precursor GO:0004197 R-HSA-5660752 USP9X deubiquitinates Ub-SNCA GO:0008234 R-HSA-5660753 SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA GO:0004842 R-HSA-5661114 KDM2A, KDM2B, KDM4A, KDM8 demethylate Me2K37-histone H3 GO:0032452 R-HSA-5661115 KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 GO:0032452 R-HSA-5661116 KDM5A-D demethylate Me3K5-histone H3 GO:0032452 R-HSA-5661117 CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 GO:0008469 R-HSA-5661120 KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 GO:0032452 R-HSA-5661121 KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 GO:0032452 R-HSA-5661122 JMJD6 demethylates Me2R3-histone H3 GO:0032452 R-HSA-5661123 KDM1A, KDM1B demethylate Me2K5-histone H3 GO:0032452 R-HSA-5661124 JMJD6 demethylates MeR4-HIST1H4 GO:0032452 R-HSA-5661125 JMJD6 demethylates Me2sR4-HIST1H4 GO:0032452 R-HSA-5661126 PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 GO:0016274 R-HSA-5661240 DCXR tetramer reduces L-xylulose to xylitol GO:0050038 R-HSA-5661256 AKR1A1 reduces D-glucuronate to L-gulonate GO:0047939 R-HSA-5661290 CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate GO:0050104 R-HSA-5662466 XYLB phosphorylates D-xylulose GO:0004856 R-HSA-5662471 SORD tetramer oxidizes xylitol to D-xylulose GO:0046526 R-HSA-5662473 KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose GO:0047842 R-HSA-5662660 Dopachrome is transformed to DHICA by DCT GO:0016491 R-HSA-5662662 Tyrosinase oxidises tyrosine to dopaquinone GO:0004497 R-HSA-5662692 Dopa is oxidized to dopaquinone by TYR GO:0004497 R-HSA-5663050 DHI and DHICA polymerise forming eumelanin GO:0004497 R-HSA-5665809 SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments GO:0003924 R-HSA-5665868 AMPK (complex) phosphorylates ULK1 (complex) GO:0004674 R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores GO:0004674 R-HSA-5667107 SIAH1, SIAH2 ubiquitinate SNCAIP GO:0004842 R-HSA-5667111 PARK2 K63-Ubiquitinates SNCAIP GO:0004842 R-HSA-5668414 TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK GO:0016740 R-HSA-5668454 K63polyUb-cIAP1,2 ubiquitinates TRAF3 GO:0004842 R-HSA-5668481 Protesomal degradation of K48polyUb-TRAF3 GO:0004175 R-HSA-5668520 26Sproteasome degrades K48polyUb-NIK GO:0004175 R-HSA-5668534 cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK GO:0004842 R-HSA-5668545 NIK autophosphorylates on T559 GO:0016301 R-HSA-5668629 Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP GO:0016175 R-HSA-5668718 NOX1 complex:RAC1:GTP generates superoxide from oxygen GO:0016175 R-HSA-5668731 NOX3 complex:RAC1:GTP generates superoxide from oxygen GO:0016175 R-HSA-5668932 PAK2 phosphorylates myosin regulatory light chain (MRLC) GO:0004674 R-HSA-5668947 PAK1 phosphorylates myosin phosphatase GO:0004674 R-HSA-5668978 MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex GO:0004687 R-HSA-5668984 PAK1 or PAK2 phosphorylates MYLK GO:0004674 R-HSA-5669250 PAK1 phosphorylates FLNA GO:0004674 R-HSA-5671707 Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA GO:0022857 R-HSA-5671749 p-T774-PKN1 phosphorylates CDC25C GO:0004674 R-HSA-5671763 p-T774-PKN1 phosphorylates PPP1R14A GO:0004674 R-HSA-5671919 Activated CIT phosphorylates MRLCs GO:0004674 R-HSA-5672008 Thr-180 of ULK1 is phosphorylated GO:0004674 R-HSA-5672010 Active mTORC1 phosphorylates ULK1 GO:0004674 R-HSA-5672012 Beclin-1 complex phosphorylates PtdIns GO:0016303 R-HSA-5672017 Rheb in the mTORC1 complex hydrolyses GTP GO:0003924 R-HSA-5672027 ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane GO:0015207 R-HSA-5672828 mTORC1 phosphorylates AKT1S1 GO:0004674 R-HSA-5672948 MARK3 phosphorylates KSR1 GO:0004674 R-HSA-5672957 PP2A dephosphorylates KSR1 GO:0004722 R-HSA-5672961 PP2A dephosphorylates inactive RAFs GO:0004722 R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange GO:0005088 R-HSA-5672969 Phosphorylation of RAF GO:0004712 R-HSA-5672973 MAP2Ks phosphorylate MAPKs GO:0004674 R-HSA-5672978 RAF phosphorylates MAP2K dimer GO:0004674 R-HSA-5673768 p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex GO:0004679 R-HSA-5674022 BRAP autoubiquitinates GO:0061630 R-HSA-5674373 MAP2Ks phosphorylate MAPK at the Golgi membrane GO:0004712 R-HSA-5674496 Activated MAPKs phosphorylate MAP2K1 GO:0004674 R-HSA-5675194 Activated MAPK phosphorylates RAF1 GO:0004674 R-HSA-5675198 Activated MAPKs phosphorylate BRAF GO:0004674 R-HSA-5675373 Nuclear DUSPs dephosphorylate MAPKs GO:0008138 R-HSA-5675376 Cytosolic DUSPs dephosphorylate MAPKs GO:0008138 R-HSA-5675431 PP2A dephosphorylates RAF1 GO:0004722 R-HSA-5675433 PP5 dephosphorylates RAF1 S338 GO:0004722 R-HSA-5675470 BIRC2/3 (cIAP1/2) is autoubiquitinated GO:0004842 R-HSA-5675868 ULK1 phosphorylates ATG13 and RB1CC1 GO:0004674 R-HSA-5676637 PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA GO:0080023 R-HSA-5676917 MRSBs reduce L-methyl-(R)-S-oxide to L-methionine GO:0033743 R-HSA-5676940 MSRA reduces L-methyl-(S)-S-oxide to L-Methionine GO:0008113 R-HSA-5676966 PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp GO:0004719 R-HSA-5678261 KCNJ11:ABCC9 transports K+ from extracellular region to cytosol GO:0005242 R-HSA-5678327 MIOX oxidises Ins to GlcA GO:0050113 R-HSA-5678490 ATG16L1 complex transfers LC3 from ATG3 to PE GO:0019787 R-HSA-5678706 ABCB4 transports PC from plasma membrane to extracellular region GO:0005548 R-HSA-5678863 CFTR transports Cl- from cytosol to extracellular region GO:0015108 R-HSA-5678992 Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region GO:0015108 R-HSA-5679041 ABCC2 transports BMG,BDG from cytosol to extracellular region GO:0015127 R-HSA-5679205 ULK1 phosphorylates Beclin-1 GO:0004674 R-HSA-5679206 MTMR14, MTMR3 dephosphorylate PI3P GO:0004722 R-HSA-5681981 ATG3 transfers LC3 from ATG7 to ATG3 GO:0019776 R-HSA-5681987 LC3 is cleaved by ATG4 GO:0004197 R-HSA-5681999 ATG10 transfers ATG12 from ATG7 to ATG10 GO:0019777 R-HSA-5682026 MRN bound to shortened telomeres activates ATM GO:0004674 R-HSA-5682044 KAT5 acetylates ATM at DNA DSBs GO:0016407 R-HSA-5682084 ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer GO:0019706 R-HSA-5682101 PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer GO:0004674 R-HSA-5682285 ABCA12 transports lipids from cytosol to extracellular region GO:0005319 R-HSA-5682377 LC3 de-lipidation by ATG4 GO:0004197 R-HSA-5682598 ATM phosphorylates HERC2 GO:0004674 R-HSA-5682607 PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs GO:0019789 R-HSA-5682858 RNF8 and RNF168 ubiquitinate H2AFX GO:0061630 R-HSA-5682965 WHSC1 dimethylates histone H4 on lysine K21 at DSBs GO:0042799 R-HSA-5682983 ATM phosphorylates WHSC1 GO:0004674 R-HSA-5683077 RNF8 and RNF168 ubiquitinate KDM4A,B GO:0036435 R-HSA-5683209 Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM). GO:0015272 R-HSA-5683405 PPP5C dephosphorylates TP53BP1 GO:0004722 R-HSA-5683425 ATM phosphorylates TP53BP1 at DNA DSBs GO:0004674 R-HSA-5683714 ABCA3 transports PC, PG from ER membrane to lamellar body GO:0005319 R-HSA-5683792 p-T68-CHEK2 autophosphorylates GO:0004674 R-HSA-5683801 CHEK2 phosphorylates BRCA1 GO:0004674 R-HSA-5683930 WICH phosphorylates H2AFX on Y142 GO:0004713 R-HSA-5683964 ATM phosphorylates EYA1-4 GO:0004674 R-HSA-5683967 EYA1-4 dephosphorylates tyrosine Y142 of H2AFX GO:0004725 R-HSA-5684052 PIAS4 SUMOylates MDC1 GO:0019789 R-HSA-5684071 RNF4 ubiquitinates MDC1 GO:0061630 R-HSA-5684096 CDK2 phosphorylates RBBP8 GO:0004674 R-HSA-5684140 ATM phosphorylates RBBP8 GO:0004674 R-HSA-5684250 SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 GO:0004842 R-HSA-5684267 IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex GO:0008384 R-HSA-5684275 IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 GO:0008384 R-HSA-5684864 NAPSA, CTSH, PGA3-5 cleave pro-SFTPB GO:0008233 R-HSA-5684887 Activation of CHEK1 at resected DNA DSBs GO:0004674 R-HSA-5685156 ATR phosphorylates RPA2 GO:0004674 R-HSA-5685230 CHEK1 phosphorylates RAD51 GO:0004674 R-HSA-5685242 CHEK1 phosphorylates BRCA2 GO:0004674 R-HSA-5685902 NAPSA, CTSH, PGA3-5 cleave pro-SFTPC GO:0008233 R-HSA-5685953 SIRT6 deacetylates RBBP8 GO:0034979 R-HSA-5685994 Long-range resection of DNA DSBs by EXO1 or DNA2 GO:0004536 R-HSA-5686071 GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS GO:0005088 R-HSA-5686304 ZDHHC2 transfers PALM from PALM-CoA to CKAP4 GO:0016409 R-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS GO:0005088 R-HSA-5686410 BLM mediates dissolution of double Holliday junction GO:0008026 R-HSA-5686440 MUS81:EME1,EME2 cleaves D-loop GO:0004520 R-HSA-5686578 Activated ATM phosphorylates ABL1 GO:0004674 R-HSA-5686587 ABL1 phosphorylates RAD52 GO:0004713 R-HSA-5686642 RAD52 promotes single strand annealing at resected DNA DSBs GO:0097617 R-HSA-5686657 ERCC1:XPF cleaves flaps generated by SSA GO:0004520 R-HSA-5686704 Activated ATM phosphorylates DCLRE1C GO:0004674 R-HSA-5687081 MAPK6 is ubiquitinated at the N-terminal GO:0061630 R-HSA-5687086 PAK1,2,3 phosphorylates MAPK6,4 GO:0004674 R-HSA-5687088 PKA phosphorylates MAPKAPK5 GO:0004691 R-HSA-5687090 p-S MAPK6 phosphorylates NCOA3 GO:0004674 R-HSA-5687094 p-S MAPK6,4 phosphorylate MAPKAPK5 GO:0004674 R-HSA-5687101 p-T182 MAPKAPK5 phosphorylates FOXO3 GO:0004674 R-HSA-5687112 MAPK6 is degraded by the 26S proteasome GO:0004175 R-HSA-5687121 p-S MAPKAPK5 phosphorylates HSPB1 GO:0004674 R-HSA-5687183 PRKDC phosphorylates DCLRE1C at DNA DSBs GO:0004674 R-HSA-5687360 POLL or POLM extends aligned DNA DSB ends to fill gaps GO:0003887 R-HSA-5687464 MRN and RBBP8 resect DNA DSBs in MMEJ GO:0004520 R-HSA-5687640 POLQ extends annealed 3'-ssDNA overhangs in MMEJ GO:0003887 R-HSA-5687653 PARP1,PARP2 dimers bound to MMEJ sites autoPARylate GO:0003950 R-HSA-5687664 FEN1 cleaves displaced ssDNA flaps during MMEJ GO:0017108 R-HSA-5687675 LIG3 ligates remaining SSBs in MMEJ GO:0003909 R-HSA-5687758 PPP4C:PPP4R2 dephosphorylates RPA2 GO:0004722 R-HSA-5688276 SIRT4 transfers ADPRib to GLUD GO:0003950 R-HSA-5688289 SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 GO:0034979 R-HSA-5688294 SIRT5 deacetylates Cytochrome C GO:0034979 R-HSA-5688797 ATXN3 family cleave Ub chains GO:0036459 R-HSA-5688837 ATXN3 deubiquitinates polyUb-PARK2 GO:0036459 R-HSA-5689000 AADAC deacetylates PHEN GO:0019213 R-HSA-5689111 PARK2 autoubiquitinates GO:0061630 R-HSA-5689950 USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN GO:0036459 R-HSA-5689972 USP2 deubiquitinates MDM2,MDM4 GO:0036459 R-HSA-5689973 USP10,USP24,USP42 deubiquitinate TP53 GO:0036459 R-HSA-5690042 Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA GO:0047617 R-HSA-5690043 Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA GO:0047617 R-HSA-5690046 PPT2 hydrolyses PALMCoA to PALM GO:0098599 R-HSA-5690066 ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA GO:0047617 R-HSA-5690080 USP3,SAGA deubiquitinate Histone H2A,H2B GO:0036459 R-HSA-5690152 USP5 cleaves polyubiquitin GO:0036459 R-HSA-5690157 USP16,USP21 deubiquitinate Histone H2A GO:0036459 R-HSA-5690159 USP21 deubiquitinates RIPK1,DDX58 GO:0036459 R-HSA-5690196 USP8 deubiquitinates RNF128 GO:0036459 R-HSA-5690250 p-T182-MAPKAPK5 phoshphorylates DNAJB1 GO:0004674 R-HSA-5690319 UCHL1, UCHL3 cleave ubiquitin adducts GO:0036459 R-HSA-5690517 PPT1 hydrolyses palmitoylated proteins GO:0008474 R-HSA-5690565 SCD desaturates ST-CoA to OLE-CoA GO:0004768 R-HSA-5690702 LYN phosphorylates CD22 GO:0004713 R-HSA-5690759 BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 GO:0036459 R-HSA-5690790 Histone H2A is dubiquitinated by the PR-DUB complex GO:0036459 R-HSA-5690808 UCHL3, SENP8 cleave NEDD8 GO:0019784 R-HSA-5690827 TNFAIP3 (A20) ubiquitinates RIPK1 GO:0061630 R-HSA-5690856 TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 GO:0061578 R-HSA-5690870 OTUD7B,TNFAIP3 deubiquitinate TRAF6 GO:1990380 R-HSA-5690911 ACO1:4Fe-4S isomerises CIT to ISCIT GO:0003994 R-HSA-5690988 3'-incision of DNA by ERCC5 (XPG) in GG-NER GO:0004520 R-HSA-5690990 5'- incision of DNA by ERCC1:ERCC4 in GG-NER GO:0004519 R-HSA-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA GO:0004386 R-HSA-5690997 Ligation of newly synthesized repair patch to incised DNA in GG-NER GO:0003909 R-HSA-5691001 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER GO:0003887 R-HSA-5691107 FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) GO:0004322 R-HSA-5691108 SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 GO:0004842 R-HSA-5691381 MYSM1 deubiquitinates Histone H2A GO:0036459 R-HSA-5691411 BRCA1-A complex deubiquitinates K63polyUb-histone H2A GO:0061578 R-HSA-5691431 PSMD14 cleaves K63-linked ubiquitin GO:0061578 R-HSA-5691439 BRISC complex deubiquitinates NLRP3 GO:0061578 R-HSA-5691507 ASPA deacetylates NAA to acetate and L-aspartate GO:0019807 R-HSA-5691512 APEH hydrolyses NAc-Ser-protein GO:0004252 R-HSA-5692232 AKR1A1 oxidises BaPtDHD to BaP-7,8-dione GO:0004033 R-HSA-5692237 ADH5 oxidises S-HMGSH to S-FGSH GO:0051903 R-HSA-5692261 ALDH3A2-1 oxidises HD2NAL to PALM GO:0004029 R-HSA-5692283 ALD3A1 oxidises 4HPCP to CXPA GO:0004030 R-HSA-5692462 ATP13A1 transports Mn2+ from cytosol to ER lumen GO:0015410 R-HSA-5692480 ATP13A2 transports cations from cytosol to lysosomal lumen GO:0019829 R-HSA-5692495 BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770) GO:0008798 R-HSA-5692754 CDC14A,B dephosphorylate p-3S,T MAPK6 GO:0004722 R-HSA-5692755 CDK1 phosphorylates MAPK6 GO:0004693 R-HSA-5692768 MAPKAPK5 phosphorylates KALRN GO:0004674 R-HSA-5692775 SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs GO:0004674 R-HSA-5692779 p-S182 MAPKAPK5 phosphorylates FOXO1 GO:0004674 R-HSA-5693001 NAT8,8B acetylate BACE1 GO:0004468 R-HSA-5693081 FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) GO:0004175 R-HSA-5693092 Unknown deacetylase deacetylates 7K-BACE1(46-501) GO:0033558 R-HSA-5693108 TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains GO:0004842 R-HSA-5693148 BCKDK phosphorylates BCKDH GO:0047323 R-HSA-5693153 PPM1K dephosphorylates p-BCKDH GO:0004722 R-HSA-5693319 CTRC hydrolyses PRSS1 GO:0008233 R-HSA-5693346 CECRI deaminates Ade-Rib to Ino GO:0004000 R-HSA-5693347 CRYM reduces P2C to PPCA GO:0047127 R-HSA-5693356 CEMIP hydrolyses HA GO:0004415 R-HSA-5693373 DDAH1,2 hydrolyses ADMA to DMA and L-Cit GO:0016403 R-HSA-5693390 HSD17B11 dehydrogenates EST17b to E1 GO:0004303 R-HSA-5693533 DCLRE1C (ARTEMIS) processes DNA DSB ends GO:0004519 R-HSA-5693536 ATM phosphorylates MDC1 GO:0004674 R-HSA-5693540 MRN activates ATM GO:0004674 R-HSA-5693549 ATM phosphorylates histone H2AFX on S139 at DNA DSBs GO:0004674 R-HSA-5693551 Phosphorylation of BRCA1-A complex at multiple sites by ATM GO:0004674 R-HSA-5693575 DNA-PKcs autophosphorylates GO:0004674 R-HSA-5693578 TDP1 and TDP2 process unligatable DSB ends GO:0008081 R-HSA-5693584 Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) GO:0004520 R-HSA-5693589 D-loop dissociation and strand annealing GO:0004003 R-HSA-5693593 D-loop extension by DNA polymerases GO:0003887 R-HSA-5693598 ATM phosphorylates NBN GO:0004674 R-HSA-5693604 XRCC4:LIG4 ligates DNA DSB ends during NHEJ GO:0003909 R-HSA-5693608 Initial resection of double-strand break ends GO:0004520 R-HSA-5693609 ATM phosphorylates TP53 at S15 GO:0004674 R-HSA-5693681 DUOX1,2 reduce O2 to H2O2 GO:0016174 R-HSA-5693691 CES1 trimer.CES2 hydrolyse COCN to BEG GO:0052689 R-HSA-5693724 ESD dimer hydrolyses S-FGSH to GSH GO:0018738 R-HSA-5693742 FAAH hydrolyses AEA to AA and ETA GO:0017064 R-HSA-5693751 FAAH2 hydrolyses AEA to AA and ETA GO:0017064 R-HSA-5693761 FA2H hydroxylates CERA GO:0080132 R-HSA-5693783 NAALADases hydrolyse NAAG GO:0016805 R-HSA-5693807 FUCA1 hydrolyses NGP:1,6-GlcNAc GO:0004560 R-HSA-5693925 FUT3 transfers L-fucose to Gal1,3GlcNAc GO:0017060 R-HSA-5693967 GLDC dimer:2xPXLP decarboxylates Gly GO:0004375 R-HSA-5693977 AMT transfers NH2CH2 from GCSH:SAMDLL to THF GO:0004047 R-HSA-5694018 DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate GO:0004148 R-HSA-5694071 GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH GO:0004462 R-HSA-5694077 EPHX1 hydrates BaP4,5O to BaP4,5-DHD GO:0033961 R-HSA-5694082 XK:KEL:Zn2+ cleaves EDN3 GO:0004222 R-HSA-5694109 LIPC dimer hydrolyses TAG to DAG and FA GO:0004806 R-HSA-5694126 NT5C3B hydrolyses 7MGP to 7MG GO:0008253 R-HSA-5694137 SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine GO:0004372 R-HSA-5694409 Nucleotide exchange on RAB1 GO:0005085 R-HSA-5694421 PP6 dephosphorylates SEC24 GO:0004722 R-HSA-5694425 NSF ATPase activity dissociates cis-SNARE GO:0016887 R-HSA-5694441 CSNK1D phosphorylates SEC23 GO:0004674 R-HSA-5694462 ABHD6,12 hydrolyse 3AG GO:0047372 R-HSA-5694485 ABHD3 hydrolyses LPC(14:0) to 1AGPC GO:0008970 R-HSA-5694487 A4GNT transfers GlcNAc to core 2 mucins GO:0008375 R-HSA-5694494 AACS ligates CoA-SH to ACA, forming ACA-CoA GO:0030729 R-HSA-5694527 Loss of SAR1B GTPase GO:0003924 R-HSA-5694563 ABHD10 hydrolyses MPAG GO:0004553 R-HSA-5694583 ABHD4 hydrolyses NAPE GO:0016787 R-HSA-5695957 ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA GO:0031957 R-HSA-5695964 ABHD14B hydrolyses PNPB GO:0016787 R-HSA-5695980 ACAD10 dehydrogenates S-2MPDA-CoA GO:0003995 R-HSA-5695989 ACAD11 dehydrogenates BH-CoA GO:0003995 R-HSA-5696004 ACSF2 ligates CoA-SH to MCFA GO:0003996 R-HSA-5696007 ACSF3 ligates CoA-SH to VLCFA GO:0031957 R-HSA-5696021 ADPGK:Mg2+ phosphorylates Glc to G6P GO:0043843 R-HSA-5696049 ADPRM hydrolyses ADP-ribose to R5P and AMP GO:0047631 R-HSA-5696074 AGK:Mg2+ phosphorylates MAG, DAG GO:0047620 R-HSA-5696080 ALDH3B1 oxidises HXAL to PALM GO:0004030 R-HSA-5696091 ALDH1B1 tetramer oxidises CH3CHO to CH3COOH GO:0004029 R-HSA-5696101 ALDH8A1 oxidises 9cRAL to 9cRA GO:0001758 R-HSA-5696119 AGMO cleaves alkylglycerol into fatty aldehyde and glycerol GO:0050479 R-HSA-5696131 AOC1 deaminates Hist GO:0052598 R-HSA-5696146 AOC2 deaminates TYR GO:0008131 R-HSA-5696183 AOC3 deaminates BZAM GO:0008131 R-HSA-5696197 NUDT2 hydrolyses GP4G to GTP, GMP GO:0004081 R-HSA-5696213 AS3MT transfers CH3 from AdoMet to methylarsonite GO:0030791 R-HSA-5696220 AS3MT transfers CH3 from AdoMet to arsenite(3-) GO:0030791 R-HSA-5696230 GSTO1 dimer reduces methylarsonate to methylarsonite GO:0050610 R-HSA-5696365 ASRGL1 hydrolyses aspartame to L-Asp, L-Phe GO:0008798 R-HSA-5696408 PHYKPL tetramer hydrolyses 5PHL GO:0016829 R-HSA-5696415 ETNPPL tetramer hydrolyses PETA GO:0050459 R-HSA-5696424 AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters GO:0047196 R-HSA-5696448 AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG GO:0003846 R-HSA-5696457 BDH2 dehydrogenates 3HBA GO:0003858 R-HSA-5696465 USP45 deubiquitinates ERCC1 GO:0004843 R-HSA-5696534 USP18 deubiquitinates TAK1:TAB1 GO:0036459 R-HSA-5696547 STAMBPL1 is a deubiquitinase GO:0061578 R-HSA-5696564 USP25 deubiquitinates DDX58 GO:0036459 R-HSA-5696600 USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 GO:0036459 R-HSA-5696605 USP12, USP26 deubiquitinate AR GO:0036459 R-HSA-5696627 CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG GO:0036459 R-HSA-5696807 TRNT1 polymerizes CCA at the 3' end of pre-tRNA GO:0034062 R-HSA-5696810 RNase P cleaves the 5' end of pre-tRNA GO:0004526 R-HSA-5696813 TSEN complex cleaves the intron from pre-tRNA GO:0004549 R-HSA-5696815 ELAC2 cleaves the 3' end of pre-tRNA GO:0004549 R-HSA-5696816 tRNA ligase complex ligates tRNA exons GO:0003972 R-HSA-5696822 AKR1B15 reduces EST17b to E1 GO:0004303 R-HSA-5696838 BHMT2 tetramer transfers CH3 group from SMM to LHCYS GO:0061627 R-HSA-5696839 MTHFD1L ligates HCOOH to THF to form 10-formyl-THF GO:0004329 R-HSA-5696872 USP30 deubiquitinates Ub-MOM proteins GO:0036459 R-HSA-5696914 USP28 deubiquitinates CLSPN and MYC GO:0036459 R-HSA-5696945 USP33 deubiquitinates CCP110,ARRB GO:0036459 R-HSA-5696947 USP47 deubiquitinates POLB GO:0036459 R-HSA-5696958 USP44 deubiquitinates CDC20 GO:0036459 R-HSA-5696960 USP49 deubiquitinates H2B GO:0036459 R-HSA-5696968 USP20, USP33 deubiquitinate ADRB2 GO:0036459 R-HSA-5696997 USP24 deubiquitinates DDB2 GO:0036459 R-HSA-5697009 USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 GO:0036459 R-HSA-597628 SLC22A18 exchanges extracellular organic cations for cytosolic H+ GO:0015307 R-HSA-622325 Activation of highly sodium permeable nicotinic acetylcholine receptors GO:0015276 R-HSA-622326 Activation of highly calcium permeable nicotinic acetylcholine receptors GO:0015276 R-HSA-622382 PIP2 hydrolysis GO:0004435 R-HSA-629595 Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors GO:0015276 R-HSA-6781764 USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 GO:0036459 R-HSA-6781779 USP13 deubiquitinates BECN1,USP10 GO:0036459 R-HSA-6781814 USP19 deubiquitinates RNF123 GO:0036459 R-HSA-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template GO:0003899 R-HSA-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II GO:0061630 R-HSA-6781897 USP11 deubiquitinates NFKBIA GO:0036459 R-HSA-6782069 UVSSA:USP7 deubiquitinates ERCC6 GO:0004843 R-HSA-6782106 USP10 deubiquitinates SNX3, CFTR GO:0036459 R-HSA-6782131 RNA Pol II backtracking in TC-NER GO:0004003 R-HSA-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER GO:0004520 R-HSA-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER GO:0003887 R-HSA-6782224 3' incision by ERCC5 (XPG) in TC-NER GO:0004520 R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER GO:0003909 R-HSA-6782264 CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs GO:0016783 R-HSA-6782286 METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 GO:0008176 R-HSA-6782296 DUS2:EPRS reduces uridine to dihydrouridine in tRNAs GO:0017150 R-HSA-6782311 ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs GO:0008251 R-HSA-6782336 ADAT1 deaminates adenosine-37 in tRNA(Ala) GO:0008251 R-HSA-6782381 PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs GO:0009982 R-HSA-6782388 NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA) GO:0016428 R-HSA-6782416 TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) GO:0004809 R-HSA-6782419 TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp) GO:0016428 R-HSA-6782434 TRG1L transfers GMP to 5' end of tRNA(His) GO:0016779 R-HSA-6782443 QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr) GO:0008479 R-HSA-6782628 USP8 deubiquitinates STAM2:HGS GO:0036459 R-HSA-6782685 EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5 GO:0004571 R-HSA-6782820 USP17 deubiquitinates SUDS3 GO:0036459 R-HSA-6782859 TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) GO:0009019 R-HSA-6782879 TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe) GO:0008175 R-HSA-6782881 LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe) GO:0008175 R-HSA-6782890 LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe) GO:0008175 R-HSA-6782893 TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) GO:0016765 R-HSA-6782895 TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe) GO:0016829 R-HSA-6782943 UV-DDB ubiquitinates XPC GO:0061630 R-HSA-6783177 USP21 deubiquitinates GATA3,IL33 GO:0036459 R-HSA-6783221 HAGH hydrolyses (R)-S-LGSH to GSH and LACT GO:0004416 R-HSA-6783455 TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe) GO:0016706 R-HSA-6783473 LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe) GO:0008175 R-HSA-6783483 tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol GO:0017056 R-HSA-6783492 TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) GO:0016429 R-HSA-6783880 PIPOX oxidises PPCA to P6C GO:0050031 R-HSA-6783939 PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro GO:0004735 R-HSA-6783955 PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro GO:0004735 R-HSA-6784006 STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 GO:0004713 R-HSA-6784213 Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix GO:0034590 R-HSA-6784224 PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate GO:0004657 R-HSA-6784319 JAK1,TYK2 phosphorylate JAK1,TYK2 GO:0004713 R-HSA-6784324 p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA GO:0004714 R-HSA-6784393 PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) GO:0047578 R-HSA-6784399 ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate GO:0003842 R-HSA-6784423 HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate GO:0008700 R-HSA-6784434 An unknown carrier transports cytosolic glyoxylate to the peroxisome GO:0022857 R-HSA-6784436 An unknown carrier transports mitochondrial glyoxylate to the cytosol GO:0022857 R-HSA-6784462 TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs GO:0052381 R-HSA-6784494 EKC complex threonylcarbamoylates A37 of tRNAs GO:0061711 R-HSA-6784620 MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) GO:0004222 R-HSA-6784628 PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer GO:0004175 R-HSA-6784676 PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer GO:0004175 R-HSA-6784959 BPHL hydrolyses VACV to ACV GO:0047658 R-HSA-6785361 Monoubiquitination of FANCD2:FANCI GO:0061630 R-HSA-6785409 NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) GO:0016428 R-HSA-6785438 NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC) GO:0016428 R-HSA-6785722 Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript GO:0004549 R-HSA-6785722 Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript GO:0004526 R-HSA-6785928 CHAC1,2 cleaves GSH to OPRO and CysGly GO:0003839 R-HSA-6785933 UGT8 transfers Gal from UDP-Gal to CERA GO:0047263 R-HSA-6785986 DNA nucleases unhook the interstrand crosslink (ICL) GO:0004536 R-HSA-6786012 CHST4 transfers SO4(2-) from PAPS to Core 2 mucins GO:0001517 R-HSA-6786034 CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin GO:0001537 R-HSA-6786048 CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 GO:0016232 R-HSA-6786095 JAK1 phosphorylates STAT3,STAT6 GO:0004715 R-HSA-6786096 IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated GO:0004715 R-HSA-6786166 Translesion synthesis across unhooked ICL by POLN GO:0003887 R-HSA-6786171 FANCD2 deubiquitination by USP1:WDR48 GO:0004843 R-HSA-6786190 CMBL hydrolyses OM to OLMS GO:0016787 R-HSA-6786205 KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 GO:0018025 R-HSA-6786239 CYP4V2 omega-hydroxylates DHA to HDoHE GO:0004497 R-HSA-6786245 CARNS1 transforms ATP, L-His, b-Ala to CARN GO:0047730 R-HSA-6786257 DCTPP1 hydrolyses 5idCTP GO:0047840 R-HSA-6786421 CHIA hydrolyses chitin GO:0004568 R-HSA-6786500 ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 GO:0008175 R-HSA-6786501 TRMT11:TRMT112 methylates guanosine-10 in tRNA GO:0004809 R-HSA-6786567 KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine GO:0008175 R-HSA-6786571 CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 GO:0035598 R-HSA-6786583 PUS7 transforms uridine to pseudouridine in tRNAs GO:0009982 R-HSA-6786621 TRMT10A methylates guanosine-9 in tRNA GO:0009019 R-HSA-6786650 DDHD1,2 hydrolyse PA GO:0004620 R-HSA-6786652 CHIT1 hydrolyses CHIT to 3xADGP GO:0004553 R-HSA-6786720 DECR2 reduces LCtE-CoA to t3enoyl-CoA GO:0019166 R-HSA-6786854 Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript GO:0004526 R-HSA-6786854 Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript GO:0004549 R-HSA-6786881 TRNT1 polymerizes CCA at the 3' end of pre-tRNA GO:0034062 R-HSA-6787321 DERA cleaves dR5P to GA3P and CH3CHO GO:0004139 R-HSA-6787329 PGM2:Mg2+ isomerises R1P to R5P GO:0008973 R-HSA-6787403 GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA GO:0016740 R-HSA-6787403 GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA GO:0016740 R-HSA-6787447 TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA GO:0061708 R-HSA-6787525 TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58 GO:0016429 R-HSA-6787533 FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc GO:0047341 R-HSA-6787540 FUK phosphorylates beta-Fuc to Fuc1P GO:0050201 R-HSA-6787566 PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser) GO:0009982 R-HSA-6787567 TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) GO:0052381 R-HSA-6787591 TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 GO:0009019 R-HSA-6787594 TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 GO:0016429 R-HSA-6787623 TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal GO:0016853 R-HSA-6787632 GMDS dehydrates GDP-Man to GDP-DHDMan GO:0008446 R-HSA-6787642 TSTA3 dimer reduces GDP-KDGal to GDP-Fuc GO:0050577 R-HSA-6787677 FUOM isomerises alpha-Fuc to beta-Fuc GO:0016857 R-HSA-6787757 GADL1 decarboxylates acidic AAs GO:0016831 R-HSA-6787811 HAO2 tetramer oxidises 2OH-PALM GO:0052853 R-HSA-6788295 HDHD1:Mg2+ dephosphorylates PURIDP GO:0016787 R-HSA-6788392 ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA GO:0004674 R-HSA-6788582 STAT1,STAT3,STAT6 phosphorylation GO:0004715 R-HSA-6788597 HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA GO:0004419 R-HSA-6788611 HYKK phosphorylates 5HLYS GO:0047992 R-HSA-6788650 ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins GO:0004671 R-HSA-6788668 TRMT13 2'-O-methylates adenosine-4 in tRNA GO:0052666 R-HSA-6788684 TRMT13 2'-O-methylates cytidine-4 in tRNA GO:0052666 R-HSA-6788707 TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) GO:0052665 R-HSA-6788798 AK4 phosphorylates (d)NMPs to (d)NDPs GO:0050145 R-HSA-6788810 AK6 phosphorylates (d)NMPs to (d)NDPs GO:0050145 R-HSA-6788855 FN3KRP phosphorylates PsiAm, RibAm GO:0016301 R-HSA-6788867 FN3K phosphorylates ketosamines GO:0016301 R-HSA-6788912 LHPP:Mg2+ dimer hydrolyses PPi GO:0004427 R-HSA-6788999 HV1-mediated H+ transfer GO:0022843 R-HSA-6789031 Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) GO:0004601 R-HSA-6789092 NOX2 generates superoxide anion from oxygen GO:0016175 R-HSA-6789126 Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) GO:0004601 R-HSA-6789310 LIPs hydrolyse TG to DAG and RCOOH GO:0004465 R-HSA-6790087 HVEM induses BTLA phosphorylation GO:0004713 R-HSA-6790454 SUMOylation of XPC GO:0019789 R-HSA-6790487 RNF111 ubiquitinates SUMOylated XPC GO:0061630 R-HSA-6790905 Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA GO:0009982 R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 GO:0070037 R-HSA-6790907 Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides GO:0008171 R-HSA-6790944 NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447 GO:0009383 R-HSA-6790982 WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 GO:0070043 R-HSA-6790987 NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842 GO:0008080 R-HSA-6790994 DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 GO:0000179 R-HSA-6791218 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA GO:0000175 R-HSA-6791218 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA GO:0000175 R-HSA-6791218 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA GO:0000175 R-HSA-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA GO:0000175 R-HSA-6791223 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol GO:0004521 R-HSA-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA GO:0000175 R-HSA-6792445 LIPH, I hydrolyse PA to 2-acyl LPA GO:0004620 R-HSA-6792572 LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs GO:0016746 R-HSA-6792712 KAT5 acetylates ATM at shortened telomeres GO:0016407 R-HSA-6792863 PP2A-PP2R5C dephosphorylates MDM2 GO:0004722 R-HSA-6793057 NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 GO:0009383 R-HSA-6793066 TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 GO:0000179 R-HSA-6793096 MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 GO:0070039 R-HSA-6793122 MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145 GO:0070039 R-HSA-6793127 MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine GO:0008650 R-HSA-6793590 LIPT2 transfers octanoyl group to GCSH GO:0033819 R-HSA-6793591 LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH GO:0016992 R-HSA-6793661 (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 GO:0004693 R-HSA-6795290 TORC2 complex phosphorylates SGK1 GO:0004674 R-HSA-6795460 SGK1 phosphorylates MDM2 GO:0004674 R-HSA-6795473 PDPK1 phosphorylates SGK1 GO:0004674 R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes GO:0004693 R-HSA-6797627 ASPG hydrolyses L-Asn to L-Asp GO:0004067 R-HSA-6797630 LRPP4(LRPP1-3,5) hydrolyse LPA GO:0008195 R-HSA-6797653 DMGDH:FAD oxidatively demethylates DMGLY to SARC GO:0047865 R-HSA-6797913 SARDH:FAD oxidatively demethylates SARC to Gly GO:0008480 R-HSA-6797955 ALDH7A1 oxidises BETALD to BET GO:0008802 R-HSA-6797956 SLC44A1 transports Cho from cytosol to mitochondrial matrix GO:0015220 R-HSA-6797961 CHDH oxidises Cho to BETALD GO:0008812 R-HSA-6798174 PIK3C3:PIK3R4 phosphorylates PI to PI3P GO:0016303 R-HSA-6798317 GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC GO:0017174 R-HSA-6798335 BPGM dimer isomerises 1,3BPG to 2,3BPG GO:0004082 R-HSA-6798345 GCAT:PXLP dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA GO:0016405 R-HSA-6798372 ATM phosphorylates DYRK2 GO:0004674 R-HSA-6798373 MDM2 ubiquitinates DYRK2 GO:0061630 R-HSA-6798374 DYRK2 phosphorylates TP53 GO:0004674 R-HSA-6798667 TDH tetramer oxidises L-Thr to 2A-3OB GO:0008743 R-HSA-6799097 ATM phosphorylates ZNF420 GO:0004674 R-HSA-6799246 CHEK1 phosphorylates TP53 GO:0004674 R-HSA-6799332 ATR phosphorylates TP53 GO:0004674 R-HSA-6799409 HIPK2 phosphorylates TP53 GO:0004674 R-HSA-6799495 GLYCTK phosphorylates DGA to 3PDGA GO:0008887 R-HSA-6799545 MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 GO:0004559 R-HSA-6799581 MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man GO:0008496 R-HSA-6799604 GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P GO:0004342 R-HSA-6799695 GPX5,6 reduce H2O2 to H2O GO:0004602 R-HSA-6799722 TP53I3 oxidoreductase generates unstable semiquinones GO:0003960 R-HSA-6799977 PGLYRP2 hydrolyzes bacterial peptidoglycan GO:0008745 R-HSA-6800138 N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer GO:0036009 R-HSA-6800149 N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII GO:0008168 R-HSA-6800198 HPN heterodimer cleaves pro-MST1 to form MST1 dimer GO:0004252 R-HSA-6800200 HPN heterodimer cleaves pro-HGF to form HGF dimer GO:0004252 R-HSA-6800299 HGFAC cleaves pro-HGF to form HGF dimer GO:0004252 R-HSA-6800334 MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG GO:0003846 R-HSA-6800490 ATM phosphorylates PIDD1 GO:0004674 R-HSA-6800797 The PIDDosome activates CASP2 GO:0097153 R-HSA-6801250 TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane GO:0005319 R-HSA-6801328 MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF GO:0004477 R-HSA-6801342 MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG GO:0030272 R-HSA-6801456 MTHFD1L transforms 10-formyl-THF to HCOOH and THF GO:0004329 R-HSA-6801462 MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF GO:0004487 R-HSA-6801666 PLK2 phosphorylates CENPJ GO:0004674 R-HSA-6801675 PLK2 phosphorylates NPM1 GO:0004674 R-HSA-6801687 PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) GO:0004252 R-HSA-6801766 Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) GO:0008236 R-HSA-6802910 Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants GO:0004712 R-HSA-6802911 High kinase activity BRAF complexes phosphorylate MAP2Ks GO:0004674 R-HSA-6802916 RAF is phosphorylated downstream of moderate kinase activity BRAF mutants GO:0004712 R-HSA-6802918 Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants GO:0004712 R-HSA-6802919 RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks GO:0004674 R-HSA-6802921 Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants GO:0004712 R-HSA-6802922 Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS GO:0004712 R-HSA-6802924 RAF is phosphorylated downstream of oncogenic RAS GO:0004712 R-HSA-6802926 Mutant RAS:p-RAF complexes phosphorylate MAP2Ks GO:0004674 R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated GO:0004712 R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks GO:0004674 R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers GO:0004674 R-HSA-6802941 RAF is paradoxically phosphorylated downstream of kinase-inactive RAF GO:0004712 R-HSA-6802943 RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks GO:0004674 R-HSA-6802973 PLK3 phosphorylates CDC25C GO:0004674 R-HSA-6803060 DCD(63-110) is processed to DCD(63-109) GO:0070011 R-HSA-6803545 ATP7A transports cytosolic Cu2+ to phagosomal lumen GO:0004008 R-HSA-6803753 NAAA hydrolyses NAEs to FAs and ethanolamine GO:0016810 R-HSA-6803761 RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc GO:0050121 R-HSA-6803771 NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P GO:0045127 R-HSA-6803789 AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA GO:0008448 R-HSA-6804253 MDM2 ubiquitinates JMY GO:0061630 R-HSA-6804266 CHEK2 phosphorylates TTC5 GO:0004674 R-HSA-6804276 ATM phosphorylates TTC5 GO:0004674 R-HSA-6804383 PRMT5 methylates TP53 GO:0035243 R-HSA-6804441 RNF34 or RFFL ubiquitinates phosphorylated TP53 GO:0061630 R-HSA-6804468 PIAS1 SUMOylates SP3 with SUMO2 GO:0019789 R-HSA-6804485 PIAS1 SUMOylates L3MBTL2 with SUMO2 GO:0019789 R-HSA-6804724 MDM2 ubiquitinates phosphorylated MDM4 GO:0061630 R-HSA-6804879 MDM2 ubiquitinates TP53 GO:0061630 R-HSA-6804942 MDM2 homodimers auto-ubiquitinate GO:0061630 R-HSA-6804955 ATM phosphorylates MDM2 GO:0004674 R-HSA-6805059 CK2:FACT phosphorylates TP53 GO:0004674 R-HSA-6805103 AURKA phosphorylates TP53 GO:0004674 R-HSA-6805109 CDK2 phosphorylates TP53 GO:0004693 R-HSA-6805126 AURKB phosphorylates TP53 GO:0004674 R-HSA-6805276 CDK5 phosphorylates TP53 GO:0004674 R-HSA-6805285 PLK3 phosphorylates TP53 GO:0004674 R-HSA-6805399 TAF1 phosphorylates TP53 GO:0004674 R-HSA-6805470 AMPK phosphorylates TP53 GO:0004679 R-HSA-6805479 TP53RK phosphorylates TP53 GO:0004674 R-HSA-6805638 KAT6A acetylates TP53 GO:0016407 R-HSA-6805640 AKT phosphorylates KAT6A GO:0004674 R-HSA-6805650 MTA2-NuRD complex deacetylates TP53 GO:0004407 R-HSA-6805730 SETD9 methylates TP53 GO:0016278 R-HSA-6805740 SETD8 methylates TP53 GO:0016278 R-HSA-6805755 EHMT1:EHMT2 dimethylates TP53 GO:0016278 R-HSA-6805785 AKT phosphorylates PHF20 GO:0004674 R-HSA-6806647 VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) GO:0047057 R-HSA-6806674 UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) GO:0004659 R-HSA-6806831 CYB5Rs reduce MetHb to HbA GO:0004128 R-HSA-6806877 NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs GO:0004550 R-HSA-6806966 APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX GO:0052857 R-HSA-6806967 CARKD dehydrates S-NAD(P)HX to NADPH GO:0047453 R-HSA-6806974 MET dimers autophosphorylate GO:0004713 R-HSA-6807008 PTPRJ dephosphorylates MET GO:0004725 R-HSA-6807027 PTPN1 and PTPN2 dephosphorylate MET GO:0004725 R-HSA-6807052 EBP isomerizes ZYMSTNL to LTHSOL GO:0004769 R-HSA-6807053 SC5D desaturates LTHSOL to 7-dehydroCHOL GO:0000248 R-HSA-6807055 DHCR7 reduces 7-dehydroCHOL to CHOL GO:0047598 R-HSA-6807064 DHCR24 reduces ZYMOL to ZYMSTNL GO:0050614 R-HSA-6807106 PTEN undergoes monoubiquitination GO:0061630 R-HSA-6807118 USP7 deubiquitinates monoubiquitinated PTEN GO:0004843 R-HSA-6807134 NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN GO:0061630 R-HSA-6807206 USP13 and OTUD3 deubiquitinate PTEN GO:0004843 R-HSA-6807214 GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) GO:0008488 R-HSA-6807224 Furin cleaves pro-BGLAP to BGLAP GO:0004252 R-HSA-6807557 NOX4, NOX5 reduce O2 to O2.- GO:0016175 R-HSA-6807826 LDHAL6B reduces PYR to LACT GO:0004459 R-HSA-6807868 GBF1 stimulates ARF nucleotide exchange GO:0005085 R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity GO:0003924 R-HSA-6808464 ALDH3B2 oxidises HXAL to PALM GO:0004030 R-HSA-6808487 ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG GO:0004029 R-HSA-6808496 ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG GO:0004029 R-HSA-6809015 NSF ATPase activity dissociates cis-SNARE at cis-Golgi GO:0016887 R-HSA-6809263 EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA GO:0016508 R-HSA-6809264 EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA GO:0003857 R-HSA-6809287 NUDT12 hydrolyses NADH to NMNH GO:0035529 R-HSA-6809320 PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane GO:0052629 R-HSA-6809325 PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane GO:0004438 R-HSA-6809354 NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT GO:0016289 R-HSA-6809561 I(1,3)P2 is dephosphorylated into I1P by MTMR7 GO:0016312 R-HSA-6809565 I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9 GO:0016312 R-HSA-6809720 PI3P is dephosphorylated to PI by MTM1:MTMR12 GO:0004438 R-HSA-6809777 PI3P is dephosphorylated to PI by MTMR2:SBF1 GO:0004438 R-HSA-6809778 PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 GO:0052629 R-HSA-6809808 ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA GO:0004165 R-HSA-6809810 PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA GO:0019166 R-HSA-6809944 PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane GO:0052629 R-HSA-6809975 PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane GO:0004438 R-HSA-6810076 DDO oxidizes D-Asp to OA GO:0008445 R-HSA-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter GO:0004674 R-HSA-6810410 PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus GO:0034597 R-HSA-6810464 NUDT14 hydrolyses UDP-Glc to G1P and UMP GO:0008768 R-HSA-6810472 NUDT13 hydrolyses AP6A to AP4 and ADP GO:0016462 R-HSA-6810474 NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT GO:0047617 R-HSA-6810594 HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) GO:0004303 R-HSA-6810894 Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking GO:0003810 R-HSA-6811414 GBF1 stimulates nucleotide exchange on ARF GO:0005086 R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane GO:0005086 R-HSA-6811422 NSF ATPase activity dissociates cis-SNARE at the ER GO:0016887 R-HSA-6811429 RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange GO:0005085 R-HSA-6811454 MAPKs phosphorylate PP2A GO:0004674 R-HSA-6811504 AKT1 dephosphorylation by PP2A-B56-beta,gamma GO:0004722 R-HSA-6811508 ING2-bound EP300 acetylates TP53 GO:0061733 R-HSA-6811522 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus GO:0016309 R-HSA-6813720 NCEH1 hydrolyzes cholesterol esters GO:0004771 R-HSA-6813740 GDE1 hydrolyzes GroPIns GO:0047395 R-HSA-6813749 ALDH1A1 oxidises GA to DGA GO:0004029 R-HSA-6814090 NatC acetylates ARFFRP1 GO:0004596 R-HSA-6814132 GDPD5 hydrolyzes GPCho GO:0047389 R-HSA-6814153 ADO oxidises 2AET to HTAU GO:0047800 R-HSA-6814165 GADL1 decarboxylates CSA to HTAU GO:0016831 R-HSA-6814254 PNPLA6 hydrolyzes LysoPtdCho GO:0004622 R-HSA-6814387 CASP14 cleaves filaggrin GO:0004197 R-HSA-6814409 CK2 phosphorylates PDCL GO:0016301 R-HSA-6814549 Pre-snRNA transcript initiation, Integrator binding, LEC binding GO:0001055 R-HSA-6814555 Integrator complex processes the 3' end of snRNA GO:0004521 R-HSA-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine GO:0004722 R-HSA-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine GO:0004674 R-HSA-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine GO:0001055 R-HSA-6814670 ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation GO:0016887 R-HSA-6814678 ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN GO:0016887 R-HSA-6814683 NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN GO:0016887 R-HSA-6814766 GDPD1 hydrolyzes LysoPtdCho GO:0004622 R-HSA-6814778 GDPD3 hydrolyzes LysoPtdCho GO:0004622 R-HSA-6814797 ENPP6 hydrolyzes lysophosphatidylcholine GO:0047390 R-HSA-6814833 TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP GO:0003924 R-HSA-688136 TNFAIP3 (A20) deubiquitinates RIP2 GO:0061578 R-HSA-688137 RIP2 is K63 polyubiquitinated GO:0019787 R-HSA-68825 Ubiquitinated geminin is degraded by the proteasome GO:0004175 R-HSA-68913 The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin GO:0003899 R-HSA-68944 Orc1 is phosphorylated by cyclin A/CDK2 GO:0004693 R-HSA-68946 Phosphorylated Orc1 is ubiquitinated while still associated with chromatin GO:0061630 R-HSA-68948 Ubiquitinated Orc1 is degraded by the proteasome GO:0004175 R-HSA-68950 The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin GO:0003887 R-HSA-68954 Mcm2-7 is phosphorylated by DDK GO:0016301 R-HSA-69005 Cdc6 protein is phosphorylated by CDK GO:0004693 R-HSA-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex GO:0061630 R-HSA-69016 Ubiquitinated Cdc6 is degraded by the proteasome GO:0004175 R-HSA-69116 Formation of Okazaki fragments GO:0003887 R-HSA-69152 Removal of remaining Flap GO:0017108 R-HSA-69173 Joining of adjacent Okazaki fragments GO:0003909 R-HSA-69195 Phosphorylation of Cyclin E:CDK2 complexes by WEE1 GO:0016301 R-HSA-69199 Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A GO:0004721 R-HSA-69227 Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes GO:0004693 R-HSA-69562 Inactivation of Cyclin E:Cdk2 complexes by p27/p21 GO:0004861 R-HSA-69598 Ubiquitination of phosphorylated Cdc25A GO:0004842 R-HSA-69600 Proteolytic degradation of ubiquitinated-Cdc25A GO:0004175 R-HSA-69604 Phosphorylation of Cdc25A at Ser-123 by Chk1 GO:0016301 R-HSA-69608 Phosphorylation of Cdc25A at Ser-123 by Chk2 GO:0004674 R-HSA-69685 CHEK2 phosphorylates TP53 GO:0004674 R-HSA-69754 Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes GO:0004693 R-HSA-69756 Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes GO:0004693 R-HSA-69889 Phosphorylation and activation of Chk1 by ATM GO:0004674 R-HSA-69891 Phosphorylation and activation of CHEK2 by ATM GO:0004674 R-HSA-70241 oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] GO:0004613 R-HSA-70262 Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate GO:0004331 R-HSA-70272 PGM:Mg2+ isomerise G6P to G1P GO:0004614 R-HSA-70286 UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose GO:0003983 R-HSA-70333 KHK dimer phosphorylates Fru to Fru 1-P GO:0004454 R-HSA-70342 ALDOB tetramer cleaves Fru-1-P to GA and DHAP GO:0061609 R-HSA-70349 DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate GO:0050354 R-HSA-70355 GALK1 phosphorylates Gal to Gal1P GO:0004335 R-HSA-70361 GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal GO:0008108 R-HSA-70369 GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc GO:0003978 R-HSA-70377 alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ GO:0004345 R-HSA-70420 HK1,2,3,GCK phosphorylate Glc to form G6P GO:0004340 R-HSA-70427 PGM:Mg2+ isomerise G1P to G6P GO:0004614 R-HSA-70449 D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ GO:0004365 R-HSA-70454 dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate GO:0004807 R-HSA-70467 D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP GO:0003872 R-HSA-70471 alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate GO:0004347 R-HSA-70475 D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate GO:0004347 R-HSA-70479 D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate GO:0042132 R-HSA-70481 D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate GO:0004807 R-HSA-70482 1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ GO:0004365 R-HSA-70486 ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate GO:0004618 R-HSA-70494 Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate GO:0004634 R-HSA-70501 Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate GO:0004736 R-HSA-70510 LDH tetramer oxidises LACT to PYR GO:0004459 R-HSA-70523 alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT] GO:0004021 R-HSA-70524 pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT] GO:0004021 R-HSA-70542 glutamate + acetyl CoA => N-acetyl glutamate + CoA GO:0004042 R-HSA-70555 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] GO:0004087 R-HSA-70560 carbamoyl phosphate + ornithine => citrulline + orthophosphate GO:0004585 R-HSA-70569 arginine + H2O => ornithine + urea [ARG1] GO:0004053 R-HSA-70573 argininosuccinate <=> fumarate + arginine GO:0004056 R-HSA-70577 ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA GO:0004055 R-HSA-70581 oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] GO:0004069 R-HSA-70589 alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] GO:0004353 R-HSA-70592 aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1] GO:0004069 R-HSA-70596 aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2] GO:0004069 R-HSA-70599 aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] GO:0004066 R-HSA-70600 glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] GO:0004353 R-HSA-70606 glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] GO:0004356 R-HSA-70609 glutamine + H2O => glutamate + NH4+ [GLS] GO:0004359 R-HSA-70613 oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] GO:0004069 R-HSA-70634 ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) GO:0000064 R-HSA-70654 ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] GO:0004587 R-HSA-70664 PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro GO:0004735 R-HSA-70666 glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] GO:0004587 R-HSA-70670 PRODH oxidises L-Pro to 1PYR-5COOH GO:0004657 R-HSA-70679 ALDH4A1 oxidises L-GluSS to Glu GO:0003842 R-HSA-70692 ornithine => putrescine + CO2 GO:0004586 R-HSA-70713 BCKDH transfers CoA group from CoA-SH to BCAAs GO:0008410 R-HSA-70723 leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] GO:0004084 R-HSA-70724 leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] GO:0004084 R-HSA-70745 isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 GO:0008470 R-HSA-70773 beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] GO:0004485 R-HSA-70785 beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA GO:0004490 R-HSA-70800 alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 GO:0003995 R-HSA-70830 tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA GO:0004300 R-HSA-70837 alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ GO:0003857 R-HSA-70844 alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA GO:0003985 R-HSA-70859 isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 GO:0003995 R-HSA-70870 methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA GO:0004300 R-HSA-70881 beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA GO:0003860 R-HSA-70885 beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ GO:0008442 R-HSA-70893 methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ GO:0004491 R-HSA-70899 histidine => urocanate + NH4+ GO:0004397 R-HSA-70903 urocanate + H2O => 4-imidazolone-5-propionate GO:0016153 R-HSA-70906 4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ GO:0016812 R-HSA-70920 N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate GO:0030412 R-HSA-70938 lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O GO:0047130 R-HSA-70940 saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ GO:0047131 R-HSA-70941 alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ GO:0004043 R-HSA-70952 alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate GO:0047536 R-HSA-70967 isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] GO:0004449 R-HSA-70971 citrate <=> isocitrate GO:0003994 R-HSA-70975 Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA GO:0004108 R-HSA-70979 (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ GO:0030060 R-HSA-70982 Fumarate + H2O <=> (S)-Malate GO:0004333 R-HSA-70994 Succinate <=> Fumarate (with FAD redox reaction on enzyme) GO:0008177 R-HSA-70997 ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA GO:0004775 R-HSA-71010 MUT isomerises L-MM-CoA to SUCC-CoA GO:0004494 R-HSA-71020 D-methylmalonyl-CoA <=> L-methylmalonyl-CoA GO:0004493 R-HSA-71031 propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate GO:0004658 R-HSA-71037 alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ GO:0034602 R-HSA-71046 glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 GO:0004361 R-HSA-71118 PAH tetramer hydroxylates L-Phe to L-Tyr GO:0004505 R-HSA-71130 q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ GO:0004155 R-HSA-71146 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O GO:0008124 R-HSA-71155 tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate GO:0004838 R-HSA-71163 p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 GO:0003868 R-HSA-71164 homogentisate + O2 => maleylacetoacetate GO:0004411 R-HSA-71173 maleylacetoacetate => fumarylacetoacetate GO:0016034 R-HSA-71181 fumarylacetoacetate => fumarate + acetoacetate GO:0004334 R-HSA-71188 TDO tetramer dioxygenates L-Trp to NFK GO:0004833 R-HSA-71189 AFMID hydrolyses NFK to L-KYN GO:0004061 R-HSA-71200 kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O GO:0004502 R-HSA-71217 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine GO:0030429 R-HSA-71218 3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde GO:0000334 R-HSA-71223 2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2 GO:0016831 R-HSA-71239 2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ GO:0047102 R-HSA-71241 TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA GO:0050353 R-HSA-71249 SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly GO:0004372 R-HSA-71260 ALDH9A1 tetramer dehydrogenates TEABL to form TEABT GO:0004028 R-HSA-71261 BBOX1:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA GO:0008336 R-HSA-71275 arginine + glycine => ornithine + guanidoacetate GO:0015068 R-HSA-71286 guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine GO:0008168 R-HSA-71296 D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate GO:0017057 R-HSA-71299 6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ GO:0004616 R-HSA-71303 RPE dimers isomerise RU5P to XY5P GO:0004750 R-HSA-71306 D-ribulose 5-phosphate <=> ribose 5-phosphate GO:0004751 R-HSA-71324 ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate GO:0004802 R-HSA-71334 sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate GO:0004801 R-HSA-71335 xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate GO:0004802 R-HSA-71397 lipo-PDH decarboxylates PYR to Ac-CoA GO:0004738 R-HSA-71401 alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ GO:0034602 R-HSA-71445 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate GO:0004619 R-HSA-71495 dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate GO:0004332 R-HSA-71496 D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate GO:0004332 R-HSA-71515 glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] GO:0008184 R-HSA-71541 glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP GO:0004689 R-HSA-71552 limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin GO:0004134 R-HSA-71588 glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP GO:0004689 R-HSA-71590 glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] GO:0008184 R-HSA-71593 ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose GO:0004135 R-HSA-71654 3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate GO:0004619 R-HSA-71660 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O GO:0004634 R-HSA-71670 phosphoenolpyruvate + ADP => pyruvate + ATP GO:0004743 R-HSA-71676 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O GO:0004602 R-HSA-71682 glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ GO:0004362 R-HSA-71691 acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] GO:0004029 R-HSA-71707 ethanol + NAD+ => acetaldehyde + NADH + H+ GO:0004024 R-HSA-71723 acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] GO:0004029 R-HSA-71732 pyrophosphate + H2O => 2 orthophosphate [cytosolic] GO:0004427 R-HSA-71735 acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] GO:0003987 R-HSA-71775 GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA GO:0004776 R-HSA-71783 Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ GO:0030060 R-HSA-71802 D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP GO:0003873 R-HSA-71825 G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) GO:0004346 R-HSA-71849 LDH tetramer reduces PYR to LACT GO:0004459 R-HSA-71850 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP GO:0004618 R-HSA-72095 Internal Methylation of mRNA GO:0001734 R-HSA-72139 Formation of the active Spliceosomal C (B*) complex GO:0016887 R-HSA-72180 Cleavage of mRNA at the 3'-end GO:0004519 R-HSA-72185 mRNA polyadenylation GO:0004652 R-HSA-72621 Ribosomal scanning GO:0003743 R-HSA-72647 Cap-bound mRNA is activated by helicases GO:0003724 R-HSA-72697 Start codon recognition GO:0003743 R-HSA-72722 eIF2 activation GO:0003743 R-HSA-727740 Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 GO:0005337 R-HSA-727749 SLC29A3 transports nucleosides from lysosomal lumen to cytosol GO:0005337 R-HSA-727759 SLC33A1 transports Ac-CoA from cytosol to Golgi lumen GO:0008521 R-HSA-727767 SLC29A3 transports nucleosides from cytosol to lysosomal lumen GO:0005337 R-HSA-727768 Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 GO:0005337 R-HSA-727807 SLC35A1 exchanges CMP-Neu5Ac for CMP GO:0005456 R-HSA-727819 TAK1 phosphorylates MKK6 GO:0004709 R-HSA-73548 (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) GO:0050145 R-HSA-73564 orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 GO:0004590 R-HSA-73567 orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate GO:0004588 R-HSA-73569 (S)-dihydroorotate + ubiquinone => orotate + ubiquinol GO:0004152 R-HSA-735702 SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP GO:0005459 R-HSA-73571 N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O GO:0004151 R-HSA-73573 carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate GO:0004070 R-HSA-73577 L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate GO:0004088 R-HSA-73580 D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate GO:0004749 R-HSA-73585 uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ GO:0017113 R-HSA-73589 5,6-dihydrouracil + H2O => beta-ureidopropionate GO:0004157 R-HSA-73591 beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 GO:0003837 R-HSA-73596 dCMP + H2O => dUMP + NH4+ GO:0004132 R-HSA-73598 (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) GO:0019206 R-HSA-73599 cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] GO:0019206 R-HSA-73605 dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate GO:0004799 R-HSA-73608 (deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) GO:0004126 R-HSA-73616 thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ GO:0017113 R-HSA-73618 5,6-dihydrothymine + H2O => beta-ureidoisobutyrate GO:0004157 R-HSA-73620 beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 GO:0003837 R-HSA-73632 thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] GO:0019206 R-HSA-73635 dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] GO:0050145 R-HSA-73646 thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ GO:0004791 R-HSA-73647 UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] GO:0003883 R-HSA-73666 dUTP + H2O => dUMP + pyrophosphate GO:0004170 R-HSA-73722 Phosphorylation of UBF-1:rDNA Promoter GO:0004707 R-HSA-73736 Acetylation of SL1 GO:0016407 R-HSA-73788 (d)GMP + ATP <=> (d)GDP + ADP (GUK1) GO:0004385 R-HSA-73792 XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate GO:0003922 R-HSA-73794 IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] GO:0003938 R-HSA-73797 FAICAR => IMP + H2O GO:0003937 R-HSA-73798 AICAR + 10-Formyl-THF => FAICAR + THF GO:0004643 R-HSA-73800 SAICAR => AICAR + Fumarate GO:0004018 R-HSA-73805 CAIR + Aspartate + ATP => SAICAR + ADP + Pi GO:0004639 R-HSA-73806 AIR + CO2 => CAIR GO:0004638 R-HSA-73810 FGAM + ATP => AIR + ADP + Pi GO:0004641 R-HSA-73812 FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi GO:0004642 R-HSA-73813 GAR + 10-Formyl-THF => FGAR + THF GO:0004644 R-HSA-73814 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi GO:0004637 R-HSA-73815 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate GO:0004044 R-HSA-73828 adenylosuccinate => adenosine 5'-monophosphate + fumarate GO:0004018 R-HSA-73892 MGMT/hAGT mediated DNA Damage Reversal GO:0003908 R-HSA-73912 acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ GO:0003858 R-HSA-73916 2 acetyl-CoA <=> acetoacetyl-CoA + CoA GO:0003985 R-HSA-73918 acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH GO:0004421 R-HSA-73920 D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ GO:0003858 R-HSA-73931 LIG3-mediated DNA ligation via the single-nucleotide replacement pathway GO:0003909 R-HSA-73932 Resynthesis of excised residue by POLB GO:0003887 R-HSA-74059 PDE6 hydrolyses cGMP to GMP GO:0047555 R-HSA-74101 Photons induce isomerization of 11c-retinyl to at-retinyl GO:0009881 R-HSA-741386 RIP2 induces K63-linked ubiquitination of NEMO GO:0004842 R-HSA-741411 CYLD deubiquitinates NEMO GO:0061578 R-HSA-741449 SLC35B2,3 transport cytosolic PAPS to Golgi lumen GO:0046964 R-HSA-741450 SLC35A3 exchanges UDP-GlcNAc for UMP GO:0005462 R-HSA-74177 OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA GO:0008260 R-HSA-74180 HMG CoA => acetoacetic acid + acetyl CoA GO:0004419 R-HSA-74181 acetoacetyl-CoA + CoA <=> 2 acetyl-CoA GO:0003985 R-HSA-74207 dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) GO:0019206 R-HSA-74213 Adenine + PRPP => AMP + PPi GO:0003999 R-HSA-74215 guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1) GO:0004422 R-HSA-74220 (d)AMP + ATP <=> (d)ADP + ADP (AK1) GO:0004017 R-HSA-742345 SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen GO:0005457 R-HSA-742354 SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen GO:0005462 R-HSA-742373 SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen GO:0005464 R-HSA-74241 (2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA) GO:0004000 R-HSA-74242 (deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP) GO:0004731 R-HSA-74247 Hypoxanthine + H2O + O2 => Xanthine + H2O2 GO:0004855 R-HSA-74248 (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) GO:0008253 R-HSA-74249 (deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP) GO:0004731 R-HSA-74255 Guanine + H2O => Xanthine + NH4+ GO:0008892 R-HSA-74258 Xanthine + H2O + O2 => Urate + H2O2 GO:0004855 R-HSA-74372 uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] GO:0004850 R-HSA-74376 (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) GO:0004850 R-HSA-744230 SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP GO:0005338 R-HSA-744231 SLC35D2 exchanges UDP-sugars for UMP GO:0005338 R-HSA-74615 PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP GO:0004672 R-HSA-74711 Phosphorylation of IRS GO:0004714 R-HSA-74715 Autophosphorylation of insulin receptor GO:0004714 R-HSA-74723 Endosome acidification GO:0015078 R-HSA-74730 Insulin degradation GO:0004175 R-HSA-74733 Insulin receptor de-phosphorylation GO:0004725 R-HSA-74742 Phosphorylation of SHC1 GO:0004714 R-HSA-74747 Dephosphorylation of p-Y-IRS1,p-Y-IRS2 GO:0004725 R-HSA-74748 De-phosphorylation of p-Y427-SHC1 GO:0004725 R-HSA-74872 RDH10,11 oxidise 11cROL to 11cRAL GO:0052650 R-HSA-74885 GUCYs converts GTP to cGMP GO:0004383 R-HSA-749453 Liganded Gz-activating GPCR acts as a GEF for Gz GO:0005085 R-HSA-74948 PP2A dephosphorylates p-RHO to RHO GO:0004722 R-HSA-74986 Elongation of pre-rRNA transcript GO:0003899 R-HSA-75010 Phosphorylation of Cdc25C at Ser 216 by Chk1 GO:0004674 R-HSA-75028 Phosphorylation of Wee1 kinase by Chk1 GO:0016301 R-HSA-75097 Transport of the export-competent mRNP complex through the NPC GO:0017056 R-HSA-751029 Liganded G12/13-activating GPCR acts as a GEF for G12/13 GO:0005085 R-HSA-751040 PKC phosphorylates G alpha (z) GO:0004697 R-HSA-75125 (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) GO:0050145 R-HSA-75126 dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] GO:0050145 R-HSA-75809 Phosphorylation of Cdc25C at Ser216 by CHEK2 GO:0016301 R-HSA-75820 Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta GO:0004674 R-HSA-75824 Ubiquitination of Cyclin D1 GO:0004842 R-HSA-75825 Proteasome mediated degradation of Cyclin D1 GO:0004175 R-HSA-75848 ACLY tetramer transforms CIT to Ac-CoA GO:0003878 R-HSA-75849 Transport of Citrate from Mitochondrial Matrix to cytosol GO:0015142 R-HSA-75850 Addition of the third nucleotide on the nascent transcript GO:0003899 R-HSA-75851 Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA GO:0003989 R-HSA-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition GO:0003899 R-HSA-75872 acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O GO:0004312 R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript GO:0003899 R-HSA-75879 palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH GO:0016287 R-HSA-75883 O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+ GO:0000140 R-HSA-75885 1-acyl LPA is acylated to PA by AGPAT (LPAAT) GO:0003841 R-HSA-75886 glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] GO:0004366 R-HSA-75887 Conversion of Glycerol to Glycerol-3-phosphate GO:0004370 R-HSA-75889 DHAP is converted to G3P by GPD1/GPD1L GO:0004367 R-HSA-75899 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate GO:0008195 R-HSA-75900 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] GO:0004144 R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition GO:0004386 R-HSA-76031 2 H2O2 => O2 + 2 H2O GO:0004096 R-HSA-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide GO:0004497 R-HSA-76373 N-hydroxylation of 4-aminobiphenyl GO:0004497 R-HSA-76386 CYP1A2 S-demethylates 6MMP GO:0004497 R-HSA-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) GO:0004497 R-HSA-76416 Benzene is hydroxylated to phenol GO:0004497 R-HSA-76426 N-atom dealkylation of caffeine GO:0004497 R-HSA-76434 Dehalogenation of carbon tetrachloride to form a free radical GO:0004497 R-HSA-76453 Coumarin is 7-hydroxylated by CYP2A6 GO:0008389 R-HSA-76456 O-atom dealkylation of dextromethorphan GO:0004497 R-HSA-76466 CYP4A11 12-hydroxylates DDCX GO:0004497 R-HSA-76472 Ethylene is oxidized to Ethylene oxide by CYP1A1 GO:0004497 R-HSA-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide GO:0004497 R-HSA-76494 POR reduces CYP450:Fe3+ to CYP450:Fe2+ GO:0003958 R-HSA-76496 PTGIS, CYP8A1 isomerise PGH2 to PGI2 GO:0008116 R-HSA-76500 TBXAS1 isomerises PGH2 to TXA2 GO:0004796 R-HSA-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition GO:0003899 R-HSA-76590 AMP + H2O => IMP + NH4+ (AMPD) GO:0003876 R-HSA-77071 Phosphorylation (Ser5) of RNA pol II CTD GO:0016301 R-HSA-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme GO:0004651 R-HSA-77081 Formation of the CE:GMP intermediate complex GO:0004484 R-HSA-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA GO:0004484 R-HSA-77090 Methylation of GMP-cap by RNA Methyltransferase GO:0004482 R-HSA-77254 (S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H GO:0003857 R-HSA-77256 2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA GO:0004300 R-HSA-77263 lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 GO:0003995 R-HSA-77271 3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA GO:0003988 R-HSA-77274 myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 GO:0003995 R-HSA-77277 trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA GO:0004300 R-HSA-77283 (S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H GO:0003857 R-HSA-77299 palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 GO:0003995 R-HSA-77301 trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA GO:0004300 R-HSA-77303 (S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H GO:0003857 R-HSA-77304 3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA GO:0003988 R-HSA-77309 3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA GO:0003988 R-HSA-77312 (S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H GO:0003857 R-HSA-77314 Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA GO:0004300 R-HSA-77319 Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 GO:0003995 R-HSA-77321 3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA GO:0003988 R-HSA-77323 (S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H GO:0003857 R-HSA-77325 trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA GO:0004300 R-HSA-77327 Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 GO:0003995 R-HSA-77329 3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA GO:0003988 R-HSA-77331 (S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H GO:0003857 R-HSA-77333 trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA GO:0004300 R-HSA-77338 Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 GO:0003995 R-HSA-77340 3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA GO:0003988 R-HSA-77342 (S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H GO:0003857 R-HSA-77344 trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA GO:0004300 R-HSA-77345 Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 GO:0003995 R-HSA-77614 Deamination at C6 position of adenosine in Editosome (ADAR1) GO:0003726 R-HSA-77615 Deamination at C6 position of adenosine in Editosome (ADAR2) GO:0003726 R-HSA-804969 HSD17B1 hydrogenates E1 to EST17b GO:0004303 R-HSA-825631 Glucagon:GCGR mediates GTP-GDP exchange GO:0005085 R-HSA-83677 C4 deamination of cytidine GO:0004126 R-HSA-870437 USP9X (FAM) deubiquitinates SMAD4 GO:0036459 R-HSA-870449 TRIM33 monoubiquitinates SMAD4 GO:0004842 R-HSA-873918 Transphosphorylation of JAK1 GO:0004713 R-HSA-873919 Phosphorylation of JAK2 GO:0004713 R-HSA-873922 Phosphorylation of STAT1 by JAK kinases GO:0004713 R-HSA-873924 Phosphorylation of IFNGR1 by JAK kinases GO:0004713 R-HSA-877187 P2X7 mediates loss of intracellular K+ GO:0004931 R-HSA-877308 Dephosphorylation of JAKs by PTPs GO:0004725 R-HSA-879528 SLCO2A1 transports PGT substrates from extracellular region to cytosol GO:0015132 R-HSA-879562 SLCO2B1 has a narrow substrate specificity GO:0015347 R-HSA-879575 SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol GO:0015349 R-HSA-879584 SLCO3A1 isoform 1 has abroad substrate specificity GO:0015347 R-HSA-879585 SLC27A1,4,6 transport LCFAs from extracellular region to cytosol GO:0015245 R-HSA-879594 SLCO4C1 mediates the transport of digoxin GO:0015347 R-HSA-879907 Tyrosine kinases phosphorylate the receptor GO:0004713 R-HSA-879909 Activation of STAT5a/b by JAK2 GO:0004713 R-HSA-879910 JAK2 is phosphorylated, activated GO:0004715 R-HSA-879925 SHC1 bound to the common beta chain becomes tyrosine phosphorylated GO:0004713 R-HSA-880002 (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate GO:0047988 R-HSA-880007 (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 GO:0051990 R-HSA-880033 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde GO:0047988 R-HSA-880050 (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 GO:0047545 R-HSA-880053 2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] GO:0051990 R-HSA-8847534 RAB43 hydrolyses GTP GO:0003924 R-HSA-8847579 SCD5 desaturates ST-CoA to OLE-CoA GO:0004768 R-HSA-8847638 ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane GO:0016887 R-HSA-8847883 CYTH proteins stimulate ARF1 GTPase activity GO:0003924 R-HSA-8847912 PNPLA7 hydrolyzes LysoPtdCho GO:0004622 R-HSA-8847977 FRK phosphorylates PTEN GO:0004713 R-HSA-8848005 ERBB2 promotes PTK6 autophosphorylation GO:0004713 R-HSA-8848053 ABCA5 transports CHOL from lysosomal lumen to cytosol GO:0005319 R-HSA-8848077 PTK6 phosphorylates STAP2 GO:0004713 R-HSA-8848124 PTK6 phosphorylates STAT3 GO:0004713 R-HSA-8848215 ACAT2 condenses 2 Ac-CoA to form ACA-CoA GO:0003985 R-HSA-8848338 PNPLA4 hydrolyzes TAG GO:0004806 R-HSA-8848339 PNPLA5 hydrolyzes TAG GO:0004806 R-HSA-8848355 PNPLA4 hydrolyzes retinyl palmitate GO:0050253 R-HSA-8848436 PTK6 phosphorylates CDKN1B GO:0004713 R-HSA-8848484 PLA2s hydrolyze phospholipids at the Golgi membrane GO:0004623 R-HSA-8848580 DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG GO:0004144 R-HSA-8848582 AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester GO:0047196 R-HSA-8848585 AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM GO:0050252 R-HSA-8848606 PTK6 phosphorylates PXN GO:0004713 R-HSA-8848618 Activation of RAC1 by the PXN:CRK complex GO:0005085 R-HSA-8848658 CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins GO:0004198 R-HSA-8848726 PTK6 phosphorylates BCAR1 GO:0004713 R-HSA-8848758 PTK6 phosphorylates AKT1 GO:0004713 R-HSA-8848776 PTK6 phosphorylates DOK1 GO:0004713 R-HSA-8848818 PTK6 phosphorylates CBL GO:0004713 R-HSA-8848829 CBL autoubiquitinates GO:0061630 R-HSA-8848873 PTK6 phosphorylates ARAP1 GO:0004713 R-HSA-8848975 PTK6 phosphorylates KHDRBS1 GO:0004713 R-HSA-8849032 PTK6 phosphorylates KHDRBS2 GO:0004713 R-HSA-8849042 PTK6 phosphorylates KHDRBS3 GO:0004713 R-HSA-8849068 PTK6 phosphorylates ARHGAP35 GO:0004713 R-HSA-8849082 ARHGAP35 stimulates RHOA GTPase activity GO:0003924 R-HSA-8849102 SRMS phosphorylates PTK6 GO:0004713 R-HSA-8849345 LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine GO:0003841 R-HSA-8849435 PTPN1 dephosphorylates PTK6 GO:0004725 R-HSA-8849463 PTK6 phosphorylates SFPQ GO:0004713 R-HSA-8849797 Membrane proteases cleave Profilaggrin producing Filaggrin GO:0004175 R-HSA-8849826 ST14 hydrolyzes and activates KLK5 GO:0004252 R-HSA-8849857 KLK5 cleaves and activates CELA2 GO:0004252 R-HSA-8849969 PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane GO:0034596 R-HSA-8850041 RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 GO:0005085 R-HSA-8850594 Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins GO:0000224 R-HSA-8850831 KLK5 cleaves and activates KLK8 GO:0004252 R-HSA-8850846 NTPDase1 hydrolyzes nucleoside triphosphates GO:0017111 R-HSA-8850854 NTPDase1 hydrolyzes nucleoside diphosphates GO:0017110 R-HSA-8850945 Casein kinase II phosphorylates PTEN GO:0004674 R-HSA-8850992 Proteasome degrades polyubiquitinated PTEN GO:0004175 R-HSA-8851011 TRIM27 polyubiquitinates PTEN GO:0061630 R-HSA-8851089 NTPDase2 hydrolyzes nucleoside triphosphates GO:0017111 R-HSA-8851110 NTPDase3 hydrolyzes nucleoside triphosphates GO:0017111 R-HSA-8851129 NTPDase3 hydrolyzes nucleoside diphosphates GO:0017110 R-HSA-8851225 NTPDase4 hydrolyzes nucleoside diphosphates GO:0017110 R-HSA-8851234 NTPDase4 hydrolyzes nucleoside triphosphates GO:0017111 R-HSA-8851356 NTPDase5 hydrolyzes nucleoside diphosphates GO:0017110 R-HSA-8851396 NTPDase6 hydrolyzes nucleoside diphosphates GO:0017110 R-HSA-8851494 NTPDase7 hydrolyzes nucleoside triphosphates GO:0017111 R-HSA-8851538 NTPDase8 hydrolyzes nucleoside triphosphates GO:0017111 R-HSA-8851550 NTPDase8 hydrolyzes nucleoside diphosphates GO:0017110 R-HSA-8851619 GALNT3 transfers GalNAc to FGF23 GO:0004653 R-HSA-8851797 ADRB2 in ADRB2:GRK complex is phosphorylated GO:0047696 R-HSA-8851827 RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 GO:0005085 R-HSA-8851877 RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET GO:0005085 R-HSA-8851890 MET phosphorylates SHC1-2 GO:0004713 R-HSA-8851899 RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET GO:0005085 R-HSA-8851929 AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) GO:0004177 R-HSA-8851933 MET phosphorylates GAB1 GO:0004713 R-HSA-8852019 MET bound PI3K generates PIP3 GO:0046934 R-HSA-8852132 Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol GO:0004839 R-HSA-8852133 UBA1 conjugates ubiquitin to UBA1 in the cytosol GO:0004839 R-HSA-8852134 UBA1 adenylates ubiquitin in the cytosol GO:0004839 R-HSA-8852200 Inactivation of LCK by PTPN22 GO:0004725 R-HSA-8852306 Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends GO:0004674 R-HSA-8852317 PLK1 phosphorylates GTSE1 GO:0004674 R-HSA-8852354 GTSE1 facilitates proteasome-mediated degradation of TP53 GO:0004175 R-HSA-8852552 MST1R autophosphorylates GO:0004714 R-HSA-8852716 Thrombin, ELANE cleave C5 GO:0004252 R-HSA-8852809 CPN, CPB2 cleave C3a, C5a GO:0004181 R-HSA-8853307 FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange GO:0005088 R-HSA-8853309 Autocatalytic phosphorylation of FGFR3 fusions GO:0004713 R-HSA-8853313 FGFR2 fusions autophosphorylate GO:0004713 R-HSA-8853315 Activated FGFR3 fusions phosphorylate FRS2 GO:0004713 R-HSA-8853323 Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3 GO:0016301 R-HSA-8853325 Plasma membrane FGFR1 fusions autophosphorylate GO:0004713 R-HSA-8853379 ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) GO:0033925 R-HSA-8853419 TPX2 promotes AURKA autophosphorylation GO:0004674 R-HSA-8853444 AURKA phosphorylates PHLDA1 GO:0004674 R-HSA-8853503 UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin GO:0004843 R-HSA-8853514 UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin GO:0004843 R-HSA-8853515 OTULIN,USP5 cleaves UBC yielding ubiquitin GO:0004843 R-HSA-8853529 OTULIN,USP5 cleaves UBB yielding ubiquitin GO:0004843 R-HSA-8853686 MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 GO:0004559 R-HSA-8853710 MANBA hydrolyses GlcNAc:Man GO:0004567 R-HSA-8853792 RET tyrosine phosphorylation GO:0004714 R-HSA-8854041 SCF-FBXL7 ubiquitinates AURKA GO:0061630 R-HSA-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 GO:0004175 R-HSA-8854051 SCF-FBXL18 ubiquitinates FBXL7 GO:0061630 R-HSA-8854071 Proteasome-mediated degradation of PolyUb-FBXL7 GO:0004175 R-HSA-8854173 TBC RabGAPs accelerate GTP hydrolysis by RAB35 GO:0003924 R-HSA-8854255 TBC1D2A accelerates GTP hydrolysis by RAB7 GO:0003924 R-HSA-8854329 TBC1D15 accelerates GTP hydrolysis by RAB7 GO:0003924 R-HSA-8854604 TBC1D16 accelerates GTP hydrolysis by RAB4A GO:0003924 R-HSA-8854612 TBC1D25 accelerates GTP hydrolysis by RAB33B GO:0003924 R-HSA-8854628 MYLIP dimer ubiquitinates VLDLR on Lys-839 GO:0061630 R-HSA-8854908 PKA phosphorylates RET:GDNF:GFRA dimer GO:0004674 R-HSA-8855062 SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy GO:0000095 R-HSA-8855237 FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 GO:0004713 R-HSA-8855381 PTPN22 dephosphorylates ZAP70 GO:0004725 R-HSA-8855490 Lactoperoxidase (LPO) produces OSCN- GO:0004601 R-HSA-8855825 HTRA1 hydrolyzes ACAN (Aggrecan) GO:0004252 R-HSA-8855954 B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD GO:0008376 R-HSA-8856223 B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides GO:0003947 R-HSA-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 GO:0004674 R-HSA-8856945 PP2A methylation by LCMT1 GO:0018423 R-HSA-8856951 PP2A demethylation by PPME1 GO:0051722 R-HSA-8857555 EGFR phosphorylates GPNMB GO:0004713 R-HSA-8857577 LINC01139 facilitates PTK6 autophosphorylation GO:0004713 R-HSA-8857583 LINC01139 promotes phosphorylation of HIF1A by PTK6 and LRRK2 GO:0004672 R-HSA-8857662 ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane GO:0005548 R-HSA-8857692 RNA demethylases demethylate N6-methyladenosine RNA GO:0035515 R-HSA-8857925 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 GO:0004713 R-HSA-8858298 HRASLS transfer acyl group from PC to PE to form NAPE GO:0016746 R-HSA-8862137 HSD17B2 oxidises estradiol (E2) to estrone (E1) GO:0004303 R-HSA-8862152 2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP GO:0004316 R-HSA-8862184 USP48 cleaves polyubiquitin GO:0036459 R-HSA-8862320 LYZ hydrolyzes peptidoglycans in the bacterial cell wall GO:0003796 R-HSA-8863007 p25-bound CDK5 phosphorylates CDC25B GO:0004674 R-HSA-8863011 p25-bound CDK5 phosphorylates CDC25C GO:0004674 R-HSA-8863012 Calpain cleaves p35 to p25 GO:0004198 R-HSA-8863014 p25-bound CDK5 phosphorylates CDC25A GO:0004674 R-HSA-8863101 SPPL2a/b cleaves TNF(1-76) GO:0042500 R-HSA-8863723 COP9 and TOR1 deneddylate STON2 GO:0019784 R-HSA-8863804 PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 GO:0004725 R-HSA-8863895 IKKB phosphorylates SNAP23 GO:0004674 R-HSA-8864029 PTPN12 dephosphorylates EGFR at Y1148 (Y1172) GO:0004725 R-HSA-8864036 PTPN12 dephosphorylates PDGFRB at Y1021 GO:0004725 R-HSA-8864125 PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 GO:0004725 R-HSA-8865050 Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol GO:0004839 R-HSA-8865090 UBA6 adenylates ubiquitin in the cytosol GO:0004839 R-HSA-8865098 UBA6 conjugates ubiquitin to UBA6 in the cytosol GO:0004839 R-HSA-8865107 MICAL1 produces NADP+, H2O2 GO:0004497 R-HSA-8865182 OTUD7A hydrolyses K11diUb GO:0036459 R-HSA-8865237 SETD6 methylates RELA in the NFkB complex GO:0016279 R-HSA-8865275 PDGF-BB clevage by Furin GO:0004252 R-HSA-8865276 PDGF-AB clevage by Furin GO:0004252 R-HSA-8865498 KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark GO:0042800 R-HSA-8865637 MFSD2A transports LPC from extracellular region to plasma membrane GO:0005548 R-HSA-8865667 LIPA hydrolyses sterol esters to sterols and fatty acids GO:0004771 R-HSA-8865774 TTLLs polyglutamylate tubulin GO:0070740 R-HSA-8866105 CCPs deglutamylate tubulin GO:0004181 R-HSA-8866268 ADBRK1,2 phosphorylate AVPR2 GO:0047696 R-HSA-8866329 MTTP lipidates APOB-100, forming a pre-VLDL GO:0005319 R-HSA-8866405 RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) GO:0036175 R-HSA-8866546 RNF5 and RNF185 ubiquitinate misfolded CFTR GO:0061630 R-HSA-8866553 misfolded CFTR is degraded by the 26S proteasome GO:0004175 R-HSA-8866601 SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate GO:0016793 R-HSA-8866856 RNF5 and RNF185 ubiquitinate CFTR F508del GO:0061630 R-HSA-8866858 CFTR F508del is degraded by the 26S proteasome GO:0004175 R-HSA-8867041 EGFR phosphorylates EPS15 GO:0004713 R-HSA-8867047 PTPN3 dephosphorylates EPS15 GO:0004725 R-HSA-8867288 OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 GO:0061630 R-HSA-8867344 OMA1 hydrolyses OPA1 GO:0004222 R-HSA-8867370 TTLL3, TTLL8, TTLL10 polyglycylate tubulin GO:0070735 R-HSA-8867667 OSBPs transport 25OH-CHOL from ER membrane to plasma membrane GO:0015248 R-HSA-8867876 OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane GO:0005548 R-HSA-8868066 PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 GO:0016308 R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 GO:0035005 R-HSA-8868260 CDK5:p25 phosphorylates GOLGA2 GO:0004674 R-HSA-8868340 CDK5:p25 phosphorylates lamin B1 GO:0004674 R-HSA-8868344 CDK5:p25 phosphorylates lamin A GO:0004674 R-HSA-8868402 OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane GO:0015248 R-HSA-8868567 CDK5:p25 phosphorylates PRDX1 GO:0004674 R-HSA-8868573 CDK5:p25 phosphorylates PRDX2 GO:0004674 R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P GO:0004439 R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating GO:0016887 R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission GO:0003924 R-HSA-8868666 CDK5:p25 phosphorylates JUN GO:0004674 R-HSA-8868783 TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 GO:0016740 R-HSA-8869206 PAFAH2 hydrolyses PAF to lyso-PAF and acetate GO:0003847 R-HSA-8869241 PITPNM1,2,3 exchange PI for PA GO:0008526 R-HSA-8869425 PLA1A hydrolyses PS to 2-acyl LPS GO:0052739 R-HSA-8869456 USP4 deubiquitinate TRAF2,TRAF6 GO:0036459 R-HSA-8869506 TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 GO:0061578 R-HSA-8869603 SLC22A13 transports NCA from extracellular region to cytosol GO:0090416 R-HSA-8869606 NMRK1 phosphorylates NAR to yield NAMN GO:0061769 R-HSA-8869607 NMRK2 phosphorylates NAR to yield NAMN GO:0061769 R-HSA-8869627 NMRK2 phosphorylates NR to yield NMN GO:0050262 R-HSA-8869633 NMRK1 phosphorylates NR to yield NMN GO:0050262 R-HSA-8870289 PUS3 transforms uridine-39 to pseudouridine-39 in tRNA GO:0009982 R-HSA-8870346 BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose GO:0003953 R-HSA-8870352 SLC36A4 transports L-Trp from extracellular region to cytosol GO:0015196 R-HSA-8870354 SLC36A4 transports extracellular L-Pro to the cytosol GO:0015193 R-HSA-8870469 RGGT geranylgeranylates RAB proteins GO:0004337 R-HSA-8870558 CDK5:p25 phosphorylates FOXO3 GO:0004674 R-HSA-8871373 BMX phosphorylates RUFY1 GO:0004715 R-HSA-8873929 Casein kinase II phosphorylates STARD10 GO:0004674 R-HSA-8873946 OTUD3 deubiquitinates PTEN GO:0036459 R-HSA-8874078 PTK2 autophosphorylates GO:0004713 R-HSA-8874080 SRC phosphorylates PTK2 GO:0004713 R-HSA-8874082 MET phosphorylates PTK2 GO:0004713 R-HSA-8874186 MBTPS1 (S1P) cleaves CREB3L4 GO:0004252 R-HSA-8874187 MBTPS2 (S2P) cleaves CREB3L2 GO:0004222 R-HSA-8874192 MBTPS2 (S2P) cleaves CREB3 GO:0004222 R-HSA-8874194 MBTPS2 (S2P) cleaves CREB3L1 GO:0004222 R-HSA-8874195 MBTPS2 (S2P) cleaves CREB3L4 GO:0004222 R-HSA-8874201 MBTPS2 (S2P) cleaves CREB3L3 GO:0004222 R-HSA-8874204 MBTPS1 (S1P) cleaves CREB3 GO:0004252 R-HSA-8874205 MBTPS1 (S1P) cleaves CREB3L2 GO:0004252 R-HSA-8874206 MBTPS1 (S1P) cleaves CREB3L3 GO:0004252 R-HSA-8874212 MBTPS1 (S1P) cleaves CREB3L1 GO:0004252 R-HSA-8874435 THEM86B hydrolyses PMCHO, PMETAM GO:0016803 R-HSA-8874470 TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane GO:0008526 R-HSA-8874745 ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH GO:0003988 R-HSA-8875013 ACSM3,ACSM6 ligate CoA to BUT GO:0047760 R-HSA-8875071 ACSS3 ligates CoA to CH3COO- GO:0003987 R-HSA-8875077 SLC27A3 ligates CoA-SH to VLCFA GO:0031957 R-HSA-8875183 CBL monoubiquitinates activated MET GO:0061630 R-HSA-8875318 RAB3 GEFs exchange GTP for GDP on RAB3A GO:0017112 R-HSA-8875320 RAB5 GEFs exchange GTP for GDP on RAB5 GO:0017112 R-HSA-8875431 LRIG1 undergoes ubiquitination GO:0061630 R-HSA-8875443 USP8 deubiquitinates LRIG1 GO:0004843 R-HSA-8875451 MET phosphorylates CBL GO:0004713 R-HSA-8875568 RAPGEF1 activates RAP1 GO:0005085 R-HSA-8875591 DOCK7 activates RAC1 GO:0005085 R-HSA-8875623 SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix GO:0005280 R-HSA-8875817 MET phosphorylates STAT3 GO:0004713 R-HSA-8875838 SLC25A19 transports ThDP from cytosol to mitochondrial matrix GO:0090422 R-HSA-8875871 SLC26A11 transports SO4(2-) from extracellular region to cytosol GO:0015116 R-HSA-8875902 SLC45A3 transports Glc from extracellular region to cytosol GO:0051119 R-HSA-8876188 DENND4s exchange GTP for GDP on RAB10 GO:0017112 R-HSA-8876190 RAB8 GEFs exchange GTP for GDP on RAB8 GO:0017112 R-HSA-8876191 RAB9 GEFs exchange GTP for GDP on RAB9 GO:0017112 R-HSA-8876193 RIC1-RGP1 exchanges GTP for GDP on RAB6 GO:0017112 R-HSA-8876230 InlB:MET dimer trans-autophophorylates GO:0004713 R-HSA-8876246 InlB-activated MET phosphorylates CBL GO:0004713 R-HSA-8876258 CBL monoubiquitinates InlB-bound MET GO:0061630 R-HSA-8876283 SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol GO:0015370 R-HSA-8876312 SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol GO:0005343 R-HSA-8876319 SLC50A1 transports Glc from cytosol to extracellular region GO:0051119 R-HSA-8876446 p-ULK1 phosphorylates DENND3 GO:0004674 R-HSA-8876454 DENND3 exchanges GTP for GDP on RAB12 GO:0017112 R-HSA-8876615 RAB13 GEFs exchange GTP for GDP on RAB13 GO:0017112 R-HSA-8876616 DENND6A,B exchange GTP for GDP on RAB14 GO:0017112 R-HSA-8876696 SOAT1,2 transfer acyl group to CHOL forming CHEST GO:0034736 R-HSA-8876789 CARNMT1 methylates CARN to Anserine GO:0030735 R-HSA-8876837 RAB21 GEFs exchange GTP for GDP on RAB21 GO:0017112 R-HSA-8876868 ECE1 cleaves EDN1(53-90) GO:0004222 R-HSA-8876889 Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA GO:0003989 R-HSA-8876948 SRC phosphorylates InlA-bound CDH1 and CTNNB1 GO:0004713 R-HSA-8877003 CBLL1 ubiqutinates the InlA-bound CDH1 complex GO:0061630 R-HSA-8877308 MADD exchanges GTP for GDP on RAB27 GO:0017112 R-HSA-8877311 RAB31 GEFs exchange GTP for GDP on RAB31 GO:0017112 R-HSA-8877451 MON1:CCZ1 exchanges GTP for GDP on RAB7 GO:0017112 R-HSA-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 GO:0017112 R-HSA-8877612 DENND1s exchange GTP for GDP on RAB35 GO:0017112 R-HSA-8877620 ECE2 cleaves EDN1(53-90) GO:0004222 R-HSA-8877691 MAP2K6 phosphorylates PIP4K2B GO:0004674 R-HSA-8877760 HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 GO:0017112 R-HSA-8877813 DENND5A,B exchange GTP for GDP on RAB39 GO:0017112 R-HSA-8877998 RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 GO:0017112 R-HSA-8878050 HIPK2 phosphorylates RUNX1 and EP300 GO:0004674 R-HSA-8878054 HIPK2 phosphorylates RUNX1 GO:0004674 R-HSA-8878581 TYRP1 oxidises DHICA to IQCA GO:0016491 R-HSA-8878654 ACP6 hydrolyses MYS-LPA GO:0052642 R-HSA-8878664 SLC4A4 cotransports Na+ with 3HCO3- GO:0008510 R-HSA-8878787 ALPI dimer hydrolyses phosphate monoesters GO:0004035 R-HSA-8878914 B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer GO:0047273 R-HSA-8879117 POMGNT2 transfers GlcNAc to Man-DAG1 GO:0008375 R-HSA-8879123 PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 GO:0016274 R-HSA-888548 Conversion of succinate semialdehyde to succinate GO:0004777 R-HSA-888572 Synthesis of GABA by GAD1 GO:0004351 R-HSA-888577 Synthesis of GABA by GAD2 GO:0004351 R-HSA-888589 Release of GABA at the synapse GO:0000149 R-HSA-888592 Loading of GABA into clathrin sculpted GABA transport vesicle lumen GO:0015171 R-HSA-888614 IDO2 dioxygenates L-Trp to NFK GO:0004833 R-HSA-8931648 B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 GO:0008376 R-HSA-8931653 POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 GO:0019200 R-HSA-8931858 ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB GO:0016279 R-HSA-8931974 N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A GO:0016279 R-HSA-8932221 METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 GO:0016279 R-HSA-8932243 EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 GO:0016279 R-HSA-8932275 METTL22 transfers 3xCH3 from 3xAdoMet to KIN GO:0016279 R-HSA-8932276 VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP GO:0016279 R-HSA-8932413 METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 GO:0016279 R-HSA-8932633 PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE GO:0102007 R-HSA-8932765 NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) GO:0016428 R-HSA-8932851 PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol GO:0015174 R-HSA-8932955 SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol GO:0005412 R-HSA-8932980 SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane GO:0015194 R-HSA-8933328 LYPLA2 hydrolyses PALM-C3,4-GAP43 GO:0008474 R-HSA-8933446 Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling GO:0004674 R-HSA-8933547 MCAT transfers Mal from Mal-CoA to NDUFAB1 GO:0004314 R-HSA-8933635 Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide GO:0004601 R-HSA-8934446 Activated PKC phosphorylates SHC1 GO:0004674 R-HSA-8934735 PRMT1 arginine-methylates RUNX1 GO:0016274 R-HSA-8934819 Cytoplasmic proteases cleave Profilaggrin producing Filaggrin GO:0004175 R-HSA-893583 kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate GO:0016212 R-HSA-893593 phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine GO:0047312 R-HSA-893596 PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu GO:0016212 R-HSA-893616 glutamine + pyruvate => 2-oxoglutaramate + alanine GO:0047945 R-HSA-8936442 MARC1,MARC2 reduce N-hydroxylated compounds GO:0016491 R-HSA-8936481 Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter GO:0042800 R-HSA-8936519 NQO2:FAD dimer reduces quinones to hydroquinones GO:0001512 R-HSA-8936584 PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter GO:0008469 R-HSA-8936608 PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter GO:0008469 R-HSA-8936621 Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter GO:0042800 R-HSA-8937016 Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter GO:0042800 R-HSA-8937022 PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter GO:0008469 R-HSA-8937050 Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter GO:0042800 R-HSA-8937113 PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter GO:0008469 R-HSA-8937419 CBR3 reduces DOX to DOXOL GO:0004090 R-HSA-8937442 CES3 hydrolyses CHEST to CHOL and LCFA(-) GO:0052689 R-HSA-8937728 SRC phosphorylates RUNX1 GO:0004713 R-HSA-8937767 PTPN11 dephosphorylates RUNX1 GO:0004725 R-HSA-8937807 SRC phosphorylates RUNX3 GO:0004713 R-HSA-8937844 SRC,YES1 phosphorylate YAP1 GO:0004713 R-HSA-8938073 PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) GO:0003950 R-HSA-8938076 CD38 hydrolyses NAD+ to NAM and ADP-ribose GO:0003953 R-HSA-8938300 Vanin hydrolyses pantetheine to PanK, 2AET GO:0017159 R-HSA-8938314 ENPPs hydrolyse CoA-SH to PPANT, PAP GO:0016787 R-HSA-8938773 RNF144A polyubiquitinates PRKDC GO:0061630 R-HSA-8938815 RNF152 polyubiquitinates RRAGA GO:0061630 R-HSA-8939203 HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex GO:0042623 R-HSA-8939335 RNF181 polyubiquinates BCL10 GO:0061630 R-HSA-8939706 SCF(SKP2) polyubiquitinates RUNX2 GO:0061630 R-HSA-8939801 26S proteasome degrades PolyUb-RUNX2 GO:0004175 R-HSA-8939959 NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ GO:0000309 R-HSA-8939963 Activated AKT phosphorylates RUNX2 GO:0004674 R-HSA-8940070 NT5E:Zn2+ hydrolyses NAD+ GO:0008253 R-HSA-8940074 NT5E:Zn2+ hydrolyses NMN GO:0008253 R-HSA-8940100 CDK1 phosphorylates VCPIP1 GO:0004674 R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins GO:0004621 R-HSA-8940554 MMP2 cleaves OPTC GO:0004222 R-HSA-8940561 MMP7 cleaves OPTC GO:0004222 R-HSA-8940641 THOP1 cleaves oligopeptide fragment (8-16aa) GO:0004222 R-HSA-8940959 Neurolysin degrades neurotensin GO:0004222 R-HSA-8941312 ZCCHC6, ZCCHC11 are mRNA uridyltransferases GO:0050265 R-HSA-8941543 VRAC heteromer transports I-, Cl- from cytosol to extracellular region GO:0005225 R-HSA-8941701 UGT1A10 transfers GlcA from UDP-GlcA to GCTN GO:0015020 R-HSA-8942101 RNF20:RNF40 monoubiquitinates Histone H2B GO:0061630 R-HSA-8942208 ALOXE3 isomerises 12R-HpETE to HXA3 GO:0051120 R-HSA-8942302 MMP13 cleaves OPTC GO:0004222 R-HSA-8942575 N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG GO:0072590 R-HSA-8942607 Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes GO:0004713 R-HSA-8942836 CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 GO:0016301 R-HSA-8943003 SHPRH polyubiquitinates monoubiquitinated PCNA GO:0061630 R-HSA-8943040 HLTF polyubiquitinates monoubiquitinated PCNA GO:0061630 R-HSA-8943080 TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 GO:0061630 R-HSA-8943279 GGT dimers hydrolyse GSH GO:0036374 R-HSA-8943959 MMP2, MMP9 cleave SCUBE3 GO:0004222 R-HSA-8944454 mTORC1 phosphorylates MAF1 GO:0004674 R-HSA-8948039 FUNDC1 is phosphorylated by CK2 GO:0016301 R-HSA-8948139 p-S13-FUNDC1 is dephosphorylated by PGAM5 GO:0004722 R-HSA-8948143 p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 GO:0016301 R-HSA-8948146 FUNDC1 is phosphorylated by ULK1 at Ser17 GO:0016301 R-HSA-8948709 DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 GO:0004842 R-HSA-8948757 AKT phosphorylates MKRN1 GO:0004674 R-HSA-8948775 MKRN1 polyubiquitinates PTEN GO:0061630 R-HSA-8948800 TNKS and TNKS2 PARylate PTEN GO:0003950 R-HSA-8948832 RNF146 polyubiquitinates PARylated PTEN GO:0061630 R-HSA-8949145 VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space GO:0005262 R-HSA-8949178 MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix GO:0005262 R-HSA-8949649 PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) GO:0004222 R-HSA-8949659 AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU GO:0004222 R-HSA-8949668 YME1L1 proteolyzes unassembled proSMDT1 GO:0004222 R-HSA-8949687 LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) GO:0015369 R-HSA-8949688 SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) GO:0005432 R-HSA-8949703 SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) GO:0005432 R-HSA-8950113 IL12A binds IL12B GO:0003756 R-HSA-8950183 IL12B binds IL23A GO:0003756 R-HSA-8950269 STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor GO:0004714 R-HSA-8950340 IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation GO:0004714 R-HSA-8950354 STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction GO:0004714 R-HSA-8950364 IL23R in IL23:IL23 receptor complex is phosphorylated GO:0004714 R-HSA-8950405 JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated GO:0004714 R-HSA-8950423 JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated GO:0004714 R-HSA-8950453 JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 GO:0004714 R-HSA-8950456 IL12B dimerizes GO:0003756 R-HSA-8950485 STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction GO:0004714 R-HSA-8950537 JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated GO:0004714 R-HSA-8950591 JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated GO:0004714 R-HSA-8950757 IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated GO:0004714 R-HSA-8951648 NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 GO:0019788 R-HSA-8951661 Transfer of NEDD8 to AcM-UBE2M GO:0019788 R-HSA-8951764 Transfer of NEDD8 to AcM-UBE2F GO:0019788 R-HSA-8951850 TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane GO:0017127 R-HSA-8951966 EP300 acetylates RUNX3 GO:0061733 R-HSA-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex GO:0019788 R-HSA-8952069 HDAC4 deacetylates RUNX3 GO:0033558 R-HSA-8952137 Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate GO:0016787 R-HSA-8952251 PLA2G15 hydrolyses LPC to GPCho and LCFA(-) GO:0047499 R-HSA-8952289 FAM20C phosphorylates FAM20C substrates GO:0004674 R-HSA-8952382 MDM2 polyubiquitinates RUNX3 GO:0061630 R-HSA-8952408 Polyubiquitinated RUNX3 is degraded by the proteasome GO:0004175 R-HSA-8952419 SMURFs ubiquitinate RUNX3 GO:0061630 R-HSA-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex GO:0019788 R-HSA-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex GO:0019788 R-HSA-8952726 SLC38A9 transports L-Arg from lysosomal lumen to cytosol GO:0015171 R-HSA-8952873 MECR dimer reduces tdec2-CoA to DEC-CoA GO:0019166 R-HSA-8952903 ADPRHL2 hydrolyses poly(ADP-ribose) GO:0004649 R-HSA-8953339 DNPH1 hydrolyses dGMP GO:0070694 R-HSA-8953398 PIR oxygenates quercetin GO:0008127 R-HSA-8953430 PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix GO:0015267 R-HSA-8953499 IMPAD1 hydrolyses PAP to AMP GO:0008441 R-HSA-8953946 PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 GO:0061630 R-HSA-8954262 TPST1,2 transfer SO4(2-) from PAPS to PODXL2 GO:0008476 R-HSA-8954327 UCKL1 phosphorylates urindine, cytidine GO:0004849 R-HSA-8954398 PLD6 dimer hydrolyses cardiolipin to PA and PG GO:0035755 R-HSA-8954468 NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA GO:0017188 R-HSA-8955010 LRTOMT transfers methyl group from AdoMet to DA, forming 3MT GO:0016206 R-HSA-8955030 NADK2 dimer phosphorylates NAD+ to NADP+ GO:0003951 R-HSA-8955706 TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin GO:0004835 R-HSA-8955712 TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin GO:0004181 R-HSA-8955760 PGM2L1:Mg2+ phosphorylates G6P to G1,6BP GO:0047933 R-HSA-8955794 PGP:Mg2+ dimer hydrolyses 3PG to glycerol GO:0043136 R-HSA-8955817 PRODH2 oxidises HPRO to 1PYR-5COOH GO:0004657 R-HSA-8955844 RBKS phosphorylates ribose to R5P GO:0004747 R-HSA-8955869 Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin GO:0070740 R-HSA-8956025 AcM-UBE2M transfers NEDD8 to CUL9:RBX1 GO:0019788 R-HSA-8956026 CUL9:RBX1 ubiquitinates BIRC5 GO:0061630 R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes GO:0019784 R-HSA-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex GO:0019784 R-HSA-8956106 VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha GO:0004842 R-HSA-8956365 ZBED1 (DREF) SUMOylates CHD3 with SUMO1 GO:0019789 R-HSA-8956427 RETSAT reduces atROL to at-13,14-dhROL GO:0051786 R-HSA-8956458 RNLS:FAD oxidises dh-beta-NAD to NAD+ GO:0016651 R-HSA-8956659 ABL1 phosphorylates YAP1 GO:0004713 R-HSA-8956684 ITCH polyubiquitinates TP73 GO:0061630 R-HSA-8957265 26S proteasome degrades TP73 polyubiquitinated by ITCH GO:0004175 R-HSA-8957389 RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA GO:0018812 R-HSA-8959462 SAMD8 transforms PE and CERA to CPE GO:0002950 R-HSA-8959510 SEPHS2 phosphorylates H2Se to form SELP GO:0004756 R-HSA-8959719 SHPK phosphorylates Sedo to Sedo7P GO:0050277 R-HSA-8959781 SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix GO:0015174 R-HSA-8959798 SLC30A10 transports Mn2+ from cytosol to extracellular region GO:0005384 R-HSA-8964242 G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC GO:0004672 R-HSA-8964252 G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC GO:0004672 R-HSA-8964604 CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated GO:0005085 R-HSA-8979996 LIPs hydrolyze TG to DAG and LCFA GO:0004465 R-HSA-8980228 LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA GO:0004465 R-HSA-8981353 RASA1 stimulates RAS GTPase activity GO:0003924 R-HSA-8981553 GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol GO:0055056 R-HSA-8981564 GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol GO:0055056 R-HSA-8981570 GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol GO:0055056 R-HSA-8981574 GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol GO:0055056 R-HSA-8982020 G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated GO:0003924 R-HSA-8982021 G alpha (z) in G alpha (z):RGS complex is inactivated GO:0003924 R-HSA-8982025 G alpha (q) in G (q):RGS complex is inactivated GO:0003924 R-HSA-8982163 IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 GO:0004714 R-HSA-8982637 Opsins binds G alpha-t GO:0005085 R-HSA-8982640 G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) GO:0005085 R-HSA-8982667 PGM2:Mg2+ isomerises dR1P to dR5P GO:0008973 R-HSA-8983059 STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex GO:0019199 R-HSA-8983063 JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated GO:0019199 R-HSA-8983300 IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 GO:0004714 R-HSA-8983309 IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 GO:0004714 R-HSA-8983371 IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 GO:0004714 R-HSA-8983424 IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 GO:0004714 R-HSA-8983680 OAS1 produces oligoadenylates GO:0001730 R-HSA-8983872 JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 GO:0004672 R-HSA-8985091 OAS3 produces oligoadenylates GO:0001730 R-HSA-8985104 OAS2 produces oligoadenylates GO:0001730 R-HSA-8985594 MYO9B inactivates RHOA GO:0005096 R-HSA-8986083 USP33 deubiquitinates ROBO1 GO:0004843 R-HSA-8986181 PITRM1 proteolyzes mitochondrial targeting peptides (presequences) GO:0008237 R-HSA-8986937 MECP2 is phosphorylated at T308 GO:0010857 R-HSA-8986985 IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 GO:0004714 R-HSA-8986994 IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 GO:0004714 R-HSA-8986995 IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA GO:0004714 R-HSA-8987012 IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 GO:0004714 R-HSA-8987040 IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 GO:0004714 R-HSA-8987042 IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 GO:0004714 R-HSA-8987070 IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 GO:0004714 R-HSA-8987084 IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 GO:0004714 R-HSA-8987096 IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 GO:0004714 R-HSA-8987129 JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated GO:0004714 R-HSA-8987141 IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 GO:0004714 R-HSA-8987150 IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 GO:0004714 R-HSA-8987179 IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 GO:0004714 R-HSA-8987202 IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 GO:0004714 R-HSA-8987255 IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 GO:0004714 R-HSA-9005561 Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308 GO:0010857 R-HSA-9006323 Phospho-JAK2 phosphorylates EPOR GO:0004713 R-HSA-9006332 JAK2 transphosphorylates and is activated in response to Erythropoietin GO:0004713 R-HSA-9006992 MECP2 is phosphorylated at S423 GO:0004683 R-HSA-9007539 CHEK1 phosphorylates E2F6 GO:0004674 R-HSA-9008076 WWP1 polyubiquitinates RUNX2 GO:0061630 R-HSA-9008110 Proteasome degrades polyubiquitinated RUNX2 GO:0004175 R-HSA-9008412 CDK4 phosphorylates RUNX2 GO:0004693 R-HSA-9008475 Proteasome degrades polyubiquitinated RUNX2 GO:0004175 R-HSA-9008479 FBXW7 polyubiquitinates RUNX2 GO:0061630 R-HSA-9008480 GSK3B phosphorylates RUNX2 GO:0004674 R-HSA-9008822 PPM1D dephosphorylates RUNX2 GO:0004674 R-HSA-9009208 Activated ERKs phosphorylate RUNX2 GO:0004674 R-HSA-9009282 CDK1 phosphorylates RUNX2 GO:0004693 R-HSA-9009308 STUB1 polyubiquitinates RUNX2 GO:0061630 R-HSA-9009362 Proteasome degrades PolyUb-RUNX2 GO:0004175 R-HSA-9009403 SMURF1 polyubiquitinates RUNX2 GO:0061630 R-HSA-9009936 RNASEL cleaves cellular ssRNA GO:0004521 R-HSA-9009941 RNASEL cleaves viral ssRNA GO:0004521 R-HSA-9009950 PDE12 cleaves 2'-5' oligoadenylates GO:0034611 R-HSA-9010034 ADAM10:Zn2+:TSPANs cleaves APP(18-770) GO:1902945 R-HSA-9010096 Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) GO:0004175 R-HSA-901024 MAN1B1 hydrolyses 1,2-linked mannose (a branch) GO:0004571 R-HSA-901036 MAN1B1 hydrolyses a second 1,2-linked mannose (a branch) GO:0004571 R-HSA-901039 MAN1B1 hydrolyses 1,2-linked mannose (c branch) GO:0004571 R-HSA-9010681 PKC phosphorylates ROBO3.1 GO:0004674 R-HSA-901074 MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) GO:0004571 R-HSA-901097 kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2] GO:0016212 R-HSA-9011241 SRC phosphorylates ROBO3.1 in response to NTN1 GO:0004713 R-HSA-9011300 ZSWIM8 ubiquitinates ROBO3.1 GO:0061630 R-HSA-9011313 Proteasome degrades ubiquitinated ROBO3.1 GO:0004175 R-HSA-9011595 GSTZ1 dimer dehalogenates DCA to glyoxylate GO:0019120 R-HSA-9011949 KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers GO:0032454 R-HSA-9011985 KDM1A demethylates H3 on MYC and BCL genes in response to estrogen GO:0032454 R-HSA-9012016 FAHD1:Zn2+ dimer hydrolyses OA to PYR GO:0008948 R-HSA-9012036 ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR GO:0004473 R-HSA-9012268 ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR GO:0004471 R-HSA-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD GO:0004674 R-HSA-9012349 ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR GO:0004473 R-HSA-9012374 VDAC1 transports PYR from cytosol to mitochondrial intermembrane space GO:0008308 R-HSA-9012556 IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 GO:0004197 R-HSA-9012597 GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu GO:0047801 R-HSA-9012650 JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 GO:0004713 R-HSA-9012721 MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR GO:0016784 R-HSA-9013069 Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 GO:0004842 R-HSA-9013198 TST transfers sulfur from S2O3(2-) to HCN to form HSCN GO:0004792 R-HSA-9013284 NOTCH3-ligand complex is cleaved to produce NEXT3 GO:0008237 R-HSA-9013361 NEXT3 is cleaved to produce NICD3 GO:0004190 R-HSA-9013471 MPST transfers sulfur from 3MPYR to HCN to form HSCN GO:0016784 R-HSA-9013533 MPST transfers sulfur from sulfanegen to HCN to form HSCN GO:0016784 R-HSA-9013895 Caspase-8 processing within TLR3 complex GO:0004197 R-HSA-9013974 Auto-ubiquitination of TRAF3 within activated TLR3 complex GO:0004842 R-HSA-9013978 Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex GO:0004674 R-HSA-9014342 K63-linked ubiquitination of RIP1 bound to the activated TLR complex GO:0004842 R-HSA-9014627 SDS dimers:PXLP dehydrate L-Thr to 2AA GO:0016836 R-HSA-9014641 HRSP12 deaminates 2AA to 2OBUTA GO:0019239 R-HSA-9014741 SRR dimer:PXLP deaminates D-Ser GO:0008721 R-HSA-9014766 SRR dimer:PXLP isomerises L-Ser to D-Ser GO:0030378 R-HSA-9017817 Gamma-secretase cleaves YBX1:NOTCH3 GO:0004190 R-HSA-9018572 EGFR phosphorylates NOTCH3 GO:0004713 R-HSA-9018858 ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE GO:0004051 R-HSA-9018859 ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE GO:0004051 R-HSA-9018862 LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 GO:0004301 R-HSA-9018863 ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE GO:0004051 R-HSA-9018867 5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 GO:0003959 R-HSA-9018868 GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE GO:0047066 R-HSA-9018874 CYP monooxygenates EPA to 18(S)-HpEPE GO:0004497 R-HSA-9018877 LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 GO:0004301 R-HSA-9018880 Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE GO:0016702 R-HSA-9018894 ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE GO:0004051 R-HSA-9018895 GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE GO:0047066 R-HSA-9018901 5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2 GO:0003959 R-HSA-9018907 ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 GO:0050473 R-HSA-9020249 Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6 GO:0016491 R-HSA-9020251 ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA GO:0004051 R-HSA-9020252 LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 GO:0004301 R-HSA-9020253 LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 GO:0004301 R-HSA-9020255 ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA GO:0004051 R-HSA-9020256 ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA GO:0004051 R-HSA-9020257 LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 GO:0004301 R-HSA-9020258 LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 GO:0004301 R-HSA-9020259 ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA GO:0004051 R-HSA-9020260 Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5 GO:0016491 R-HSA-9020261 Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA GO:0050473 R-HSA-9020262 ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA GO:0050473 R-HSA-9020264 ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA GO:0004051 R-HSA-9020270 LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 GO:0004301 R-HSA-9020271 GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA GO:0047066 R-HSA-9020273 GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA GO:0047066 R-HSA-9020274 ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA GO:0016702 R-HSA-9020275 ALOX15 oxidises DHA to 17(S)-Hp-DHA GO:0050473 R-HSA-9020277 ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA GO:0004051 R-HSA-9020278 ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA GO:0004051 R-HSA-9020282 ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA GO:0004051 R-HSA-9020610 ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 GO:0050473 R-HSA-9021357 PRKCI phosphorylates ELF3 GO:0004674 R-HSA-9021523 WWP2 ubiquitinates NOTCH3 GO:0061630 R-HSA-9021627 EPOR-associated PI3K phosphorylates PIP2 to PIP3 GO:0046934 R-HSA-9022314 HIPK2 phosphorylates MECP2 GO:0004674 R-HSA-9023132 AURKB phosphorylates MECP2 at S423 GO:0004674 R-HSA-9023159 Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87)) GO:0004181 R-HSA-9023163 Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) GO:0004181 R-HSA-9023171 Insulin secretory granule translocates across the cortical actin network GO:0000146 R-HSA-9023173 Insulin secretory granule docks at the plasma membrane GO:0000149 R-HSA-9023178 PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) GO:0004252 R-HSA-9023196 PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) GO:0004252 R-HSA-9023617 Butyrylcholinesterase hydrolyzes acyl Ghrelin GO:0016788 R-HSA-9023619 Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin GO:0016788 R-HSA-9023626 DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) GO:0004252 R-HSA-9023627 DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) GO:0004252 R-HSA-9023632 DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) GO:0004252 R-HSA-9023633 DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) GO:0004252 R-HSA-9023909 C3PO hydrolyzes cleaved passenger strand GO:0004521 R-HSA-9023912 AGO2 cleaves passenger strand of duplex siRNA GO:0004521 R-HSA-9023941 MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 GO:0004520 R-HSA-9023943 MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end GO:0008296 R-HSA-9023968 HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 GO:0016404 R-HSA-9024159 FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe) GO:0052666 R-HSA-9024161 FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) GO:0009020 R-HSA-9024624 Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6 GO:0016491 R-HSA-9024630 Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5 GO:0016491 R-HSA-9024726 LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 GO:0004713 R-HSA-9024766 HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 GO:0016404 R-HSA-9024872 ALOX15 oxidises 17(S)-Hp-DHA to PDX GO:0050473 R-HSA-9024881 ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA GO:0050473 R-HSA-9024890 LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 GO:0004301 R-HSA-9024973 Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 GO:0004301 R-HSA-9024983 ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA GO:0004052 R-HSA-9024993 EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 GO:0004301 R-HSA-9024997 ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA GO:0004051 R-HSA-9025007 Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1 GO:0016491 R-HSA-9025152 ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 GO:0050473 R-HSA-9025957 ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 GO:0004052 R-HSA-9025995 ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 GO:0004051 R-HSA-9025996 ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 GO:0004051 R-HSA-9025998 Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA GO:0004301 R-HSA-9025999 ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 GO:0004051 R-HSA-9026000 Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA GO:0004301 R-HSA-9026001 Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA GO:0016491 R-HSA-9026003 ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 GO:0050473 R-HSA-9026005 ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA GO:0004051 R-HSA-9026006 ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 GO:0004052 R-HSA-9026007 ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 GO:0004052 R-HSA-9026008 Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA GO:0004301 R-HSA-9026405 ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 GO:0004051 R-HSA-9026408 PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 GO:0016702 R-HSA-9026464 BDNF-bound NTRK2 dimers trans-autophosphorylate GO:0004713 R-HSA-9026502 NTF3-bound NTRK2 dimers trans-autophosphorylate GO:0004713 R-HSA-9026510 NTF4-bound NTRK2 dimers trans-autophosphorylate GO:0004713 R-HSA-9026579 NTRK2 phosphorylates PLCG1 GO:0004713 R-HSA-9026757 GGT hydrolyses MCTR1 to MCTR2 GO:0036374 R-HSA-9026771 DPEP hydroyses MCTR2 to MCTR3 GO:0016805 R-HSA-9026777 GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 GO:0004364 R-HSA-9026780 LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 GO:0004364 R-HSA-9026890 NTRK2 phosphorylates SHC1 GO:0004713 R-HSA-9026891 NTRK2 activates RAS signaling through SHC1 GO:0005088 R-HSA-9026901 GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1 GO:0004364 R-HSA-9026907 GGT hydrolyses PCTR2 to PCTR3 GO:0036374 R-HSA-9026911 LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 GO:0004364 R-HSA-9026912 GGT hydrolyses PCTR1 to PCTR2 GO:0036374 R-HSA-9026916 GGT hydrolyses RCTR2 to RCTR3 GO:0036374 R-HSA-9026917 Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA GO:0016491 R-HSA-9026918 Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA GO:0016702 R-HSA-9026927 GGT hydrolyses RCTR1 to RCTR2 GO:0036374 R-HSA-9027033 Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA GO:0016491 R-HSA-9027042 CPY4 -oxidises 14(S)-HDHA to MaR-L1 GO:0004497 R-HSA-9027043 CYPs hydroxylate DHA to 14(R)-HDHA GO:0004497 R-HSA-9027044 CYP4 -oxidises 14(R)-HDHA to MaR-L2 GO:0004497 R-HSA-9027272 EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 GO:0004713 R-HSA-9027273 JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 GO:0004713 R-HSA-9027302 CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA GO:0004497 R-HSA-9027321 CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA GO:0004497 R-HSA-9027425 LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 GO:0004713 R-HSA-9027531 Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA GO:0004033 R-HSA-9027532 PTGS2 dimer oxidises DHA to 13-HDHA GO:0050473 R-HSA-9027562 Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA GO:0004033 R-HSA-9027598 Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3 GO:0004033 R-HSA-9027600 Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3 GO:0004033 R-HSA-9027607 Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 GO:0050473 R-HSA-9027624 ALOX5 oxidises DHA to 7-HDHA GO:0004051 R-HSA-9027625 5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 GO:0003959 R-HSA-9027627 Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) GO:0050473 R-HSA-9027628 ALOX5 oxidises EPA to 5-HEPE GO:0004051 R-HSA-9027631 5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA GO:0003959 R-HSA-9027632 5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA GO:0003959 R-HSA-9027633 ALOX5 oxidises DPAn-3 to 7-HDPAn-3 GO:0004051 R-HSA-9028255 PTGS2 dimer oxidises EPA to PGH3 GO:0050473 R-HSA-9028519 NTRK2-activated PI3K generates PIP3 GO:0035004 R-HSA-9028728 NTRK2 phosphorylates FRS2 GO:0004713 R-HSA-9029151 JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 GO:0004713 R-HSA-9029155 JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 GO:0004713 R-HSA-9029158 EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS GO:0005088 R-HSA-9032067 NTRK2 activates RAS signaling through FRS2 GO:0005088 R-HSA-9032426 NTRK2 phosphorylates FRS3 GO:0004713 R-HSA-9032478 EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate GO:0004435 R-HSA-9032532 NTRK2-bound FYN autophosphorylates GO:0004713 R-HSA-9032601 FYN-mediated phosphorylation of GRIN2B GO:0004713 R-HSA-9032751 Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 GO:0004674 R-HSA-9032798 DOCK3 activates RAC1 GO:0030676 R-HSA-9032854 NTRK2 phosphorylates CDK5 GO:0004713 R-HSA-9032863 CDK5 phosphorylates NTRK2 GO:0004674 R-HSA-9033284 NTRK2 promotes TIAM1 phosphorylation GO:0004713 R-HSA-9033292 NTRK2 and CDK5 promote activation of RAC1 by TIAM1 GO:0030676 R-HSA-9033478 USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin GO:0036459 R-HSA-9033485 PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 GO:0061630 R-HSA-9033490 TYSND1 cleaves PHYH GO:0004252 R-HSA-9033491 USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin GO:0036459 R-HSA-9033499 PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol GO:0043492 R-HSA-9033505 PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 GO:0043492 R-HSA-9033506 TYSND1 cleaves AGPS GO:0004252 R-HSA-9033515 TYSND1 cleaves ACOX1 GO:0004252 R-HSA-9033520 TYSND1 cleaves TYSND1 GO:0004252 R-HSA-9033524 TYSND1 cleaves SCP2 GO:0004252 R-HSA-9033529 TYSND1 cleaves ACAA1 GO:0004252 R-HSA-9033530 TYSND1 cleaves HSD17B4 GO:0004252 R-HSA-9034539 SRR dimer:PXLP deaminates L-Ser GO:0008721 R-HSA-9034714 NTRK3 dimers trans-autophosphorylate GO:0004713 R-HSA-9034756 MPST transfers sulfur atom from 3MPYR to form CysS248-MPST GO:0016784 R-HSA-9034814 NTRK3 phosphorylates PLCG1 GO:0004713 R-HSA-9034875 NTRK3 phosphorylates SHC1 GO:0004713 R-HSA-9036727 GAA hydrolyzes lysosomal glycogen GO:0090599 R-HSA-9037040 SRC,FYN phosphorylate NTRK2 GO:0004713 R-HSA-9037761 CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 GO:0004497 R-HSA-9038161 Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG GO:0042623 R-HSA-904830 SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region GO:0005381 R-HSA-904864 Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate GO:0008453 R-HSA-909552 Phosphorylation of STAT1 at Ser727 GO:0004674 R-HSA-909718 Formation of p-STAT1 homodimer GO:0004713 R-HSA-909726 Phosphorylation of STAT1 GO:0004713 R-HSA-909729 Activation of JAK kinases GO:0004713 R-HSA-909730 Phosphorylation of INFAR1 by TYK2 GO:0004713 R-HSA-909732 Phosphorylation of STAT2 GO:0004713 R-HSA-909776 beta-alanine + pyruvate => 3-oxopropanoate + alanine GO:0016223 R-HSA-909780 (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine GO:0047305 R-HSA-912368 SPO11 hydrolyzes DNA forming double-strand breaks GO:0016888 R-HSA-912458 Formation of meiotic heteroduplex GO:0000150 R-HSA-912470 ATR phosphorylates Histone H2A.X at unsynapsed regions GO:0004674 R-HSA-912629 CBL is tyrosine phosphorylated GO:0004713 R-HSA-913451 IL3RB is phosphorylated on Ser-585 GO:0004691 R-HSA-913675 GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens GO:0004653 R-HSA-913996 PKA/PKG phosphorylate Rap1GAP2 GO:0004674 R-HSA-914010 Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein GO:0008499 R-HSA-914012 GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins GO:0003829 R-HSA-914018 Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein GO:0003829 R-HSA-914036 SHP1 and SHP2 dephosphorylate Y628 of IL3RB GO:0004725 R-HSA-916855 Conversion of GABA to Succinate Semialdehyde GO:0003867 R-HSA-917693 ESCRT Disassembly GO:0016887 R-HSA-917744 GABA loaded synaptic vesicle Docking and Priming GO:0000149 R-HSA-917805 CYBRD1:Heme reduces Fe3+ to Fe2+ GO:0016722 R-HSA-917811 STEAP3-like proteins reduce Fe3+ to Fe2+ GO:0016723 R-HSA-917841 Acidification of Tf:TfR1 containing endosome GO:0015078 R-HSA-917870 SLC46A1 transports FeHM from extracellular region to cytosol GO:0015232 R-HSA-917891 SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ GO:0004322 R-HSA-917892 FLVCR transports heme from cytosol to extracellular region GO:0015232 R-HSA-917933 SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ GO:0004322 R-HSA-917936 MCOLN1 transports Fe2+ from endosome lumen to cytosol GO:0005381 R-HSA-917979 ABCG2 dimer transports heme from cytosol to extracellular region GO:0015232 R-HSA-918224 DDX58 is K63 polyubiquitinated GO:0004842 R-HSA-918229 Phosphorylation and release of IRF3/IRF7 GO:0004672 R-HSA-927836 SMG6 hydrolyzes mRNA with premature termination codon GO:0004521 R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) GO:0004674 R-HSA-933525 Phosphorylation and release of IRF7 GO:0004672 R-HSA-933530 Activation of IKK by MEKK1 GO:0004672 R-HSA-933532 Processing of caspases GO:0004197 R-HSA-934559 SPRY2 is phosphorylated by phosphorylated MNK1 GO:0004674 R-HSA-934604 Phosphorylated SPRY2 is ubiquitinated by CBL GO:0061630 R-HSA-936381 OTUD5 deubiquitinates TRAF3 GO:0061578 R-HSA-936390 CYLD mediated deubiquitination of DDX58 (RIG-I) GO:0061578 R-HSA-936412 RNF125 mediated ubiquitination of DDX58, IFIH1 and MADS GO:0004842 R-HSA-936462 PIN1 mediated IRF3 degradation GO:0061630 R-HSA-936475 Negative regulation of DDX58/IFIH1 signaling by RNF216 GO:0061630 R-HSA-936802 ATP7A transports cytosolic Cu2+ to extracellular region GO:0004008 R-HSA-936883 ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen GO:0005388 R-HSA-936895 ATP7B transports cytosolic Cu2+ to Golgi lumen GO:0043682 R-HSA-936897 ATP1A:ATP1B:FXYD exchanges Na+ for K+ GO:0005391 R-HSA-936942 Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 GO:0004842 R-HSA-936951 Activation of TAK1 complex bound to activated TLR4 complex GO:0004674 R-HSA-936986 Activated TRAF6 synthesizes unanchored polyubiquitin chains GO:0004842 R-HSA-936991 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 GO:0004674 R-HSA-937022 IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP GO:0004674 R-HSA-937034 IRAK1 phosphorylates Pellino GO:0004672 R-HSA-937050 Pellino ubiquitinates hp-IRAK1 GO:0034450 R-HSA-937059 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex GO:0004672 R-HSA-937311 ATP4A/12A:ATP4B exchanges K+ for H+ GO:0008900 R-HSA-939265 Activation of Rap1 by membrane-associated GEFs GO:0005085 R-HSA-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane GO:0004012 R-HSA-947499 Exchange of oxygen with sulfur in MoCo GO:0008265 R-HSA-947514 NFS1 transfers sulfur from cysteine onto MOCS3 GO:0031071 R-HSA-947531 Molybdenum ion transfer onto molybdopterin GO:0061599 R-HSA-947535 Cyclisation of GTP to precursor Z GO:1904047 R-HSA-947538 Transfer of sulfur from MOCS3-S-S onto MOCS2A GO:0016783 R-HSA-947541 Sulfhydrylation and ring cleavage of precursor Z GO:0030366 R-HSA-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane GO:0004012 R-HSA-947991 Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi GO:0005537 R-HSA-9603420 Activated NTRK3 promotes SRC autophosphorylation GO:0004713 R-HSA-9603445 Activated NTRK3 stimulates PI3K activity GO:0046934 R-HSA-9603534 Unknown caspase cleaves NTRK3 GO:0004197 R-HSA-9603719 Protein tyrosine phosphatases dephosphorylate NTRK3 GO:0004725 R-HSA-9604264 ADAM10 cleaves NOTCH4 GO:0008237 R-HSA-9604294 Gamma-secretase cleaves NOTCH4 GO:0004190 R-HSA-9604328 AKT1 phosphorylates NOTCH4 GO:0004674 R-HSA-9604606 Unknown kinase phosphorylates NICD4 GO:0004672 R-HSA-9604629 FBXW7 promotes ubiquitination of p-NICD4 GO:0061630 R-HSA-9604642 Proteasome degrades ubiquitinated NICD4 GO:0004175 R-HSA-9604829 SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters GO:0046969 R-HSA-9606159 BTK autophosphorylates GO:0004713 R-HSA-9606162 Phosphorylated BTK phosphorylates PLCG2 GO:0004713 R-HSA-9606163 p-SYK and LYN phosphorylate BTK GO:0004713 R-HSA-9612085 SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs GO:0004713 R-HSA-9612980 BRAF in Rap1-GTP complex:BRAF complex autophosphorylates GO:0004674 R-HSA-9612996 NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates GO:0004713 R-HSA-9613023 NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates GO:0004713 R-HSA-9613490 Unwinding of DNA for the nascent HIV-1 transcript: Second Transition GO:0004386 R-HSA-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition GO:0004386 R-HSA-9613497 Unwinding DNA for the nascent transcript GO:0004386 R-HSA-9613498 Unwinding of DNA for the nascent HIV-1 transcript GO:0004386 R-HSA-9615042 Viral 2',5'-PDE cleaves 2'-5' oligoadenylates GO:0034611 R-HSA-9617583 CaMKII autophosphorylates GO:0004683 R-HSA-9617735 TXN disrupts FOXO4 complex with EP300 GO:0004791 R-HSA-9617758 EP300,CREBBP acetylate FOXO4 GO:0061733 R-HSA-9618750 CaMKII phosphorylates AMPA receptor GO:0004683 R-HSA-9619024 CES1trimer hydrolyses ACEI pro-drugs to ACEIs GO:0052689 R-HSA-9619125 CaMKK phosphorylates CAMK4 GO:0004683 R-HSA-9619355 CaMKK autophosphorylates in the cytosol GO:0004683 R-HSA-9619367 CaMKKs phosphorylate CAMK1 GO:0004683 R-HSA-9619430 PPM1E dephosphorylates CAMK4 GO:0004722 R-HSA-9619449 PPM1F dephosphorylates p-T286-CaMKII GO:0004722 R-HSA-9619467 PPM1F dephosphorylates CAMK1 GO:0004722 R-HSA-9619478 CAMKK2 phosphorylates AMPK GO:0004683 R-HSA-9619515 AMPK phosphorylates MAPT GO:0004674 R-HSA-9619783 CAMK1 phosphorylates ARHGEF7-1 GO:0004683 R-HSA-9619803 p-S516-ARHGEF7 activates RAC1 GO:0030676 R-HSA-9619843 ERKs phosphorylate RSKs GO:0004674 R-HSA-9620004 RSKs autophosphorylate GO:0004674 R-HSA-9620515 KAT2B,EP300 acetylate FOXO3 under oxidative stress GO:0061733 R-HSA-9620532 SIRT1,SIRT3 deacetylate FOXO3 GO:0034979 R-HSA-9626816 PIN1 binds p-S345-NCF1 GO:0003755 R-HSA-9626817 PKC phosphorylates NCF1 GO:0004697 R-HSA-9626832 MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 GO:0004707 R-HSA-9626880 MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 GO:0004674 R-HSA-9626945 CREBBP acetylates FOXO1 GO:0061733 R-HSA-9626962 SIRT1 deacetylates FOXO1 GO:0033558 R-HSA-9627089 CASP9 is phosphorylated at T125 GO:0004674 R-HSA-9628444 Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation GO:0004842 R-HSA-964737 Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 GO:0004571 R-HSA-964759 Alternative endo-mannosidase I route GO:0004569 R-HSA-964768 Addition of GlcNAc to the glycan on the A arm GO:0003827 R-HSA-964825 Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 GO:0004571 R-HSA-964830 Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 GO:0004571 R-HSA-964958 2xPDXK:2xZn2+ phosphorylates PXA GO:0008478 R-HSA-964962 2xPDKX:2xZn2+ phosphorylates PDX GO:0008478 R-HSA-964970 2xPDXK:2xZn2+ phosphorylates PXL GO:0008478 R-HSA-965019 2xPNPO:2xFMN oxidizes PDXP to PXLP GO:0004733 R-HSA-965067 THTPA:Mg2+ hydrolyzes ThTP to TDP GO:0050333 R-HSA-965079 2xPNPO:2xFMN oxidizes PXAP to PXLP GO:0004733 R-HSA-975118 TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation GO:0004842 R-HSA-975122 Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
GO:0034450 R-HSA-975125 Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 GO:0004674 R-HSA-975134 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 GO:0004674 R-HSA-975139 IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation GO:0004672 R-HSA-975147 Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane GO:0004842 R-HSA-975160 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 GO:0004674 R-HSA-975170 IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 GO:0004674 R-HSA-975180 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 GO:0004674 R-HSA-975311 HTR3 pentamer:5HT transports Na+,K+, and Ca2+ GO:0022850 R-HSA-975340 GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol GO:0005254 R-HSA-975389 GLRA:GLRB:Gly transports extracellular Cl- to cytosol GO:0016934 R-HSA-975449 GABRR pentamer:GABA transports extracellular Cl- to cytosol GO:0005254 R-HSA-975593 PNLIP:CLPS hydrolyses RPALM to atROL and PALM GO:0050253 R-HSA-975594 PLB1 hydrolyses RPALM to atROL GO:0050253 R-HSA-975608 LRAT esterifies RBP2:atROL and FACYLs to atREs GO:0047173 R-HSA-975629 RDH11 reduces RBP2:atRAL to RBP2:atROL GO:0016616 R-HSA-975635 BCMO1:Fe2+ cleaves betaC to atRAL GO:0003834 R-HSA-975814 Trimming of mannoses on the alpha1,6 arm by MAN2A1 GO:0004572 R-HSA-975829 Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 GO:0008455 R-HSA-975853 Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR GO:0004672 R-HSA-975861 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex GO:0004672 R-HSA-975865 IRAK4 autophosphorylation within the complex activated TLR:MyD88 GO:0004674 R-HSA-975874 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex GO:0004672 R-HSA-975878 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR GO:0004672 R-HSA-975902 ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans GO:0003835 R-HSA-975903 Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV GO:0008454 R-HSA-975916 Addition of GlcNAc to position 5 by MGAT5 GO:0030144 R-HSA-975919 Addition of galactose by beta 4-galactosyltransferases GO:0003831 R-HSA-975926 Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 GO:0003830 R-HSA-976743 Factor I inactivates plasma Factor H-bound C3b GO:0004252 R-HSA-977071 Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position GO:0003835 R-HSA-977228 Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position GO:0003835 R-HSA-977301 Histidine is decarboxylated to histamine GO:0004398 R-HSA-977317 malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome GO:0050080 R-HSA-977324 phosphoserine is dephosphorylated GO:0004647 R-HSA-977333 3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate GO:0004648 R-HSA-977348 3-phosphoglycerate is dehydrogenated GO:0004617 R-HSA-977371 Factor I inactivates Factor H-boundC3b GO:0004252 R-HSA-977615 Factor I inactivates MCP/CR1-bound C4b/C3b GO:0004252 R-HSA-981497 ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position GO:0003836 R-HSA-981809 ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen GO:0047290 R-HSA-981814 GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position GO:0008373 R-HSA-982807 JAK2 phosphorylation of GHR GO:0004713 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 GO:0004842 R-HSA-983144 Transport of Antigen peptide in to ER GO:0015433 R-HSA-983150 Proteasomal cleavage of substrate GO:0004175 R-HSA-983152 Transfer of ubiquitin from E1 to E2 GO:0043130 R-HSA-983153 E1 mediated ubiquitin activation GO:0004842 R-HSA-983156 Polyubiquitination of substrate GO:0004842 R-HSA-983158 Trimming of peptides in ER GO:0004175 R-HSA-983162 Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases GO:0004177 R-HSA-983422 Disassembly of COPII coated vesicle GO:0003924 R-HSA-983703 p-6Y-SYK phosphorylates BLNK (SLP65) GO:0004713 R-HSA-983707 SYK autophosphorylates at the activated BCR GO:0004713 R-HSA-983709 LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) GO:0004713 R-HSA-990526 Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1 GO:0061630 R-HSA-994137 ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 GO:0047325 R-HSA-994140 ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 GO:0052726 R-HSA-997263 JMJD1C demethylates H3K9 mono- and di-methylation GO:0032454 R-HSA-997309 Dephosphorylation of STAT1 by SHP2 GO:0004725 R-HSA-997311 Dephosphorylation of TYK2 by PTP1B GO:0004725 R-HSA-997314 Dephosphorylation of JAK1 by SHP1 GO:0004725 R-HSA-997326 Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP GO:0004725 R-HSA-997381 TDPK phosphorylates ThDP to ThTP GO:0050331